II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamides

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 713-717

  Anilkumar, Gopinadhan N ^a   Selyutin, Oleg ^a   Rosenblum, Stuart B ^a   Zeng, Qingbei ^a   Jiang, Yueheng ^a   Chan, Tin Yau ^a   Pu, Haiyan ^a   Wang, Li ^a   Bennett, Frank ^a   Chen, Kevin X ^a   Lesburg, Charles A ^a   Duca, Jose ^a   Gavalas, Stephen ^a   Huang, Yuhua ^a   Pinto, Patrick ^a   Sannigrahi, Mousumi ^a   Velazquez, Francisco ^a   Venkatraman, Srikanth ^a   Vibulbhan, Bancha ^a   Agrawal, Sony ^a   Ferrari, Eric ^a   Jiang, Chuan Kui ^a   Huang, H C ^a   Shih, Neng Yang ^a   George Njoroge, F ^a   Kozlowski, Joseph A ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

HCV; NS5B Polymerase

Indexed keywords

CARBOXYLIC ACID; INDOLE C2 ACYL SULFONAMIDE; NONSTRUCTURAL PROTEIN 5B; NONSTRUCTURAL PROTEIN 5B INHIBITOR; PROTEIN INHIBITOR; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG SCREENING; HEPATITIS C VIRUS; REPLICON; STRUCTURE ACTIVITY RELATION;

ANTIVIRAL AGENTS; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; HYDROGEN BONDING; INDOLES; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 84655161591     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.10.041     Document Type: Article

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15. Figures 1and 2 were generated using the program pymol (The pymol Molecular Graphics System, Version 1.2r1, Schrödinger, LLC).
16. Crystal structures of HCV NS5B in complex with 1 and 7q have been deposited in the Protein Data Bank with accession numbers 3U4O, 3U4R, respectively.
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