Cyclosporin A inhibits HTLV-I tax expression and shows anti-tumor effects in combination with VP-16

Journal of Medical Virology

Volumn 79, Issue 12, 2007, Pages 1906-1913

  Ozaki, Atsuo ^a   Arima, Naomichi ^b   Matsushita, Kakushi ^a   Uozumi, Kimiharu ^b   Akimoto, Masaki ^b   Hamada, Heiichiro ^b   Kawada, Hideaki ^a   Horai, Sawako ^b   Tanaka, Yuetsu ^c   Tei, Chuwa ^b  

^a KAGOSHIMA UNIVERSITY HOSPITAL   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

Anti tumor effect; Apoptosis; Cyclosporin A; HTLV I tax; Immune suppressant

Indexed keywords

COMPLEMENTARY DNA; CYCLOSPORIN A; ETOPOSIDE; TAX PROTEIN; TRANSFER FACTOR;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CLINICAL EXAMINATION; CLINICAL FEATURE; CONTROLLED STUDY; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; IMMUNOSUPPRESSIVE TREATMENT; PROTEIN EXPRESSION; T CELL LEUKEMIA; T LYMPHOCYTE; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE; CELL LINE, TUMOR; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETOPOSIDE; GENE EXPRESSION REGULATION, VIRAL; GENE PRODUCTS, TAX; HERPES SIMPLEX VIRUS PROTEIN VMW65; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS;

HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 35548967888     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.21028     Document Type: Article

References (60)

1. I. J Virol 76:3494-3501.
2. Arima N. 1997. Autonomous and interleukin resposive growth of leukemia cells in adult T-cell leukemia (ATL): A review of the clinical significance and molecular basis of ATL cell growth. Leuk Lymphoma 26:479-487.
3. Arima N, Tei C. 2003. HTLV-1 Tax protein involved refractoriness of ATL: Molecular mechanisms and clinical significance. Recent Res Devel Haematol 1:103-115 Transworld Research Network, Kerala, India.
4. Arima N, Molitor JA, Smith MR, Kim JH, Daitoku Y, Greene WC. 1991. Human T-cell leukemia virus type 1 Tax induces expression of the rel-related family of κB enhancer-binding proteins: Evidence for a pretranslational component of regulation. J Virol 65:6892-6899.
5. Arima N, Matsushita K, Obata H, Ohtsubo H, Fujiwara H, Arimura K, Kukita T, Suruga Y, Wakamatsu S, Hidaka S, Tei C. 1999. NF-κB involvement in the activation of primary adult T-cell leukemia cells and its clinical implication. Exp Hematol 27:1168-1175.
6. Arima N, Arimura K, Tokito Y, Sakaki Y, Matsushita K, Orihara K, Akimoto M, Ozaki A, Kukita T, Hagiwara T, Hamada H, Tei C. 2004. HTLV-1 Tax protein inhibits apoptosis induction but not G1 arrest by pyrrolidinedithiocarbamate, an anti-oxidant, in adult T cell leukemia cells. Exp Hematol 32:195-201.
7. Arimitage JO, Vose JM, Linder J, Weisenburger D, Harrinton D, Casey J, Bierman P, Sorensen S, Hutchins M, Moravec DF, Howe D, Dowling MD, Mailliard J, Johnson S, Pevnick W, Packard WM, Okerbloom J, Hompson RF, Langdon RM, Soori G, Peterson C, Prtilo D. 1989. Clinical significance of immunophenotype in diffuse aggressive non-Hodgkin's lymphoma. J Clin Oncol 7:1783-1790.
8. Ballard DW, Bohnlein E, Lowenthal JW, Wano Y, Franza BR, Greene WC. 1988. HTLV-1 Tax induces cellular proteins that activate the κB element in the IL-2 receptor-α gene. Science 241:1652-1655.
9. Borst P, Evers Kool M, Wijnholds J. 2000. A family of drug transporters: The multidrug resistance-associated protein. J Natl Cancer Inst 92:1295-1302.
10. Bullock G, Tang C, Tourkina E, Ibrado AM, Lutzky J, Huang Y, Mahoney ME, Bhalla K. 1993. Effect of combined treatment with interleukin-3 and interleukin-6 on cell death or apoptosis in human myeloid leukemia cells. Exp Hematol 21:1640-1647.
11. Felber BK, Paskalis H, Kleinman-Ewing C, Wong-Staal F, Pavlakis GN. 1985. The pX protein of HTLV-1 is a transcriptional activator of its long terminal repeats. Science 229:675-679.
12. Fujii M, Sassone-Corsi P, Verma IM. 1988. c-fos promoter transactivation by the Tax-1 protein of human T-cell leukemia virus type I. Proc Natl Acad Sci USA 85:8526-8530.
13. Furukawa Y, Tara M, Ohmori K, Kannagi R. 1994. Variant type of sialyl Lewis X antigen expressed on adult T cell leukemia cells is associated with skin involvement. Cancer Res 54:6533-6538.
14. Gary DK. 2003. Introduction to resistance to anticancer agents. Oncogene 22:2762-2764.
15. Gisselbrecht C, Gaulard P, Lepage F, Coiffier B, Briere J, Haioun C, Cazals-Hatem D, Bosly A, Xerri L, Tilly H, Berger E, Bouhabdallah R, Diebold J, for the Groupe d'Eludes des Lymphomes l'Adulte (GELA). 1998. Prognostic significance of T-cell phenotype in aggressive non-Hodgkin's lymphomas. Blood 92:76-82.
16. Hai T, Liu F, Coukos WJ, Green MR. 1989. Transcription factor ATF cDNA clones: An extensive family of leucine zipper proteins able to selectively from DNA-binding heterodimers. Genes Dev 3:2083-2090.
17. Hamaoka M. 1992. Progress in adult T cell leukemia research. Acta Pathol Jpn 321:171-185.
18. Hasegawa H, Sawa H, Jewis MJ, Orba Y, Sheehy N, Yamamoto Y, Ichinohe T, Tsunetsugu-Yokota Y, Katano H, Takahashi H, Matsuda J, Sat T, Kurata T, Nagashima K, Hall W. 2006. Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I. Nature Medicine 12:466-472.
19. Hiraiwa N, Hiraiwa M, Kannnagi R. 1997. Human T-cell leukemia virus-1 encoded Tax protein transactivates al-3 fucosyltransferase Fuc-T VII, which synthesizes sialyl Lewis X, a selectin legand expressed on adult T-cell leukemia cells. Biochem Biophys Res Commun 231:183-186.
20. Huang X, Lee C. 2003. From TGF-beta to cancer therapy. Curr Drug Targets 4:243-250.
21. Inoue J, Seiki M, Taniguchi T, Truss S, Yoshida M. 1986. Induction of interleukin-2 receptor gene expression by p40x encoded by human T-cell leukemia virus type I. EMBO J 5:2883-2888.
22. Ishikawa T, Imura A, Tanaka K, Shirane H, Okuma M, Uchiyama T. 1993. E-selectin and vascular cell adhesion molecule-1 mediate adult T-cell leukemia cell adhesion to endothelial cells. Blood 82:1590-1598.
23. Jeang KT, Widen SG, Semmes OJ, Wilson SH. 1990. HTLV-1 transactivator protein, Tax, is a transrepressor of the human β-polymerase gene. Science 247:1082-1084.
24. Kawakami A, Nakashima T, Sakai H, Urayama S, Yamasaki S, Hida A, Tsuboi M, Nakamura H. 1999. Inhibition of caspase cascade by HTLV-1 tax through induction of NF-κ nuclear translocation. Blood 94:3847-3854.
25. Kieran M, Blank V, Logeat F, Vandekerckhove J, Lottspeich F, Le Bail O, Urban MB, Kourilsky P, Baeuerle PA, Israel A. 1990. The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product. Cell 62:1007-1018.
26. Kranke M, Leonard WJ, Depper JM, Arya SK, Wong-Staal F, Gallo RC, Waldmann TA, Greene WC. 1984. Cyclosporin A inhibits T-cell growth gene expression at the level of mRNA transcription. Proc Natl Acad Sci USA 81:5214-5219.
27. Lau A, Nightingale S, Taylor GP, Gant TW, Cann AJ. 1998. Enhanced MDR1 gene expression in human T-cell leukemia virus-I-infected patients offers new prospects for therapy. Blood 91:2467-2474.
28. Leung K, Nabel GJ. 1988. HTLV-1 transactivator induces interleukin-2 receptor expression through and NF-κB-like factor. Nature 333:776-778.
29. Liu J. 1993. FK506 and cyclosporine, molecular probes for studying intracellular signal transduction. Immunol Today 14:290-295.
30. Maruyama M, Shibuya H, Harada H, Hatakeyama M, Seiki M, Fujita T, Inoue J, Yoshida M, Taniguchi T. 1987. Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-I encoded p40x and T3/Ti complex triggering. Cell 48:343-350.
31. Matsushita K, Matsumoto T, Ohtsubo H, Fujiwara H, Imamura N, Hidaka S, Kukita T, Tei C, Matsumoto M, Arima N. 1999. Long-term maintenance combination chemotherapy with OPEC/MPEC (vincristine or methotrexate, prednisolone, etoposide and cyclophosphamide) or with daily oral etoposide and prednisolone can improve survival and quality of life in adult T-cell leukemia/lymphoma. Leuk Lymphoma 36:67-75.
32. Morgan DA, Ruscetti FW, Gallo R. 1976. Selective in vitro growth of T-lymphocytes from normal human bone marrows. Science 193: 1007-1008.
33. Mulloy JC, Kislyakova T, Cereseto A, Casareto L, LoMonico A, Fullen J, Lorenzi MY, Cara A, Nicot C, Giam C, Franchini G. 1998. Human T-cell lymphotropic leukemia virus type 1 Tax abrogates p53-induced cell cycle arrest and apoptosis through its CREB/ATF functional domain. J Virol 72:8852-8860.
34. Neumann JR, Morency CA, Russian KO. 1987. A novel rapid assay for chloramphenicol acetyltransferase gene expression. Biotechniques 5:444-447.
35. Okamura J, Utsunomiya A, Tanosaki R, Uike N, Sonoda S, Kannagi M, Tomonaga M, Harada M, Kimura N, Masuda M, Kawano F, Yufu Y, Hattori H, Kikuchi H, Saburi Y, for ATL-NST study group. 2006. Non-myeloablative allogeneic hematopoietic stem cell transplantation (NST) for adult T-cell leukemia/lymphoma (ATL)-multicenter phase I clinical trial. Blood 102:2704a.
36. Pise-Masison CA, Choi KS, Radonovich M, Dittmer J, Kim SJ, Brady J. 1998. Inhibition of p53 transactivation function by the human T-cell lymphotropic virus type I Tax protein. J Virol 72:1165-1170.
37. Qadir M, O'Loughlin KL, Fricke SM, Williamson NA, Greco WR, Minderman H, Baer MR. 2005. Cyclosporin A is a broad-spectrum multidrug resistance modulator. Clin Cancer Res 11:2320-2326.
38. Ruben S, Poteat H, Tan TH, Kawakami K, Roeder R, Haseltine W, Rosen CA. 1988. Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-1 Tax gene product. Science 241:89-92.
39. Sakaki Y, Terashi K, Yamaguchi M, Kawamata N, Tokito Y, Mori H, Umehara M, Yoshiyama T, Ohtsubo H, Arimura K, Arima N, Tei C. 2002. Human T-cell lymphotropic virus type I Tax activates lung resistance-related protein expression in leukemic clones established from an adult T-cell leukemia patient. Exp Hematol 30:340-345.
40. Sakashita A, Hattori T, Miller CW, Suzushima H, Asou N, Takatsuki K, Koeffler HP. 1992. Mutations of the p53 gene in adult T-cell leukemia. Blood 79:477-480.
41. Scheper RJ, Broxterman HJ, Scheffer GL, Kaaijk P, Dalton WS, van Heijningen TH, van Kalken CK, Slovak ML, de Vries EG, vann der Vlk P. 1993. Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein- mediated multidrug resistance. Cancer Res 53:1475-1479.
42. Schreiber SL. 1991. Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science 251:283-287.
43. Seiki M, Hattori S, Hirayama Y, Yoshida M. 1983. Human adult T cell leukemia virus: Complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proc Natl Acad Sci USA 80:3618-3622.
44. Seiki M, Eddy R, Show TB. 1984. Nonspecific integration of the HTLV provirus genome into adult T-cell leukaemia cells. Nature 309:640-642.
45. Shimoyama M, for members of the Lymphoma Study Group. 1991. Diagnostic criteria and classification of clinical subtypes of adult T-cell leukemia-lymphoma. Br J Haematol 79:428-437.
46. Siekevitz M, Feinberg MB, Holbrook N, Wong-Staal F, Greene WC. 1987. Activation of interleukin-2 and interleukin-2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T cell leukemia virus, type I. Proc Natl Acad Sci USA 84:5389-5393.
47. Sodroski JG, Rosen CA, Haseltine HA. 1984. Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells. Science 225:381-385.
48. Stein B, Rhamsdorf HJ, Steffen A, Litfin M, Herrlich P. 1989. UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein. Mol Cell Biol 9:5169-5189.
49. Suzuki T, Kitao S, Matsushime H, Yoshida Y. 1996. HTLVl-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16 INK4A and counteracts its inhibitory activity towards C DK4. EMBO J 5:1607-1614.
50. Takewaki M, Yamaguchi K, Matsuoka M, Ishii T, Miyasaka M, Mori S, Takatsuki K, Watanabe T. 1995. Constitutive overexpression of the L-selectin gene in fresh leukemic cells of adult T-cell leukemia that can be transactivated by human T-cell lymphotropic virus type 1 Tax. Blood 86:3109-3117.
51. Tanaka Y, Fukudome K, Hayashi M, Takagi S, Yoshie O. 1995. Induction of ICAM-1 and LFA-3 by Tax1 of human T-cell leukemia virus type 1 and mechanism of down-regulation of ICAM-1 or LFA-1 in adult T-cell leukemia cell lines. Int J Cancer 60:554-561.
52. Taniguchi T, Matsui H, Fujita T, Takaoka C, Kashima N, Yoshimoto R, Hamura J. 1983. Structure and expression of a cloned cDNA for human interleukin-2. Nature 302:305-310.
53. Uchiyama T, Yodoi J, Sagawa K, Takatsuki K, Uchino H. 1977. Adult T-cell leukemia: Clinical and hematologic features of 16 cases. Blood 50:481-492.
54. Uozumi K, Arima N. 2005. Recent advances and future perspectives in the treatment of adult T-cell leukemia/lymphoma. Recent research development in Haematology. Transworld Res Network 2:1-19 Kerala.
55. Utsunomiya A, Miyazaki Y, Takatsuka Y, Hanada S, Uozumi K, Yashiki S, Tara M, Kawano F, Saburi Y, Kikuchi H, Hara M, Sao H, Morishima Y, Kodera Y, Sonoda S, Tomonaga M. 2001. Improved outcome of adult T cell leukemia/lymphoma with allogenic hematopoietic stem cell transplantation. Bone Marrow Transplant 27:15-20.
56. Wano Y, Feinberg M, Hosking JB, Bogerd H, Greene WC. 1988. Stable expression of the tax gene of type 1 human T-cell leukemia virus in human T cells activates specific cellular genes involved in growth. Proc Natl Acad Sci USA 85:9733-9737.
57. Yamada Y, Tomonaga M, Fukuda H, Hanada S, Utsunomiya A, Tara M, Sano M, Ikeda S, Takatsuki K, Kozuru M, Araki K, Kawano F, Niimi M, Tobinai K, Hotta T, Shimoyama M, other members of the lymphoma study group of the Japan clinical oncology group (1994-1996). 2001. A new G-CSF-supported combination chemotherapy, LSG 15,for adult T-cell leukaemia-lymphoma: Japan Clinical Oncology Group Study 9303. Br J Haematol 113:375-382.
58. Yoshida M, Miyoshi I, Hinuma Y. 1982. Isolation and characterization of retrovirus (ATLV) from cell lines of adult T cell leukemia and its implication in the disease. Proc Natl Acad Sci USA 79:2031-2035.
59. Yoshimura T, Fujisawa J, Yoshida M. 1990. Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: All contain a leucine zipper structure and basic amino acid domain. EMBO J 9:2537-2542.
60. Yoshioka R, Yamaguchi K, Yoshinaga T, Takatsuki K. 1985. Pulmonary complications in patients with adult T-cell leukemia. Cancer 55:2491-2494.