Characterisation of freeze-dried wafers and solvent evaporated films as potential drug delivery systems to mucosal surfaces

International Journal of Pharmaceutics

Volumn 389, Issue 1-2, 2010, Pages 24-31

  Boateng, Joshua S ^a   Auffret, Anthony D ^b   Matthews, Kerr H ^c   Humphrey, Michael J ^b   Stevens, Howard N E ^a   Eccleston, Gillian M ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c ROBERT GORDON UNIVERSITY   (United Kingdom)

Author keywords

Carboxymethyl cellulose; Freeze dried wafers; Physical properties; Sodium alginate; Solvent evaporated films

Indexed keywords

ALGINIC ACID; CARBOXYMETHYLCELLULOSE; PARACETAMOL; POLYMER;

ARTICLE; CHEMICAL ANALYSIS; COMPRESSION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DESORPTION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; EVAPORATION; FILM; FREEZE DRYING; HYDRATION; MOISTURE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; WAFER;

ACETAMINOPHEN; ALGINATES; CARBOXYMETHYLCELLULOSE; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FREEZE DRYING; GELS; GLUCURONIC ACID; HEXURONIC ACIDS; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, SCANNING; MUCOUS MEMBRANE; SOLVENTS; WATER; WOUNDS AND INJURIES;

EID: 77349122061     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.01.008     Document Type: Article

References (22)

1. Boateng J.S., Matthews K.H., Stevens H.N.E., and Eccleston G.M. Wound healing dressings and drug delivery systems: a review. J. Pharm. Sci. 97 (2008) 2892-2923
2. Boateng J.S., Stevens H.N., Eccleston G.M., Auffret A.D., Humphrey M.J., and Matthews K.H. Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces. Drug Dev. Ind. Pharm. 35 (2009) 986-996
3. Boateng J.S., Matthews K.H., Auffret A.D., Humphrey M.J., Stevens H.N., and Eccleston G.M. In vitro drug release studies of polymeric freeze-dried wafers and solvent-cast films using paracetamol as a model soluble drug. Int. J. Pharm. 378 (2009) 66-72
4. Boldyreva E.V., Drebushchak V.A., Paukov I.E., Kovalevskaya Y.A., and Drebushchak T.N. DSC and adiabatic calorimetry study of the polymorphs of paracetamol. J. Therm. Anal. Calorim. 77 (2004) 607-623
5. Capes J.S., and Cameron R.E. CrystEngComm. 9 (2007) 84 DOI:10.1039/b613663j
6. Di Martino P., Conflant P., Drache M., and Guyot J.C. A new pure paracetamol for direct compression: the orthorhombic form. Int. J. Pharm. 128 (1996) 1-8
7. Di Martino P., Conflant P., Drache M., Huvenne J.P., and Guyot-Herman A.-M. Preparation and physical characterisation of forms II and III of paracetamol. J. Therm. Anal. 48 (1997) 447-458
8. Espeau P., Ceolin R., Tamirit J., Perrin M.-A., Gauchi J.-P., and Levelier F. Polymorphism of paracetamol: relative stabilities of the monoclinic and orthorhombic phases inferred from topological pressure-temperature and temperature-volume phase diagrams. J. Pharm. Sci. 94 (2005) 524-539
9. Femi-Oyewo M.N., and Spring M.S. Studies on paracetamol crystals produced by growth in aqueous solutions. Int. J. Pharm. 112 (1994) 17-28
10. Gatti A.M., Pinchiorri P., and Monari E. Physical characterization of a new biomaterial for wound management. J. Mater. Sci. Mater. Med. 5 (2004) 190-193
11. Jones D.S., Woolfson A.D., and Brown A.F. Textural, viscoelastic and mucoadhesive properties of pharmaceutical gels composed of cellulose polymers. Int. J. Pharm. 151 (1997) 223-233
12. Jones D.S., Woolfson A.D., Djokic J., and Coulter W.A. Development and mechanical characterisation of bioadhesive semi-solid. polymeric systems containing tetracycline for the treatment of periodontal diseases. Pharm. Res. 13 (1996) 1734-1738
13. Jones D.S., Lawlor M.S., and Woolfson A.D. Rheological and mucoadhesive characterization of polymeric systems composed of poly(methylvinylether-co-maleic anhydride) and poly(vinylpyrrolidone), designed as platforms for topical drug delivery. J. Pharm. Sci. 92 (2003) 995-1007
14. Lansdown A.B. Calcium: a potential central regulator in wound healing in the skin. Wound Repair Regen. 10 (2002) 271-285
15. Lawlor M.S., Jones D.S., and Woolfson A.D. Mechanical and rheological characterisation of bioadhesive tetracycline-containing gels designed for the treatment of periodontal disease. J. Pharm. Pharmacol. s51 (1999) 78
16. Matthews, K.H., Stevens, H.N.E., Auffret, A.D., Humphrey, M.J., Eccleston, G.M., 2003. Wafer for wounds. International Patent. Pfizer Ltd., WO 03,037,395, August 05.
17. Matthews K.H., Stevens H.N.E., Auffret A.D., Humphrey M.J., and Eccleston G.M. Wafers for wound healing. Int. J. Pharm. 289 (2005) 51-62
18. Matthews K.H., Stevens H.N.E., Auffret A.D., Humphrey M.J., and Eccleston G.M. Gamma irradiation of lyophilised wound healing wafers. Int. J. Pharm. 313 (2006) 78-86
19. Matthews K.H., Stevens H.N.E., Auffret A.D., Humphrey M.J., and Eccleston G.M. Formulation, stability and thermal analysis of lyophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant. Int. J. Pharm. 356 (2008) 110-120
20. Morgan D.A. Wounds-what should a dressing formulary include?. Hosp. Pharm. 9 (2002) 261-266
21. Schultz G.S. Molecular regulation of wound healing. In: Bryant R.A. (Ed). Acute and Chronic Wounds: Nursing Management. 2nd ed. (1999), St Louis, MO, Mosby 413-429
22. Thomas A., Harding K.G., and Moore K. Alginates from wound dressings activate human macrophages to secrete tumour necrosis factor-α. Biomaterials 21 (2000) 1797-1802