Association of nuclear factor κb expression with a poor outcome in nasopharyngeal carcinoma

Medical Oncology

Volumn 28, Issue 4, 2011, Pages 1338-1342

  Zhang, Y ^a   Lang, J Y ^b   Liu, L ^b   Wang, J ^a   Feng, G ^a   Jiang, Y ^c   Deng, Y L ^c   Wang, X J ^c   Yang, Y H ^a   Dai, T Z ^a   Xie, G ^a   Pu, J ^a   Du, X B ^a  

^a MIANYANG CENTRAL HOSPITAL   (China)

^b SICHUAN CANCER HOSPITAL   (China)

^c SICHUAN UNIVERSITY   (China)

Author keywords

Immunohistochemical; Nasopharyngeal carcinoma; NF B; Prognosis

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ADULT; AGED; ARTICLE; CANCER RELAPSE; CLINICAL ARTICLE; DISEASE FREE SURVIVAL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NASOPHARYNX CARCINOMA; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION;

DISEASE-FREE SURVIVAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; NEOPLASM STAGING; NF-KAPPA B; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 84655165074     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-010-9571-7     Document Type: Article

References (43)

1. RT Hoppe J Williams R Warnke DR Goffinet MA Bagshaw 1978 Carcinoma of the nasopharynx -the significance of histology Int J Radiat Oncol Biol Phys 4 199 205
2. SH Cheng TW Liu JJ Jian SY Tsai SP Hao CH Huang MC Liu B Yu AT Huang 1997 Concomitant chemotherapy and radiotherapy for locally advanced nasopharyngeal carcinoma Cancer J Sci Am 3 100 106
3. TP Farias FL Dias RALJ Kligerman GMD Sa MM Barbosa FB Gonc Jr 2003 Prognostic factors and outcome for nasopharyngeal carcinoma Arch Otolaryngol Head Neck Surg 129 794 799
4. DM Heng J Wee KW Fong LG Lian VK Sethi ET Chua 1999 Prognostic factors in 677 patients in Singapore with nondisseminated nasopharyngeal carcinoma Cancer 86 1912 1920
5. P Teo P Yu WY Lee SF Leung WH Kwan KH Yu 1996 Significant prognosticators after primary radiotherapy in 903 nondisseminated nasopharyngeal carcinoma evaluated by computer tomography Int J Radiat Oncol Biol Phys 36 291 304
6. B O'Sullivan V Chong MK Gospodarowicz 2001
7. YMD Lo ATC Chan LYS Chan 2000 Molecular prognostication of nasopharyngeal carcinoma by quantitative analysis of circulating Epstein-Barr virus DNA Cancer Res 60 6878 6881
8. R Sen D Baltimore 1986 Inducibility of kappa immunoglobulins enhancer-binding protein NF-kB by a posttranslational mechanism Cell 47 921 929
9. M Karin Y Cao FR Greten Z Li 2002 NF-kB in cancer: from innocent bystander to major culprit Nature Rev Cancer 2 301 310
10. V Bours G Bonizzi M Bentires-Alj F Bureau J Piette P Lekeux M Merville 2000 NF-kB activation in response to toxical and therapeutical agents: role in inflammation and cancer treatment Toxicology 153 27 38
11. PJ Barnes M Karin 1997 Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases N Engl J Med 336 1066 1071
12. P Baeuerle T Henkel 1994 Function and activation of NF-kB in the immune system Annu Rev Immunol 12 141 179
13. G Chen D Goeddel 2002 TNF-R1 signaling: a beautiful pathway Science 296 1634 1635
14. DC Guttridge C Albanese JY Reuther RG Pestell JAS Baldwin 1999 NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1 Mol Cell Biol 19 5785 5799
15. M Barkett TD Gilmore 1999 Control of apoptosis by Rel/NF-kB transcription factors Oncogene 18 6910 6924
16. AS Baldwin 2001 Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB J Clin Invest 107 241 246
17. N Li M Karin 1998 Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms Proc Natl Acad Sci USA 95 13012 13017
18. JG Izzo U Malhotra TT Wu J Ensor R Luthra JH Lee 2006 Association of activated transcription factor nuclear factor -kB with chemoradiation resistance and poor outcome in esophageal carcinoma J Clin Oncol 24 748 754
19. M Scartozzi I Bearzi C Pierantoni A Mandolesi F Loupakis A Zaniboni 2007 Nuclear factor-kB tumor expression predicts response and survival in irinotecan-refractory metastatic colorectal cancer treated with cetuximab-irinotecan therapy J Clin Oncol 25 3930 3935
20. TA Buchholz AK Garg N Chakravarti BB Aggarwal FJ Esteva HM Kuerer 2005 The nuclear transcription factor kappaB/bcl-2 pathway correlates with pathologic complete response to doxorubicin-based neoadjuvant chemotherapy in human breast cancer Clin Cancer Res 11 8398 8402
21. G Chen MS Bhojani AC Heaford DC Chang B Laxman DG Thomas 2005 Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas Proc Natl Acad Sci USA 102 12507 12512
22. NJ Thornburg R Pathmanathan N Raab-Traub 2003 Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma Cancer Res 63 8293 8301
23. JH Wong VW Lui K Umezawa Y Ho EY Wong MH Ng 2010 A small molecule inhibitor of NF-kappaB, dehydroxymethylepoxyquinomicin (DHMEQ), suppresses growth and invasion of nasopharyngeal carcinoma (NPC) cells Cancer Lett 287 23 32
24. IM Verma JK Stevenson EM Schwarz D Van Antwerp 1995 Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation Genes Dev 9 2723 2735
25. U Siebenlist G Franzoso K Brown 1994 Structure, regulation and function of NF-kappa B Annu Rev Cell Biol 10 405 455
26. F Balkwill A Mantovani 2001 Inflammation and cancer: back to Virchow? Lancet 357 539 545
27. F Greten L Eckmann T Greten J Park Z Li L Egan M Kagnoff M Karin 2004 IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer Cell 118 285 296
28. E Pikarsky RM Porat I Stein R Abramovitch S Amit S Kasem PE Gutkovich SS Urieli E Galun NY Ben 2004 NF-κB functions as a tumour promoter in inflammation-associated cancer Nature 431 461 466
29. AS Smirnov AS Ruzov AV Budanov AV Prokhortchouk AV Ivanov EB Prokhotchouk 2001 High constitutive level of NF-kappaB is crucial for viability of adenocarcinoma cells Cell Death Differ 8 621 630
30. PF Lindholm J Bub S Kaul VB Shidman A Kajdacsy-Balla 2000 The role of constitutive NF-kB activity in PC-3 human prostate cancer cell invasive behavior Clin Exp Metastasis 18 471 479
31. H Nakayama T Ikebe M Beppu K Shirasuna 2001 High expression levels of nuclear factor kappaB, IkappaB kinase alpha and Akt kinase in squamous cell carcinoma of the oral cavity Cancer 92 3037 3044
32. S Huang A DeGuzman CD Bucana IJ Fidler 2000 Nuclear factorkappaB activity correlates with growth, angiogenesis, and metastasis of human melanoma cells in nude mice Clin Cancer Res 6 2573 2581
33. S Huang CA Pettaway H Uehara CD Bucana I Fidler 2001 Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis Oncogene 20 31 4188 4197
34. D Lesage V Metelev O Borisova N Dolinnaya T Oretskaya F Baran-Marszak E Taillandier M Raphael R Fagard 2003 Specific covalent binding of a NF-kappaB decoy hairpin oligonucleotide targeted to the p50 subunit and induction of apoptosis FEBS Lett 547 115 118
35. N Yamagishi J Miyakoshi H Takebe 1997 Enhanced radiosensitivity by inhibition of nuclear factor kappa B activation in human malignant glioma cells Int J Radiat Biol 72 157 162
36. CY Wang MW Mayo AS Baldwin Jr 1996 TNF-a and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kB Science 274 784 787
37. C Didelot M Barberi-Heyob A Bianchi P Becuwe JF Mirjolet M Dauca JL Merlin 2001 Constitutive NF-kB activity influences basal apoptosis and radiosensitivity of head-and-neck carcinoma cell lines Int J Radiat Oncol Biol Phys 51 1354 1360
38. T Kato DC Duffey FG Ondrey G Dong Z Chen JA Cook JB Mitchell C Van Waes 2000 Cisplatin and radiation sensitivity in human head and neck squamous carcinomas are independently modulated by glutathione and transcription factor NF-kB Head Neck 22 748 759
39. KR Kim T Yoshizaki H Miyamori K Hasegawa T Horikawa M Furukawa S Harada M Seiki H Sato 2000 Transformation of Madin-Darby canine kidney (MDCK) epithelial cells by Epstein-Barr virus latent membrane protein 1 (LMP1) induces expression of Ets1 and invasive growth Oncogene 19 14 1764 1771
40. L Yin W Liao X Deng M Tang H Gu X Li W Yi Y Cao 2001 LMP1 activates NF-kappa B via degradation of I kappa B alpha in nasopharyngeal carcinoma cells Chin Med J 114 7 718 722
41. JH Lu YL Tang HB Yu JH Zhou CY Fu X Zeng ZY Yu HL Yin MH Wu JY Zhang XL Li GY Li 2010 Epstein-Barr virus facilitates the malignant potential of immortalized epithelial cells: from latent genome to viral production and maintenance Lab Invest 90 196 209
42. H Liu H Zheng Z Duan D Hu M Li S Liu Z Li X Deng Z Wang M Tang Y Shi W Yi Y Cao 2009 LMP1-augmented kappa intron enhancer activity contributes to upregulation expression of Ig kappa light chain via NF-kappaB and AP-1 pathways in nasopharyngeal carcinoma cells Mol Cancer 8 92
43. HM Li C Man Y Jin W Deng YL Yip HC Feng YC Cheung KW Lo PS Meltzer ZG Wu YL Kwong AP Yuen SW Tsao 2006 Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase Int J Cancer 119 1567 1576