Cellular mechanism of bile acid-accelerated hepatocyte polarity

Small GTPases

Volumn 2, Issue 6, 2011, Pages 314-317

  Fu, Dong ^a   Lippincott Schwartz, Jennifer ^a   Arias, Irwin M ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Apical trafficking; Bile acid; Bile canalicular formation; Hepatocyte; Polarity; Tight junction

Indexed keywords

BILE ACID; CYCLIC AMP; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN KINASE LKB1; RAP1 PROTEIN; TAUROCHOLIC ACID;

ARTICLE; CELL ACTIVITY; CELL CULTURE; CELL CYCLE; CELL MIGRATION; CELL POLARITY; CELL STRUCTURE; CYTOSKELETON; ENDOSOME; INTRACELLULAR SIGNALING; LIVER CELL; PROTEIN FUNCTION; REGULATORY MECHANISM; TIGHT JUNCTION;

EID: 84255176125     PISSN: 21541248     EISSN: 21541256     Source Type: Journal    
DOI: 10.4161/sgtp.18087     Document Type: Article

References (30)

1. Vinken M, Papeleu P, Snykers S, De Rop E, Henkens T, Chipman JK, et al. Involvement of cell junctions in hepatocyte culture functionality. Crit Rev Toxicol 2006; 36:299-318; http://dx.doi.org/10.1080/10408440600599273
2. Kojima T, Yamamoto T, Murata M, Chiba H, Kokai Y, Sawada N. Regulation of the blood-biliary barrier: interaction between gap and tight junctions in hepatocytes. Med Electron Microsc 2003; 36:157-64; http://dx.doi.org/10.1007/s00795-003-0220-5
3. Rodriguez-Boulan E, Kreitzer G, Musch A. Organization of vesicular trafficking in epithelia. Nat Rev Mol Cell Biol 2005; 6:233-47; http://dx.doi.org/10.1038/nrm1593
4. Rodriguez-Boulan E, Salas PJ. External and internal signals for epithelial cell surface polarization. Annu Rev Physiol 1989; 51:741-54; http://dx.doi.org/10.1146/annurev.ph.51.030189.003521
5. Bryant DM, Mostov KE. From cells to organs: building polarized tissue. Nat Rev Mol Cell Biol 2008; 9:887-901; http://dx.doi.org/10.1038/nrm2523
6. Mostov K, Su T, ter Beest M. Polarized epithelial membrane traffic: conservation and plasticity. Nat Cell Biol 2003; 5:287-93; http://dx.doi.org/10.1038/ncb0403-287
7. Hoekstra D, Tyteca D. van ISC. The subapical compartment: a traffic center in membrane polarity development. J Cell Sci 2004; 117:2183-92; http://dx.doi.org/10.1242/jcs.01217
8. Wakabayashi Y, Dutt P, Lippincott-Schwartz J, Arias IM. Rab11a and myosin Vb are required for bile canalicular formation in WIF-B9 cells. Proc Natl Acad Sci USA 2005; 102:15087-92; http://dx.doi.org/10.1073/pnas.0503702102
9. Gerloff T, Stieger B, Hagenbuch B, Madon J, Landmann L, Roth J, et al. The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J Biol Chem 1998; 273:10046-50 http://dx.doi.org/10.1074/jbc.273.16.10046
10. Thomas C, Pellicciari R, Pruzanski M, Auwerx J, Schoonjans K. Targeting bile-acid signalling for metabolic diseases. Nat Rev Drug Discov 2008; 7: 678-93; http://dx.doi.org/10.1038/nrd2619
11. Hofmann AF, Hagey LR. Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics. Cell Mol Life Sci 2008; 65:2461-83; http://dx.doi.org/10.1007/s00018-008-7568-6
12. Nguyen A, Bouscarel B. Bile acids and signal transduction: role in glucose homeostasis. Cell Signal 2008; 20:2180-97; http://dx.doi.org/10.1016/j.cellsig.2008.06.014
13. Houten SM, Watanabe M, Auwerx J. Endocrine functions of bile acids. EMBO J 2006; 25:1419-25; http://dx.doi.org/10.1038/sj.emboj.7601049
14. Looby E, Long A, Kelleher D, Volkov Y. Bile acid deoxycholate induces differential subcellular localization of the PKC isoenzymes beta 1, epsilon and delta in colonic epithelial cells in a sodium butyrate insensitive manner. Int J Cancer 2005; 114:887-95; http://dx.doi.org/10.1002/ijc.20803
15. Fang Y, Studer E, Mitchell C, Grant S, Pandak WM, Hylemon PB, et al. Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling. Mol Pharmacol 2007; 71:1122-8; http://dx.doi.org/10.1124/mol.106.032060
16. Huang W, Ma K, Zhang J, Qatanani M, Cuvillier J, Liu J, et al. Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science 2006; 312:233-6; http://dx.doi.org/10.1126/science.1121435
17. Fu D, Wakabayashi Y, Lippincott-Schwartz J, Arias IM. Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway. Proc Natl Acad Sci USA 2011; 108:1403-8; http://dx.doi.org/10.1073/pnas.1018376108
18. Zheng B, Cantley LC. Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase. Proc Natl Acad Sci USA 2007; 104:819-22; http://dx.doi.org/10.1073/pnas.0610157104
19. Zhang L, Li J, Young LH, Caplan MJ. AMP-activated protein kinase regulates the assembly of epithelial tight junctions. Proc Natl Acad Sci USA 2006; 103:17272-7; http://dx.doi.org/10.1073/pnas.0608531103
20. Fu D, Wakabayashi Y, Ido Y, Lippincott-Schwartz J, Arias IM. Regulation of bile canalicular network formation and maintenance by AMP-activated protein kinase and LKB1. J Cell Sci 2010; 123:3294-302; http://dx.doi.org/10.1242/jcs.068098
21. Mitonaka T, Muramatsu Y, Sugiyama S, Mizuno T, Nishida Y. Essential roles of myosin phosphatase in the maintenance of epithelial cell integrity of Drosophila imaginal disc cells. Dev Biol 2007; 309:78-86; http://dx.doi.org/10.1016/j.ydbio.2007.06.021
22. Terry SJ, Zihni C, Elbediwy A, Vitiello E, Leefa Chong San IV, Balda MS, et al. Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis. Nat Cell Biol 2011; 13:159-66; http://dx.doi.org/10.1038/ncb2156
23. Wong K, Van Keymeulen A, Bourne HR. PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells. J Cell Biol 2007; 179:1141-8; http://dx.doi.org/10.1083/jcb.200706167
24. Marzesco AM, Dunia I, Pandjaitan R, Recouvreur M, Dauzonne D, Benedetti EL, et al. The small GTPase Rab13 regulates assembly of functional tight junctions in epithelial cells. Mol Biol Cell 2002; 13:1819-31; http://dx.doi.org/10.1091/mbc.02-02-0029
25. Bos JL, de Rooij J, Reedquist KA. Rap1 signalling: adhering to new models. Nat Rev Mol Cell Biol 2001; 2:369-77; http://dx.doi.org/10.1038/35073073
26. Wakabayashi Y, Fu D, Lippincott-Schwartz J, Arias IM. Rab11A and myosin VB are required for canalicular network formation and ABC transporter cycling in primary rat hepatocytes. Hepatology 2009; 50:378A.
27. Nakano A, Kato H, Watanabe T, Min KD, Yamazaki S, Asano Y, et al. AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation. Nat Cell Biol 2010; 12:583-90; http://dx.doi.org/10.1038/ncb2060
28. Tuerk RD, Thali RF, Auchli Y, Rechsteiner H, Brunisholz RA, Schlattner U, et al. New candidate targets of AMP-activated protein kinase in murine brain revealed by a novel multidimensional substratescreen for protein kinases. J Proteome Res 2007; 6: 3266-77; http://dx.doi.org/10.1021/pr070160a
29. Cohen D, Fernandez D, Lazaro-Dieguez F, Musch A. The serine/threonine kinase Par1b regulates epithelial lumen polarity via IRSp53-mediated cell-ECM signaling. J Cell Biol 2011; 192:525-40; http://dx.doi.org/10.1083/jcb.201007002
30. Zagórska A, Deak M, Campbell DG, Banerjee S, Hirano M, Aizawa S, et al. New roles for the LKB1- NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. Sci Signal 2010; 3:ra25; http://dx.doi.org/10.1126/scisignal.2000616