Target-specific action of organochlorine compounds in reproductive and nonreproductive tissues of estrogen-reporter male mice

Toxicology and Applied Pharmacology

Volumn 201, Issue 2, 2004, Pages 137-148

  Villa, R ^a   Bonetti, E ^a   Penza, M L ^a   Iacobello, C ^a   Bugari, G ^a   Bailo, M ^b   Parolini, O ^b   Apostoli, P ^c   Caimi, L ^c   Ciana, P ^d   Maggi, A ^d   Di Lorenzo, D ^a  

^a Civic Hospital   (Italy)

^b Ospedale Poliambulanza   (Italy)

^c UNIVERSITY OF BRESCIA   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

Endocrine disruptors; Estrogen receptors; Estrogen responsive elements; In vivo imaging; Organochlorines; Reporter mice

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; BETA HEXACHLOROCYCLOHEXANE; CHLORPHENOTANE; ESTROGEN; ESTROGEN RECEPTOR; FULVESTRANT; LUCIFERASE; ORGANOCHLORINE DERIVATIVE; PROGESTERONE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG BLOOD LEVEL; GENE CONTROL; HORMONE ACTION; HORMONE DETERMINATION; LIVER; LUNG; MALE; MOUSE; NONHUMAN; PROSTATE; PROTEIN EXPRESSION; REPRODUCTIVE TOXICITY; TARGET ORGAN; TESTIS; TISSUE SPECIFICITY;

ADIPOSE TISSUE; ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; DDT; DICHLORODIPHENYL DICHLOROETHYLENE; ESTROGENS; ESTROGENS, NON-STEROIDAL; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GENES, REPORTER; GENITALIA, MALE; HUMANS; HYDROCARBONS, CHLORINATED; LINDANE; LUMINESCENT MEASUREMENTS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TISSUE DISTRIBUTION;

EID: 8444246730     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2004.05.007     Document Type: Article

References (71)

1. Ahmed S.A. The immune system as a potential target for environmental estrogens (endocrine disruptors): a new emerging field. Toxicology. 150:2000;191-206
2. Barrett-Connor E., Bush T.L. Estrogen and coronary heart disease in women. JAMA. 265:1991;1861-1867
3. Barrett-Connor E., Grady D., Sashegyi A., Anderson P.W., Cox D.A., Hoszowski K., Rautaharju P., Harper K.D. Raloxifene and cardiovascular events in osteoporotic postmenopausal women: four-year results from the MORE (multiple outcomes of raloxifene evaluation) randomized trial. JAMA. 287:2002;847-857
4. Beaufrand M.J., Poullain B., Klein D., Derby G. Release of organochloride pesticides during acute weight losses. Toxicol. Eur. Res. 1:1978;39-43
5. Behl C. Estrogen can protect neurons: modes of action. J. Steroid Biochem. Mol. Biol. 83:2002;195-197
6. Bigsby R.M., Caperell-Grant A., Madhukar B.V. Xenobiotics released from fat during fasting produce estrogenic effects in ovariectomized mice. Cancer Res. 57:1997;869
7. Bradford M.M. A rapid and sensitive method for the quantification of microgram quantities of proteins utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-251
8. Charlier C., Desaive C., Plomteux G. Human exposure to endocrine disrupters: consequences of gastroplasty on plasma concentration of toxic pollutants. Int. J. Obes. Relat. Metab. Disord. 26:2002;1465-1468
9. Chowdhury A.R., Gautam A.K. BHC induced testicular impairments in rats. Indian J. Physiol. Pharmacol. 34:1990;215-217
10. Ciana P., Di Luccio G., Belcredito S., Pollio G., Vegeto E., Tatangelo L., Tiveron C., Maggi A. Engineering of a mouse for the in vivo profiling of estrogen receptor activity. Mol. Endocrinol. 15:2001;1104-1113
11. Ciana P., Raviscioni M., Mussi P., Vegeto E., Que I., Parker M.G., Lowik C., Maggi A. In vivo imaging of transcriptionally active estrogen receptors. Nat. Med. 9:2003;82-86
12. Contag C.H., Spilman S.D., Contag P.R., Oshiro M., Eames B., Dennery P., Stevenson D.K., Benaron D.A. Visualizing gene expression in living mammals using a bioluminescent reporter. Photochem. Photobiol. 66:1997;523-531
13. Dale W.E., Gaines T.B., Hayes W.J. Storage and excretion of DDT in starved rats. Toxicol. Appl. Pharmacol. 4:1962;89-106
14. Daling J.R., Malone K.E., Doody D.R., Voigt L.F., Bernstein L., Coates R.J., Marchbanks P.A., Norman S.A., Weiss L.K., Ursin G., Berlin J.A., Burkman R.T., Deapen D., Folger S.G., McDonald J.A., Simon M.S., Strom B.L., Wingo P.A., Spirtas R. Relation of regimens of combined hormone replacement therapy to lobular, ductal, and other histologic types of breast carcinoma. Cancer. 95:2002;2455-2464
15. Degen G.H., Bolt H.M. Endocrine disruptors: update on xenoestrogens. Int. Arch. Occup. Environ. Health. 73:2000;433-441
16. Del Priore G., Hatami M. Hormone replacement therapy in breast cancer patients and survivors. Curr. Women's Health Rep. 3:2003;165-169
17. Den Hond E., Roels H.A., Hoppenbrouwers K., Nawrot T., Thijs L., Vandermeulen C., Winneke G., Vanderschueren D., Staessen J.A. Sexual maturation in relation to polychlorinated aromatic hydrocarbons: Sharpe and Skakkebaek's hypothesis revisited. Environ. Health Perspect. 110:2001;771-776
18. de Vet J.R., Wood K.V., De Luca M., Helinski D.R., Subramani S. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell. Biol. 7:1987;725-737
19. Diel P., Schultz T., Smolnikar K., Strunck E., Vollmer G., Michna H. Ability of xeno- and phytoestrogens to modulate expression of estrogen-sensitive genes in rat uterus: estrogenicity profiles and uterotrophic activity. J. Steroid Biochem. Mol. Biol. 73:2000;1-10
20. Dikshith T.S., Datta K.K., Kushwah H.S., Raizada R.B. Histopathological and biochemical changes in guinea pigs after repeated dermal exposure to benzene hexachloride. Toxicology. 10:1978;55-66
21. Di Lorenzo D., Villa R., Biasiotto G., Belloli S., Ruggeri G., Albertini A., Apostoli P., Raviscioni M., Ciana P., Maggi A. Isomer-specific activity of dichlorodyphenyltrichloroethane with estrogen receptor in adult and suckling reporter mice. Endocrinology. 143:2002;4544-4551
22. Dimitrova K.R., De Groot K., Myers A.K., Kim Y.D. Estrogen and homocysteine. Cardiovasc. Res. 53:2002;577-588
23. Duchiron C., Reynaud S., Deschaux P. Lindane-induced macrophage activating factor (MAF) production by peripheral blood leukocytes (PBLs) of rainbow trout (Oncorhynchus mykiss): involvement of intracellular cAMP mobilization. Aquat. Toxicol. 56:2002;81-91
24. Eckert R.L., Mullick A., Rorke E.A., Katzenellenbogen B.S. Estrogen receptor synthesis and turnover in MCF-7 breast cancer cells measured by a density shift technique. Endocrinology. 114:1984;629-637
25. Eddy E.M., Washburn T.F., Bunch D.O., Goulding E.H., Gladen B.C., Lubahn D.B., Korach K.S. Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility. Endocrinology. 137:1996;4796-4805
26. Frigo D.E., Burow M.E., Mitchell K.A., Chiang T.C., McLachlan J.A. DDT and its metabolites alter gene expression in human uterine cell lines through estrogen receptor-independent mechanisms. Environ. Health Perspect. 110:2002;1239-1245
27. Grigoriadis S., Kennedy S.H. Role of estrogen in the treatment of depression. Am. J. Ther. 9:2002;503-509
28. Herron R.E., Fagan J.B. Lipophilic-mediated reduction of toxicants in humans: an evaluation of an ayurvedic detoxification procedure. Altern. Ther. Health Med. 8:2002;40-51
29. Hess R.A., Bunick D., Lee K.H., Bahr J., Taylor J.A., Korach K.S., Lubahn D.B. A role for oestrogens in the male reproductive system. Nature. 390:1997;509-512
30. Hinton C.P., Coventry C., Borrowclough B. Making decisions about hormone replacement therapy: preparations containing oestrogen should not be given during treatment for breast cancer. BMJ. 326:2003;1398-1399. (author reply)
31. Honigman A., Zeira E., Ohana P., Abramovitz R., Tavor E., Bar I., Zilberman Y., Rabinovsky R., Gazit D., Joseph A., Panet A., Shai E., Palmon A., Laster M., Galun E. Imaging transgene expression in live animals. Mol. Ther. 4:2001;239-249
32. Hoyer P.B. Reproductive toxicology: current and future directions. Biochem. Pharmacol. 62:2001;1557-1564
33. Imbeault P., Chevrier J., Dewailly E., Ayotte P., Despres J.P., Mauriege P., Tremblay A. Increase in plasma pollutant levels in response to weight loss is associated with the reduction of fasting insulin levels in men but not in women. Metabolism. 51:2002;482-486
34. Jaga K., Dharmani C. Global surveillance of DDT and DDE levels in human tissues. Int. J. Occup. Med. Environ. Health. 16:2003;7-20
35. Kuiper G.G.J.M., Lemmen J.G., Carlsson B.O., Corton J.C., Safe S.H., van der Saag P.T., van der Burg B., Gustafsson J.A. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β Endocrinology. 139:1998;4252-4263
36. Lascombe I., Beffa D., Ruegg U., Taradellas J., Wahli W. Estrogenic activity assessment of environmental chemicals using in vitro assays: identification of two new estrogenic compounds. Environ. Health Perspect. 108:2000;621-629
37. Lonard D.M., Tsai S.Y., O'Malley B.W. Selective estrogen receptor modulators 4-hydroxytamoxifen and raloxifene impact the stability and function of SRC-1 and SRC-3 coactivator proteins. Mol. Cell. Biol. 24:2004;14-24
38. Lordo R.A., Dinh K.T., Schwemberger J.G. Semivolatile organic compounds in adipose tissue: estimated averages for the US population and selected subpopulations. Am. J. Public. Health. 86:1996;1253-1259
39. Lydrup M.L., Ferno M. Correlation between estrogen receptor alpha expression, collagen content and stiffness in human uterine arteries. Acta Obstet. Gynecol. Scand. 82:2003;610-615
40. Marsaud V., Gougelet A., Maillard S., Renoir J.M. Various phosphorylation pathways, depending on agonist and antagonist binding to endogenous estrogen receptor alpha (ERalpha), differentially affect ERalpha extractability, proteasome-mediated stability, and transcriptional activity in human breast cancer cells. Mol. Endocrinol. 17:2003;2013-2027
41. McCauley L.K., Tozum T.F., Rosol T.J. Estrogen receptors in skeletal metabolism: lessons from genetically modified models of receptor function. Crit. Rev. Eukaryot. Gene Expr. 12:2002;89-100
42. McFarland V.A., Clarke J.U. Environmental occurrence, abundance and potential toxicity of polychlorinated biphenyl congeners: consideration for a congener-specific analysis. Environ. Health Perspect. 81:1989;225-239
43. Meegan M.J., Lloyd D.G. Advances in the science of estrogen receptor modulation. Curr. Med. Chem. 10:2003;181-210
44. Moggs J.G., Orphanides G. Estrogen receptors: orchestrators of pleiotropic cellular responses. EMBO Rep. 9:2001;775-781
45. Nagel C.S., Hagelberger J.L., McDonnell D.P. Development of an ER action indicator mouse for the study of estrogens selective ER modulators (SERMs) and xenobiotics. Endocrinology. 142:2001;4721-4727
46. Nardulli A.M., Katzenellenbogen B.S. Dynamics of estrogen receptor turnover in uterine cells in vitro and in uteri in vivo. Endocrinology. 119:1986;2038-2046
47. Nilsson S., Makela S., Treuter E., Tujague M., Thomsen J., Andersson G., Enmark E., Palanza P., Parmigiani S., vom Saal F.S. Effects of prenatal exposure to low doses of diethylstilbestrol, o,p′DDT and methoxychlor on postnatal growth and neurobehavioural development in male and female mice. Horm. Behav. 40:2001;252-265
48. Palanza P., Parmigiani S., vom Saal F.S. Effects of prenatal exposure to low doses of diethylstilbestrol, o,p′DDT and methoxychlor on postnatal growth and neurobehavioural development in male and female mice. Horm. Behav. 40:2001;252-265
49. Pelletier C., Imbeault P., Tremblay A. Energy balance and pollution by organochlorines and polychlorinated biphenyls. Obes. Rev. 4:2003;17-24
50. Petz L.N., Ziegler Y.S., Loven M.A., Nardulli A.M. Estrogen receptor alpha and activating protein-1 mediate estrogen responsiveness of the progesterone receptor gene in MCF-7 breast cancer cells. Endocrinology. 143:2002;4583-4591
51. Phillips L.J., Birchard G.F. Regional variations in human toxics exposure in the USA: an analysis based on the National Human Adipose Tissue Survey. Arch. Environ. Contam. Toxicol. 21:1991;159-168
52. Ren L., Marquardt M.A., Lech J.J. Estrogen effects of nonylphenol on Ps2,ER and MUC1 gene expression in human breast cancer cells-MCF-7. Chem. Biol. Intect. 104:1997;55-64
53. Richthoff J., Rylander L., Jonsson B.A., Akesson H., Hagmar L., Nilsson-Ehle P., Stridsberg M., Giwercman A. Serum levels of 2,2′,4,4′,5,5′-hexachlorobiphenyl (CB-153) in relation to markers of reproductive function in young males from the general Swedish population. Environ. Health Perspect. 111:2003;409-413
54. Routledge E.J., White R., Parker M.G., Sumpter J.P. Differential effects of xenoestrogens on coactivator recruitment by estrogen receptor (ER) alpha and beta. J. Biol. Chem. 275:2000;35986-35993
55. Saceda M., Lindsey R.K., Solomon H., Angeloni S.V., Martin M.B. Estradiol regulates estrogen receptor mRNA stability. Steroid Biochem. Mol. Biol. 66:1998;113-120
56. Safe S. Toxicology, structure-function relationship and human and environmental health impacts of polychlorinated biphenyls: progress and problems. Environ. Health Perspect. 100:1992;258-268
57. Scippo M.L., Argiris C., Van De Weerdt C., Muller M., Willemsen P., Martial J., Maghuin-Rogister G. Recombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors. Anal. Bioanal. Chem. 378:2004;664-669
58. Shupnik M.A., Gordon M.S., Chin W.W. Tissue-specific regulation of rat estrogen receptor mRNAs. Mol. Endocrinol. 3:1989;660-665
59. Simonich S.L., Hites R.A. Global distribution of persistent organochlorine compounds. Science. 269:1995;1851-1854
60. Siris E., Adachi J.D., Lu Y., Fuerst T., Crans G.G., Wong M., Harper K.D., Genant H.K. Effects of raloxifene on fracture severity in postmenopausal women with osteoporosis: results from the MORE study. Multiple Outcomes of Raloxifene Evaluation. Osteoporos. Int. 13:2002;907-913
61. Sonnenschein C., Soto A.M. An updated review of environmental estrogen and androgen mimics and antagonists. J. Steroid Biochem. Mol. Biol. 65:1998;143-150
62. Steinmetz R., Young P.C., Caperell-Grant A., Gize E.A., Madhukar B.V., Ben-Jonathan N., Bigsby R.M. Novel estrogenic action of the pesticide residue beta-hexachlorocyclohexane in human breast cancer cells. Cancer Res. 56:1996;5403-5439
63. Stephenson J. FDA orders estrogen safety warnings: agency offers guidance for HRT use. JAMA. 289:2003;537-538
64. Tilson H.A. The role of developmental neurotoxicology studies in risk assessment. Toxicol. Pathol. 28:2000;149-156
65. Tin Zhu B., Conney A.H. Functional role of estrogen metabolism in target cells: review and perspectives. Carcinogenesis. 1:1998;1-27
66. Ulrich E.M., Caperell-Grant A., Jung S.H., Hites R.A., Bigsby R.M. Environmentally relevant xenoestrogen tissue concentrations correlated to biological responses in mice. Environ. Health Perspect. 108:2000;973-977
67. Vendrell J.A., Magnino F., Danis E., Duchesne M.J., Pinloche S., Pons M., Birnbaum D., Nguyen C., Theillet C., Cohen P.A. Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J. Mol. Endocrinol. 32:2004;397-414
68. Wijayaratne A.L., McDonnell D.P. The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators. J. Biol. Chem. 276:2001;35684-35692
69. Yang C., Chen S. Two organochlorine pesticides, toxaphene and chlordane, are antagonists for estrogen-related receptor alpha-1 orphan receptor. Cancer Res. 59:1999;4519-4524
70. Yue W., Wang J.P., Conaway M., Masamura S., Li Y., Santen R.J. Activation of the MAPK pathway enhances sensitivity of MCF-7 breast cancer cells to the mitogenic effect of estradiol. Endocrinology. 143:2002;3221-3229
71. Zandi P.P., Carlson M.C., Plassman B.L., Welsh-Bohmer K.A., Mayer L.S., Steffens D.C., Breitner J.C. Cache County Memory Study Investigators Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study. JAMA. 288:2002;2123-2139