RGD peptide-modified adenovirus expressing hepatocyte growth factor and X-linked inhibitor of apoptosis improves islet transplantation

Journal of Gene Medicine

Volumn 13, Issue 12, 2011, Pages 658-669

  Wu, Hao ^a   Yoon, A Rum ^b   Li, Feng ^a   Yun, Chae Ok ^b   Mahato, Ram I ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b Hanyang University   (South Korea)

Author keywords

Adenovirus; Apoptosis; Islets; Revascularization; RGD

Indexed keywords

ADENOVIRUS VECTOR; ARGINYLGLYCYLASPARTIC ACID; GLUCOSE; INSULIN; VON WILLEBRAND FACTOR; X LINKED INHIBITOR OF APOPTOSIS;

ARTICLE; CELL DEATH; DIABETES MELLITUS; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IN VITRO STUDY; MOUSE; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; TREATMENT OUTCOME; VIRAL GENE DELIVERY SYSTEM; VON WILLEBRAND DISEASE;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; GENE EXPRESSION REGULATION, VIRAL; GENETIC VECTORS; HEPATOCYTE GROWTH FACTOR; HUMANS; INSULIN; ISLETS OF LANGERHANS TRANSPLANTATION; KIDNEY; MALE; MICE; MICE, SCID; OLIGOPEPTIDES; VON WILLEBRAND FACTOR; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 84255194235     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.1626     Document Type: Article

References (48)

1. Ryan EA, Paty BW, Senior PA, et al. Five-year follow-up after clinical islet transplantation. Diabetes 2005; 54: 2060-2069.
2. Narang AS, Mahato RI. Biological and biomaterial approaches for improved islet transplantation. Pharmacol Rev 2006; 58: 194-243.
3. Mandel TE, Koulmanda M. Effect of ischemia and temperature on fetal mouse pancreas. Insulin production in vitro, and function after isotransplantation. Diabetes 1984; 33: 376-382.
4. Sarvetnick N, Shizuru J, Liggitt D, et al. Loss of pancreatic islet tolerance induced by beta-cell expression of interferon-gamma. Nature 1990; 346: 844-847.
5. Kessler L, Jesser C, Lombard Y, et al. Cytotoxicity of peritoneal murine macrophages against encapsulated pancreatic rat islets: in vivo and in vitro studies. J Leukoc Biol 1996; 60: 729-736.
6. Pawelec K, Juszczak MT, Kumar A, et al. Time course of islet loss after intraportal transplantation. Ann NY Acad Sci 2008; 1150: 230-233.
7. Cheng G, Zhu L, Mahato RI. Caspase-3 gene silencing for inhibiting apoptosis in insulinoma cells and human islets. Mol Pharm 2008; 5: 1093-1102.
8. Panakanti R, Mahato RI. Bipartite adenoviral vector encoding hHGF and hIL-1Ra for improved human islet transplantation. Pharm Res 2009; 26: 587-596.
9. Wu H, Panakanti R, Li F, et al. XIAP Gene expression protects beta-cells and human islets from apoptotic cell death. Mol Pharm 2010; 7: 1655-1666.
10. Narang AS, Sabek O, Gaber AO, et al. Co-expression of vascular endothelial growth factor and interleukin-1 receptor antagonist improves human islet survival and function. Pharm Res 2006; 23: 1970-1982.
11. Garcia-Ocana A, Takane KK, Reddy VT, et al. Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death. J Biol Chem 2003; 278: 343-351.
12. Garcia-Ocana A, Vasavada RC, Cebrian A, et al. Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice. Diabetes 2001; 50: 2752-2762.
13. Kay MA, Glorioso JC, Naldini L. Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics. Nat Med 2001; 7: 33-40.
14. Contreras JL, Wu H, Smyth CA, et al. Double genetic modification of adenovirus fiber with RGD polylysine motifs significantly enhances gene transfer to isolated human pancreatic islets. Transplantation 2003; 76: 252-261.
15. Dmitriev I, Krasnykh V, Miller CR, et al. An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism. J Virol 1998; 72: 9706-9713.
16. Kurozumi K, Nakamura K, Tamiya T, et al. BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model. Mol Ther 2004; 9: 189-197.
17. Ricordi C, Gray DW, Hering BJ, et al. Islet isolation assessment in man and large animals. Acta Diabetol 1990; 27: 185-195.
18. Yun CO, Kim E, Koo T, et al. ADP-overexpressing adenovirus elicits enhanced cytopathic effect by induction of apoptosis. Cancer Gene Ther 2005; 12: 61-71.
19. Chartier C, Degryse E, Gantzer M, et al. Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli. J Virol 1996; 70: 4805-4810.
20. Xiao GH, Jeffers M, Bellacosa A, et al. Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. Proc Natl Acad Sci USA 2001; 98: 247-252.
21. Huang Y, Park YC, Rich RL, et al. Structural basis of caspase inhibition by XIAP: differential roles of the linker vs. the BIR domain. Cell 2001; 104: 781-790.
22. Deveraux QL, Leo E, Stennicke HR, et al. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J 1999; 18: 5242-5251.
23. Bratton SB, Lewis J, Butterworth M, et al. XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis. Cell Death Differ 2002; 9: 881-892.
24. Hering BJ, Kandaswamy R, Ansite JD, et al. Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes. JAMA 2005; 293: 830-835.
25. Polastri L, Galbiati F, Bertuzzi F, et al. Secretory defects induced by immunosuppressive agents on human pancreatic beta-cells. Acta Diabetol 2002; 39: 229-233.
26. Scharp DW, Lacy PE, Santiago JV, et al. Results of our first nine intraportal islet allografts in type 1, insulin-dependent diabetic patients. Transplantation 1991; 51: 76-85.
27. Dinarello CA. Inflammatory cytokines: interleukin-1 and tumor necrosis factor as effector molecules in autoimmune diseases. Curr Opin Immunol 1991; 3: 941-948.
28. Donath MY, Storling J, Maedler K, et al. Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes. J Mol Med (Berl) 2003; 81: 455-470.
29. Panakanti R, Mahato RI. Bipartite vector encoding hVEGF and hIL-1Ra for ex vivo transduction into human islets. Mol Pharm 2009; 6: 274-284.
30. Wu H, Panakanti R, Li F, et al. XIAP gene expression protects beta-cells and human islets from apoptotic cell death. Mol Pharm 2010; 7: 1655-1666.
31. Ozaki M, Haga S, Zhang HQ, et al. Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: role of PI3-K and Akt kinase upon rac1. Cell Death Differ 2003; 10: 508-515.
32. Cheng K, Fraga D, Zhang C, et al. Adenovirus-based vascular endothelial growth factor gene delivery to human pancreatic islets. Gene Ther 2004; 11: 1105-1116.
33. Menger MD, Beger C, Vajkoczy P. Restitution of intra-islet portal system in pancreatic islet isografts. Transplant Proc 1994; 26: 688.
34. Ozawa CR, Banfi A, Glazer NL, et al. Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis. J Clin Invest 2004; 113: 516-527.
35. Mahato RI. Gene expression and silencing for improved islet transplantation. J Control Release 2009; 140: 262-267.
36. Mahato RI, Rolland A, Tomlinson E. Cationic lipid-based gene delivery systems: pharmaceutical perspectives. Pharm Res 1997; 14: 853-859.
37. Kay MA, Holterman AX, Meuse L, et al. Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration. Nat Genet 1995; 11: 191-197.
38. Yang Y, Wilson JM. Clearance of adenovirus-infected hepatocytes by MHC class I-restricted CD4+ CTLs in vivo. J Immunol 1995; 155: 2564-2570.
39. Wickham TJ, Mathias P, Cheresh DA, et al. Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell 1993; 73: 309-319.
40. Vigne E, Mahfouz I, Dedieu JF, et al. RGD inclusion in the hexon monomer provides adenovirus type 5-based vectors with a fiber knob-independent pathway for infection. J Virol 1999; 73: 5156-5161.
41. Hidaka C, Milano E, Leopold PL, et al. CAR-dependent and CAR-independent pathways of adenovirus vector-mediated gene transfer and expression in human fibroblasts. J Clin Invest 1999; 103: 579-587.
42. Wickham TJ, Tzeng E, Shears LL II, et al. Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins. J Virol 1997; 71: 8221-8229.
43. Mistry SJ, Bank A, Atweh GF. Targeting stathmin in prostate cancer. Mol Cancer Ther 2005; 4: 1821-1829.
44. Silvertown JD, Geddes BJ, Summerlee AJ. Adenovirus-mediated expression of human prorelaxin promotes the invasive potential of canine mammary cancer cells. Endocrinology 2003; 144: 3683-3691.
45. Sever CE, Demetris AJ, Zeng J, et al. Composition of human islet cell preparations for transplantation. Acta Diabetol 1992; 28: 233-238.
46. Street CN, Lakey JR, Shapiro AM, et al. Islet graft assessment in the Edmonton Protocol: implications for predicting long-term clinical outcome. Diabetes 2004; 53: 3107-3114.
47. Deng S, Vatamaniuk M, Huang X, et al. Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects. Diabetes 2004; 53: 624-632.
48. Szot GL, Koudria P, Bluestone JA. Transplantation of pancreatic islets into the kidney capsule of diabetic mice. J Vis Exp 2007; 9: 404.