4,5-Dihydropyridazin-3-one derivatives as histamine H 3 receptor inverse agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 194-198

  Hudkins, Robert L ^a   Aimone, Lisa D ^a   Dandu, Reddeppa Reddy ^a   Dunn, Derek ^a   Gruner, John A ^a   Huang, Zeqi ^a   Josef, Kurt A ^a   Lyons, Jacquelyn A ^a   Mathiasen, Joanne R ^a   Tao, Ming ^a   Zulli, Allison L ^a   Raddatz, Rita ^a  

^a CEPHALON INC   (United States)

Author keywords

4,5 Dihydropyridazin 3 one; CEP 26401; H 3 inverse agonist; Histamine H 3 receptor; Sleep wake

Indexed keywords

4,4 DIMETHYL 6 [4 [3 (2 METHYL PYRROLIDIN 1 YL)PROPOXY]PHENYL] 4,5 DIHYDRO 2H PYRIDAZIN 3 ONE; 4,5 DIHYDROPYRIDAZIN 3 ONE DERIVATIVE; HISTAMINE H3 RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AROUSAL; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG IDENTIFICATION; DRUG POTENCY; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; IN VIVO STUDY; NONHUMAN; RAT;

ANIMALS; AREA UNDER CURVE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; HISTAMINE AGONISTS; KINETICS; MODELS, CHEMICAL; PYRIDAZINES; RATS; RECEPTORS, HISTAMINE H3; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

RATTUS;

EID: 84655174952     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.11.037     Document Type: Article

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