Discovery of 2-(4-cyano-3-trifluoromethylphenyl amino)-4-(4-quinazolinyloxy)-6-piperazinyl(piperidinyl)-s-triazines as potential antibacterial agents

Medicinal Chemistry Research

Volumn 21, Issue 12, 2012, Pages 4177-4192

  Patel, Rahul V ^a   Kumari, Premlata ^a   Rajani, Dhanji P ^b   Chikhalia, Kishor H ^c  

^a SARDAR VALLABHBHAI NATIONAL INSTITUTE OF TECHNOLOGY   (India)

^b Microcare Laboratory   (India)

^c GUJARAT UNIVERSITY   (India)

Author keywords

2,4,6 Trichloro 1,3,5 triazine; 4 Amino 2 trifluoromethyl benzonitrile; 4 Hydroxyquinazoline; Antimicrobial activity; Antitubercular activity; Piperazine

Indexed keywords

4 [4 (4 ACETYL PIPERAZIN 1 YL) 6 (QUINAZOLIN 4 YLOXY) 1,3, 5 TRIAZIN 2 YLAMINO] 2 TRIFLUOROMETHYL BENZONITRILE; 4 [4 (4 BENZYL PIPERAZIN 1 YL) 6 (QUINAZOLIN 4 YLOXY) 1,3,5 TRIAZIN 2 YLAMINO] 2 TRIFLUOROMETHYL BENZONITRILE; 4 [4 (4 ETHYL PIPERAZIN 1 YL) 6 (QUINAZOLIN 4 YLOXY) 1,3,5 TRIAZIN 2 YLAMINO] 2 TRIFLUOROMETHYL BENZONITRILE; 4 [4 (4 ISOPROPYL PIPERAZIN 1 YL) 6 (QUINAZOLIN 4 YLOXY) 1,3,5 TRIAZIN 2 YLAMINO] 2 TRIFLUOROMETHYL BENZONITRILE; 4 [4 (4 METHYL PIPERAZIN 1 YL) 6 (QUINAZOLIN 4 YLOXY) 1,3,5 TRIAZIN 2 YLAMINO] 2 TRIFLUOROMETHYL BENZONITRILE; 4 [4 (4 PHENYL PIPERAZIN 1 YL) 6 (QUINAZOLIN 4 YLOXY) 1,3,5 TRIAZIN 2 YLAMINO] 2 TRIFLUOROMETHYL BENZONITRILE; 4 [4 (4 PYRIDIN 2 YL PIPERAZIN 1 YL) 6 (QUINAZOLIN 4 YLOXY) 1,3,5 TRIAZIN 2 YLAMINO] 2 TRIFLUOROMETHYL BENZONITRILE; 4 [4 (4 PYRIMIDIN 2 YL PIPERAZIN 1 YL) 6 (QUINAZOLIN 4 YLOXY) 1,3,5 TRIAZIN 2 YLAMINO] 2 TRIFLUOROMETHYL BENZONITRILE; 4 [4 (QUINAZOLIN 4 YLOXY) 6 [4 (2,3,4 TRIMETHOXY BENZYL)PIPERAZIN 1 YL] 1,3,5 TRIAZIN 2 YLAMINO] 2 TRIFLUOROMETHYL BENZONITRILE; 4 [4 (QUINAZOLIN 4 YLOXY) 6 [4 (3 TRIFLUOROMETHYL PHENYL)PIPERAZIN 1 YL] 1,3,5 TRIAZIN 2 YLAMINO] 2 TRIFLUOROMETHYL BENZONITRILE; 4 [4 MORPHOLIN 4 YL 6 (QUINAZOLIN 4 YLOXY) 1,3,5 TRIAZIN 2 YLAMINO] 2 TRIFLUOROMETHYL BENZONITRILE; 4 [4 PIPERIDIN 1 YL 6 (QUINAZOLIN 4 YLOXY) 1,3,5 TRIAZIN 2 YLAMINO] 2 TRIFLUOROMETHYL BENZONITRILE; 4 [4 [4 (2 FLUORO PHENYL)PIPERAZIN 1 YL] 6 (QUINAZOLIN 4 YLOXY) 1,3,5 TRIAZIN 2 YLAMINO] 2 TRIFLUOROMETHYL BENZONITRILE; 4 [4 [4 (2,3 DICHLORO PHENYL) PIPERAZIN 1 YL] 6 (QUINAZOLIN 4 YLOXY) 1,3,5 TRIAZIN 2 YLAMINO] 2 TRIFLUOROMETHYL BENZONITRILE; 4 [4 [4 (3 CHLORO PHENYL) PIPERAZIN 1 YL] 6 (QUINAZOLIN 4 YLOXY) 1,3,5 TRIAZIN 2 YLAMINO] 2 TRIFLUOROMETHYL BENZONITRILE; 4 [4 [4 (4 METHOXY PHENYL)PIPERAZIN 1 YL] 6 (QUINAZOLIN 4 YLOXY) 1,3,5 TRIAZIN 2 YLAMINO] 2 TRIFLUOROMETHYL BENZONITRILE; 4 [4 [4 [(4 CHLORO PHENYL)PHENYL METHYL]PIPERAZIN 1 YL] 6 (QUINAZOLIN 4 YLOXY) 1,3,5 TRIAZIN 2 YLAMINO] 2 TRIFLUOROMETHYL BENZONITRILE; ANTIFUNGAL AGENT; CIPROFLOXACIN; DIMETHYL SULFOXIDE; ETHAMBUTOL; ISONIAZID; KETOCONAZOLE; PIPERAZINE DERIVATIVE; PYRAZINAMIDE; QUINAZOLINE DERIVATIVE; RIFAMPICIN; TRIAZINE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AGAR DILUTION; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS CLAVATUS; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIGER; BACILLUS CEREUS; BACTERIAL STRAIN; BIOASSAY; CANDIDA ALBICANS; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ELEMENTAL ANALYSIS; ESCHERICHIA COLI; FLUORINE NUCLEAR MAGNETIC RESONANCE; FUNGAL STRAIN; IN VITRO STUDY; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS COMPLEX; NONHUMAN; NUCLEOPHILICITY; PROTEUS VULGARIS; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; SALMONELLA ENTERICA SEROVAR TYPHI; SHIGELLA; SHIGELLA FLEXNERIA; STAPHYLOCOCCUS AUREUS; SUBSTITUTION REACTION; ZONE OF INHIBITION;

EID: 84855171928     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-011-9950-4     Document Type: Article

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