Role of steroid sulfatase in local formation of estrogen in post-menopausal breast cancer patients

Journal of Steroid Biochemistry and Molecular Biology

Volumn 86, Issue 3-5, 2003, Pages 455-460

  Nakata, Taisuke ^a   Takashima, Shigemitsu ^b   Shiotsu, Yukimasa ^a   Murakata, Chikara ^a   Ishida, Hiroyuki ^a   Akinaga, Shiro ^a   Li, Pui Ki ^c   Sasano, Hironobu ^d   Suzuki, Takashi ^d   Saeki, Toshiaki ^b  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

^b NATIONAL HOSPITAL ORGANIZATION SHIKOKU CANCER CENTER   (Japan)

^c OHIO STATE UNIVERSITY   (United States)

^d TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Breast tumor; Estrogen; Inhibitor; Sulfatase

Indexed keywords

(4 O SULFAMOYL) N TETRADECANOYLTYRAMINE; AROMATASE INHIBITOR; ESTERASE INHIBITOR; SELECTIVE ESTROGEN RECEPTOR MODULATOR; STERYL SULFATASE; STERYL SULFATASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; BREAST CARCINOMA; CANCER PATIENT; CONFERENCE PAPER; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INDUCTION; ESTROGEN ACTIVITY; ESTROGEN SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; POSTMENOPAUSE; PROTEIN EXPRESSION;

HUMAN ECHOVIRUS 1;

EID: 10744226017     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(03)00357-1     Document Type: Conference Paper

References (34)

1. Leymarie P., Savard K. Steroid hormone formation in the human ovary. VI. Evidence for two pathways of synthesis of androgens in the stromal compartment. J. Clin. Endrocrinol. Metab. 28(11):1968;1547-1554.
2. Carlstom K. Influence of intratumoral estradiol synthesis on estrogen receptors. Recent Results Cancer Res. 91:1984;145-149.
3. Utsumi T. Local production of estrogen via aromatase and estrone sulfatase in breast cancer tissue. Nippon Gekagakkai Zasshi J. Japan Surg. Soc. 90(6):1989;920-927.
4. Millington D.S. Determination of hormonal steroid concentrations in biological extracts by high-resolution mass fragmentography. J. Steroid Biochem. 6:1975;239-245.
5. Fishman J., Nisselbaum J.S., Menendez-Botet C.J., Schwartz M.K. Estrone and estradiol concentration in human breast tumors: relationship to estradiol receptors. J. Steroid Biochem. 8:1977;893-896.
6. Edery M., Goussard J., Dehennin L., Scholler R., Reiffsteck J., Drosdowsky M.A. Endogenous oestradiol-17 beta concentration in breast tumors determined by mass fragmentography and by radio immunoassay: relationship to receptor content. Eur. J. Cancer. 17:1981;115-120.
7. van Landeghem A.A.J., Poortman J., Nabuurs M., Thijssen J.H.H. Endogenous concentration and sub cellular distribution of estrogens in normal and malignant human breast tissue. Cancer Res. 45:1985;2900-2906.
8. Vermeulen A., Deslypere J.P., Paridaens R., Leclercq G., Roy F., Heuson J.C. Aromatase, 17 beta hydroxysteroid dehydrogenase and intratissular sex hormone concentrations in cancerous and normal glandular breast tissue in postmenopausal women. Eur. J. Cancer Clin. Oncol. 22:1986;515-525.
9. Pasqualini J.R., Chetrite G., Blacker C., Feinstein M.C., Delalonde L., Talbi M., Maloche C. Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer. J. Clin. Endocr. Metab. 81:1996;1460-1464.
10. Santner S.J., Feil P.D., Santen R.J. In situ estrogen production via the estrone sulfatase pathway in breast tumors: relative importance versus the aromatase pathway. J. Clin. Endocr. Metab. 59(1):1984;29-33.
11. Pasqualini J.R., Cortes-Prieto J., Chetrite G., Talbi M., Ruiz A. Concentrations of estrone, estradiol and their sulfates and evaluation of sulfatase and aromatase activities in patients with breast fibroadenoma. Int. J. Cancer. 70:1997;639-643.
12. Santner S.J., Leszczynski D., Wright C., Manni A., Feil P.D., Santen R.J. Estrone sulfate: a potential source of estradiol in human breast cancer tissues. Breast Cancer Res. Treat. 7:1986;35-44.
13. R. Smith, Y. Sun, A. Garin, L. Fein, H.P. Sleeboom, H. Chaudi, M. Dugan, B. Staffler, C. Brandy, Femara™ (Letrozole) showed significant improvement in efficacy over Tamoxifen as first-line treatment in postmenopausal women with advanced breast cancer, in: Proceedings of the 23rd Annual Breast Cancer Symposium, San Antonio, 1999 (Abstracts).
14. Saeki T., Takashima S., Sasaki H., Hanai N., Salomon D. Localization of estrone sulfatase in human breast carcinomas. Breast Cancer. 6(4):1999;331-337.
15. Bradlow H.L. A reassessment of the role of breast tumor aromatization. Cancer Res. 42:1982;3382s-3386s.
16. Tilson-Mallett N., Santner S.J., Feil P.D., Santen P.D. Biological significance of aromatase activity in human breast tumors. J. Clin. Endocrinol. 57:1983;1125-1128.
17. Santner S.J., Levin M.C., Santen R.J. Estrone sulfate stimulates growth of nitrosomethylurea-induced breast carcinoma in vivo in the rat. Int. J. Cancer. 46:1990;73-78.
18. Dauvois S., Labrie F. Androstenedione and androst-5-ene-3 beta, 17beta-diol stimulate DMBA-induced rat mammary tumors, role of aromatase. Breast Cancer Res. Treat. 13:1989;61-69.
19. Boccuzzi G., Brignardiello E., Monaco M.D., Forte C., Leonardi L., Pizzini A. Influence of dehydroepiandrosterone and 5-en-androstene-3 beta, 17 beta-diol on the growth of MCF-7 human breast cancer cells induced by 17 beta-estradiol. Anticancer Res. 12:1992;799-804.
20. Boccuzzi G., Brignardiello E., Monaco M.D., Gatto V., Leonardi L., Pizzini A., Gallo M. 5-en-Androstene-3 beta, 17 beta-diol inhibits the growth of MCF-7 breast cancer cells when oestrogen receptors are blocked by oestradiol. Br. J. Cancer. 70:1994;1035-1039.
21. Ruder H.J., Loriaux D.L., Lipsett M.B. Oestrone sulphate: production rate and metabolism in man. J. Clin. Invest. 51:1972;1020-1023.
22. Utsumi T., Yoshimura N., Takeuchi S., Ando J., Maruta M., Maeda K., Harada N. Cancer Res. 59:1999;377-381.
23. Li P.K., Pillai R., Dibbelt L. Estrone sulfate analogs as estrone sulfatase inhibitors. Steroids. 60:1995;299-306.
24. Li P.K., Chu G.-O., Guo J.P., Peters A., Selcer K.W. Development of potent non-estrogenic estrone sulfatase inhibitors. Steroids. 63:1998;425-432.
25. Howarth N.M., Purohit A., Reed M.J., Potter B.V.L. Estrone sulfamates: potent inhibitors of estrone sulfatase with therapeutic potential. J. Med. Chem. 37:1994;219-221.
26. Poirier D., Boivin R.P. 17α-Substituted benzyl-17β-estradiols: a new family of estrone-sulfatase inhibitors. Bioorg. Med. Chem. Lett. 8:1998;1891-1896.
27. Li P.K., Milano S., Kluth L., Rhodes M.E. Synthesis and sulfatase inhibitory activities of nonsteroidal sulfatase inhibitors. J. Med. Chem. 59:1996;41-48.
28. Woo L.W.L., Purohit A., Reed M.J., Potter B.V.L. Active site directed inhibition of estrone sulfatase by nonsteroidal coumarin sulfamate. J. Med. Chem. 39:1996;1349-1351.
29. Billich A., Nussbaumer P., Lehr P. Stimulation of MCF-7 breast cancer proliferation by estrone sulfate and dehydroepiandrosterone sulfate: inhibition by novel non-steroidal steroid sulfatase inhibitors. J. Steroid Biochem. Mol. Biol. 73:2000;225-235.
30. Purohit A., Woo L.W.L., Potter B.V.L., Reed M.J. In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE. Cancer Res. 60:2000;3394-3396.
31. Eckert R.L., Katzenellenbogen B.S. Effect estrogens and antiestrogens on estrogen receptor dynamics and the induction of progesterone receptor in MCF-7 human breast cancer cells. Cancer Res. 42:1982;139-144.
32. Wilkinson J.R., Williams J.C., Singh D., Goss P.E., Eastman D., Coombes R.C. Response of nitrosomethylurea-induced rat mammary tumor to endocrine therapy and comparison with clinical response. Cancer Res. 46:1986;4862-4865.
33. Pasqualini J.R., Gelly C., Nguyen B.L., Vella C. Importance of estrogen sulfates in breast cancer. J. Steroid Biochem. 34:1989;155-163.
34. Evans T.R., Rowlands M.G., Law M., Coombes R.C. Intratumoral oestrone sulphatase activity as a prognostic marker in human breast carcinoma. Br. J. Cancer. 69:1994;555-561.