Unmasking Potential Intracellular Roles For Dysferlin through Improved Immunolabeling Methods

Journal of Histochemistry and Cytochemistry

Volumn 59, Issue 11, 2011, Pages 964-975

  Roche, Joseph A ^a   Ru, Lisa W ^a   O'Neill, Andrea M ^a   Resneck, Wendy G ^a   Lovering, Richard M ^a   Bloch, Robert J ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

antigen retrieval; dysferlin; LGMD2B Miyoshi myopathy; muscular dystrophy; sarcoplasmic reticulum; T tubules

Indexed keywords

1,4 DIHYDROPYRIDINE RECEPTOR; DYSFERLIN; DYSTROPHIN; DYSF PROTEIN, HUMAN; DYSF PROTEIN, MOUSE; DYSFERLIN PROTEIN, RAT; MEMBRANE PROTEIN; MUSCLE PROTEIN;

ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; CADAVER; CONTROLLED STUDY; FROZEN SECTION; HUMAN; HUMAN TISSUE; IMMUNOLOCALIZATION; MALE; MOUSE; MUSCLE BIOPSY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; SARCOPLASMIC RETICULUM; SKELETAL MUSCLE; TIBIALIS ANTERIOR MUSCLE; TISSUE FIXATION; ANIMAL; CHEMISTRY; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; METHODOLOGY; MUSCULAR DYSTROPHY; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

RATTUS;

ANIMALS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MALE; MEMBRANE PROTEINS; MICE; MUSCLE PROTEINS; MUSCLE, SKELETAL; MUSCULAR DYSTROPHIES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84555203376     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1369/0022155411423274     Document Type: Article

References (26)

1. Ampong BN, Imamura M, Matsumiya T, Yoshida M, Takeda S. Intracellular localization of dysferlin and its association with the dihydropyridine receptor. Acta Myol. 2005;24:134-144.
2. Anderson LV, Davison K, Moss JA, Young C, Cullen MJ, Walsh J, et al.Dysferlin is a plasma membrane protein and is expressed early in human development. Hum Mol Genet. 1999;8:855-861.
3. Bansal D, Campbell KP. Dysferlin and the plasma membrane repair in muscular dystrophy. Trends Cell Biol. 2004;14:206-213.
4. Bansal D, Miyake K, Vogel SS, Groh S, Chen CC, Williamson R, et al. Defective membrane repair in dysferlin-deficient muscular dystrophy.Nature. 2003;423:168-172.
5. Fujita E,Kouroku Y,Isoai A,Kumagai H,Misutani A,Matsuda C, et al.Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II).Hum Mol Genet. 2007;16:618-629.
6. Glover L, Brown RH. Dysferlin in membrane trafficking and patch repair. Traffic. 2007;8:785-794.
7. Guo LT, Moore SA, Forcales S, Engvall E, Diane Shelton G. Evaluation of commercial dysferlin antibodies on canine, mouse and human skeletal muscle. Neuromuscul Disord. 2010;20:820-825.
8. Han R, Campbell KP. Dysferlin and muscle membrane repair. Curr Opin Cell Biol. 2007;19:409-416.
9. Ho M, Post CM, Donahue LR, Lidov HG, Bronson RT, Goolsby H, et al. Disruption of muscle membrane and phenotype divergence in two novel mouse models of dysferlin deficiency.Hum Mol Genet. 2004;13:1999-2010.
10. Ikezoe K, Furuya H, Ohyagi Y, Osoegawa M, Nishino I, Nonaka I, et al. Dysferlin expression in tubular aggregates: their possible relationship to endoplasmic reticulum stress. Acta Neuropathol. 2003;105:603-609.
11. Klinge L,Harris J,Sewry C,Charlton R,Anderson L,Laval S, et al.Dysferlin associates with the developing T-tubule system in rodent and human skeletal muscle.Muscle Nerve. 2010;41:166-173.
12. Krahn M, Wein N, Bartoli M, Lostal W, Courrier S, Bourg-Alibert N, et al. A naturally occurring human minidysferlin protein repairs sarcolemmal lesions in a mouse model of dysferlinopathy. Sci Transl Med. 2010;2 (50): 50-69.
13. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.Nature. 1970;227:680-685.
14. Lostal W, Bartoli M, Bourg N, Roudaut C, Bentaib A, Miyake K, et al. Efficient recovery of dysferlin deficiency by dual adeno-associated vector-mediated gene transfer. Hum Mol Genet. 2010;19:1897-1907.
15. Lovering RM, O'Neill A, Roche JA, Bloch RJ. Identification of skeletal muscle mutations in tail snips from neonatal mice using immunohistochemistry. Biotechniques. 2007;42:702-704.
16. Mundegar RR, Franke E, Schafer R, Zweyer M, Wernig A. Reduction of high background staining by heating unfixed mouse skeletal muscle tissue sections allows for detection of thermostable antigens with murine monoclonal antibodies. J Histochem Cytochem. 2008;56:969-975.
17. Nguyen K, Bassez G, Bernard R, Krahn M, Labelle V, Figarella-Branger D, et al. Dysferlin mutations in LGMD2B, Miyoshi myopathy, and atypical dysferlinopathies. Hum Mutat. 2005;26:165.
18. Piccolo F, Moore SA, Ford GC, Campbell KP. Intracellular accumulation and reduced sarcolemmal expression of dysferlin in limb-girdle muscular dystrophies. Ann Neurol. 2000;48:902-912.
19. Reed P, Porter NC, Strong J, Pumplin DW, Corse AM, Luther PW, et al. Sarcolemmal reorganization in facioscapulohumeral muscular dystrophy. Ann Neurol. 2006;59:289-297.
20. Roche JA, Lovering RM, Bloch RJ. Impaired recovery of dysferlin-null skeletal muscle after contraction-induced injury in vivo. Neuroreport. 2008;19:1579-1584.
21. Roche JA, Lovering RM, Roche R, Ru LW, Reed PW, Bloch RJ. Extensive mononuclear infiltration and myogenesis characterize recovery of dysferlin-null skeletal muscle from contraction-induced injuries. Am J Physiol Cell Physiol. 2010;298:C298-C312.
22. Urtizberea JA,Bassez G,Leturcq F,Nguyen K,Krahn M,Levy N.Dysferlinopathies.Neurol India. 2008;56:289-297.
23. von der Hagen M, Laval SH, Cree LM, Haldane F, Pocock M, Wappler I, et al. The differential gene expression profiles of proximal and distal muscle groups are altered in pre-pathological dysferlin-deficient mice. Neuromuscul Disord. 2005;15:863-877.
24. Waddell LB, Lemckert FA, Zheng XF, Tran J, Evesson FJ, Hawkes JM, et al. Dysferlin, annexin A1, and mitsugumin 53 are upregulated in muscular dystrophy and localize to longitudinal tubules of the T-system with stretch. J Neuropathol Exp Neurol. 2011;70:302-313.
25. Wenzel K, Carl M, Perrot A, Zabojszcza J, Assadi M, Ebeling M, et al. Novel sequence variants in dysferlin-deficient muscular dystrophy leading to mRNA decay and possible C2-domain misfolding. Hum Mutat. 2006;27:599-600.
26. Williams MW, Bloch RJ. Differential distribution of dystrophin and beta-spectrin at the sarcolemma of fast twitch skeletal muscle fibers. J Muscle Res Cell Motil. 1999;20:383-393.