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Volumn 16, Issue 12, 2011, Pages 10387-10408

Synthesis and antibacterial activities of novel 2,5-diphenylindolo[2,3-e] pyrazolo[1',5':3",4"]pyrimido[2",1"-c] [1,2,4]triazines

Author keywords

Antibacterial activity; Hydrazone; Indolopyrazolopyrimidotriazine; Isatin; Pyrazolopyrimidine

Indexed keywords

ANTIINFECTIVE AGENT; INDOLE DERIVATIVE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; TRIAZINE DERIVATIVE;

EID: 84555188049     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules161210387     Document Type: Article
Times cited : (13)

References (39)
  • 1
    • 0001386435 scopus 로고
    • Synthesis of thieno[2,3-d]pyrimidines from 4,6-dichloropyrimidine-5- carbaldehydes
    • Clark, J.; Shohhet, M.S.; Korakas, D.; Varvounis, G. Synthesis of thieno[2,3-d]pyrimidines from 4,6-dichloropyrimidine-5-carbaldehydes. J. Heterocycl. Chem. 1993, 30, 1065-1072.
    • (1993) J. Heterocycl. Chem. , vol.30 , pp. 1065-1072
    • Clark, J.1    Shohhet, M.S.2    Korakas, D.3    Varvounis, G.4
  • 2
    • 0027372032 scopus 로고
    • Syntheses of substituted 2,4-dioxothienopyrimidin- 1-acetic acids and their evaluation as aldose reductase inhibitors
    • Kogowwra, I.Y.; Yimatsusita, N.N.; Pfkador, J.K. Syntheses of substituted 2,4-dioxothienopyrimidin- 1-acetic acids and their evaluation as aldose reductase inhibitors. Eur. J. Med. Chem. 1993, 28, 769-781.
    • (1993) Eur. J. Med. Chem. , vol.28 , pp. 769-781
    • Kogowwra, I.Y.1    Yimatsusita, N.N.2    Pfkador, J.K.3
  • 3
    • 0032825505 scopus 로고    scopus 로고
    • Synthesis and anti-inflammatory activities of some thiazolo[3,2-a] pyrimidine derivatives
    • DOI 10.1016/S0014-827X(99)00068-3, PII S0014827X99000683
    • Tozkoparan, B.; Ertan, M.; Kelicen, P.; Demirdamar, R. Synthesis and anti-inflammatory activities of some thiazolo[3,2-a]pyrimidine derivatives. Il Farmaco 1999, 54, 588-593. (Pubitemid 29462619)
    • (1999) Farmaco , vol.54 , Issue.9 , pp. 588-593
    • Tozkoparan, B.1    Ertan, M.2    Kelicen, P.3    Demirdamar, R.4
  • 5
    • 0030065816 scopus 로고    scopus 로고
    • Synthesis of aminothienopyrimidine and thienotriazolopyrimidine derivatives as potential anticonvulsant agents
    • Santagati, M.; Modica, M.; Santagati, A.; Russo, F.; Spampinato, S. Synthesis of aminothienopyrimidine and thienotriazolopyrimidine derivatives as potential anticonvulsant agents. Pharmazie 1996, 51, 7-11. (Pubitemid 26056292)
    • (1996) Pharmazie , vol.51 , Issue.1 , pp. 7-11
    • Santagati, M.1    Modica, M.2    Santagati, A.3    Russo, F.4    Spampinato, S.5
  • 6
    • 0034084739 scopus 로고    scopus 로고
    • A Convenient Synthesis of Novel Pyrimidine Analogues of o-Hydroxy Chalcones and Pyrano[2,3-d]pyrimidines and Their Biological Activities
    • Ahluwalia, V.K.; Chopra, M.; Chandra, R. A Convenient Synthesis of Novel Pyrimidine Analogues of o-Hydroxy Chalcones and Pyrano[2,3-d]pyrimidines and Their Biological Activities. J. Chem. Res. 2000, 2000, 162-163.
    • (2000) J. Chem. Res. , vol.2000 , pp. 162-163
    • Ahluwalia, V.K.1    Chopra, M.2    Chandra, R.3
  • 7
    • 0028279946 scopus 로고
    • Synthesis and antibacterial activity of substituted 4-aryloxypyrimido[5, 4-c]cinnolines
    • DOI 10.1016/0223-5234(94)90043-4
    • Nargund, L.V.G.; Badiger, V.V.; Yarnal, S.U. Synthesis and antibacterial activity of substituted 4-aryloxypyrimido[5,4-c]cinnolines. Eur. J. Med. Chem. 1994, 29, 245-247. (Pubitemid 24103885)
    • (1994) European Journal of Medicinal Chemistry , vol.29 , Issue.3 , pp. 245-247
    • Nargund, L.V.G.1    Badiger, V.V.2    Yarnal, S.M.3
  • 8
    • 0035114901 scopus 로고    scopus 로고
    • 2A/2C antagonist ritanserin on driving performance, slow wave sleep and daytime sleepiness in healthy volunteers
    • DOI 10.1007/s002130000633
    • Vanlaar, M.; Volerts, E.; Verbaten, M. Subchronic effects of the GABA-agonist lorazepam and the 5-HT2A/2C antagonist ritanserin on driving performance, slow wave sleep and daytime sleepiness in healthy volunteers. Psychopharmacology 2001, 154, 189-197. (Pubitemid 32186504)
    • (2001) Psychopharmacology , vol.154 , Issue.2 , pp. 189-197
    • Van Laar, M.1    Volkerts, E.2    Verbaten, M.3
  • 9
    • 0031942724 scopus 로고    scopus 로고
    • Synthesis and anti-HIV-1 activity of novel 2,3-dihydro-7H-thiazolo[3,2- a]pyrimidin-7-ones
    • DOI 10.1021/jm970443m
    • Danel, K.; Pedersen, E.B.; Nielsen, C. Synthesis and anti-HIV-1 activity of novel 2,3-dihydro-7Hthiazolo[ 3,2-a]pyrimidin-7-ones. J. Med. Chem. 1998, 41, 191-198. (Pubitemid 28114361)
    • (1998) Journal of Medicinal Chemistry , vol.41 , Issue.2 , pp. 191-198
    • Danel, K.1    Pedersen, E.B.2    Nielsen, C.3
  • 10
    • 34250731830 scopus 로고    scopus 로고
    • Synthesis, analgesic, and antiparkinsonian profiles of some pyridine, pyrazoline, and thiopyrimidine derivatives
    • Nehad, A.A.; Nermien, M.S.; Ashraf, M.M.; Abdulla, M.M. Synthesis, Analgesic, and Antiparkinsonian Profiles of Some Pyridine, Pyrazoline, and Thiopyrimidine Derivatives. Monatsh. Chem. 2007, 138, 715-724.
    • (2007) Monatsh. Chem. , vol.138 , pp. 715-724
    • Nehad, A.A.1    Nermien, M.S.2    Ashraf, M.M.3    Abdulla, M.M.4
  • 11
    • 34848919763 scopus 로고    scopus 로고
    • Synthesis, Reactions, and Antiarrhythmic activity of Substituted Heterocyclic Systems Using 5-Chloroanisic Acid as Starting Material
    • Ahmed, F.A.S.; Abdulla, M.M.; Amr, A.E.; Azza, A.H. Synthesis, Reactions, and Antiarrhythmic activity of Substituted Heterocyclic Systems Using 5-Chloroanisic Acid as Starting Material. Monatsh. Chem. 2007, 138, 1019-1027.
    • (2007) Monatsh. Chem. , vol.138 , pp. 1019-1027
    • Ahmed, F.A.S.1    Abdulla, M.M.2    Amr, A.E.3    Azza, A.H.4
  • 12
    • 0141704527 scopus 로고    scopus 로고
    • Synthesis of novel tricyclic heterocyclic compounds as potential anticancer agents using chromanone and thiochromanoneas synthons
    • Hammam, A.G.; Fahmy, A.F.M.; Amr, A.E.; Mohamed, A.M. Synthesis of novel tricyclic heterocyclic compounds as potential anticancer agents using chromanone and thiochromanoneas synthons. Indian J. Chem. 2003, 42B, 1985-1993.
    • (2003) Indian J. Chem. , vol.42 B , pp. 1985-1993
    • Hammam, A.G.1    Fahmy, A.F.M.2    Amr, A.E.3    Mohamed, A.M.4
  • 13
    • 0346846769 scopus 로고    scopus 로고
    • Synthesis and Reactions of Some Fused Oxazinone, Pyrimidinone, Thiopyrimidinone, and Triazinone Derivatives with a Thiophene Ring as Analgesic, Anticonvulsant, and Antiparkinsonian Agents
    • DOI 10.1007/s00706-003-0051-z
    • Amr, A.E.; Hegab, M.I.; Ibrahim, A.A.; Abdalah, M.M. Synthesis and Reactions of Some Fused Oxazinone, Pyrimidinone, Thiopyrimidinone, and Triazinone Derivatives with a Thiophene Ring as Analgesic, Anticonvulsant, and Antiparkinsonian Agents. Monatsh. Chem. 2003, 134, 1395-1409. (Pubitemid 38005182)
    • (2003) Monatshefte fur Chemie , vol.134 , Issue.10 , pp. 1395-1409
    • Amr, A.-G.E.1    Hegab, M.I.2    Ibrahiem, A.A.3    Abdulla, M.M.4
  • 14
    • 0036823559 scopus 로고    scopus 로고
    • Synthesis and pharmacological screening of some new pyrimidine and cyclohexenone fused steroidal derivatives
    • Amr, A.E.; Abdulla, M.M. Synthesis and pharmacological screening of some new pyrimidine and cyclohexenone fused steroidal derivatives. Indian J. Heterocycl. Chem. 2002, 12, 129-134. (Pubitemid 36419364)
    • (2002) Indian Journal of Heterocyclic Chemistry , vol.12 , Issue.2 , pp. 129-134
    • Amr, A.E.-G.E.1    Abdulla, M.M.2
  • 15
    • 34249656734 scopus 로고    scopus 로고
    • Synthesis, Reactions, and Pharmacological Screening of Heterocyclic Derivatives Using Nicotinic Acid as a Natural Synthon
    • Nehad, A.A.; Amr, A.E.; Alhusien, A.I. Synthesis, Reactions, and Pharmacological Screening of Heterocyclic Derivatives Using Nicotinic Acid as a Natural Synthon. Monatsh. Chem. 2007, 138, 559-567.
    • (2007) Monatsh. Chem. , vol.138 , pp. 559-567
    • Nehad, A.A.1    Amr, A.E.2    Alhusien, A.I.3
  • 16
    • 34250693141 scopus 로고    scopus 로고
    • Synthesis, Reactions, and Anti-inflammatory Activity of Heterocyclic Systems Fused to a Thiophene Moiety Using Citrazinic Acid As Synthon
    • Amr, A.E.; Nermien, M.S.; Abdulla, M.M. Synthesis, Reactions, and Anti-inflammatory Activity of Heterocyclic Systems Fused to a Thiophene Moiety Using Citrazinic Acid As Synthon. Monatsh. Chem. 2007, 138, 699-707.
    • (2007) Monatsh. Chem. , vol.138 , pp. 699-707
    • Amr, A.E.1    Nermien, M.S.2    Abdulla, M.M.3
  • 17
    • 33745604932 scopus 로고    scopus 로고
    • Anticancer activities of some newly synthesized pyridine, pyrane, and pyrimidine derivatives
    • Amr, A.E.; Ashraf, M.M.; Salwa, F.M.; Nagla, A.A.; Hammam, A.G. Anticancer activities of some newly synthesized pyridine, pyrane, and pyrimidine derivatives. Bioorg. Med. Chem. 2006, 14, 5481-5488.
    • (2006) Bioorg. Med. Chem. , vol.14 , pp. 5481-5488
    • Amr, A.E.1    Ashraf, M.M.2    Salwa, F.M.3    Nagla, A.A.4    Hammam, A.G.5
  • 18
    • 25444432551 scopus 로고    scopus 로고
    • Synthesis and reactions of some new substituted pyridine and pyrimidine derivatives as analgesic, anticonvulsant and antiparkinsonian agents
    • DOI 10.1002/ardp.200500982
    • Amr, A.E.; Sayed, H.H.; Abdulla, M.M. Synthesis and Reactions of Some New Substituted Pyridine and Pyrimidine Derivatives as Analgesic, Anticonvulsant and Antiparkinsonian Agents. Arch. Pharm. 2005, 338, 433-440. (Pubitemid 41367854)
    • (2005) Archiv der Pharmazie , vol.338 , Issue.9 , pp. 433-440
    • Amr, A.E.-G.E.1    Sayed, H.H.2    Abdulla, M.M.3
  • 19
    • 0017226660 scopus 로고
    • Proline determination with isatin, in the presence of amino acids
    • Elliott, R.J.; Gardner, D.L. Proline determination with isatin, in the presence of amino acids. Anal. Biochem. 1976, 70, 268-273.
    • (1976) Anal. Biochem. , vol.70 , pp. 268-273
    • Elliott, R.J.1    Gardner, D.L.2
  • 20
    • 0008934178 scopus 로고
    • Testing the age and viability of airborne pollen
    • Kapyla, M. Testing the age and viability of airborne pollen. Grana 1991, 30, 430-433.
    • (1991) Grana , vol.30 , pp. 430-433
    • Kapyla, M.1
  • 21
    • 0001427995 scopus 로고    scopus 로고
    • Development of colorimetric method for the detection of amines bound to solid support
    • Shah, A.; Rahman, S.S.; deBiasi, V.; Camilleri, P. Development of Colorimetric Method for the Detection of Amines Bound to Solid Support. Anal. Commun. 1997, 34, 325-328.
    • (1997) Anal. Commun. , vol.34 , pp. 325-328
    • Shah, A.1    Rahman, S.S.2    Debiasi, V.3    Camilleri, P.4
  • 22
    • 0018170260 scopus 로고
    • Non-chromatographic screening test for hyperprolinemia
    • Yamaguchi, Y. Non-chromatographic screening test for hyperprolinemia. Clin. Chem. 1978, 12, 2178-2179. (Pubitemid 9079591)
    • (1978) Clinical Chemistry , vol.24 , Issue.12 , pp. 2178-2179
    • Yamaguchi, Y.1
  • 23
    • 0026085001 scopus 로고
    • Assay of HIV-1 proteinase: A colorimetric method using small peptide substrates
    • Broadhurst, A.V.; Roberts, N.A.; Ritchie, A.J.; Handa, B.K.; Kay, C. Assay of HIV-1 proteinase: A colorimetric method using small peptide substrates. Anal. Biochem. 1991, 193, 280-286.
    • (1991) Anal. Biochem. , vol.193 , pp. 280-286
    • Broadhurst, A.V.1    Roberts, N.A.2    Ritchie, A.J.3    Handa, B.K.4    Kay, C.5
  • 24
    • 0017132302 scopus 로고
    • Determination of the amino acid spectrum as an aid in the up-dating of skeletal findings
    • Bonte, W.; Johansson, J.; Garbe, G.; Berg, S. Determination of the amino acid spectrum as an aid in the up-dating of skeletal findings. Arch. Kriminol. 1976, 158, 163-174.
    • (1976) Arch. Kriminol. , vol.158 , pp. 163-174
    • Bonte, W.1    Johansson, J.2    Garbe, G.3    Berg, S.4
  • 26
    • 84555193897 scopus 로고
    • [Chem. Abstr. 1989, 111, 160356j].
    • (1989) Chem. Abstr. , vol.111
  • 27
    • 0347736827 scopus 로고
    • Isatin 3-hydrazone as a new reagent for determination of 3-oxosteroids
    • Dochinets, D.I.; Petrenko, V.V.; Zorya, B.P. Isatin 3-hydrazone as a new reagent for determination of 3-oxosteroids. Zh. Anat. Khim. 1989, 44, 510-513
    • (1989) Zh. Anat. Khim. , vol.44 , pp. 510-513
    • Dochinets, D.I.1    Petrenko, V.V.2    Zorya, B.P.3
  • 28
    • 84555193898 scopus 로고
    • [Chem. Abstr. 1989, 110, 219165f].
    • (1989) Chem. Abstr. , vol.110
  • 30
    • 80052240655 scopus 로고    scopus 로고
    • Synthesis of 4-(1-phenyl-1H-pyrazol-3-yl)-[1,2,4]triazolo[4,3- a]quinoxalines and their 4-halogenopyrazoyl analogs
    • Atta, K.F.M.; El Ashry, E.S.H. Synthesis of 4-(1-phenyl-1H-pyrazol-3-yl)- [1,2,4]triazolo[4,3- a]quinoxalines and their 4-halogenopyrazoyl analogs. J. Heterocycl. Chem. 2011, 48, 1216-1223.
    • (2011) J. Heterocycl. Chem. , vol.48 , pp. 1216-1223
    • Atta, K.F.M.1    El Ashry, E.S.H.2
  • 31
    • 79952010615 scopus 로고    scopus 로고
    • Synthesis and reactions of a new series of 1,2,4-triazolo[4,3-c] quinazolines
    • Atta, K.F.M.; Marei, M.G.; Mohamed, F.A.M. Synthesis and reactions of a new series of 1,2,4-triazolo[4,3-c]quinazolines. Heterocycles 2011, 83, 339-349.
    • (2011) Heterocycles , vol.83 , pp. 339-349
    • Atta, K.F.M.1    Marei, M.G.2    Mohamed, F.A.M.3
  • 32
    • 79961157183 scopus 로고    scopus 로고
    • Annulation and Evaluation of Antibacterial Activity of the New Fused Tricyclic(5,5,6) Ring System of Pyrazolo[1,5-c]- 1,2,4-triazolo[4,3-a] pyrimidines
    • Atta, K.F.M.; Marei, M.G.; Abd El Magiad, S.M.; El-Nashar, F.H.A. Annulation and Evaluation of Antibacterial Activity of The New Fused Tricyclic(5,5,6) Ring System of Pyrazolo[1,5-c]- 1,2,4-triazolo[4,3-a] pyrimidines. Heterocycles 2011, 83, 1873-1888.
    • (2011) Heterocycles , vol.83 , pp. 1873-1888
    • Atta, K.F.M.1    Marei, M.G.2    Abd El Magiad, S.M.3    El-Nashar, F.H.A.4
  • 33
    • 80052216062 scopus 로고    scopus 로고
    • Synthesis and Electrophilic Substitutions of Novel Pyrazolo[1,5-c]-1,2,4- triazolo[4,3-a]pyrimidines
    • Atta, K.F.M. Synthesis and Electrophilic Substitutions of Novel Pyrazolo[1,5-c]-1,2,4- triazolo[4,3-a]pyrimidines. Molecules 2011, 16, 7081-7096.
    • (2011) Molecules , vol.16 , pp. 7081-7096
    • Atta, K.F.M.1
  • 34
    • 82455205765 scopus 로고    scopus 로고
    • Study of the reaction of 5-aryl-7-hydrazino-2-phenylpyrazolo[1,5-c] pyrimidines with 1,3-dicarbonyl compounds
    • Atta, K.F.M. Study of the reaction of 5-aryl-7-hydrazino-2- phenylpyrazolo[1,5-c]pyrimidines with 1,3-dicarbonyl compounds. Chin. J. Chem. 2011, 29, 2451-2460.
    • (2011) Chin. J. Chem. , vol.29 , pp. 2451-2460
    • Atta, K.F.M.1
  • 35
    • 34247265250 scopus 로고
    • New synthesis of pyrazolo(1,5-c)pyrimidines from acetylenic ?- diketones
    • Marei, M.G.; Mishrikey, M.M.; Aly, D.M. New Synthesis of Pyrazolo(1,5-c)pyrimidines from Acetylenic ?- Diketones. Bull. Chem. Soc. Jpn. 1992, 65, 3419-3422.
    • (1992) Bull. Chem. Soc. Jpn. , vol.65 , pp. 3419-3422
    • Marei, M.G.1    Mishrikey, M.M.2    Aly, D.M.3
  • 36
    • 84555193900 scopus 로고
    • ChemInform Abstract: Reaction of pyrazolo[1,5-c]pyrimidinethiones with hydrazine: Synthesis of novel substituted pyrazolo[1,5-c]pyrimidine and pyrazolo[1,5- c]tetrazolo[1,5-a]pyrimidine derivatives
    • doi:10.1002/chin.199351206
    • Marei, M.G.; El-Ghanam, M. ChemInform Abstract: Reaction of pyrazolo[1,5-c]pyrimidinethiones with hydrazine: Synthesis of novel substituted pyrazolo[1,5-c]pyrimidine and pyrazolo[1,5- c]tetrazolo[1,5-a]pyrimidine derivatives. ChemInform 1993, 24, doi:10.1002/chin.199351206.
    • (1993) ChemInform , vol.24
    • Marei, M.G.1    El-Ghanam, M.2
  • 39
    • 79952217185 scopus 로고    scopus 로고
    • Bis 4,5-diazafluoren-9-one silver(I) nitrate: Synthesis, X-ray structures, solution chemistry, hydrogel loading, DNA coupling and antibacterial screening
    • Massoud, A.A.; Gohar, Y.M.; Langer, V.; Lincoln, P.; Svensson, F.R.; Jänis, J.; Gårdebjer, S.T.; Haukka, M.; Jonsson, F.; Aneheim, E.; et al. Bis 4,5-diazafluoren-9-one silver(I) nitrate: Synthesis, X-ray structures, solution chemistry, hydrogel loading, DNA coupling and antibacterial screening. New J. Chem. 2011, 35, 640-648.
    • (2011) New J. Chem. , vol.35 , pp. 640-648
    • Massoud, A.A.1    Gohar, Y.M.2    Langer, V.3    Lincoln, P.4    Svensson, F.R.5    Jänis, J.6    Gårdebjer, S.T.7    Haukka, M.8    Jonsson, F.9    Aneheim, E.10


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