-
1
-
-
0028928973
-
The natural history of multiple sclerosis
-
Weinshenker BG. The natural history of multiple sclerosis. Neurol Clin 1995;16:119-46
-
(1995)
Neurol Clin
, vol.16
, pp. 119-146
-
-
Weinshenker, B.G.1
-
2
-
-
33644891895
-
Diagnosis and treatment of multiple sclerosis
-
Murray TJ. Diagnosis and treatment of multiple sclerosis. BMJ 2006;332:525-7 (Pubitemid 44364370)
-
(2006)
British Medical Journal
, vol.332
, Issue.7540
, pp. 525-527
-
-
Murray, T.J.1
-
3
-
-
54149084585
-
Multiple sclerosis
-
Compston A, Coles A. Multiple sclerosis. Lancet 2008;372:1502-17
-
(2008)
Lancet
, vol.372
, pp. 1502-1517
-
-
Compston, A.1
Coles, A.2
-
4
-
-
77954364428
-
The natural history of multiple sclerosis: A geographically based study 10: Relapses and long-term disability
-
Scalfari A, Neuhaus A, Degenhardt A, et al. The natural history of multiple sclerosis: a geographically based study 10: relapses and long-term disability. Brain 2010;133(Pt 7):1914-12
-
(2010)
Brain
, vol.133
, Issue.PART 7
, pp. 1914-1922
-
-
Scalfari, A.1
Neuhaus, A.2
Degenhardt, A.3
-
5
-
-
73449084774
-
The pathological spectrum of CNS inflammatory demyelinating diseases
-
Hu W, Lucchinetti CF. The pathological spectrum of CNS inflammatory demyelinating diseases. Semin Immunopathol 2009;31:439-53
-
(2009)
Semin Immunopathol
, vol.31
, pp. 439-453
-
-
Hu, W.1
Lucchinetti, C.F.2
-
6
-
-
16244368038
-
US FDA-approved disease-modifying treatments for multiple sclerosis: Review of adverse effect profiles
-
DOI 10.2165/00023210-200519030-00005
-
Galetta SL, Markowitz C. US FDA-approved disease-modifying treatments for multiple sclerosis: review of adverse effect profiles. CNS Drugs 2005;19:239-52 (Pubitemid 40460663)
-
(2005)
CNS Drugs
, vol.19
, Issue.3
, pp. 239-252
-
-
Galetta, S.L.1
Markowitz, C.2
-
7
-
-
84856765648
-
-
Available from
-
Available from: http://www.fda.gov/NewsEvents/Newsroom/ PressAnnouncements/ucm226755.htm
-
-
-
-
8
-
-
79951806432
-
-
Australian Therapeutic Goods Administration Available from Accessed 20 June 2011
-
Australian Therapeutic Goods Administration. Australian public assessment report for cladribine tablets online. Available from: http://www.tga.gov.au/ pdf/auspar/auspar-movectro.pdf Accessed 20 June 2011
-
Australian Public Assessment Report for Cladribine Tablets Online
-
-
-
9
-
-
0020612685
-
Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes
-
Carson DA, Wasson DB, Taetle R, et al. Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes. Blood 1983;62:737-43 (Pubitemid 13008659)
-
(1983)
Blood
, vol.62
, Issue.4
, pp. 737-743
-
-
Carson, D.A.1
Wasson, D.B.2
Taetle, R.3
Yu, A.4
-
10
-
-
0028029143
-
New chemotherapeutic agent: 2-Chlorodeoxyadenosine
-
Beutler E. New chemotherapeutic agent: 2-chlorodeoxyadenosine. Semin Hematol 1994;31(1):40-5 (Pubitemid 24031130)
-
(1994)
Seminars in Hematology
, vol.31
, Issue.1
, pp. 40-45
-
-
Beutler, E.1
-
11
-
-
0030780827
-
The safety profile of low-dose cladribine in refractory rheumatoid arthritis: A pilot trial
-
Schirmer M, Mur E, Pfeiffer KP, et al. The safety profile of low-dose cladribine in refractory rheumatoid arthritis. A pilot trial. Scand J Rheumatol 1997;26:376-9 (Pubitemid 27471223)
-
(1997)
Scandinavian Journal of Rheumatology
, vol.26
, Issue.5
, pp. 376-379
-
-
Schirmer, M.1
Mur, E.2
Pfeiffer, K.P.3
Thaler, J.4
Konwalinka, G.5
-
12
-
-
0029983154
-
The treatment of chronic progressive multiple sclerosis with cladribine
-
DOI 10.1073/pnas.93.4.1716
-
Beutler E, Sipe JC, Romine JS, et al. The treatment of chronic progressive multiple sclerosis with cladribine. Proc Natl Acad Sci USA 1996;93:1716-20 (Pubitemid 26075191)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.4
, pp. 1716-1720
-
-
Beutler, E.1
Sipe, J.C.2
Romine, J.S.3
Koziol, J.A.4
Mcmillan, R.5
Zyroff, J.6
-
13
-
-
0034646216
-
Cladribine and progressive MS: Clinical and MRI outcomes of a multicenter controlled trial
-
Rice GP, Filippi M, Comi G. Cladribine and progressive MS: clinical and MRI outcomes of a multicenter controlled trial. Cladribine MRI Study Group. Neurology 2000;54:1145-55 (Pubitemid 30151860)
-
(2000)
Neurology
, vol.54
, Issue.5
, pp. 1145-1155
-
-
Rice, G.P.A.1
Filippi, M.2
Comi, G.3
-
14
-
-
60049093599
-
Cladribine impedes in vitro migration of mononuclear cells: A possible implication for treating multiple sclerosis
-
Kopadze T, Dobert M, Leussink VI, et al. Cladribine impedes in vitro migration of mononuclear cells: a possible implication for treating multiple sclerosis. Eur J Neurol 2009;16:409-12
-
(2009)
Eur J Neurol
, vol.16
, pp. 409-412
-
-
Kopadze, T.1
Dobert, M.2
Leussink, V.I.3
-
15
-
-
0031043125
-
The clinical pharmacokinetics of cladribine
-
Liliemark J. The clinical pharmacokinetics of cladribine. Clin Pharmacokinet 1997;32:120-31 (Pubitemid 27104411)
-
(1997)
Clinical Pharmacokinetics
, vol.32
, Issue.2
, pp. 120-131
-
-
Liliemark, J.1
-
16
-
-
53549088887
-
Characterisation of an inclusion complex between cladribine and 2-Hydroxypropyl-beta-cyclodextrin
-
Van Axel Castelli V, Trivieri G, Zucchelli I, et al. Characterisation of an inclusion complex between cladribine and 2-hydroxypropyl-beta-cyclodextrin. J Pharm Sci 2008;97(9):3897-906
-
(2008)
J Pharm Sci
, vol.97
, Issue.9
, pp. 3897-3906
-
-
Van Axel Castelli, V.1
Trivieri, G.2
Zucchelli, I.3
-
17
-
-
79951797436
-
Cladribine tablets: In relapsing-remitting multiple sclerosis
-
Muir VJ, Plosker GL. Cladribine tablets: in relapsing-remitting multiple sclerosis. CNS Drugs 2011;25:239-4
-
(2011)
CNS Drugs
, vol.25
, pp. 239-244
-
-
Muir, V.J.1
Plosker, G.L.2
-
18
-
-
76149083915
-
CLARITY study group. A placebo controlled trial of oral cladribine for relapsing multiple sclerosis
-
Giovannoni G, Comi G, Cook S, et al. CLARITY Study Group. A placebo controlled trial of oral cladribine for relapsing multiple sclerosis. N Engl J Med 2010;362:416-26
-
(2010)
N Engl J Med
, vol.362
, pp. 416-426
-
-
Giovannoni, G.1
Comi, G.2
Cook, S.3
-
19
-
-
66149179141
-
Effect of parenteral cladribine on relapse rates in patients with relapsing forms of multiple sclerosis: Results of a 2-Year, double-blind, placebo-controlled, crossover study
-
Stelmasiak Z, Solski J, Nowicki J, et al. Effect of parenteral cladribine on relapse rates in patients with relapsing forms of multiple sclerosis: results of a 2-year, double-blind, placebo-controlled, crossover study. Mult Scler 2009;15:767-70
-
(2009)
Mult Scler
, vol.15
, pp. 767-770
-
-
Stelmasiak, Z.1
Solski, J.2
Nowicki, J.3
-
20
-
-
80053448175
-
Safety and tolerability of cladribine tablets in multiple sclerosis: The CLARITY (CLAdRIbine tablets treating multiple sclerosis orallY) study
-
Cook S, Vermersch P, Comi G, et al. Safety and tolerability of cladribine tablets in multiple sclerosis: the CLARITY (CLAdRIbine Tablets treating multiple sclerosis orallY) study. Mult Scler 2011;17:578-93
-
(2011)
Mult Scler
, vol.17
, pp. 578-593
-
-
Cook, S.1
Vermersch, P.2
Comi, G.3
-
21
-
-
77249128651
-
Cladribine tablets in relapsing-remitting multiple sclerosis: Study design of the 2-Year, phase iiib CLARITY (CLAdRibine tablets treating multiple sclerosis orallY) extension study
-
Rieckmann P, Giovannoni G, Cook SD, et al. Cladribine tablets in relapsing-remitting multiple sclerosis: study design of the 2-year, Phase IIIb CLARITY (CLAdRibine tablets Treating multiple sclerosis orallY) extension study. Mult Scler 2008;14:S161-2
-
(2008)
Mult Scler
, vol.14
-
-
Rieckmann, P.1
Giovannoni, G.2
Cook, S.D.3
-
22
-
-
33751165437
-
FTY720 versus MMF with cyclosporine in de novo renal transplantation: A 1-year, randomized controlled trial in Europe and Australasia
-
Salvadori M, Budde K, Charpentier B, et al. FTY720 versus MMF with cyclosporine in de novo renal transplantation: a 1-year, randomized controlled trial in Europe and Australasia. Am J Transplant 2006;6:2912-21
-
(2006)
Am J Transplant
, vol.6
, pp. 2912-2921
-
-
Salvadori, M.1
Budde, K.2
Charpentier, B.3
-
23
-
-
0037379202
-
Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment
-
DOI 10.1124/jpet.102.045658
-
Fujino M, Funeshima N, Kitazawa Y, et al. Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment. J Pharmacol Exp Ther 2003;305:70-7 (Pubitemid 36378136)
-
(2003)
Journal of Pharmacology and Experimental Therapeutics
, vol.305
, Issue.1
, pp. 70-77
-
-
Fujino, M.1
Funeshima, N.2
Kitazawa, Y.3
Kimura, H.4
Amemiya, H.5
Suzuki, S.6
Li, X.-K.7
-
24
-
-
77951073508
-
Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis
-
Chun J, Hartung HP. Mechanism of action of oral Fingolimod (FTY720) in multiple sclerosis. Clin Neuropharmacol 2010;33:91-10
-
(2010)
Clin Neuropharmacol
, vol.33
, pp. 91-10
-
-
Chun, J.1
Hartung, H.P.2
-
25
-
-
46949104885
-
Inside-out signaling of sphingosine-1-phosphate: Therapeutic targets
-
DOI 10.1124/pr.107.07113
-
Takabe K, Paugh SW, Milstien S, et al. "Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol Rev 2008;60:181-95 (Pubitemid 351962008)
-
(2008)
Pharmacological Reviews
, vol.60
, Issue.2
, pp. 181-195
-
-
Takabe, K.1
Paugh, S.W.2
Milstien, S.3
Spiegel, S.4
-
26
-
-
36549047503
-
Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis
-
DOI 10.1016/j.pharmthera.2007.08.005, PII S0163725807001738
-
Dev KK, Mullershausen F, Mattes H, et al. Brain sphingosine-1-phosphate receptors: implication for FTY720 in the treatment of multiple sclerosis. Pharmacol Ther 2008;117:77-93 (Pubitemid 350192672)
-
(2008)
Pharmacology and Therapeutics
, vol.117
, Issue.1
, pp. 77-93
-
-
Dev, K.K.1
Mullershausen, F.2
Mattes, H.3
Kuhn, R.R.4
Bilbe, G.5
Hoyer, D.6
Mir, A.7
-
27
-
-
79952026310
-
Clinical immunology of the sphingosine 1-Phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis
-
Mehling M, Johnson TA, Antel J, et al. Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis. Neurology 2011;76:S20-7
-
(2011)
Neurology
, vol.76
-
-
Mehling, M.1
Johnson, T.A.2
Antel, J.3
-
28
-
-
2142851264
-
Lysophospholipid receptors: Signaling and biology
-
DOI 10.1146/annurev.biochem.73.011303.073731
-
Ishii I, Fukushima N, Ye X, et al. Lysophospholipid receptors: signaling and biology. Annu Rev Biochem 2004;73:321-54 (Pubitemid 39050372)
-
(2004)
Annual Review of Biochemistry
, vol.73
, pp. 321-354
-
-
Ishii, I.1
Fukushima, N.2
Ye, X.3
Chun, J.4
-
29
-
-
1942508223
-
Multiple-Dose FTY720: Tolerability, Pharmacokinetics, and Lymphocyte Responses in Healthy Subjects
-
DOI 10.1177/0091270004264165
-
Kovarik JM, Schmouder R, Barilla D, et al. Multiple-dose FTY720: tolerability, pharmacokinetics, and lymphocyte responses in healthy subjects. J Clin Pharmacol 2004;44:532-7 (Pubitemid 38509722)
-
(2004)
Journal of Clinical Pharmacology
, vol.44
, Issue.5
, pp. 532-537
-
-
Kovarik, J.M.1
Schmouder, R.2
Barilla, D.3
Riviere, G.-J.4
Wang, Y.5
Hunt, T.6
-
30
-
-
77955799815
-
Oral fingolimod (FTY720) for relapsing multiple sclerosis
-
DOI 10.1056/NEJMoa052643
-
Kappos L, Antel J, Comi G, et al. Oral fingolimod (FTY720) for relapsing multiple sclerosis. N Engl J Med 2006;355(11):1124-40 (Pubitemid 44394919)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.11
, pp. 1124-1140
-
-
Kappos, L.1
Antel, J.2
Comi, G.3
Montalban, X.4
O'Connor, P.5
Polman, C.H.6
Haas, T.7
Korn, A.A.8
Karlsson, G.9
Radue, E.W.10
-
31
-
-
63849147004
-
Oral fingolimod (FTY720) in multiple sclerosis: Two-year results of a phase II extension study
-
O'Connor P, Comi G, Montalban X, et al. Oral fingolimod (FTY720) in multiple sclerosis: two-year results of a phase II extension study. Neurology 2009;72:73-9
-
(2009)
Neurology
, vol.72
, pp. 73-79
-
-
O'Connor, P.1
Comi, G.2
Montalban, X.3
-
32
-
-
76449120437
-
For the fty720d2201 study group. Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-Year results
-
Comi G, O'Connor P, Montalban X, et al. for the FTY720D2201 Study Group. Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results. Mult Scler 2010;16:197-207
-
(2010)
Mult Scler
, vol.16
, pp. 197-207
-
-
Comi, G.1
O'Connor, P.2
Montalban, X.3
-
33
-
-
76149140914
-
Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
-
Cohen JA, Barkhof F, Comi G, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med 2010;362:402-15
-
(2010)
N Engl J Med
, vol.362
, pp. 402-415
-
-
Cohen, J.A.1
Barkhof, F.2
Comi, G.3
-
34
-
-
76149093586
-
A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
-
Kappos L, Radue EW, O'Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 2010;362:387-401
-
(2010)
N Engl J Med
, vol.362
, pp. 387-401
-
-
Kappos, L.1
Radue, E.W.2
O'Connor, P.3
-
35
-
-
64049116465
-
Hemorrhaging focal encephalitis under fingolimod (FTY720) treatment: A case report
-
Leypoldt F, Munchau A, Moeller F, et al. Hemorrhaging focal encephalitis under fingolimod (FTY720) treatment: a case report. Neurology 2009;72:1022-4
-
(2009)
Neurology
, vol.72
, pp. 1022-1024
-
-
Leypoldt, F.1
Munchau, A.2
Moeller, F.3
-
36
-
-
84856765751
-
-
Available from
-
Available from: http://www.ema.europa.eu/docs/en-GB/document-library/ EPAR-Conditions-imposed-on-member-states-for-safe-and-effective-use/human/ 002202/WC500104527.pdf
-
-
-
-
37
-
-
84555192408
-
A phase i study to evaluate safety tolerability pharmacological properties of a selective sphingosine-1-phosphate (S1P) receptor agonist ONO-4641 in patients with multiple sclerosis poster no. P991
-
ONO-4641 Study Group 13-16 October 2010; Gothenburg
-
Kasper LH, Due BR, et al. ONO-4641 Study Group. A phase I study to evaluate safety, tolerability and pharmacological properties of a selective sphingosine-1-phosphate (S1P) receptor agonist ONO-4641 in patients with multiple sclerosis poster no. P991. 26th Congress of the European Committee for the Treatment and Research in Multiple Sclerosis; 13-16 October 2010; Gothenburg
-
26th Congress of the European Committee for the Treatment Research in Multiple Sclerosis
-
-
Kasper, L.H.1
Due, B.R.2
-
38
-
-
0034122123
-
Leflunomide: An immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases
-
DOI 10.1016/S0162-3109(00)00191-0, PII S0162310900001910
-
Herrmann ML, Schleyerbach R, Kirschbaum BJ. Leflunomide: an immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases. Immunopharmacology 2000;47:273-89 (Pubitemid 30394543)
-
(2000)
Immunopharmacology
, vol.47
, Issue.2-3
, pp. 273-289
-
-
Herrmann, M.L.1
Schleyerbach, R.2
Kirschbaum, B.J.3
-
39
-
-
80054722184
-
Immune mechanisms of new therapeutic strategies in MS-Teriflunomide
-
Feb 28. Epub ahead of print
-
Claussen MC, Korn T. Immune mechanisms of new therapeutic strategies in MS-Teriflunomide. Clin Immunol 2011 Feb 28. Epub ahead of print
-
(2011)
Clin Immunol
-
-
Claussen, M.C.1
Korn, T.2
-
40
-
-
62149096116
-
Teriflunomide reduces behavioral, electrophysiological, and histopathological deficits in the dark agouti rat model of experimental autoimmune encephalomyelitis
-
Merrill JE, Hanak S, Pu SF, et al. Teriflunomide reduces behavioral, electrophysiological, and histopathological deficits in the Dark Agouti rat model of experimental autoimmune encephalomyelitis. J Neurol 2009;256:89-103
-
(2009)
J Neurol
, vol.256
, pp. 89-103
-
-
Merrill, J.E.1
Hanak, S.2
Pu, S.F.3
-
41
-
-
0032374063
-
Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide
-
Bruneau JM, Yea CM, Spinella-Jaegle S, et al. Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide. Biochem J 1998;336:299-303 (Pubitemid 28564384)
-
(1998)
Biochemical Journal
, vol.336
, Issue.2
, pp. 299-303
-
-
Bruneau, J.-M.1
Yea, C.M.2
Spinella-Jaegle, S.3
Fudali, C.4
Woodward, K.5
Robson, P.A.6
Sautes, C.7
Westwood, R.8
Kuo, E.A.9
Williamson, R.A.10
Ruuth, E.11
-
42
-
-
33645799680
-
A phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses
-
DOI 10.1212/01.wnl.0000203121.04509.31, PII 0000611420060328000022
-
O'Connor PW, Li D, Freedmann MS, et al. A phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses. Neurology 2006;66:894-900 (Pubitemid 43739766)
-
(2006)
Neurology
, vol.66
, Issue.6
, pp. 894-900
-
-
O'Connor, P.W.1
Li, D.2
Freedman, M.S.3
Bar-Or, A.4
Rice, G.P.A.5
Confavreux, C.6
Paty, D.W.7
Stewart, J.A.8
Scheyer, R.9
-
43
-
-
84877270422
-
Oral teriflunomide is effective and well tolerated in multiple sclerosis with relapses: Results of an open-label 144-week extension study Poster 379
-
on behalf of the Teriflunomide Multiple Sclerosis Trial Group. 28 September Madrid, Spain
-
O'Connor P, Li D, Freedman M, et al. on behalf of the Teriflunomide Multiple Sclerosis Trial Group. Oral teriflunomide is effective and well tolerated in multiple sclerosis with relapses: results of an open-label 144-week extension study Poster 379. Program and abstracts of the 22nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis; 28 September 2006; Madrid, Spain
-
(2006)
Program and Abstracts of the 22nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis
-
-
O'Connor, P.1
Li, D.2
Freedman, M.3
-
44
-
-
78649839271
-
A placebo controlled phase III trial (TEMSO) of oral teriflunomide in relapsing multiple sclerosis: Clinical efficacy and safety outcomes abstract
-
O'Connor P, Wolinsky J, Confavreux C, et al. A placebo controlled phase III trial (TEMSO) of oral teriflunomide in relapsing multiple sclerosis: clinical efficacy and safety outcomes abstract. Mult Scler 2010;16:S23-79
-
(2010)
Mult Scler
, vol.16
-
-
O'Connor, P.1
Wolinsky, J.2
Confavreux, C.3
-
45
-
-
77949285625
-
Oral teriflunomide or placebo added to interferon beta for 6 months in patients with relapsing multiple sclerosis: Safety and efficacy results abstract p878
-
September 2009; Dusseldorf, Germany, Mult Scler
-
Freedman M, Wolinsky JS, Byrnes WJ, et al. Oral teriflunomide or placebo added to interferon beta for 6 months in patients with relapsing multiple sclerosis: safety and efficacy results abstract P878. Presented at: 25th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); 9-12 September 2009; Dusseldorf, Germany. Mult Scler 2009;15(9):S273
-
(2009)
Presented At: 25th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); 9-12
, vol.15
, Issue.9
-
-
Freedman, M.1
Wolinsky, J.S.2
Byrnes, W.J.3
-
46
-
-
78651364988
-
Oral teriflunomide or placebo added to glatiramer acetate for 6 months in patients with relapsing multiple sclerosis: Safety and efficacy results abstract s21.001
-
10-17 April 2010; Toronto, Ont., Canada, Neurology Available from
-
Freedman M, Wolinsky JS, Frangin GA, et al. Oral teriflunomide or placebo added to glatiramer acetate for 6 months in patients with relapsing multiple sclerosis: Safety and efficacy results abstract S21.001. Presented at: 62nd Annual Meeting of the American Academy of Neurology (AAN); 10-17 April 2010; Toronto, Ont., Canada. Neurology 2010;74(9 SUPPL. 2):A293 Available from: http://clinicaltrials.gov/
-
(2010)
Presented At: 62nd Annual Meeting of the American Academy of Neurology (AAN)
, vol.74
, Issue.9 SUPPL. 2
-
-
Freedman, M.1
Wolinsky, J.S.2
Frangin, G.A.3
-
47
-
-
0036710356
-
The new orally active immunoregulator laquinimod (ABR-215062) effectively inhibits development and relapses of experimental autoimmune encephalomyelitis
-
DOI 10.1016/S0165-5728(02)00225-4, PII S0165572802002254
-
Brunmark C, Runstrom A, Ohlsson L, et al. The new orally active immunoregulator laquinimod (ABR-215062) effectively inhibits development and relapses of experimental autoimmune encephalomyelitis. J Neuroimmunol 2002;130:163-72 (Pubitemid 35240003)
-
(2002)
Journal of Neuroimmunology
, vol.130
, Issue.1-2
, pp. 163-172
-
-
Brunmark, C.1
Runstrom, A.2
Ohlsson, L.3
Sparre, B.4
Brodin, T.5
Astrom, M.6
Hedlund, G.7
-
48
-
-
77951218761
-
Laquinimod suppress antigen presentation in relapsing-remitting multiple sclerosis: In-vitro high-throughput gene expression study
-
Gurevich M, Gritzman T, Orbach R, et al. Laquinimod suppress antigen presentation in relapsing-remitting multiple sclerosis: in-vitro high-throughput gene expression study. J Neuroimmunol 2010;221:87-94
-
(2010)
J Neuroimmunol
, vol.221
, pp. 87-94
-
-
Gurevich, M.1
Gritzman, T.2
Orbach, R.3
-
49
-
-
77956649428
-
Laquinimod interferes with migratory capacity of T cells and reduces il-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitis
-
Wegner C, Stadelmann C, Pfortner R, et al. Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitis. J Neuroimmunol 2010;227:133-4
-
(2010)
J Neuroimmunol
, vol.227
, pp. 133-134
-
-
Wegner, C.1
Stadelmann, C.2
Pfortner, R.3
-
50
-
-
15244353263
-
Treatment with laquinimod reduces development of active MRI lesions in relapsing MS
-
Polman C, Barkhof F, Sandberg-Wollheim M, et al. Treatment with laquinimod reduces development of active MRI lesions in relapsing MS. Neurology 2005;64:987-91 (Pubitemid 40388448)
-
(2005)
Neurology
, vol.64
, Issue.6
, pp. 987-991
-
-
Polman, C.1
Barkhof, F.2
Sandberg-Wollheim, M.3
Linde, A.4
Nordle, O.5
Nederman, T.6
-
51
-
-
45249107267
-
Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: A multicentre, randomised, double-blind, placebo-controlled phase IIb study
-
DOI 10.1016/S0140-6736(08)60918-6, PII S0140673608609186
-
Comi G, Pulizzi A, Rovaris M, et al. Effect of laquinimod on MRI-monitored disease activity in patients with relapsing remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study. Lancet 2008;371:2085-92 (Pubitemid 351842581)
-
(2008)
The Lancet
, vol.371
, Issue.9630
, pp. 2085-2092
-
-
Comi, G.1
Pulizzi, A.2
Rovaris, M.3
Abramsky, O.4
Arbizu, T.5
Boiko, A.6
Gold, R.7
Havrdova, E.8
Komoly, S.9
Selmaj, K.10
Sharrack, B.11
Filippi, M.12
-
52
-
-
78449302875
-
Oral laquinimod in patients with relapsing-remitting multiple sclerosis: 36-week double-blind active extension of the multicentre, randomized, double-blind, parallel-group placebo controlled study
-
Comi G, Abramsky O, Arbizu T, et al. Oral laquinimod in patients with relapsing-remitting multiple sclerosis: 36-week double-blind active extension of the multicentre, randomized, double-blind, parallel-group placebo controlled study. Mult Scler 2010;16:1360-6
-
(2010)
Mult Scler
, vol.16
, pp. 1360-1366
-
-
Comi, G.1
Abramsky, O.2
Arbizu, T.3
-
53
-
-
84555207429
-
Oral laquinimod reduced relapse rate delayed progression of disability in ALLEGRO a placebo-controlled phase III trial for relapsing-remitting multiple sclerosis abstract #P05.288
-
9-16 April
-
Comi G, Jeffrey D, Kappos L, et al. Oral laquinimod reduced relapse rate and delayed progression of disability in ALLEGRO, a placebo-controlled phase III trial for relapsing-remitting multiple sclerosis abstract #P05.288. Presented at: American Academy of Neurology (AAN) 63rd Annual Meeting; 9-16 April 2011
-
(2011)
Presented at American Academy of Neurology (AAN) 63rd Annual Meeting
-
-
Comi, G.1
Jeffrey, D.2
Kappos, L.3
-
54
-
-
84857350991
-
Arnold DL on behalf of the BRAVO study. A placebo-controlled and active comparator phase III trial (BRAVO) for relapsing-remitting multiple sclerosis (abstract)
-
Vollmer TL, Soelberg Sorensen P. Arnold DL on behalf of the BRAVO study. A placebo-controlled and active comparator phase III trial (BRAVO) for relapsing-remitting multiple sclerosis. (abstract). Mult Scler 2011;17:S507-24
-
(2011)
Mult Scler
, vol.17
-
-
Vollmer, T.L.1
Soelberg Sorensen, P.2
-
55
-
-
70449253356
-
Treatment of psoriasis vulgaris
-
Schweckendiek W. Treatment of psoriasis vulgaris. Med Monatsschr 1959;13:103-4
-
(1959)
Med Monatsschr
, vol.13
, pp. 103-104
-
-
Schweckendiek, W.1
-
56
-
-
63849201620
-
15 Years of fumaderm: Fumaric acid esters for the systemic treatment of moderately severe and severe psoriasis vulgaris
-
Mrowietz U, Rostami-Yazdi M, Neureither M, et al. 15 years of fumaderm: fumaric acid esters for the systemic treatment of moderately severe and severe psoriasis vulgaris. J Dtsch Dermatol Ges 2009;7(SUPPL. 2):S3-16
-
(2009)
J Dtsch Dermatol Ges
, vol.7
, Issue.SUPPL. 2
-
-
Mrowietz, U.1
Rostami-Yazdi, M.2
Neureither, M.3
-
57
-
-
79952136166
-
Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the nrf2 antioxidant pathway
-
Linker RA, Lee DH, Ryan S, et al. Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 2011;134:678-92
-
(2011)
Brain
, vol.134
, pp. 678-692
-
-
Linker, R.A.1
Lee, D.H.2
Ryan, S.3
-
58
-
-
0030913951
-
Dimethylfumarate is an inhibitor of cytokine-induced E-selectin, VCAM-1, and ICAM-1 expression in human endothelial cells
-
DOI 10.1006/bbrc.1997.6570
-
Vandermeeren M, Janssens S, Borgers M, et al. Dimethylfumarate is an inhibitor of cytokine-induced E-selectin, VCAM-1, and ICAM-1 expression in human endothelial cells. Biochem Biophys Res Commun 1997;234:19-23 (Pubitemid 27267523)
-
(1997)
Biochemical and Biophysical Research Communications
, vol.234
, Issue.1
, pp. 19-23
-
-
Vandermeeren, M.1
Janssens, S.2
Borgers, M.3
Geysen, J.4
-
59
-
-
0345732760
-
Dimethylfumarate Is a Potent Inducer of Apoptosis in Human T Cells
-
DOI 10.1111/j.1523-1747.2003.12605.x
-
Treumer F, Zhu K, Glaser R, et al. Dimethylfumarate is a potent inducer of apoptosis in human T cells. J Invest Dermatol 2003;121:1383-8 (Pubitemid 38005490)
-
(2003)
Journal of Investigative Dermatology
, vol.121
, Issue.6
, pp. 1383-1388
-
-
Treumer, F.1
Zhu, K.2
Glaser, R.3
Mrowietz, U.4
-
60
-
-
0035675207
-
Dimethyl fumarate inhibits tumor-necrosis factor-induced cd62e expression in an nf-kappa b-dependent manner
-
Loewe R, Pillinger M, De Martin R, et al. Dimethyl fumarate inhibits tumor-necrosis factor-induced CD62E expression in an NF-kappa B-dependent manner. J Invest Dermatol 2001;117:1363-8
-
(2001)
J Invest Dermatol
, vol.117
, pp. 1363-1368
-
-
Loewe, R.1
Pillinger, M.2
De Martin, R.3
-
61
-
-
1642329197
-
Monomethylfumarate affects polarization of monocyte-derived dendritic cells resulting in down-regulated Th1 lymphocyte responses
-
DOI 10.1002/eji.200324174
-
Litjens NH, Rademaker M, Ravensbergen B, et al. Monomethylfumarate affects polarization of monocyte-derived dendritic cells resulting in down-regulated Th1 lymphocyte responses. Eur J Immunol 2004;34:565-75 (Pubitemid 39255966)
-
(2004)
European Journal of Immunology
, vol.34
, Issue.2
, pp. 565-575
-
-
Litjens, N.H.R.1
Rademaker, M.2
Ravensbergen, B.3
Rea, D.4
Van Der Plas, M.J.A.5
Thio, B.6
Walding, A.7
Van Dissel, J.T.8
Nibbering, P.H.9
-
62
-
-
33745162188
-
Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltration
-
DOI 10.1111/j.1365-2249.2006.03094.x
-
Schilling S, Goelz S, Linker R, et al. Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltration. Clin Exp Immunol 2006;145:101-7 (Pubitemid 43893938)
-
(2006)
Clinical and Experimental Immunology
, vol.145
, Issue.1
, pp. 101-107
-
-
Schilling, S.1
Goelz, S.2
Linker, R.3
Luehder, F.4
Gold, R.5
-
63
-
-
33745051595
-
Oral fumaric acid esters for the treatment of active multiple sclerosis: An open-label, baseline-controlled pilot study
-
DOI 10.1111/j.1468-1331.2006.01292.x
-
Schimrigk S, Brune N, Hellwig K, et al. Oral fumaric acid esters for the treatment of active multiple sclerosis: an open-label, baseline-controlled pilot study. Eur J Neurol 2006;13:604-10 (Pubitemid 43873632)
-
(2006)
European Journal of Neurology
, vol.13
, Issue.6
, pp. 604-610
-
-
Schimrigk, S.1
Brune, N.2
Hellwig, K.3
Lukas, C.4
Bellenberg, B.5
Rieks, M.6
Hoffmann, V.7
Pohlau, D.8
Przuntek, H.9
-
64
-
-
54149116366
-
Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: A multicentre, randomised, double-blind, placebo controlled phase iib study
-
Kappos L, Gold R, Miller DH, et al. Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo controlled phase IIb study. Lancet 2008;372:1463-72
-
(2008)
Lancet
, vol.372
, pp. 1463-1472
-
-
Kappos, L.1
Gold, R.2
Miller, D.H.3
-
65
-
-
79953769528
-
Bg-12 reduces evolution of new enhancing lesions to t1-hypointense lesions in patients with multiple sclerosis
-
MacManus DG, Miller DH, Kappos L, et al. BG-12 reduces evolution of new enhancing lesions to T1-hypointense lesions in patients with multiple sclerosis. J Neurol 2011;258:449-5
-
(2011)
J Neurol
, vol.258
, pp. 449-455
-
-
MacManus, D.G.1
Miller, D.H.2
Kappos, L.3
-
66
-
-
0042413498
-
Long-term safety aspects of systemic therapy with fumaric acid esters in severe psoriasis
-
DOI 10.1046/j.1365-2133.2003.05433.x
-
Hoefnagel JJ, Thio HB, Willemze R, et al. Long-term safety aspects of systemic therapy with fumaric acid esters in severe psoriasis. Br J Dermatol 2003;149:363-9 (Pubitemid 37100263)
-
(2003)
British Journal of Dermatology
, vol.149
, Issue.2
, pp. 363-369
-
-
Hoefnagel, J.J.1
Thio, H.B.2
Willemze, R.3
Bouwes Bavinck, J.N.4
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