Differential response to IV carfentanil in chronic cocaine users and healthy controls

Addiction Biology

Volumn 17, Issue 1, 2012, Pages 149-155

  Minkowski, Carolynne P ^a   Epstein, David ^a   Frost, J James ^b   Gorelick, David A ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Agonist; carfentanil; cocaine; mu opioid receptor; PET scan; receptor

Indexed keywords

CARFENTANIL;

ADULT; AGE DISTRIBUTION; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT TOOL; COCAINE DEPENDENCE; CONTROLLED STUDY; DIZZINESS; DRUG ERUPTION; DRUG HALF LIFE; DRUG SAFETY; FEMALE; HEADACHE; HUMAN; IMAGE ANALYSIS; LIKERT SCALE; MALE; NAUSEA; PATIENT ASSESSMENT; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SELF REPORT; VOMITING;

ADULT; ANALGESICS, OPIOID; BRAIN; COCAINE-RELATED DISORDERS; DIZZINESS; FEMALE; FENTANYL; HALF-LIFE; HEADACHE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; NAUSEA; POSITRON-EMISSION TOMOGRAPHY; PRURITUS; TIME FACTORS; VOMITING;

EID: 84255177259     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/j.1369-1600.2010.00256.x     Document Type: Article

References (31)

1. Compton MA, (1994) Cold-pressor pain tolerance in opiate and cocaine abusers: correlates of drug type and use status. J Pain Symptom Manage 9: 462-473. (Pubitemid 24338148)
2. Dackis CA, O'Brien CP, (2001) Cocaine dependence: a disease of the brain's reward centers. J Subst Abuse Treat 21: 111-117. (Pubitemid 33109059)
3. Daunais JB, Nader MA, Porrino LJ, (1997) Long term cocaine self-administration decreases striatal preproenkephalin mRNA in rhesus monkeys. Pharmacol Biochem Behav 57: 471-475. (Pubitemid 27296758)
4. Gorelick DA, Kim Y-K, Bencherif B, Boyd SJ, Nelson R, Copersino ML, Dannals RF, Frost JJ, (2008) Brain mu-opioid receptor binding: relationship to relapse to cocaine use after monitored abstinence. Psychopharmacology 200: 475-486.
5. Gorelick DA, Kim YK, Bencherif B, Boyd SJ, Nelson R, Copersino M, Endres CJ, Dannals RF, Frost JJ, (2005) Imaging brain mu-opioid receptors in abstinent cocaine users: time course and relation to cocaine craving. Biol Psychiatry 57: 1573-1582. (Pubitemid 40805388)
6. Gutstein HB, Akil H, (2006) Opioid analgesics. In:, Brunton LL, Lazo JS, Parker KL, eds. Goodman & Gilman's the Pharmacological Basis of Therapeutics, 11th edn. New York: McGraw-Hill. Available from (accessed 7 June 2010).
7. Hammer RP, (1989) Cocaine alters opiate receptor binding in critical brain reward regions. Synapse 3: 55-60.
8. Hilton J, Yokoi F, Dannals RF, Ravert HT, Szabo Z, Wong DF, (2000) Column-switching HPLC for the analysis of plasma in PET imaging studies. Nucl Med Biol 27: 627-630.
9. Izenwasser S, Heller B, Cox BM, (1996) Continuous cocaine administration enhances mu- but not delta-opioid receptor-mediated inhibition of adenylyl cyclase activity in nucleus accumbens. Eur J Pharmacol 297: 187-191.
10. Kennedy SE, Koeppe RA, Young EA, Zubieta J-K, (2006) Dysregulation of endogenous opioid emotion regulation circuitry in major depression in women. Arch Gen Psychiatry 63: 1199-1208. (Pubitemid 44708077)
11. Ladona MG, Gonzalez ML, Rane A, Peter RM, (2000) Cocaine metabolism in human fetal and adult liver microsomes is related to cytochrome P450 3A expression. Life Sci 68: 431-443. (Pubitemid 32011895)
12. Laforge KS, Yoferov V, Zhou Y, Ho A, Nyberg F, Kreek J, (2003) "Binge" cocaine differentially alters preproenkephalin mRNA levels in guinea pig brain. Brain Res Bull 59: 353-357. (Pubitemid 36042830)
13. Lutfy K, Maidment NT, (2002) Sensitization does not develop to cocaine-induced potentiation of the antinociceptive effect of morphine. Brain Res Bull 58: 7-12. (Pubitemid 34732989)
14. Matussek N, Hoehe M, (1989) Investigations with the specific mu-opiate receptor agonist fentanyl in depressive patients: growth hormone, prolactin, cortisol, noradrenaline and euphoric responses. Neuropsychopharmacology 21: 1-8. (Pubitemid 19245945)
15. Pellinen P, Stenback F, Kojo A, Honkakoski P, Gelboin HV, Pasanen M, (1996) Regenerative changes in hepatic morphology and enhanced expression of CYP2B10 and CYP3A during daily administration of cocaine. Hepatology 23: 515-523. (Pubitemid 26087165)
16. Porreca F, Ossipov MH, (2009) Nausea and vomiting side effects with opioid analgesics during treatment of chronic pain: mechanisms, implications, and management options. Pain Med 10: 654-662.
17. Przewlocka B, Lason W, (1995) Adaptive changes in the proenkephalin and D2 dopamine receptor mRNA expression after chronic cocaine in the nucleus accumbens and striatum of the rat. Eur Neuropsychopharmacol 5: 465-469.
18. Reich A, Szepietowski JC, (2010) Opioid-induced pruritus: an update. Clin Exp Dermatol 35: 2-6.
19. Ross VH, Moore CH, Pan PH, Fragnato RY, James RL, Justis GB, (2003) Reduced duration of intrathecal sufentanil analgesia in laboring cocaine users. Anesth Analg 97: 1504-1508. (Pubitemid 37310157)
20. Scholz J, Steinfath M, Schulz M, (1996) Clinical pharmaco kinetics of alfentanil, fentanyl and sufentanil. An update. Clin Pharmacokinet 31: 275-292.
21. Schroeder JA, Niculescu M, Unterwald EM, (2003) Cocaine alters mu but not delta or kappa opioid receptor-stimulated in situ [35S]GTPgammaS binding in rat brain. Synapse 47: 26-32. (Pubitemid 35424540)
22. Titeler M, Lyon RA, Kuhar MJ, Frost JJ, Dannals RF, Leonhardt S, Bullock A, Rydelek LT, Price DL, Struble RG, (1989) Mu opiate receptors are selectively labelled by [3H]carfentanil in human and rat brain. Eur J Pharmacol 167: 221-228. (Pubitemid 19215472)
23. University of Washington (1997) Clinical Nutrition: A Source Book for Delivering Enteral and Parenteral Nutrition for Adults. Available at: (accessed 10 January 2010).
24. Unterwald EM, (2001) Regulation of opioid receptors by cocaine. Ann N Y Acad Sci 937: 74-92. (Pubitemid 32613880)
25. Unterwald EM, Cox BM, Kreek MJ, Cote TE, Izenwasser S, (1993) Chronic repeated cocaine administration alters basal and opioid-regulated adenylyl cyclase activity. Synapse 15: 33-38. (Pubitemid 23262753)
26. Unterwald EM, Rubenfeld JM, Kreek MJ, (1994) Repeated cocaine administration upregulates kappa and mu, but not delta, opioid receptors. Neuroreport 5: 1613-1616. (Pubitemid 24265254)
27. Vezina P, Stewart J, (1990) Amphetamine administered to the ventral tegmental area but not to the nucleus accumbens sensitizes rats to systematic morphine: Lack of conditioned effects. Brain Res 516: 99-106. (Pubitemid 20189205)
28. Yokoo H, Yamada S, Yoshida M, Tanaka T, Mizoguchi K, Emoto H, Koga C, Ishii H, Ishikawa M, Kuraasaki N, Matsui M, Tanaka M, (1994) Effect of opioid peptides on dopamine release from nucleus accumbens after repeated treatment with methamphetamine. Eur J Pharmacol 256: 335-338. (Pubitemid 24134896)
29. Yun CH, Wood M, Wood AJ, Guengerich FP, (1992) Identification of the pharmacogenetic determinants of alfentanil metabolism: cytochrome P450 3A4. An explanation of the variable elimination clearance. Anesthesiology 77: 467-474.
30. Zubieta JK, Dannals RF, Frost JJ, (1999) Gender and age influences on human brain mu-opioid receptor binding measured by PET. Am J Psychiatry 156: 842-848. (Pubitemid 29260337)
31. Zubieta JK, Gorelick DA, Stauffer R, Ravert HT, Dannals RF, Frost JJ, (1996) Increased mu opioid receptor binding detected by PET in cocaine-dependent men is associated with cocaine craving. Nat Med 2: 1225-1228.