Synthesis and activity of folate conjugated didemnin B for potential treatment of inflammatory diseases

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 709-712

  Henne, Walter A ^a,b   Kularatne, Sumith A ^a   Ayala López, Wilfredo ^a   Doorneweerd, Derek D ^a   Stinnette, Torian W ^c   Lu, Yingjuan ^c   Low, Philip S ^a  

^a PURDUE UNIVERSITY   (United States)

^b GOVERNORS STATE UNIVERSITY   (United States)

^c Endocyte Inc   (United States)

Author keywords

Folate; Folate didemnin B; Folate receptor; Inflammation; Macrophage

Indexed keywords

ANTIINFLAMMATORY AGENT; CARBONIC ACID DERIVATIVE; DIDEMNIN B; DISULFIDE CARBONATE; FOLATE DIDEMNIN B; FOLATE RECEPTOR; FOLIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG CONJUGATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; IC 50; INFLAMMATORY DISEASE; MACROPHAGE;

ANIMALS; CARBON; DEPSIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; FOLIC ACID; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INFLAMMATION; INHIBITORY CONCENTRATION 50; MACROPHAGES; MICE; MODELS, BIOLOGICAL; MODELS, CHEMICAL; PEPTIDES; PRODRUGS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84655169611     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.10.042     Document Type: Article

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