Novel cytotoxic isolated from Jamaican Hyptis verticillata jacq induces apoptosis and overcomes multidrug resistance

Anticancer Research

Volumn 31, Issue 12, 2011, Pages 4251-4257

  White, Yohann ^a   Hamada, Toshiyuki ^b   Yoshimitsu, Makoto ^a,c   Nakashima, Mitsuyoshi ^b   Hachiman, Miho ^a   Kozako, Tomohiro ^a,d   Matsushita, Kakushi ^c   Uozumi, Kimiharu ^a   Suzuki, Shinsuke ^a,c   Kofune, Hiroki ^a   Furukawa, Tatsuhiko ^a   Arima, Naomichi ^a,c  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c KAGOSHIMA UNIVERSITY HOSPITAL   (Japan)

^d FUKUOKA UNIVERSITY   (Japan)

Author keywords

ATL; HTLV 1; Hyptis verticillata jacq; Leukemia; Multidrug resistance

Indexed keywords

4 METHOXY 9 (3,4,5 TRIMETHOXYPHENYL) 8,9 DIHYDROFURO[3',4':6,7]NAPHTHO[2,3 D][1,3]DIOXOL 6(5H) ONE; CASPASE 3; CASPASE 9; ETOPOSIDE; LIGNAN DERIVATIVE; MITOXANTRONE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG ISOLATION; DRUG STRUCTURE; ENZYME ACTIVATION; FRACTIONATION; HUMAN; HUMAN CELL; HYPTIS VERTICILLATA; MEDICINAL PLANT; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; RECEPTOR UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CYTOTOXINS; DIOXOLANES; DNA DAMAGE; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; ETOPOSIDE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; HYPTIS; LEUKEMIA, T-CELL; LIGNANS; MITOXANTRONE; PLANT EXTRACTS; POLY(ADP-RIBOSE) POLYMERASES; TOPOISOMERASE INHIBITORS;

EID: 84855164728     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Yoshida M, Miyoshi I and Hinuma Y: Isolation and characterization of retrovirus (ATLV) from cell lines of adult T-cell leukemia and its implication in the disease. Proc Natl Acad Sci USA 79: 2031-2035, 1982. (Pubitemid 12088563)
2. Shimoyama M: Diagnostic criteria and classification of clinical sub-types of adult T-cell leukemia-lymphoma. A report from the Lymphoma Study Group. Br J Haematol 79: 428-437, 1991.
3. Kawasaki C, Okamura S, Omori F, Shimoda K, Hayashi S, Kondo S, Yamada M and Niho Y: Both granulocyte-macrophage colony-stimulating factor and monocyte colony-stimulating factor are produced by the human T-cell line, HUT 102. Exp Hematol 18: 1090-1093, 1990.
4. Nimer SD, Gasson JC, Hu K, Smalberg I, Williams JL, Chen IS and Rosenblatt JD: Activation of the GM-CSF promoter by HTLV-I and -II tax proteins. Oncogene 4: 671-676, 1989. (Pubitemid 19150646)
5. Ballard DW, Bohnlein E, Lowenthal JW, Wano Y, Franza BR and Greene WC: HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene. Science 241: 1652-1655, 1988.
6. Lueng K and Nabel GJ: HTLV-1 transactivator induces interleukin-2 receptor expression through NF-κB-like factor. Nature 33: 776-778, 1988.
7. Arima N, Arimura K, Tokito Y, Sakaki Y, Matsushita K, Orihara K, Akimoto M, Ozaki A, Kukita T, Hagiwara T, Hamada H and Tei C: HTLV-1 Tax protein inhibits apoptosis induction but not G1 arrest by pyrrolidinedithiocarbamate, an antioxidant, in adult T-cell leukemia cells. Exp Hematol 32: 195-201, 2004. (Pubitemid 38177645)
8. Ozaki A, Arima N, Matsushita K, Uozumi K, Akimoto M, Hamada H, Kawada H, Horai S, Tanaka Y and Tei C: Cyclosporin A inhibits HTLV-1 tax expression and shows antitumor effects in combination with VP-16. J Med Virol 79: 1906-1913, 2007. (Pubitemid 350006317)
9. Borst P, Evers R, Kool M and Wijnholds J: A family of drug transporters: the multidrug resistance-associated proteins. J Natl Cancer Inst 92: 1295-1302, 2000. (Pubitemid 30662093)
10. Ford JM and Hait WN: Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacol Rev 42: 155-159, 1990.
11. Chen Z, Aoki S, Komatsu M, Ueda K, Sumizawa T, Furukawa T, Okumura H, Ren X, Belinsky MG, Lee K, Kruh GD, Kobayashi M and Akiyama S: Reversal of drug resistance mediated by multidrug-resistant protein (MRP) 1 by dual effects of agosterol A on MRP1 function. Int J Cancer 93: 107-113, 2001. (Pubitemid 32539509)
12. Versantvoort CHM, Schuurhuis GJ, Pinedo HM, Eekman CA, Kuiper CM, Lankelma J and Broxterman HJ: Genistein modulates the decreased drug accumulation in P-glycoprotein-mediated multidrug-resistant tumor cells. Br J Cancer 68: 939-946, 1993. (Pubitemid 23315227)
13. Fernandes-Alnemri T, Litwack G and Alnemri ES: CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein ced-3 and mammalian interleukin-1 beta-converting enzyme. J Biol Chem 269: 30761-30764, 1994. (Pubitemid 24377553)
14. Nicholson DA, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gareau MY, Griffin PR, Labelle M, Lazebnik YA, Munday MA, Raju SM, Smulson ME, Yamin T, Yu VL and Miller DK: Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376: 37-43, 2002.
15. Novelo M, Cruz JG, Hernandez L and Pereda-Miranda R: Cytotoxic constituents from Hyptis verticillata. J Nat Prod 56: 1728-1736, 1993. (Pubitemid 23326292)