Dietary iron promotes azoxymethane-induced colon tumors in mice

Nutrition and Cancer

Volumn 49, Issue 2, 2004, Pages 162-169

  Ilsley, Jillian N M ^a   Belinsky, Glenn S ^a   Guda, Kishore ^a   Zhang, Qi ^b   Huang, Xi ^b   Blumberg, Jeffrey B ^c   Milbury, Paul E ^c   Roberts II, L Jackson ^d   Stevens, Richard G ^a   Rosenberg, Daniel W ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c TUFTS UNIVERSITY   (United States)

^d VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYGUANOSINE; 8 ISOPROSTAGLANDIN F2 ALPHA; AZOXYMETHANE; BIOLOGICAL MARKER; CARCINOGEN; CYCLINE; FURAN DERIVATIVE; IRON; ISOFURAN; ISOPROSTANE; UNCLASSIFIED DRUG;

ABERRANT CRYPT FOCUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; COLON CARCINOGENESIS; COLON MUCOSA; COLON TUMOR; CONTROLLED STUDY; HISTOPATHOLOGY; HOMEOSTASIS; IRON ABSORPTION; IRON INTAKE; MOUSE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRECANCER; TUMOR GROWTH;

ANIMALIA;

EID: 8444230390     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1207/s15327914nc4902_7     Document Type: Article

References (39)

1. Landis SH, Murray T, Bolden S, and Wingo PA: Cancer statistics, 1999. CA Cancer J Clin 49, 8-31, 31, 1999.
2. Freudenheim JL, Graham S, Marshall JR, Haughey BP, and Wilkinson GA: Case-control study of diet and rectal cancer in western New York. Am J Epidemiol 131, 612-624, 1990.
3. Willen WC: Epidemiologic studies of diet and cancer. Med Oncol Tumor Pharmacother 7, 93-97, 1990.
4. Siegers CP, Bumann D, Baretton G, and Younes M: Dietary iron enhances the tumor rate in dimethylhydrazine-induced colon carcinogenesis in mice. Cancer Lett 41, 251-256, 1988.
5. Siegers CP, Bumann D, Trepkau HD, Schadwinkel B, and Baretton G: Influence of dietary iron overload on cell proliferation and intestinal tumorigenesis in mice. Cancer Lett 65, 245-249, 1992.
6. Hann HW, Stahlhut MW, and Blumberg BS: Iron nutrition and tumor growth: decreased tumor growth in iron-deficient mice. Cancer Res 48, 4168-4170, 1988.
7. Nunez MT, Tapia V, Toyokuni S, and Okada S: Iron-induced oxidative damage in colon carcinoma (Caco-2) cells. Free Radic Res 34, 57-68, 2001.
8. Feig DI, Reid TM, and Loeb LA: Reactive oxygen species in tumorigenesis. Cancer Res 54, 1890s-1894s, 1994.
9. Babbs CF: Free radicals and the etiology of colon cancer. Free Radic Biol Med 8, 191-200, 1990.
10. Rosenberg DW and Kappas A: Characterization of heme oxygenase in the small intestinal epithelium. Arch Biochem Biophys 274, 471-480, 1989.
11. Glei M, Latunde-Dada GO, Klinder A, Becker TW, Hermann U, et al.: Iron-overload induces oxidative DNA damage in the human colon carcinoma cell line HT29 clone 19A. Mutat Res 519, 151-161, 2002.
12. Stevens RG, Morris JE, Cordis GA, Anderson LE, Rosenberg DW, et al.: Oxidative damage in colon and mammary tissue of the HFE-knockout mouse. Free Rad Biol Med, in press.
13. Lund EK, Fairweather-Tait SJ, Wharf SG, and Johnson IT: Chronic exposure to high levels of dietary iron fortification increases lipid peroxidation in the mucosa of the rat large intestine. J Nutr 131, 2928-2931, 2001.
14. Wright MO, Burden V, Lee J, Eitenmiller RR, and Fischer JG: High dietary iron enhances oxidative stress in liver but does not increase aberrant crypt foci development in rats with low vitamin E status. Nutr Cancer 35, 143-152, 1999.
15. Porres JM, Stahl CH, Cheng WH, Fu Y, Roneker KR, et al.: Dietary intrinsic phytate protects colon from lipid peroxidation in pigs with a moderately high dietary iron intake. Proc Soc Exp Biol Med 221, 80-86, 1999.
16. Lillie RD: Histopathologic Technic and Practical Histochemistry, 3rd ed. Philadelphia: Blackiston, 1965.
17. Delker DA, Wang QS, Papanikolaou A, Whiteley HE, and Rosenberg DW: Quantitative assessment of azoxymethane-induced aberrant crypt foci in inbred mice. Exp Mol Pathol 65, 141-149, 1999.
18. Papanikolaou A, Wang QS, Papanikolaou D, Whiteley HE, and Rosenberg DW: Sequential and morphological analyses of aberrant crypt foci formation in mice of differing susceptibility to azoxymethane-induced colon carcinogenesis. Carcinogenesis 21, 1567-1572, 2000.
19. Pretlow TP, O'Riordan MA, Pretlow TG, and Stellato TA: Aberrant crypts in human colonic mucosa: putative preneoplastic lesions. J Cell Biochem Suppl 16G, 55-62, 1992.
20. Fessel JP, Porter NA, Moore KP, Sheller JR, and Roberts LJ II: Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension. Proc Natl Acad Sci U S A 99, 16713-16718, 2002.
21. Morrow JD and Roberts LJ II: Mass spectrometric quantification of F2-isoprostanes in biological fluids and tissues as measure of oxidant stress. Methods Enzymol 300, 3-12, 1999.
22. Maclouf J, Corvazier E, and Wang ZY: Development of a radioimmunoassay for prostaglandin D2 using an antiserum against 11-methoximeprostaglandin D2. Prostaglandins 31, 123-132, 1986.
23. Pradelles P, Grassi J, and Maclouf J: Enzyme immunoassays of eicosanoids using acetylcholine esterase as label: an alternative to radioimmunoassay. Anal Chem 57, 1170-1173, 1985.
24. Pradelles P, Grassi J, and Maclouf J: Enzyme immunoassays of eicosanoids using acetylcholinesterase. Methods Enzymol 187, 24-34, 1990.
25. Osawa E, Nakajima A, Wada K, Ishimine S, Fujisawa N, et al.: Peroxisome proliferator-activated receptor gamma ligands suppress colon carcinogenesis induced by azoxymethane in mice. Gastroenterology 124, 361-367, 2003.
26. Papanikolaou A, Wang QS, Delker DA, and Rosenberg DW: Azoxymethane-induced colon tumors and aberrant crypt foci in mice of different genetic susceptibility. Cancer Lett 130, 29-34, 1998.
27. Nambiar PR, Girnun G, Lillo NA, Guda K, Whiteley HE, et al.: Preliminary analysis of azoxymethane induced colon tumors in inbred mice commonly used as transgenic/knockout progenitors. Int J Oncol 22, 145-150, 2003.
28. Soyars KE and Fischer JG: Iron supplementation does not affect cell proliferation or aberrant crypt foci development in the colon of sprague-dawley rats. J Nutr 128, 764-770, 1998.
29. Siegers CP, Bumann D, Trepkau HD, Schadwinkel B, and Baretton G: Role of iron in cell proliferation and tumorigenesis. Prog Clin Biol Res 369, 439-444, 1991.
30. Kuratko CN and Pence BC: Dietary lipid and iron modify normal colonic mucosa without affecting phospholipase A2 activity. Cancer Lett 95, 181-187, 1995.
31. Lund EK, Wharf SG, Fairweather-Tait SJ, and Johnson IT: Increases in the concentrations of available iron in response to dietary iron supplementation are associated with changes in crypt cell proliferation in rat large intestine. J Nutr 128, 175-179, 1998.
32. Poljak-Blazi M, Kralj M, Hadzija MP, Zarkovic N, Zarkovic K, et al.: Involvement of lipid peroxidation, oncogene expression and induction of apoptosis in the antitumorous activity of ferric-sorbitol-citrate. Cancer Biother Radiopharm 15, 285-293, 2000.
33. Liu Z, Tomotake H, Wan G, Watanabe H, and Kato N: Combined effect of dietary calcium and iron on colonic aberrant crypt foci, cell proliferation and apoptosis, and fecal bile acids in 1,2-dimethylhydrazine-treated rats. Oncol Rep 8, 893-897, 2001.
34. Sesink AL, Termont DS, Kleibeuker JH, and Van der Meer R: Red meat and colon cancer: the cytotoxic and hyperproliferative effects of dietary heme. Cancer Res 59, 5704-5709, 1999.
35. Rao CV, Wang CX, Simi B, Lubet R, Kelloff G, et al.: Enhancement of experimental colon cancer by genistein. Cancer Res 57, 3717-3722, 1997.
36. Owen RW: Biomarkers in colorectal cancer. IARC Sci Publ 154, 101-111, 2001.
37. Lund EK, Wharf SG, Fairweather-Tait SJ, and Johnson IT: Oral ferrous sulfate supplements increase the free radical-generating capacity of feces from healthy volunteers. Am J Clin Nutr 69, 250-255, 1999.
38. Santos M, Clevers H, de Sousa M, and Marx JJ: Adaptive response of iron absorption to anemia, increased erythropoiesis, iron deficiency, and iron loading in beta2-microglobulin knockout mice. Blood 91, 3059-3065, 1998.
39. Santos M, Wienk KJ, Schilham MW, Clevers H, de Sousa M, et al.: In vivo mucosal uptake, mucosal transfer and retention of iron in mice. Lab Anim 31, 264-270, 1997.