Acid solution is a suitable medium for introducing QX-314 into nociceptors through TRPV1 channels to produce sensory-specific analgesic effects

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Liu, He ^a   Zhang, Hong Xing ^a   Hou, Hui Yan ^a   Lu, Xian Fu ^a   Wei, Jing Qiu ^a   Wang, Chun Guang ^a   Zhang, Li Cai ^a   Zeng, Yin Ming ^a   Wu, Yong Ping ^b   Cao, Jun Li ^a,b  

^a XUZHOU MEDICAL UNIVERSITY   (China)

^b Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4 CHLORO N (3 METHOXYPHENYL)CINNAMAMIDE; ACID SENSING ION CHANNEL; AMILORIDE; LIDOCAINE ETHOBROMIDE; MITOGEN ACTIVATED PROTEIN KINASE; NORADRENALIN; PROTEIN FOS; VANILLOID RECEPTOR 1; VOLTAGE GATED SODIUM CHANNEL; ACID; ANALGESIC AGENT; DRUG DERIVATIVE; LIDOCAINE; QX-314; SODIUM CHANNEL BLOCKING AGENT; TRPV1 PROTEIN, MOUSE; TRPV1 PROTEIN, RAT; VANILLOID RECEPTOR;

ACTION POTENTIAL; ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NEUROPATHIC PAIN; NOCICEPTIVE RECEPTOR; NONHUMAN; PATCH CLAMP; PH; PROTEIN EXPRESSION; SCIATIC NERVE; SODIUM CURRENT; SPINAL CORD NERVE CELL; SPINAL GANGLION; WESTERN BLOTTING; ANIMAL; CHEMISTRY; DRUG EFFECT; METABOLISM; SOLUTION AND SOLUBILITY; SPRAGUE DAWLEY RAT;

MUS; RATTUS;

ACIDS; ANALGESICS; ANIMALS; BLOTTING, WESTERN; GANGLIA, SPINAL; IMMUNOHISTOCHEMISTRY; LIDOCAINE; MALE; MICE; NOCICEPTORS; PATCH-CLAMP TECHNIQUES; RATS, SPRAGUE-DAWLEY; SODIUM CHANNEL BLOCKERS; SOLUTIONS; TRPV CATION CHANNELS;

EID: 84555205265     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029395     Document Type: Article

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