Development and physico-mechanical characterisation of lyophilised chitosan wafers as potential protein drug delivery systems via the buccal mucosa

Colloids and Surfaces B: Biointerfaces

Volumn 91, Issue 1, 2012, Pages 258-265

  Ayensu, Isaac ^a,b   Mitchell, John C ^a   Boateng, Joshua S ^a  

^a UNIVERSITY OF GREENWICH   (United Kingdom)

^b KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

Author keywords

Buccal delivery; Chitosan; Lyophilised wafers; Mucoadhesion; Protein

Indexed keywords

ANNEALING PROCESS; BOVINE SERUM ALBUMINS; BUCCAL DELIVERY; BUCCAL MUCOSA; CRYOPROTECTANTS; CRYSTALLINITIES; D-MANNITOL; DRUG RELEASE; DRUG RELEASE STUDY; FURTHER DEVELOPMENT; HYDRATION CAPACITY; IN-VITRO; LYOPHILISED WAFERS; MUCOADHESION; MUCOADHESIVE PROPERTIES; PHOSPHATE-BUFFERED SALINES; PHYSICOMECHANICAL PROPERTIES; POTENTIAL PROTEINS; RESIDUAL MOISTURE CONTENT; TENSILE MODE; TEXTURE ANALYSIS; THERMAL EVENTS;

ANNEALING; BODY FLUIDS; CHITOSAN; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY; GLYCEROL; GRAVIMETRIC ANALYSIS; HYDRATION; MAMMALS; PHASE SEPARATION; PLASTICIZERS; PROTEINS; REINFORCED PLASTICS; SCANNING ELECTRON MICROSCOPY; X RAY DIFFRACTION ANALYSIS;

MECHANICAL PROPERTIES;

BOVINE SERUM ALBUMIN; CHITOSAN; GLYCEROL; LYOPHILISED CHITOSAN WAFER; MANNITOL; PHOSPHATE BUFFERED SALINE; PLASTICIZER; UNCLASSIFIED DRUG;

ARTICLE; CHEEK MUCOSA; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; FREEZE DRYING; GEL; GLASS TRANSITION TEMPERATURE; HYDRATION; MOISTURE; MORPHOLOGY; MUCOADHESION; PHASE SEPARATION; POROSITY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; THERMOGRAVIMETRY; X RAY DIFFRACTION;

CALORIMETRY, DIFFERENTIAL SCANNING; CHEEK; CHITOSAN; FREEZE DRYING; HUMANS; MICROSCOPY, ELECTRON, SCANNING; MOUTH MUCOSA; PROTEINS; X-RAY DIFFRACTION;

BOVINAE;

EID: 84855188370     PISSN: 09277765     EISSN: 18734367     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2011.11.004     Document Type: Article

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