Novel estrogenic action of the pesticide residue β-hexachlorocyclohexane in human breast cancer cells

Cancer Research

Volumn 56, Issue 23, 1996, Pages 5403-5409

  Steinmetz, Rosemary ^a   Young, Peter C M ^a   Caperell Grant, Andrea ^a   Gize, Edward A ^a   Madhukar, Burra V ^a   Ben Jonathan, Nira ^b   Bigsby, Robert M ^a  

^a INDIANA UNIVERSITY   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA HEXACHLOROCYCLOHEXANE; ESTRADIOL; ESTROGEN RECEPTOR; ORGANOCHLORINE PESTICIDE; XENOBIOTIC AGENT;

ANIMAL CELL; ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER RISK; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; GENE EXPRESSION; HORMONE RESPONSIVE ELEMENT; HUMAN; HUMAN CELL; NONHUMAN; PESTICIDE SPRAYING; PRIORITY JOURNAL; RAT; UTERUS CARCINOMA;

ADENOCARCINOMA; ANIMALS; BINDING, COMPETITIVE; BREAST NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; ESTROGEN ANTAGONISTS; ESTROGENS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LINDANE; MALE; MICE; MICE, NUDE; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; NEOPLASMS, HORMONE-DEPENDENT; PESTICIDE RESIDUES; PITUITARY NEOPLASMS; POLYUNSATURATED ALKAMIDES; PROMOTER REGIONS (GENETICS); PROTEIN BIOSYNTHESIS; PROTEINS; RATS; RECEPTORS, ESTROGEN; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; RNA, NEOPLASM; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0030477412     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Li, J J , Li, S. A., Klicka, J. K., and Heller, J. A. Some biological and toxicological studies of various estrogen mycotoxins and phytoestrogens In. J A. McLachlan (ed), Estrogens in the Environment II: Infuences on Development, pp 168-181. New York: Elsevier Science Publishing Co , Inc , 1985
2. Wolff, M. S., Toniolo, P G., Lee, E W , Rivera, M., and Dubin, N. Blood levels of organochlorine residues and risk of breast cancer. J. Natl Cancer Inst., 85 648-652, 1993
3. White, R., Jobling, S , Hoare, S. A., Sumpter, J. P., and Parker, M G. Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology, 135. 175-182, 1994.
4. Krishnan, A. V., Stathis, P , Permuth, S F., Tokes, L , and Feldman, D. Bisphenol-A an estrogenic substance is released from polycarbonate flasks during autoclaving Endocrinology, 132 2279-2286, 1993
5. Peterson, R Environmental estrogens stir debate. Science (Washington DC), 265: 308-310, 1994.
6. Korach, K S Surprising places for estrogenic activity Endocrinology, 132: 2277-2278, 1993.
7. Mussalo-Rauhamaa, H. Partitioning and levels of neutral organochlorine compounds in human serum, blood cells, and adipose and liver tissue. Sci. Total Environ , 103: 159-175, 1991.
8. Shy, C M. Chemical contamination of water supplies Environ Health Perspect., 62: 399-406, 1985.
9. Robison, A. K., Schmidt, W. A., and Stancel, G M. Estrogenic activity of DDT: estrogen-receptor profiles and the responses of individual uterine cell types following o,p′-DDT administration. J. Toxicol Environ. Health, 16: 493-508, 1985
10. Robinson, A. K., Sirbasku, D. A., and Stancel, G. M. DDT supports growth of an estrogen-responsive tumor. Toxicol. Lett. (Amst.), 27. 109-113, 1985.
11. Mason, R. R , and Schulte, G. J. Interaction of o,p′-DDT with the estrogen-binding protein (EBP) of DMBA-induced rat mammary tumors. Res. Commun. Chem. Pathol. Pharmacol., 33: 119-128, 1981.
12. Mason, R. R., and Schulte, G. J Estrogen-like effects of o,p′-DDT on the progesterone receptor of rat uterine cytosol. Res. Commun. Chem. Pathol. Pharmacol., 29: 281-290, 1980.
13. Bitman, J., Cell, H. S., Harris, S J., and Fries, G. F. Estrogenic activity of o,p′-DDT in the mammalian uterus and avian oviduct. Science (Washington DC), 62: 371-372, 1968.
14. Ireland, J. S , Mukku, V. R., Robinson, A. K., and Stancel, G. M. Stimulation of uterine deoxyribonucleic acid synthesis by 1.1.1-trichloro-2-(o-chlorophenyl)-ethane. Biochem. Pharmacol., 29: 1469-1474, 1980.
15. Coosen, R., and van Velsen, F. L Effects of the β-isomer of hexachlorocyclohexane on estrogen-sensitive human mammary tumor cells. Toxicol. Appl. Pharmacol., 101: 310-318, 1989.
16. Loeber, J. G., and van Velsen, F. L. Uterotropic effects of the β-HCH, a food chain contaminant. Food Addit. Contam., 1: 63-66, 1984.
17. Scribner, J. D., and Mottet, N K. DDT acceleration of mammary gland tumors induced in the male Sprague Dawley rat by 2-acetamidophenanthrene. Carcinogenesis (Lond.), 2: 1235-1239, 1981.
18. Arnold, S. F., Klotz, D. M., Collins, B. M., Vonier, P. M., Guillette, L. J., and McLachlan, J. A. Synergistic activation of estrogen receptor with combinations of environmental chemicals. Science (Washington DC), 272. 1489-1492, 1996.
19. Frank, R., Rasper, J., Smout, M S., and Braun, H. E. Organochlorine residues in adipose tissue, blood and milk from Ontario Residents, 1976-1985. Can. J. Public Health, 79: 150-158, 1988.
20. Kashyap, R., Iyer, L. R., and Singh, M. M Evaluation of human exposure to the persistent insecticides DDT and HCH in Ahmedabad, India. Jour. Anal. Toxicol., 17: 211-214, 1993.
21. Kanja, L W., Skaare, J U , Ojwang, S. B. O., and Maitai, C. K A comparison of organochlorine pesticide residues in maternal adipose tissue, maternal blood, cord blood, and human milk from mother/infant pairs. Arch. Environ. Contam. Toxicol , 22: 21-24, 1992.
22. Mussalo-Rauhamaa, H., Hasanen, E., Pyysalo, H., Antervo, K , Kauppila, R., and Pantzar, P. Occurrence of β-hexachlorocyclohexane in breast cancer patients. Cancer (Phila.), 66: 2124-2128, 1990.
23. Falck, F. J , Ricci, A J., Wolff, M. S., Godbold, J., and Deckers, P. Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer Arch. Environ. Health. 47: 143-146, 1992.
24. Labarca, C., and Paigen, K. A simple, rapid and sensitive DNA assay procedure. Anal. Biochem , 102: 344-352, 1980
25. Green, L. M., Reade, J L., and Ware, C. F Rapid colorimetric assay for cell viability, application to the quantitation of cytotoxic and growth inhibitory lymphokines. J Immunol. Methods, 70: 257-2681, 1984.
26. Bigsby, R M , and Young, P C. M Estrogenic effects of the antiprogestin onapristone (ZK98.299) in the rodent uterus. Am. J Obstet. Gynecol., 171: 188-194, 1994.
27. Maurer, R. A. Both isoforms of the cAMP-dependent protein kinase catalytic subunit can activate transcription of the prolactin gene. J. Biol. Chem., 264: 6870-6873, 1989.
28. Meyer, T., Koop, R , von Angerer, E., Schonenberger, H., and Holler, E. A rapid luciferase transfection assay for transcription activation effects and stability control of estrogenic drugs in cell cultures. J Cancer Res Clin. Oncol., 120: 359-364, 1994.
29. Steinmetz, R., Gutierrez-Hartmann, A., Bigsby, R., and Ben-Jonathan, N. Activation of the prolactin promoter in transfected GH3 cells by posterior pituitary cells. Endocrinology. 135: 2737-2741, 1994.
30. Corcia, A , Steinmetz, R., Liu, J , and Ben-Jonathan, N. Coculturing posterior pituitary and GH3 cells dramatic stimulation of prolactin gene expression. Endocrinology, 132: 80-85, 1993
31. Zacharewski, T. R., Bondy, K. L., McDonell, P., and Wu, Z. F Antiestrogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17β-estradiol-induced pS2 expression. Cancer Res., 54: 2707-2713, 1996.
32. Nunez, A. M., Berry, M , Imler, J L , and Chambon, P. The 5′ flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA). the c-Ha-Ras oncoprotein, and the c-Jun protein. EMBO J., 8. 823-829, 1989.
33. Murdoch, F. E., and Gorski, J. The role of ligand in estrogen receptor regulation of gene expression. Mol Cell Endocrinol, 78: C103-C108, 1991.
34. Day, R N., Koike, S., Sakai, M., Muramatsu, M., and Maurer, R. A Both pit-1 and the estrogen receptor are required for estrogen responsiveness of the rat prolactin gene. Mol. Endocrinol., 4. 1964-1971, 1990.
35. Vignon, F., Bouton, M M., and Rochefort, H. Antiestrogens inhibit the mitogenic effect of growth factors on breast cancer cells in the total absence of estrogens. Biochem. Biophys. Res. Commun., 146: 1502-1508, 1987.
36. Ignar-Trowbridge, D M , Pimental, M., Teng, C. T., Korach, K. S., and McLachlan, J. A. Cross talk between peptide growth factor and estrogen receptor signaling systems Environ. Health Perspect., 103: 35-38, 1995
37. Aronica, S. M., and Katzenellenbogen, B. S. Stimulation of the estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I. Mol. Endocrinol , 7: 743-752, 1993.
38. Phillips, A , Chalbos, D., and Rochefort, H. Estradiol increases and anti-estrogens antagonize the growth factor-induced activator protein-1 activity in MCF7 breast cancer cells without affecting c-fos and c-jun synthesis. J. Biol Chem., 268: 14103-14108, 1993.
39. Korach, K S. Estrogen action in the mouse uterus: characterization of the cytosol and nuclear receptor systems Endocrinology, 104. 1324-1332, 1979.
40. Carson-Jurica, M. A , Schrader, W. T , and O'Malley, B. W. Steroid receptor family: structure and functions. Endocr Rev., 11: 201-220, 1990.
41. Buetti, E , and Kuhnel, B Distinct sequence elements involved in the glucocorticoid regulation of the mouse mammary tumor virus promoter identified by linker scanning mutagenesis. J. Mol. Biol., 190: 379-389, 1986.
42. Danesch, U , Gloss, B., Schmid, W., Schutz, G., Schule, R., and Renkawitz, R. Glucocorticoid induction of the rat tryptophan oxygenase gene is mediated by two widely separated glucocorticoid-responsive elements. EMBO J., 6. 625-630, 1987.
43. Webb, P., Lopez, G. N., Uht, R. M., and Kushner, P J Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens Mol. Endocrinol , 9: 443-456, 1995
44. Delidow, B C., Billis, W. M , Agarwal, P., and White, B. A. Inhibition of prolactin gene transcription by transforming growth factor-β in GH3 cells. Mol. Endocrinol., 5: 1716-1722, 1991
45. Jordan, V. C., and Murphy, C S. Endocrine pharmacology of antiestrogens as antitumor agents. Endocr Rev., 11: 578-610, 1990.