Blood chemical changes and renal histological alterations induced by gentamicin in rats

Saudi Journal of Biological Sciences

Volumn 19, Issue 1, 2012, Pages 103-110

  Alarifi, Saud ^a   Al Doaiss, Amin ^a   Alkahtani, Saad ^a   Al Farraj, S A ^a   Al Eissa, Mohammed Saad ^b   Al Dahmash, B ^a   Al Yahya, Hamad ^a   Mubarak, Mohammed ^c  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b UNIVERSITY OF HAIL   (Saudi Arabia)

^c Assiut University   (Egypt)

Author keywords

Creatinine; Free radicals; Gentamicin; Histopathology; Nephrotoxicity; Rattus norvegicus; Transaminases; Tubular necrosis; Urea

Indexed keywords

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 84855169823     PISSN: 1319562X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sjbs.2011.11.002     Document Type: Article

References (57)

1. Abdel-Naim A.B., Abdel-Wahab M.H., Attia F.F. Protective effects of vitamin E and probucol against gentamicin-induced nephrotoxicity in rats. Pharmacol. Res. 1999, 40(2):183-187.
2. Abdel-Raheem I.T., Abdel-Ghany A.A., Mohamed G.A. Protective effect of quercetin against gentamicin-induced nephrotoxicity in rats. Biol. Pharm. Bull. 2009, 32(1):61-67.
3. Abdel-Raheem I.T., EL-Sherbeny G.A., Taye A. Green tea ameliorates of renal oxidative damage induced by gentamicin in rats. Pak. J. Pharm. Sci. 2010, 1(23):21-28.
4. Abo El-Sooud K. Comparative disposition kinetic and plasma protein binding of gentamicin sulphate in three juvenile animal species. J. Vet. Med. Appl. 2003, 50:196-200.
5. Ali B.H., Al-Wabel N., Mahmoud O., Mousa H.M., Hashad M. Curcumin has palliative action on gentamicin-induced nephrotoxicity in rats. Fundam. Clin. Pharmacol. 2005, 19:473-477.
6. Ali B.H., Al-Salam S., Al-Husseinia I., Nemmar A. Comparative protective effect of N-acetyl cysteine and tetramethylpyrazine in rats with gentamicin nephrotoxicity. J. Appl. Toxicol. 2008, 29:302-307.
7. Ali B.H., Al Záabi M., Blunden G., Nemmar A. Experimental gentamicin nephrotoxicity and agents that modify it: a mini-review of recent research. Mini Review. Basic Clin. Pharmacol. Toxicol. 2011, 9:225-232.
8. Alkahtani S., Alarifi Saud A., Al-Doaiss Amin Abdullah Detection of apoptotsis induced by gentamicin in rat hepatocytes. Int. J. Zoolog. Res. 2009, 5:161-170.
9. Al-Majed A.A., Mostafa A.M., Al-Rikabi A.C., Al-Shabanah O.A. Protective effects of oral Arabic gum administration on gentamicin-induced nephrotoxicity in rats. Pharmacol. Res. 2002, 46(5):445-450.
10. Amici M., Eusebi F., Miledi R. Effects of the antibiotic gentamicin on nicotinic acetylcholine receptors. Neuropharmacology 2005, 49(5):79-88.
11. Babu S.V., Urolagin D.K., Veeresh B., Attanshetty N. Anogeissus latifolia prevents gentamicin induced nephrotoxicity in rats. Int. J. Pharm. Sci. 2011, 3(1):1091-1095.
12. Bancroft, J.D., Stevens, A., 1999. Theory and Practice of Histological Techniques, fourth ed. Churchill-Livingstone, London.
13. Banday, A.A., Farooq, Neelam, Priyamvada, Shubha, Yusufi, Ahad N.K., Khan, Farah, 2008. Time dependent effects of gentamicin on the enzymes of carbohydrate metabolism, brush border membrane and oxidative stress in rat kidney tissues. Life Sci. 82 (9-10), 450-459.
14. Begg E.J., Barclay M.L. Aminoglycisides-50 years on. Br. J. Clin. Pharmacol. 1995, 39:597-603.
15. Can C., Sen S., Boztok N., Lular I. Protective effect of oral l-arginine administration on gentamicin-induced renal failure in rats. Eur. J. Pharmacol. 2000, 390(3):327-334.
16. Chambers, H.F., 2001. The aminoglycosides. In: Hardman, J.G., Limbird, L.E., Gilman, A.G. (Eds), Goodman and Gilman's The Pharmacological Basis of Therapeutics, 10th ed. McGraw-Hill, New York, pp. 1219-1238.
17. Chaware V.J., Chaudhary B.P., Vaishnav M.K., Biyani K.R. Protective effect of the aqueous extract of Momordica charantia leaves on gentamicin-induced iephrotoxicity in rats. Int. J. Pharm. Tech. Res. 2011, 3(1):553-555.
18. Cuzzocrea S., Mazzon E., Dugo L., Serraino I., Di Paola R., Britti D., De Sarro A., Pierpaoli S., Caputi A., Masini E., Salvemini D. A role for superoxide in gentamicin-mediated nephropathy in rats. Eur. J. Pharmacol. 2002, 16:67-76.
19. Dehghani F., Namavar M.R., Noorafshan A., Karbalay-Doust S., Esmaeilpour T. Evaluation of the kidney extract on gentamicin-induced nephrotoxicity in rat. Kidney Res. J. 2011, 1(1):24-32.
20. Dhanarajan R., Abraham P., Isaac B. Protective effect of Ebselen, a selenoorganic drug, against gentamicin-induced renal damage in rats. Basic Clin. Pharmacol. Toxicol. 2006, 99(3):267-272.
21. Ekor M., Farombi E.O., Emerole G.O. Modulation of gentamicin-induced renal dysfunction and injury by the phenolic extract of soybean (glycine max). Fundam. Clin. Pharmacol. 2006, 20(3):263-271.
22. El-Ashmawy H.M., El-Nahas E.F., Salama O.M. Grape seed extract prevents gentamicin-induced nephrotoxicity and genotoxicity in bone marrow cells of mice. Basic Clin. Pharmacol. Toxicol. 2006, 99(3):230-236.
23. Erdem A., Gündogan N.ü., Usubütün A., Kilinç K., Erdem R., Kara A., Bozkurt A. The protective effect of taurine against gentamicin-induced acute tubular necrosis in rats. Nephrol. Dial. Transplant. 2000, 15:1175-1182.
24. Eslami Sh., Ebrahimzadeh M.A., Hajizadeh Moghaddam A., Nabavi S.F., Jafari N., Nabavi S.M. Renoprotective effect of Eryngium caucasicum in gentamicin-induced nephrotoxic mice. Arch. Biol. Sci., Belgrade 2011, 63(1):157-160.
25. Frank, C.M.D., 1993. Clinical Significance of Tests Available from Dupont. Clinical Laboratories, University Hospitals, The University of Wisconsin.
26. Hansen M., Christrup L.L., Jarlov J.O., Kampmann J.P., Bonde J. Gentamicin dosing in critically ill patients. Acta Anaesthesiol. Scand. 2001, 45(9):734-740.
27. Hong, S.H., Park, S.K., Cho, Y., Lee, H., Kim, K.R., Kim, M.G., Chang, W., 2006. Gentamicin-induced nitric oxide-related oxidative damages on vestibular afferents in the guinea pigs. Hear. Res. 211 (1-2), 46-53.
28. Houghton D.C., Hartnett M., cambell-Boswell M., Porter G., Bennett W. A light and electron microscopic analysis of gentamicin nephrotoxicity in rats. Am. J. Pathol. 1976, 82:589-612.
29. Kadkhodaee M., Khastar H., Faghihi M., Ghaznavi R., Zahmatkesh M. Effect of co-supplementation of vitamin E and C on gentamicin-induced nephrotoxicity in rat. Exp. Physiol. 2005, 90(4):571-576.
30. Kandeel, M., Abdelaziz, I., Elhabashy, N., Hegazy, H., Tolba, Y., 2011. Nephrotoxicity and oxidative stress of single large dose or two divided doses of gentamicin in rats. Pak. J. Biol. Sci. 1, 1-7.
31. Karahan I., Atessahin A., Yilmaz S., Ceribaşi A.O., Sakin F. Protective effect of lycopene on gentamicin-induced oxidative stress and nephrotoxicity in rats. Toxicology 2005, 215:198-204.
32. Khan S.A., Priyamvada S., Farooq N., Khan S., Khan M.W., Yusufi A.N.K. Protective effect of green tea extract on gentamicin-induced nephrotoxicity and oxidative damage in rat kidney. Pharmacol. Res. 2009, 59:254-262.
33. Kore K.J., Shete R.V., Kale B.N., Borade A.S. Protective role of hydroalcoholic extract of Ficus carica in gentamicin induced nephrotoxicity in rats. Int. J. Pharm. Life Sci. 2011, (2):978-982.
34. Kuhad A., Tirky N., Pilkhwal S., Chopra K. Effect of Spirulina, a blue green algae, on gentamicin-induced oxidative stress and renal dysfunction in rats. Fundam. Clin. Pharmacol. 2006, 20(2):121-128.
35. Kumer K.V., Shifow A.A., Naidn M.U.R., Ratnaker K.S. Carvedilol, a beta-bloker with antioxidant property protects against gentamicin-induced nephrotoxicityin rats. Life Sci. 2000, 66:2603-2611.
36. Mahmood D.H., Waters A. Comparative study of uranyl nitrate and cisplatin induced renal failure in rat. Eur. J. Drug Metab. Pharmacol. 1994, 19:327-336.
37. Mayne, P.D., 1994. Clinical Chemistry in Diagnosis and Treatment, sixth ed. Oxford University Press, Inc., New York, USA, p. 478. ISBN-13:978-0340576472.
38. Mingeot-Leclercq M.P., Tulkens P.M. Aminoglycoside nephrotoxicity. Antimicrob. Agents Chemother. 1999, 43(5):1003-1012.
39. Nagai J., Saito M., Adachi Y., Yumoto R., Takano M. Inhibition of gentamicin binding to rat renal brush-border membrane by megalin ligands and basic peptides. J. Control Release 2006, 112(1):43-50.
40. Nitha B., Janardhanan K.K. Aqueous-ethanolic extract of morel mushroom mycelium Morchella esculenta, protects cisplatin and gentamicin induced nephrotoxicity in mice. Food Chem. Toxicol. 2008, 46(9):3193-3199.
41. Parlakpinar H., Ozer M.K., Sahna E., Vardi N., Cigremis Y., Acet A. Amikacin induced acute renal injury in rats: protective role of melatonin. J. Pineal Res. 2003, 35(2):85-90.
42. Parlakpinar H., Tasdemir S., Polat A., Bay-Karabulut A., Vardi N., Ucar M., Acet A. Protective role of caffeic acid phenethyl ester (cape) on gentamicin-induced acute renal toxicity in rats. Toxicology 2005, 207:169-177.
43. Priyamvada S., Priyadarshini M., Arivarasu N.A., Farooq N., Khan S., Khan S.A., Khan M.W., Yusufi A.N. The protective effect of dietary fish oil on gentamicin-induced nephrotoxicity and oxidative damage in rat kidney. Prostaglandins Leukot. Essent. Fatty Acids 2008, 78(6):369-381.
44. Saleemi M.K., Khan M.Z., Javed I., Khan A. Pathological effects of gentamicin administered intramuscularly to day-old broiler chicks. Exp. Toxicol. Pathol. 2009, 61:425-432.
45. SAS (2002). SAS User's Guide, Statistics Version (8.2) edition. SAS Institute Incorporation, Cary, NC, USA.
46. Schulze S., Wollina U. Gentamicin-induced anaphylaxis. Allergy 2003, 58(1):88-98.
47. Sener G., Sehirli A.O., Altunbas H.Z., Ersoy Y., Paskalylu K., Arbak S., Ayanoglu-Dulger G. Melatonin protects against gentamicin-induced nephrotoxicity in rats. J. Pineal Res. 2002, 32(4):231-236.
48. Sharifzadeh M., Mahsa R., Amir Abbas Z., Nourollah A., Kurdistan S., Mohammad A. Effects of chronic lead exposure on aminoglycosides-induced changes in guinea pig auditory brainstem responses. Int. J. Pharmacol. 2005, 1:74-78.
49. Sharma R., Rajani G.P., Sharma V., Komala N. Effect of ethanolic and aqueous extracts of Bauhinia variegata Linn. on gentamicin-induced nephrotoxicity in rats. Ind. J. Pharm. Educ. Res. 2011, 45(2):192-198.
50. Smith, R.L., Hill, L.R., Ilehman, R.J., Lefkwitz, P., Handler, A., White, 1988. Principles of Biochemistry: Mammalian Biochemistry, seventh ed. McGraw-Hill, New York, USA.
51. Soliman K.M., Abdul-Hamid M., Othman A.I. Effect of carnosine on gentamicin-induced nephrotoxicity. Med. Sci. Monit. 2007, 13:73-83.
52. Stryer, L., 1988. Biochemistry, third ed. Stanford University, Stanford, p. 939.
53. Tietz, N.W., 1996. Fundamentals of Clinical Chemistry, fourth ed. W.B. Saunders Company, USA.
54. Travlos G.S., Morris R.W., Elwell M.R., Duke A., Resenblum S., Thompson M.B. Frequency and relationships of clinical chemistry and liver and kidney histopathology findings in 13-week toxicity studies in rats. Toxicology 1996, 107(1):17-29.
55. Whelton, A., Neu, H.C., 1982. The Aminoglycosides, Microbiology, Clinical Use, and Toxicology. Marcel Dekker, Inc., New York, Basel, p. 640.
56. Yasin K.F., Sabir M., Sherwani M.K., Zafer M., Yasmin S., Alam M.I. Amelioration of gentamicin nephrotoxicity by vitamin B6 (a general and histochemical profile). Pak. J. Med. Res. 2003, 42(2):69-73.
57. Zeeni N., Selmaoui B., Beachamp D., Labrecque G., Thibault L. Dietary protein level alters gentamicin-induced nephrotoxicity in rats. Physiol. Behav. 2007, 90(5):760-770.