PH-titratable superparamagnetic iron oxide for improved nanoparticle accumulation in acidic tumor microenvironments

ACS Nano

Volumn 5, Issue 12, 2011, Pages 9592-9601

  Crayton, Samuel H ^a   Tsourkas, Andrew ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

EPR; glycol chitosan; metabolic imaging; pH; SPIO; Warburg effect

Indexed keywords

BLOOD CIRCULATION; CELLULAR ASSOCIATION; CONTROL AGENT; ENHANCED PERMEABILITY AND RETENTION EFFECT; EXTRACELLULAR PH; GLYCOL CHITOSAN; IN-VITRO; IRON OXIDE NANOPARTICLE; METABOLIC IMAGING; METABOLIC PHENOTYPE; METABOLIC PROFILES; METABOLIC SHIFT; METASTATIC CANCERS; MICROENVIRONMENTS; MR CONTRAST AGENTS; OXIDATIVE PHOSPHORYLATION; OXYGEN TENSION; PH SENSITIVITY; PH-DEPENDENT; PH-RESPONSIVE; RECEPTOR-LIGAND INTERACTIONS; SPIO; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES; SUPERPARAMAGNETIC IRON OXIDES; TUMOR MICROENVIRONMENT; TUMOR MODELS; TUMOR SITE; TUMORIGENESIS; WARBURG EFFECT; WATERSOLUBLE POLYMERS;

CARDIOVASCULAR SYSTEM; CHITOSAN; CONJUGATED POLYMERS; ENZYME ACTIVITY; GLYCOLS; INDUCTIVELY COUPLED PLASMA; INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY; IRON; LACTIC ACID; METABOLISM; NANOPARTICLES; PARAMAGNETIC RESONANCE; PH; PH EFFECTS; PHOSPHORYLATION; SUPERPARAMAGNETISM; TUMORS;

IRON OXIDES;

CONTRAST MEDIUM; DEXTRAN; DIAGNOSTIC AGENT; FERUMOXTRAN-10; MAGNETITE NANOPARTICLE; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE;

ANIMAL; ARTICLE; CHEMISTRY; IMAGE ENHANCEMENT; METHODOLOGY; MOUSE; NUCLEAR MAGNETIC RESONANCE IMAGING; NUDE MOUSE; PATHOLOGY; PH; SOFT TISSUE TUMOR; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CONTRAST MEDIA; DEXTRANS; HYDROGEN-ION CONCENTRATION; IMAGE ENHANCEMENT; MAGNETIC RESONANCE IMAGING; MAGNETITE NANOPARTICLES; MICE; MICE, NUDE; SOFT TISSUE NEOPLASMS;

EID: 84555169257     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn202863x     Document Type: Article

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