Development of a biodegradable nanoparticle platform for sildenafil: Formulation optimization by factorial design analysis combined with application of charge-modified branched polyesters

Journal of Controlled Release

Volumn 157, Issue 3, 2012, Pages 469-477

  Beck Broichsitter, Moritz ^a,b   Schmehl, Thomas ^b   Gessler, Tobias ^b   Seeger, Werner ^b   Kissel, Thomas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Biodegradable branched polyesters; Colloidal stability; Factorial design; Nanoparticles; Pulmonary drug delivery; Sildenafil

Indexed keywords

BIODEGRADABLE NANOPARTICLE; CARRIER SYSTEMS; COLLOIDAL STABILITY; DIFFUSION PROCESS; DRUG CARRIER; DRUG CONTENT; DRUG DIFFUSION; DRUG LOADING; DRUG RELEASE; EXPERIMENTAL FACTORS; FACTORIAL DESIGN; FORMULATION OPTIMIZATION; IN-VITRO; NANOPARTICLE FORMULATION; POLYMERIC NANOPARTICLES; PREPARATION PROCESS; PULMONARY DRUG DELIVERY; PULMONARY HYPERTENSION; RELEASE RATE; SILDENAFIL; SOLVENT EVAPORATION TECHNIQUES; SUSTAINED RELEASE; THERAPEUTIC AGENTS; TREATMENT MODALITY;

CONTROLLED DRUG DELIVERY; DESIGN; DRUG INTERACTIONS; DRUG PRODUCTS; ESTERS; FACTOR ANALYSIS; FUNCTIONAL POLYMERS; LOADING; OPTIMIZATION; POLYESTERS; STABILIZATION;

NANOPARTICLES;

NANOPARTICLE; POLYESTER; SILDENAFIL;

ARTICLE; BIODEGRADABLE IMPLANT; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; EVAPORATION; FACTORIAL DESIGN; FREEZE DRYING; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PULMONARY HYPERTENSION; STATIC ELECTRICITY;

ADMINISTRATION, INHALATION; AEROSOLS; DRUG CARRIERS; DRUG STABILITY; FACTOR ANALYSIS, STATISTICAL; FREEZE DRYING; NANOPARTICLES; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; POLYESTERS; PURINES; SULFONES; VASODILATOR AGENTS;

EID: 84655164025     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.09.058     Document Type: Article

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