HTLV-I Tax protein inhibits apoptosis induction but not G1 arrest by pyrrolidinedithiocarbamate, an anti-oxidant, in adult T cell leukemia cells

Experimental Hematology

Volumn 32, Issue 2, 2004, Pages 195-201

  Arima, Naomichi ^a,b   Arimura, Kosei ^a   Tokito, Yuichi ^a   Sakaki, Yoshimune ^a   Matsushita, Kakushi ^a   Orihara, Koji ^a   Akimoto, Masaki ^a   Ozaki, Atsuo ^a   Kukita, Toshimasa ^a   Hagiwara, Takafumi ^a   Hamada, Hciichiro ^a   Tei, Chuwa ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CARBAMIC ACID; DNA FRAGMENT; PROTEIN BAX; PROTEIN P21; PROTEIN P53; PYRROLIDINEDITHIOCARBAMATE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; GENETIC TRANSFECTION; HISTOGRAM; HUMAN; HUMAN CELL; LEUKEMIA CELL; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN EXPRESSION; T CELL LEUKEMIA; WESTERN BLOTTING;

HTLV; HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 10744225520     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2003.11.008     Document Type: Article

References (64)

1. Yoshid M., Miyoshi I., Hinuma Y. Isolation and characterization of retrovirus (ATLV) from cell lines of adult T cell leukemia and its implication in the disease. Proc Natl Acad Sci U S A. 79:1982;2031-2035.
2. Seiki M., Hattori S., Hirayama Y., Yoshida M. Human adult T cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proc Natl Acad Sci U S A. 80:1983;3618-3622.
3. Sciki M., Eddy R., Shows T.B., Yoshida M. Nonspecific integration of the HTLV provirus genome into adult T-cell leukaemia cells. Nature. 309:1984;640-642.
4. Cross S.L., Feinberg M.B., Wolf J.B., Holbrook N.J., Wong-Staal F., Leonard W.J. Regulation of the human interleukin-2 receptor α chain promoter: activation of a non-functional promoter by the transactivator gene of HTLV-I. Cell. 49:1987;47-56.
5. Fujii M., Sassone-Corsi P., Verma I.M. c-fos promoter trans-activation by the Tax-1 protein of human T-cell leukemia virus type I. Proc Natl Acad Sci U S A. 85:1988;8526-8530.
6. Inoue J., Seiki M., Taniguchi T., Tsuru S., Yoshida M. Induction of interleukin-2 receptor gene expression by p40x encoded by human T-cell leukemia virus type I. EMBO J. 5:1986;2883-2888.
7. Maruyama M., Shibuya H., Harada H., et al. Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1 encoded p40x and T3/Ti complex triggering. Cell. 48:1987;343-350.
8. Siekevitz M., Feinberg M.B., Holbrook N., Wong-Staal F., Greene W.C. Activation of interleukin-2 and interleukin-2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T cell leukemia virus, type I. Proc Natl Acad Sci U S A. 84:1987;5389-5393.
9. Ballard D.W., Bohnlein E., Lowenthal J.W., Wano Y., Franza B.R., Greene W.C. HTLV-1 Tax induces cellular proteins that activate the κB element in the IL-2 receptor-α gene. Science. 241:1988;1652-1655.
10. Kieran M., Blank V., Logeat F., et al. The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product. Cell. 62:1990;1007-1018.
11. Leung K., Nabel G.J. HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor. Nature. 333:1988;776-778.
12. Ruben S., Poteat H., Tan T.H., et al. Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-1 Tax gene product. Science. 241:1988;89-92.
13. Smith M.R., Greene W.C. Identification of HTLV-I Tax transactivator mutants exhibiting novel transcriptional phenotypes. Genes Dev. 4:1990;1875-1885.
14. Shimoyama M. Diagnostic criteria and classification of clinical subtypes of adult T-cell leukemia-lymphoma. A report from the Lymphoma Study Group. Br J Haematol. 79:1991;428-437.
15. Takatsuki K., Yamaguchi K., Kawano F., et al. Clinical diversity in adult T-cell leukemia lymphoma. Cancer Res. 45:1985;4644s-4645s.
16. Kawano F., Yamaguchi K., Nishimura H., Tsuda H., Takatsuki K. Variation in the clinical courses of adult T-cell leukemia. Cancer. 55:1985;851-856.
17. Arima N., Hidaka S., Fujiwara H., et al. Relation of autonomous and interleukin-2 responsive growth of leukemic cells to survival in adult T-cell leukemia. Blood. 87:1996;2900-2904.
18. Arima N., Matsushita K., Obata H., et al. NF-κB involvement in the activation of primary adult T-cell leukemia cells and its clinical implications. Exp Hematol. 27:1999;1168-1175.
19. Chinery R., Brockman J.A., Peeler M.O., Shyr Y., Beauchamp R.D., Coffey R.J. Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: a p53-independent induction of p21WAF1/CIP1 via C/EBP β Nat Med. 3:1997;1233-1241.
20. Arima N., Molitor J.A., Smith M.R., Kim J.H., Daitoku Y., Greene W.C. Human T-cell leukemia virus type 1 Tax induces expression of the el-related family of κB enhancer-binding proteins: Evidence for a pretranslational component of regulation. J Virol. 65:1991;6892-6899.
21. Wano Y., Feinberg M., Hosking J.B., Bogerd H., Greene W.C. Stable expression of the tax gene of type 1 human T-cell leukemia virus in human T cells activates specific cellular genes involved in growth. Proc Natl Acad Sci U S A. 85:1988;9733-9737.
22. Sakaki Y., Terashi K., Yamaguchi A., et al. Human T-lymphotropic virus type 1 Tax activates lung resistance-related protein expression in leukemic clones established from an adult T-cell leukemia patient. Exp Hematol. 30:2002;340-345.
23. Orihara K., Biro S., Hamasaki S., et al. Hypothermia at 43°C for 2 h inhibits the proliferation of vascular smooth muscle cells, but not endothelial cells. J Mol Cell Cardiol. 34:2002;1205.
24. Bullock G., Tang C., Tourkina E., et al. Effect of combined treatment with interleukin-3 and interleukin-6 on cell death or apoptosis in human myeloid leukemia cells. Exp Hematol. 21:1993;1640-1647.
25. Tsukasaki K., Ikeda S., Murata K., et al. Characteristics of chemotherapy-induced clinical remission in long survivors with aggressive adult T-cell leukemia/lymphoma. Leuk Res. 17:1993;157-166.
26. Taguchi H., Kinoshita K., Takatsuki K., et al. An intensive chemotherapy of adult T-cell leukemia/lymphoma: CHOP followed by etoposide, vineristine, ranimustine, and mitoxantrone with granulocyte colony-stimulating factor support. J Acq Immun Def Synd Hum Retrovirol. 12:1996;182-186.
27. Uozumi K., Hanada S., Ohno N., et al. Combination chemotherapy (RCM protocol: response-oriented cyclic multidrug protocol) for the acute or lymphoma type adult T-cell leukemia. Leuk Lymphoma. 18:1995;317-323.
28. Matsushita K., Matsumoto T., Ohtsubo H., et al. Long-term maintenance combination chemotherapy with OPEC/MPEC (vincristine or methotrexate, prednisolone, etoposide and cyclophosphamide) or with daily oral etoposide and prednisolone can improve survival and quality of life in adult T cell leukemia/lymphoma. Leuk Lymphoma. 36:1999;67-75.
29. Chuang S.E., Doong S.L., Lin M.T., Cheng A.L. Tax of the human T-lymphotropic virus type I transactivates promoter of the MDR-1 gene. Biochem Biophys Res Commun. 238:1997;482-486.
30. Lau A., Nightingale S., Taylor G.P., Gant T.W., Cann A.J. Enhanced MDR1 gene expression in human T-cell leukemia virus-I-infected patients offers new prospects for therapy. Blood. 91:1998;2467-2474.
31. Ikeda K., Oka M., Yamada Y., et al. Adult T-cell leukemia cells over-express the multidrug-resistance-protein (MRP) and lung-resistance-protein (LRP) genes. Int J Cancer. 82:1999;599-604.
32. Yoshida M., Suzuki T., Fujisawa J., Hirai H. HTLV-1 oncoprotein tax and cellular transcription factors. Curr Top Microbiol Immunol. 193:1995;79-89.
33. Lau A., Gant T.W., Cann A.J. The mechanism of trans-activation of the MDR1 gene by human T-cell leukemia virus. Biochem Biophys Res Commun. 249:1998;397-404.
34. Sherr C.J., Roberts J.M. Inhibitions of mammalian G1 cyclin-dependent kinases. Genes Dev. 9:1995;1149-1163.
35. Serrano M., Hannon G.J., Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature. 366:1993;704-707.
36. El-Deiry W.S., Tokino T., Velculeseu V.E., et al. WAF1, a potential mediator of p53 tumor suppression. Cell. 75:1993;817-825.
37. Kastan M.B., Onyekwere O., Sidransky D., Vogelstein B., Craig R. Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 5:1991;6304-6311.
38. Yonish-Rouach E., Resnitzky D., Lotem J., Sachs L., Kimchi A., Oren M. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature. 352:1991;345-347.
39. Dameron K.M., Volpert O.V., Tainsky M.A., Bouck N. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science. 265:1994;1582-1584.
40. Miyashita T., Reed J.C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell. 80:1995;293-299.
41. Hannon G.J., Beach D. p15INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature. 371:1994;257-261.
42. Guan K.L., Jenkins C.W., Li Y., et al. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev. 8:1994;2939-2952.
43. Duro D., Bernard O., Della-Valley V., Berger R., Larsen C.J. A new type of p16INK4/MTS1 gene transcript expressed in B-cell malignancies. Oncogene. 11:1995;21-29.
44. Stone S., Jiang P., Dayananth P., et al. Complex structure and regulation of the p16(MTS1) locus. Cancer Res. 55:1995;2988-2994.
45. Mao L., Merlo A., Bedi G., et al. A novel p16INK4A transcript. Cancer Res. 55:1994;2995-2997.
46. Quelle D.E., Zindy F., Ashmun R.A., Sherr C.J. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell. 83:1995;993-1000.
47. Kamijo T., Weber J.D., Zambetti G., Zindy F., Roussel M.F., Sherr C.J. Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2. Proc Natl Acad Sci U S A. 95:1998;8292-8297.
48. Mulloy J.C., Kislyakova T., Cereseto A., et al. Human T-cell lymphotropic/leukemia virus type 1 Tax abrogates p53-induced cell cycle arrest and apoptosis through its CREB/ATF functional domain. J Virol. 72:1998;8852-8860.
49. Pisc-Masison C.A., Choi K.S., Radonovich M., Dittmer J., Kim S.J., Brady J.N. Inhibition of p53 transactivation function by the human T-cell lymphotropic virus type I Tax protein. J Virol. 72:1998;1165-1170.
50. Sakashita A., Hattori T., Miller C.W., et al. Mutations of the p53 gene in adult T-cell leukemia. Blood. 79:1992;477-480.
51. Suzuki T., Kitao S., Matsushime H., Yoshida Y. HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16 INK4A and counteracts its inhibitory activity towards CDK4. EMBO J. 5:1996;1607-1614.
52. Hatta Y., Hirama T., Miller C.W., Yamada Y., Tomonaga M., Koeffler H.P. Homozygous deletions of the p15 (MTS2) and p16 (CKDN2/MTS1) genes in adult T-cell leukemia. Blood. 85:1995;2699-2704.
53. Uchida T., Kinoshita T., Watanabe T., et al. The CDKN2 gene alterations in various types of adult T-cell leukaemia. Br J Haematol. 94:1996;665-670.
54. Yamada Y., Hatta Y., Murata K., et al. Deletion of p15 and/or p16 genes as a poor-prognosis factor in adult T-cell leukemia. J Clin Oncol. 15:1997;1778-1785.
55. Fujiwara H., Arima N., Hashimoto-Tamaoki T., et al. Alteration of p16 (CKDN2) gene is associated with interleukin-2-induced tumor cell growth in adult T-cell leukemia. Exp Hematol. 27:1999;1004-1009.
56. Jeang K.T., Widen S.G., Semmes O.J., Wilson S.H. HTLV-1 trans-activator protein, Tax, is a transrepressor of the human DNA β-polymerase gene. Science. 247:1990;1082-1084.
57. Chen X., Zachar V., Zdravkovic M., Guo M., Ebbesen P., Liu X. Role of the Fas/Fas ligand pathway in apoptotic cell death induced by the human T cell lymphotropic virus type 1 Tax transactivator. J Gen Virol. 78:1997;3277-3285.
58. Chlichlia K., Busslinger M., Peter M.E., et al. ICE-proteases mediate HTLV-1 Tax-induced apoptotic T-cell death. Oncogene. 14:1997;2265-2272.
59. Yamada T., Yamaoka S., Goto T., Nakai M., Tsujimoto Y., Hatanaka M. The human T-cell leukemia virus type 1 Tax protein induces apoptosis which is blocked by the bcl-2 protein. J Virol. 68:1994;3374-3379.
60. Copcland K.F., Haaksma A.G., Goudsmit J., Krammer P.H., Heeney J.L. Inhibition of apoptosis in T cells expressing human T cell leukemia virus type 1 Tax. AIDS Res Hum Retroviruses. 10:1994;1259-1268.
61. Kawakami A., Nakashima T., Sakai H., et al. Inhibition of caspasc cascade by HTLV-1 tax through induction of NF-κB nuclear translocation. Blood. 94:1999;3847-3854.
62. Brauweiler A., Garrus J.E., Reed J.C., Nyborg J.K. Repression of bax gene expression by the HTLV-1 Tax protein: implications for suppression of apoptosis in virally infected cells. Virology. 231:1997;135-140.
63. Bentires Alj M., Dejardin E., Viatour P., et al. Inhibition of the NF-κB transcription factor increases Bax expression in cancer cells. Oncogene. 20:2001;2805-2813.
64. Schreck R., Grassmann R., Fleckenstein B., Baeuerle P.A. Antioxidants selectively suppress activation of NF-κB by human T-cell leukemia virus type I Tax protein. J Virol. 66:1992;6288-6293.