A pilot study on the effect of short-term consumption of a polyphenol rich drink on biomarkers of coronary artery disease defined by urinary proteomics

Journal of Agricultural and Food Chemistry

Volumn 59, Issue 24, 2011, Pages 12850-12857

  Mullen, W ^a   Gonzalez, J ^a   Siwy, J ^b   Franke, J ^b   Sattar, N ^a   Mullan, A ^a   Roberts, S ^c   Delles, C ^a   Mischak, H ^a,b   Albalat, A ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b MOSAIQUES DIAGNOSTICS GMBH   (Germany)

^c The Coca Cola Company   (United States)

Author keywords

antioxidants; biomarkers; CE MS; coronary artery disease; Polyphenol drink

Indexed keywords

ANTIOXIDANTS; ANTITRYPSIN; BENEFICIAL EFFECTS; CARDIO-VASCULAR DISEASE; CE-MS; CORONARY ARTERY DISEASE; MULTIPLE TESTING; P-VALUES; PILOT STUDIES; PLACEBO GROUPS; POLYPHENOLS; PROSPECTIVE STUDY; PROTEOMICS; URINARY BIOMARKERS; URINE SAMPLE;

BIOMARKERS; CAPILLARY ELECTROPHORESIS; MOLECULAR BIOLOGY; NUTRITION;

DISEASES;

BIOLOGICAL MARKER; PLACEBO; POLYPHENOL;

AGED; ARTICLE; BEVERAGE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MALE; MIDDLE AGED; OBESITY; PILOT STUDY; PROTEOMICS; RANDOMIZED CONTROLLED TRIAL; URINE;

AGED; BEVERAGES; BIOLOGICAL MARKERS; CORONARY DISEASE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; OVERWEIGHT; PILOT PROJECTS; PLACEBOS; POLYPHENOLS; PROTEOMICS;

EID: 84255186294     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf203369r     Document Type: Article

References (48)

1. Margetts, B.; Buttriss, J. Epidemiology linking consumption of plant foods and their constituents with health. In Plants: Diet and Health; Goldberg, G., Ed.; Blackwell Publishing: Oxford, U.K., 2003; pp 49-64.
2. Renaud, S.; Delorgeril, M. Wine, Alcohol, Platelets, and the French Paradox for Coronary Heart-Disease Lancet 1992, 339, 1523-1526
3. Hertog, M. G. L.; Feskens, E. J. M.; Hollman, P. C. H.; Katan, M. B.; Kromhout, D. Dietary antioxidant flavonoids and risk of coronary heart-disease-the Zutphen elderly study Lancet 1993, 342, 1007-1011
4. Aviram, M.; Rosenblat, M.; Gaitini, D.; Nitecki, S.; Hoffman, A.; Dornfeld, L.; Volkova, N.; Presser, D.; Attias, J.; Liker, H.; Hayek, T. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation Clin. Nutr. 2004, 23, 423-433
5. Serafini, M.; Laranjinha, J. A. N.; Almeida, L. M.; Maiani, G. Inhibition of human LDL lipid peroxidation by phenol-rich beverages and their impact on plasma total antioxidant capacity in humans J. Nutr. Biochem. 2000, 11, 585-590
6. Duffy, S. J.; Keaney, J. F.; Holbrook, M.; Gokce, N.; Swerdloff, P. L.; Frei, B.; Vita, J. A. Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease Circulation 2001, 104, 151-156
7. Schroeter, H.; Heiss, C.; Balzer, J.; Kleinbongard, P.; Keen, C. L.; Hollenberg, N. K.; Sies, H.; Kwik-Uribe, C.; Schmitz, H. H.; Kelm, M. (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 1024-1029
8. Stewart, A. J.; Mullen, W.; Crozier, A. On-line high-performance liquid chromatography analysis of the antioxidant activity of phenolic compounds in green and black tea Mol. Nutr. Food Res. 2005, 49, 52-60
9. Crozier, A.; Yokota, T.; Jaganath, I. B.; Marks, S.; Saltmarsh, M.; Clifford, M. N.; Ashihara, H. Secondary metabolites in fruits, vegetables, beverages and other plant based dietary components. In Plant Secondary Metabolites and Diet; Blackwell: Oxford, 2006.
10. Nutrient and Food Based Guidlines for UK Institutions. In Food Standards Agency: 2006.
11. Dietary Guidelines for Americans. In USDA and the US Department of Health and Human Services: 2005.
12. Mullen, W.; Marks, S. C.; Crozier, A. Evaluation of phenolic compounds in commercial fruit juices and fruit drinks J. Agric. Food Chem. 2007, 55, 3148-3157
13. Mullen, W.; Borges, G.; Lean, M. E. J.; Roberts, S. A.; Crozier, A. Identification of Metabolites in Human Plasma and Urine after Consumption of a Polyphenol-Rich Juice Drink J. Agric. Food Chem. 2010, 58, 2586-2595
14. Borges, G.; Mullen, W.; Mullan, A.; Lean, M. E.; Roberts, S. A.; Crozier, A. Bioavailability of multiple components following acute ingestion of a polyphenol-rich juice drink Mol. Nutr. Food Res. 2010, 54 (Suppl. 2) S268-S277
15. Delles, C.; Schiffer, E.; von Zur Muhlen, C.; Peter, K.; Rossing, P.; Parving, H. H.; Dymott, J. A.; Neisius, U.; Zimmerli, L. U.; Snell-Bergeon, J. K.; Maahs, D. M.; Schmieder, R. E.; Mischak, H.; Dominiczak, A. F. Urinary proteomic diagnosis of coronary artery disease: identification and clinical validation in 623 individuals J. Hypertens. 2010, 28, 2316-2322
16. Snell-Bergeon, J. K.; Maahs, D. M.; Ogden, L. G.; Kinney, G. L.; Hokanson, J. E.; Schiffer, E.; Rewers, M.; Mischak, H. Evaluation of Urinary Biomarkers for Coronary Artery Disease, Diabetes, and Diabetic Kidney Disease Diabetes Technol. Ther. 2009, 11, 1-9
17. Siwy, J.; Mullen, W.; Golovko, I.; Franke, J.; Zurbig, P. Human urinary peptide database for multiple disease biomarker discovery Proteomics Clin. Appl. 2011, 5, 367-374
18. Mischak, H.; Kolch, W.; Aivaliotis, M.; Bouyssie, D.; Court, M.; Dihazi, H.; Dihazi, G. H.; Franke, J.; Garin, J.; Gonzalez de Peredo, A.; Iphofer, A.; Jansch, L.; Lacroix, C.; Makridakis, M.; Masselon, C.; Metzger, J.; Monsarrat, B.; Mrug, M.; Norling, M.; Novak, J.; Pich, A.; Pitt, A.; Bongcam-Rudloff, E.; Siwy, J.; Suzuki, H.; Thongboonkerd, V.; Wang, L. S.; Zoidakis, J.; Zurbig, P.; Schanstra, J. P.; Vlahou, A. Comprehensive human urine standards for comparability and standardization in clinical proteome analysis Proteomics Clin. Appl. 2010, 4, 464-478
19. Theodorescu, D.; Fliser, D.; Wittke, S.; Mischak, H.; Krebs, R.; Walden, M.; Ross, M.; Eltze, E.; Bettendorf, O.; Wulfing, C.; Semjonow, A. Pilot study of capillary electrophoresis coupled to mass spectrometry as a tool to define potential prostate cancer biomarkers in urine Electrophoresis 2005, 26, 2797-2808
20. Theodorescu, D.; Wittke, S.; Ross, M. M.; Walden, M.; Conaway, M.; Just, I.; Mischak, H.; Frierson, H. F. Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis Lancet Oncol. 2006, 7, 230-240
21. Wittke, S.; Mischak, H.; Walden, M.; Kolch, W.; Radler, T.; Wiedemann, K. Discovery of biomarkers in human urine and cerebrospinal fluid by capillary electrophoresis coupled to mass spectrometry: towards new diagnostic and therapeutic approaches Electrophoresis 2005, 26, 1476-1487
22. Neuhoff, N.; Kaiser, T.; Wittke, S.; Krebs, R.; Pitt, A.; Burchard, A.; Sundmacher, A.; Schlegelberger, B.; Kolch, W.; Mischak, H. Mass spectrometry for the detection of differentially expressed proteins: a comparison of surface-enhanced laser desorption/ionization and capillary electrophoresis/mass spectrometry Rapid Commun. Mass Spectrom. 2004, 18, 149-156
23. Coon, J. J.; Zurbig, P.; Dakna, M.; Dominiczak, A. F.; Decramer, S.; Fliser, D.; Frommberger, M.; Golovko, I.; Good, D. M.; Herget-Rosenthal, S.; Jankowski, J.; Julian, B. A.; Kellmann, M.; Kolch, W.; Massy, Z.; Novak, J.; Rossing, K.; Schanstra, J. P.; Schiffer, E.; Theodorescu, D.; Vanholder, R.; Weissinger, E. M.; Mischak, H.; Schmitt-Kopplin, P. CE-MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics Proteomics Clin. Appl. 2008, 2, 964
24. Benjamini, Y.; Hochberg, Y. Controlling the False Discovery Rate-a Practical and Powerful Approach to Multiple Testing J. R. Stat. Soc. B 1995, 57, 289-300
25. Dakna, M.; Harris, K.; Kalousis, A.; Carpentier, S.; Kolch, W.; Schanstra, J. P.; Haubitz, M.; Vlahou, A.; Mischak, H.; Girolami, M. Addressing the challenge of defining valid proteomic biomarkers and classifiers BMC Bioinformatics 2010, 11, 594
26. Stalmach, A.; Mullen, W.; Steiling, H.; Williamson, G.; Lean, M. E. J.; Crozier, A. Absorption, metabolism, and excretion of green tea flavan-3-ols in humans with an ileostomy Mol. Nutr. Food Res. 2010, 54, 323-334
27. Mullen, W.; Archeveque, M. A.; Edwards, C. A.; Matsumoto, H.; Crozier, A. Bioavailability and metabolism of orange juice flavanones in humans: Impact of a full-fat yogurt J. Agric. Food Chem. 2008, 56, 11157-11164
28. Marks, S. C.; Mullen, W.; Borges, G.; Crozier, A. Absorption, metabolism, and excretion of cider dihydrochalcones in healthy humans and subjects with an ileostomy J. Agric. Food Chem. 2009, 57, 2009-2015
29. Mullen, W.; Borges, G.; Donovan, J. L.; Edwards, C. A.; Serafini, M.; Lean, M. E. J.; Crozier, A. Milk decreases urinary excretion but not plasma pharmacokinetics of cocoa flavan-3-ol metabolites in humans Am. J. Clin. Nutr. 2009, 89, 1784-1791
30. Stalmach, A.; Troufflard, S.; Serafini, M.; Crozier, A. Absorption, metabolism and excretion of Choladi green tea flavan-3-ols by humans Mol. Nutr. Food Res. 2009, 53 (Suppl. 1) S44-S53
31. Hertog, M. G. L.; Feskens, E. J. M.; Hollman, P. C. H.; Katan, M. B.; Kromhout, D. Dietary flavonoids and cancer risk in the Zutphen elderly study Nutr. Cancer 1994, 22, 175-184
32. Hertog, M. G. L.; Hollman, P. C. H.; Katan, M. B.; Kromhout, D. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands Nutr. Cancer 1993, 20, 21-29
33. Arts, I. C.; Hollman, P. C.; Feskens, E. J.; Bueno de Mesquita, H. B.; Kromhout, D. Catechin intake and associated dietary and lifestyle factors in a representative sample of Dutch men and women Eur. J. Clin. Nutr. 2001, 55, 76-81
34. Chun, O. K.; Chung, S. J.; Song, W. O. Estimated dietary flavonoid intake and major food sources of U.S. adults J. Nutr. 2007, 137, 1244-1252
35. Beking, K.; Vieira, A. An assessment of dietary flavonoid intake in the UK and Ireland Int. J. Food Sci. Nutr. 2011, 62, 17-19
36. Auclair, S.; Chironi, G.; Milenkovic, D.; Hollman, P. C.; Renard, C. M.; Megnien, J. L.; Gariepy, J.; Paul, J. L.; Simon, A.; Scalbert, A. The regular consumption of a polyphenol-rich apple does not influence endothelial function: a randomised double-blind trial in hypercholesterolemic adults Eur. J. Clin. Nutr. 2010, 64, 1158-1165
37. van Mierlo, L. A.; Zock, P. L.; van der Knaap, H. C.; Draijer, R. Grape polyphenols do not affect vascular function in healthy men J. Nutr. 2010, 140, 1769-1773
38. Princen, H. M.; van Duyvenvoorde, W.; Buytenhek, R.; Blonk, C.; Tijburg, L. B.; Langius, J. A.; Meinders, A. E.; Pijl, H. No effect of consumption of green and black tea on plasma lipid and antioxidant levels and on LDL oxidation in smokers Arterioscler. Thromb. Vasc. Biol. 1998, 18, 833-841
39. Wannamethee, S. G.; Welsh, P.; Lowe, G. D.; Gudnason, V.; Di Angelantonio, E.; Lennon, L.; Rumley, A.; Whincup, P. H.; Sattar, N. N-terminal pro-brain natriuretic Peptide is a more useful predictor of cardiovascular disease risk than C-reactive protein in older men with and without pre-existing cardiovascular disease J. Am. Coll. Cardiol. 2011, 58, 56-64
40. Mischak, H.; Allmaier, G.; Apweiler, R.; Attwood, T.; Baumann, M.; Benigni, A.; Bennett, S. E.; Bischoff, R.; Bongcam-Rudloff, E.; Capasso, G.; Coon, J. J.; D'Haese, P.; Dominiczak, A. F.; Dakna, M.; Dihazi, H.; Ehrich, J. H.; Fernandez-Llama, P.; Fliser, D.; Frokiaer, J.; Garin, J.; Girolami, M.; Hancock, W. S.; Haubitz, M.; Hochstrasser, D.; Holman, R. R.; Ioannidis, J. P.; Jankowski, J.; Julian, B. A.; Klein, J. B.; Kolch, W.; Luider, T.; Massy, Z.; Mattes, W. B.; Molina, F.; Monsarrat, B.; Novak, J.; Peter, K.; Rossing, P.; Sanchez-Carbayo, M.; Schanstra, J. P.; Semmes, O. J.; Spasovski, G.; Theodorescu, D.; Thongboonkerd, V.; Vanholder, R.; Veenstra, T. D.; Weissinger, E.; Yamamoto, T.; Vlahou, A. Recommendations for biomarker identification and qualification in clinical proteomics Sci. Transl. Med. 2010, 2, 46ps42
41. Ransohoff, D. F. Lessons from controversy: ovarian cancer screening and serum proteomics J. Natl. Cancer Inst. 2005, 97, 315-319
42. Carty, D. M.; Siwy, J.; Brennand, J. E.; Zurbig, P.; Mullen, W.; Franke, J.; McCulloch, J. W.; North, R. A.; Chappell, L. C.; Mischak, H.; Poston, L.; Dominiczak, A. F.; Delles, C. Urinary Proteomics for Prediction of Preeclampsia Hypertension 2011, 57, 561-569
43. Good, D. M.; Zurbig, P.; Argiles, A.; Bauer, H. W.; Behrens, G.; Coon, J. J.; Dakna, M.; Decramer, S.; Delles, C.; Dominiczak, A. F.; Ehrich, J. H.; Eitner, F.; Fliser, D.; Frommberger, M.; Ganser, A.; Girolami, M. A.; Golovko, I.; Gwinner, W.; Haubitz, M.; Herget-Rosenthal, S.; Jankowski, J.; Jahn, H.; Jerums, G.; Julian, B. A.; Kellmann, M.; Kliem, V.; Kolch, W.; Krolewski, A. S.; Luppi, M.; Massy, Z.; Melter, M.; Neususs, C.; Novak, J.; Peter, K.; Rossing, K.; Rupprecht, H.; Schanstra, J. P.; Schiffer, E.; Stolzenburg, J. U.; Tarnow, L.; Theodorescu, D.; Thongboonkerd, V.; Vanholder, R.; Weissinger, E. M.; Mischak, H.; Schmitt-Kopplin, P. Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease Mol. Cell. Proteomics 2010, 9, 2424-2437
44. Decramer, S.; Wittke, S.; Mischak, H.; Zurbig, P.; Walden, M.; Bouissou, F.; Bascands, J. L.; Schanstra, J. P. Predicting the clinical outcome of congenital unilateral ureteropelvic junction obstruction in newborn by urinary proteome analysis Nat. Med. 2006, 12, 398-400
45. Rossing, K.; Mischak, H.; Dakna, M.; Zurbig, P.; Novak, J.; Julian, B. A.; Good, D. M.; Coon, J. J.; Tarnow, L.; Rossing, P. Urinary proteomics in diabetes and CKD J. Am. Soc. Nephrol. 2008, 19, 1283-90
46. Pasterkamp, G.; Schoneveld, A. H.; Hijnen, D. J.; de Kleijn, D. P.; Teepen, H.; van der Wal, A. C.; Borst, C. Atherosclerotic arterial remodeling and the localization of macrophages and matrix metalloproteases 1, 2 and 9 in the human coronary artery Atherosclerosis 2000, 150, 245-253
47. El Bedoui, J.; Oak, M. H.; Anglard, P.; Schini-Kerth, V. B. Catechins prevent vascular smooth muscle cell invasion by inhibiting MT1-MMP activity and MMP-2 expression Cardiovasc. Res. 2005, 67, 317-325
48. Oak, M. H.; El Bedoui, J.; Anglard, P.; Schini-Kerth, V. B. Red wine polyphenolic compounds strongly inhibit pro-matrix metalloproteinase-2 expression and its activation in response to thrombin via direct inhibition of membrane type 1-matrix metalloproteinase in vascular smooth muscle cells Circulation 2004, 110, 1861-1867