Genetic testing in psychiatry: A review of attitudes and beliefs

Psychiatry

Volumn 74, Issue 4, 2011, Pages 315-331

  Lawrence, Ryan E ^a   Appelbaum, Paul S ^b  

^a NewYork Presbyterian Hospital   (United States)

^b Neurologic and Behavioral Genetics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATTITUDE TO ABORTION; COPING BEHAVIOR; DISEASE SEVERITY; EDITORIAL; EMPIRICISM; FAMILY; FEAR; GENETIC SCREENING; HEALTH CARE PERSONNEL; HEALTH CARE POLICY; HUMAN; LIFESTYLE; MARRIAGE; MENTAL DISEASE; PARENTAL ATTITUDE; PATIENT CARE; PREDICTION; PRENATAL SCREENING; PSYCHIATRIST; SOCIAL DISCRIMINATION;

ATTITUDE OF HEALTH PERSONNEL; ATTITUDE TO HEALTH; CULTURE; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; HUMANS; MENTAL DISORDERS; PARENTS; PSYCHIATRY;

EID: 84255188580     PISSN: 00332747     EISSN: 1943281X     Source Type: Journal    
DOI: 10.1521/psyc.2011.74.4.315     Document Type: Editorial

References (51)

1. Appelbaum, P. S. (2004). Ethical issues in psychiatric genetics. Journal of Psychiatric Practice, 10(6), 343-351.
2. Austin, J. C., & Honer, W. G. (2007). The genomic era and serious mental illness: A potential application for psychiatric genetic counseling. Psychiatric Services, 58(2), 254-261.
3. Austin, J. C., Smith, G. N., & Honer, W. G. (2006). The genomic era and perceptions of psychotic disorders: Genetic risk estimation, associations with reproductive decisions and views about predictive testing. American Journal of Medical Genetics, Part B, 141B, 926-928.
4. Baruch, S., & Hudson, K. (2008). Civilian and military genetics: Nondiscrimination policy in a post-GINA world. American Journal of Human Genetics, 83(4), 435-444.
5. Bloss, C.S., Schork, N.J., & Topol, E.J. (2011). Effect of direct-to-consumer genomewide profiling to assess disease risk. New England Journal of Medicine, 364(6), 524-534.
6. Bombard, Y., Palin, J., Friedman, J. M., Veenstra, G., Creighton, S., Paulsen, J. S., Bottorff, J.L., & Hayden, M.R. (2011). Factors associated with experiences of genetic discrimination among individuals at risk for Huntington disease. American Journal of Medical Genetics, Part B europsychiatric Genetics, 156(B)(1): 19-27.
7. Braff, D., & Freedman, R. (2008). Clinically responsible genetic testing in neuropsychiatric patients: A bridge too far and too soon. American Journal of Psychiatry, 165(8), 952-955.
8. Campbell, E., & Ross, L. F. (2004). Attitudes of healthcare professionals and parents regarding genetic testing for violent traits in childhood. Journal of Medical Ethics, 30, 580-586.
9. Clayton, E.W. (2003). Ethical, legal, and social implications of genomic medicine. New England Journal of Medicine, 349, 562-569.
10. Corcoran, C., Malaspina, D., & Hercher, L. (2005). Prodromal interventions for schizophrenia vulnerability: The risks of being "at risk." Schizophrenia Research, 73(2-3), 173-184.
11. DeLisi, L. E., & Bertisch, H. (2006). A preliminary comparison of the hopes of researchers, clinicians, and families for the future ethical use of genetic findings on schizophrenia. American Journal of Medical Genetics, Part B Neuropsychiatric Genetics, 141B(1), 110-115.
12. Finn, C. T., & Smoller, J. W. (2006). Genetic counseling in psychiatry. Harvard Review of Psychiatry, 14(2), 109-121.
13. Finn, C. T., Wilcox, M. A., Korf, B. R., Blacker, D., Racette, S. R., Sklar, P., & Smoller, J. W. (2005). Psychiatric genetics: A survey of psychiatrists' knowledge, opinions, and practice patterns. Journal of Clinical Psychiatry, 66(7), 821-830.
14. Green, R.C., Roberts, J.S., Cupples, L.A., Relkin, N.R., Whitehouse, P.J., Brown, T., Eckert, S.L., Butson, M., Sadovnick, A.D., Quaid, K.A., Chen, C., Cook-Deegan, R., & Farrer, L.A. (2009). Disclosure of APOE genotype for risk of Alzheimer's disease. New England Journal of Medicine, 361, 245-254.
15. Grimaldi, K.A., Look, M.P., Scioli, G. A., Claver, J.C., Marinos, S., & Tagaris, T. (2010). Personal genetics: Regulatory framework in Europe from a service provider's perspective. European Journal of Human Genetics, 19, 382-388.
16. Health Law - genetics - Congress restricts use of genetic information by insurers and employers. - Genetic Information Nondiscrimination Act of 2008, Pub. L. No. 110-233, 122 Stat. 881 (to be codified in scattered sections of 26, 29, and 42 U.S.C.). Harvard Law Review (2009) 122(3), 1038-1045.
17. Hoop, J. G. (2008). Ethical considerations in psychiatric genetics. Harvard Review of Psychiatry, 16(6), 322-338.
18. Hoop, J. G., Roberts, L. W., Green Hammond, K. A., & Cox, N. J. (2008a). Psychiatrists' attitudes regarding genetic testing and patient safeguards: A preliminary study. Genetic Testing, 12(2), 245-252.
19. Hoop, J. G., Roberts, L. W., Green Hammond, K. A., & Cox, N. J. (2008b). Psychiatrists' attitudes, knowledge, and experience regarding genetics: A preliminary study. Genetics in Medicine, 10(6), 439-449.
20. Jones, I., Scourfield, J., McCandless, F., & Craddock, N. (2002). Attitudes towards future testing for bipolar disorder susceptibility genes: A preliminary investigation. Journal of Affective Disorders, 71, 189-193.
21. Kass, N. A., Medley, A. M., Natowicz, M. R., Hull, S. C., Faden, R. R., Plantinga, L., & Gostin, L. O. (2007). Access to health insurance: Experiences and attitudes of those with genetic versus non-genetic medical conditions. American Journal of Human Genetics, Part A, 143(7), 707-717.
22. Laegsgaard, M. M., Kristensen, A. S., & Mors, O. (2009). Potential consumers' attitudes toward psychiatric genetic research and testing and factors influencing their intentions to test. Genetic Testing and Molecular Biomarkers, 13(1), 57-65.
23. Laegsgaard, M. M., & Mors, O. (2008). Psychiatric genetic testing: Attitudes and intentions among future users and providers. American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics, 147(3), 375-384.
24. Meiser, B., & Dunn S. (2000) Psychological impact of genetic testing for Huntington's disease: An update of the literature. Journal of Neurology, Neurosurgery & Psychiatry, 69(5), 574-578.
25. Meiser, B., Kasparian, N. A., Mitchell, P. B., Strong, K., Simpson, J. M., Tabassum, L., Mireskandari, S., & Schofield, P. R. (2008). Attitudes to genetic testing in families with multiple cases of bipolar disorder. Genetic Testing, 12(2), 233-244.
26. Meiser, B., Mitchell, P. B., McGirr, H., Van Herten, M., & Schofield, P. R. (2005). Implications of genetic risk information in families with a high density of bipolar disorder: an exploratory study. Social Science and Medicine, 60(1), 109-118.
27. Meiser, B., Mitchell, P. B., Kasparian, N. A., Strong, K., Simpson, J. M., Mireskandari, S., Tabassum, L., & Schofield, P. R. (2007). Attitudes towards childbearing, causal attributions for bipolar disorder and psychological distress: A study of families with multiple cases of bipolar disorder. Psychological Medicine, 37(11), 1601-1611.
28. Milner, K. K., Han, T., & Petty, E. M. (1999). Support for the availability of prenatal testing for neurological and psychiatric conditions in the psychiatric community. Genetic Testing, 3(3), 279-286.
29. Mitchell, P. B., Meiser, B., Wilde, A., Fullerton, J., Donald, J., Wilhelm, K., & Schofield, P. R. (2010). Predictive and diagnostic genetic testing in psychiatry. Psychiatric Clinics of North America, 33(1), 225-243.
30. Molloy v. Meier, 679 N.W>2d 711 (Minn. 2004).
31. Mrazek, M., Koenig, B., Skime, M., Snyder, K., Hook, C., Black, J., & Mrazek, D. (2007). Assessing attitudes about genetic testing as a component of continuing medical education. Academic Psychiatry, 31, 447-451.
32. Murphy, E., & Thompson, A. (2009). An exploration of attitudes among black Americans toward psychiatric genetic research. Psychiatry, 72(2), 177-194.
33. Offit, K., Groeger, E., Turner, S., Wadsworth, E. A., & Weiser, M. A. (2004). The "duty to warn" a patient's family members about hereditary disease risk. Journal of the American Medical Association, 292(12), 1469-1473.
34. Pate v. Threlkel, 661 So.2d 278 (Fla. 1995).
35. Peterson, E. A., Milliron, K. J., Lewis, K. E., Goold, S. D., & Maerajver, S. D. (2002). Health Insurance and discrimination concerns and BRCA1/2 testing in a clinic population. Cancer Epidemiology, Biomarkers, and Prevention, 11(1), 79-87.
36. Rhodes, R. (2006). Why test children for adultonset genetic diseases. Mount Sinai Journal of Medicine, 73(3), 609-616.
37. Rivers, P.A., Dobalian, A., & Germinario, F.A. (2005). A review and analysis of the Clinical Laboratory Improvement Amendment of 1988: Compliance plans and enforcement policy. Health Care Management Review, 30(2), 93-102.
38. Roberts, L. W., Geppert, C. M. A., Warner, T. D., Green Hammond, K. A., Rogers, M., Smrcka, J., & Roberts, B. B. (2005). Perspectives on use and protection of genetic information in work settings: Results of a preliminary study. Social Science and Medicine, 60, 1855-1858.
39. Rothstein, M. A. (2005). Genetic exceptionalism and legislative pragmatism. Hastings Center Report, 35(4), 27-33.
40. Quaid, K. A., Aschen, S. R., Smiley, C. L., & Nurnberger, J. I. (2001). Perceived genetic risks for bipolar disorder in a patient population: An exploratory study. Journal of Genetic Counseling, 10(1), 41-51.
41. Safer v. Pack, 677 A.2d 1188 (N.J. App. 1996).
42. Salkovskis, P. M., Rimes, K. A., Bolton, J., & Wroe, A.L. (2010). An experimental investigation of factors involved in the decision to undertake genetic testing for schizophrenia. Journal of Mental Health, 19(2), 202-210.
43. Smith, L. B., Sapers, B., Reus, V. I., & Freimer, N. B. (1996). Attitudes towards bipolar disorder and predictive genetic testing among patients and providers. Journal of Medical Genetics, 33, 544-549.
44. Smoller, J.W., Sheidley, B.R., & Tsuang, M.T. (2008). Psychiatric genetics: Applications in clinical practice. Arlington, VA: American Psychiatric Press.
45. Trippitelli, C. L., Jamison, K. R., Folstein, M. F., Bartko, J. J., & DePaulo, J. R. (1998). Pilot study on patients' and spouses' attitudes toward potential genetic testing for bipolar disorder. American Journal of Psychiatry, 155(7), 899-904.
46. Tsuang, D. W., Faraone, S. V., & Tsuang, M. T. (2001). Genetic counseling for psychiatric disorders. Current Psychiatry Reports, 3, 138-143.
47. Vorhaus, D. (2011). Closer scrutiny ahead for DTC genetic testing claims. Genomics Law Report, March 24, 2011, accessed at http://www.genomicslawreport.com/index.php/2011/03/24/closer-scrutiny-ahead-for-dtcclaims/
48. Wilde, A., Meiser, B., Mitchell, P. B., & Schofield, P. R. (2009). Community attitudes towards mental health interventions for healthy people on the basis of genetic susceptibility. Australia and New Zealand Journal of Psychiatry, 43(11), 1070-1076.
49. Wilde, A., Meiser, B., Mitchell, P. B., & Schofield, P. R. (2010). Public interest in predictive genetic testing, including direct-to-consumer testing, for susceptibility to major depression: Preliminary findings. European Journal of Human Genetics, 18(1), 47-51.
50. Wilhelm, K., Meiser, B., Mitchell, P. B., Finch, A. W., Siegel, J. E., Parker, G., & Schofield, P. R. (2009). Issues concerning feedback about genetic testing and risk of depression. British Journal of Psychiatry, 194(5), 404-410.
51. Winner, J. G., Goebert, D., Matsu, C., & Mrazek, D. A. (2010). Training in psychiatric genomics during residency: A new challenge. Academic Psychiatry, 34(2), 115-118.