Indole RSK inhibitors. Part 1: Discovery and initial SAR

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 733-737

  Boyer, Stephen J ^a   Burke, Jennifer ^a   Guo, Xin ^a   Kirrane, Thomas M ^a   Snow, Roger J ^a   Zhang, Yunlong ^a   Sarko, Chris ^a   Soleymanzadeh, Lida ^a   Swinamer, Alan ^a   Westbrook, John ^a   Dicapua, Frank ^a   Padyana, Anil ^a   Cogan, Derek ^a   Gao, Amy ^a   Xiong, Zhaoming ^a   Madwed, Jeffrey B ^a,b   Kashem, Mohammed ^a   Kugler, Stanley ^a   O'Neill, Margaret M ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

Kinase inhibitor; MAPKAP K1; RSK

Indexed keywords

1 OXO 2,3,4,5 TETRAHYDRO 1H [1,4]DIAZEPINO[1,2 A]INDOLE 8 CARBOXAMIDE; INDOLE DERIVATIVE; S6 KINASE; S6 KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; HIGH THROUGHPUT SCREENING; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

AMIDES; AZEPINES; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MOLECULAR CONFORMATION; NITROGEN; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84655161939     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.10.030     Document Type: Article

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