Amine-constrained pyridazinone histamine H 3 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5543-5546

  Sundar, Babu G ^a   Bailey, Thomas ^a   Bacon, Edward ^a   Aimone, Lisa ^a   Huang, Zeqi ^a   Lyons, Jacquelyn ^a   Raddatz, Rita ^a   Hudkins, Robert ^a  

^a CEPHALON INC   (United States)

Author keywords

H 3R antagonist; Pyridazinone; Rat PK

Indexed keywords

2 PYRROLIDIN 1 YLMETHYL 1 PYRROLIDINYL AMIDE DERIVATIVE; 6 (3 CYCLOBUTYL 2,3,4,5 TETRAHYDRO 1H 3 BENZAZEPIN 7 YLOXY) N METHYLNICOTINAMIDE; HISTAMINE H3 RECEPTOR ANTAGONIST; PYRIDAZINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG ACTIVITY; DRUG BINDING; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG SYNTHESIS; HUMAN; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

AMINES; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HISTAMINE H3 ANTAGONISTS; HUMANS; MOLECULAR STRUCTURE; PYRIDAZINES; RATS; RECEPTORS, HISTAMINE H3; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 80051931946     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.094     Document Type: Article

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