Nebulization performance of biodegradable sildenafil-loaded nanoparticles using the Aeroneb® Pro: Formulation aspects and nanoparticle stability to nebulization

International Journal of Pharmaceutics

Volumn 422, Issue 1-2, 2012, Pages 398-408

  Beck Broichsitter, Moritz ^a,b   Kleimann, Pia ^a   Gessler, Tobias ^a   Seeger, Werner ^a   Kissel, Thomas ^b   Schmehl, Thomas ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Biodegradable polyesters; Nanoparticles; Nebulization; Pulmonary arterial hypertension; Pulmonary drug delivery; Sildenafil

Indexed keywords

NANOPARTICLE; POLYGLACTIN; POLYVINYL ALCOHOL; SILDENAFIL;

AEROSOL; ARTICLE; CONTROLLED STUDY; DENSITY; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; EVAPORATION; IN VITRO STUDY; NANOENCAPSULATION; NEBULIZATION; PARTICLE SIZE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; SCANNING ELECTRON MICROSCOPY; SOLVENT EVAPORATION; SURFACE TENSION; THICKNESS; TRANSMISSION ELECTRON MICROSCOPY; ULTRAVIOLET SPECTROSCOPY; VISCOSITY;

ADMINISTRATION, INHALATION; AEROSOLS; ANTIHYPERTENSIVE AGENTS; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; EXCIPIENTS; HYPERTENSION, PULMONARY; KINETICS; LACTIC ACID; NANOPARTICLES; NANOTECHNOLOGY; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; POLYGLYCOLIC ACID; POLYVINYL ALCOHOL; PURINES; SOLUBILITY; SOLVENTS; SPECTROPHOTOMETRY, ULTRAVIOLET; SULFONES; TECHNOLOGY, PHARMACEUTICAL; VASODILATOR AGENTS; VISCOSITY;

EID: 84655176510     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.10.012     Document Type: Article

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