메뉴 건너뛰기




Volumn 821, Issue , 2012, Pages 45-58

MTOR activity under hypoxia

Author keywords

14 3 3; Hypoxia; mTOR; Phospho 4E BP1; Phospho p70S6K; Phospho S6; Protein translation; REDD1; TSC2

Indexed keywords

ANTIBODY; CRTC2 PROTEIN, HUMAN; DDIT4 PROTEIN, HUMAN; MTORC1 COMPLEX, HUMAN; PROTEIN; TRANSCRIPTION FACTOR;

EID: 84555189441     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-430-8_4     Document Type: Article
Times cited : (39)

References (19)
  • 1
    • 32444433450 scopus 로고    scopus 로고
    • Hypoxia-induced energy stress regulates mRNA translation and cell growth
    • DOI 10.1016/j.molcel.2006.01.010, PII S1097276506000116
    • Liu L, Cash TP, Jones RG, Keith B, Thompson CB, and Simon MC (2006) Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell 21: 521-531 (Pubitemid 43228007)
    • (2006) Molecular Cell , vol.21 , Issue.4 , pp. 521-531
    • Liu, L.1    Cash, T.P.2    Jones, R.G.3    Keith, B.4    Thompson, C.B.5    Simon, M.C.6
  • 4
    • 0042031047 scopus 로고    scopus 로고
    • A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets
    • DOI 10.1074/jbc.M212770200
    • Arsham AM, Howell JJ, and Simon MC (2003) A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J Biol Chem 278: 29655-29660 (Pubitemid 36962350)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.32 , pp. 29655-29660
    • Arsham, A.M.1    Howell, J.J.2    Simon, M.C.3
  • 6
    • 77952007543 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR): Conducting the cellular signaling symphony
    • Foster KG and Fingar DC (2010) Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony. J Biol Chem 285: 14071-14077
    • (2010) J Biol Chem , vol.285 , pp. 14071-14077
    • Foster, K.G.1    Fingar, D.C.2
  • 7
    • 67349217986 scopus 로고    scopus 로고
    • Molecular mechanisms of mTOR-mediated translational control
    • Ma XM, and Blenis J (2009) Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol 10: 307-318
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 307-318
    • Ma, X.M.1    Blenis, J.2
  • 8
    • 33750068623 scopus 로고    scopus 로고
    • MTOR, translation initiation and cancer
    • DOI 10.1038/sj.onc.1209888, PII 1209888
    • Mamane Y, Petroulakis E, LeBacquer O, and Sonenberg N (2006) mTOR, translation initiation and cancer. Oncogene 25: 6416-6422 (Pubitemid 44582285)
    • (2006) Oncogene , vol.25 , Issue.48 , pp. 6416-6422
    • Mamane, Y.1    Petroulakis, E.2    LeBacquer, O.3    Sonenberg, N.4
  • 11
    • 33646550165 scopus 로고    scopus 로고
    • Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells
    • DOI 10.1128/MCB.26.10.3955-3965.2006
    • Connolly E, Braunstein S, Formenti S, and Schneider RJ (2006) Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells. Mol Cell Biol 26: 3955-3965 (Pubitemid 43726410)
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.10 , pp. 3955-3965
    • Connolly, E.1    Braunstein, S.2    Formenti, S.3    Schneider, R.J.4
  • 14
    • 10044276784 scopus 로고    scopus 로고
    • The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila
    • DOI 10.1101/gad.322704
    • Reiling JH and Hafen E (2004) The hypoxiainduced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. Genes Dev 18: 2879-2892 (Pubitemid 39602307)
    • (2004) Genes and Development , vol.18 , Issue.23 , pp. 2879-2892
    • Reiling, J.H.1    Hafen, E.2
  • 16
    • 38349056675 scopus 로고    scopus 로고
    • Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
    • DeYoung MP, Horak P, Sofer A, Sgroi D, and Ellisen LW (2008) Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev 22: 239-251
    • (2008) Genes Dev , vol.22 , pp. 239-251
    • Deyoung, M.P.1    Horak, P.2    Sofer, A.3    Sgroi, D.4    Ellisen, L.W.5
  • 17
    • 34347220473 scopus 로고    scopus 로고
    • Defining the Role of mTOR in Cancer
    • DOI 10.1016/j.ccr.2007.05.008, PII S1535610807001511
    • Guertin DA and Sabatini DM (2007) Defining the role of mTOR in cancer. Cancer Cell 12: 9-22 (Pubitemid 47001784)
    • (2007) Cancer Cell , vol.12 , Issue.1 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 18
    • 55849109650 scopus 로고    scopus 로고
    • Hypoxia-induced energy stress inhibits the mTOR pathway by activating an AMPK/ REDD1 signaling axis in head and neck squamous cell carcinoma
    • Schneider A, Younis RH, and Gutkind JS (2008) Hypoxia-induced energy stress inhibits the mTOR pathway by activating an AMPK/ REDD1 signaling axis in head and neck squamous cell carcinoma. Neoplasia 10: 1295-1302
    • (2008) Neoplasia , vol.10 , pp. 1295-1302
    • Schneider, A.1    Younis, R.H.2    Gutkind, J.S.3
  • 19
    • 21744459535 scopus 로고    scopus 로고
    • Regulation of mTOR and cell growth in response to energy stress by REDD1
    • DOI 10.1128/MCB.25.14.5834-5845.2005
    • Sofer A, Lei K, Johannessen CM, and Ellisen LW (2005) Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol 25: 5834-5845 (Pubitemid 40946541)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.14 , pp. 5834-5845
    • Sofer, A.1    Lei, K.2    Johannessen, C.M.3    Ellisen, L.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.