Synthesis and structure-activity relationships of 4,5-fused pyridazinones as histamine H 3 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 20, 2011, Pages 6126-6130

  Tao, Ming ^a   Raddatz, Rita ^a   Aimone, Lisa D ^a   Hudkins, Robert L ^a  

^a CEPHALON INC   (United States)

Author keywords

Affinity; Fused; Histamine H3; Pyridazinone

Indexed keywords

2,5,6,7 TETRAHYDROCYCLOPENTA[D]PYRIDAZIN 1 ONE; 5,6,7,8 TETRAHYDRO 2H PHTHALAZIN 1 ONE; HISTAMINE H3 RECEPTOR ANTAGONIST; PYRIDAZINONE DERIVATIVE; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; HISTAMINE H3 ANTAGONISTS; HUMANS; PYRIDAZINES; RATS; RECEPTORS, HISTAMINE H3; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 80052946852     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.08.045     Document Type: Article

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