Sodium depletion enhances fibrosis and the expression of TGF-β1 and matrix proteins in experimental chronic cyclosporine nephropathy

American Journal of Kidney Diseases

Volumn 30, Issue 1, 1997, Pages 71-81

  Shihab, Fuad S ^a   Andoh, Takeshi F ^b   Tanner, Amie M ^b   Bennett, William M ^b  

^a UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^b NONE

Author keywords

Chronic nephrotoxicity; Collagen; Cyclosporine; Extracellular matrix; Fibrosis; Glycoprotein; Plasminogen activator inhibitor 1; Proteoglycan; Rats; Salt; Transforming growth factor

Indexed keywords

BIGLYCAN; COLLAGEN TYPE 1; CYCLOSPORIN A; FIBRONECTIN; MATRIX PROTEIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; RENIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE CLEARANCE; EXTRACELLULAR MATRIX; KIDNEY FIBROSIS; MALE; NEPHROTOXICITY; NONHUMAN; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SODIUM DEPLETION; SODIUM RESTRICTION; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030745637     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0272-6386(97)90567-9     Document Type: Article

References (50)

1. Kahan BD: Cyclosporine. N Engl J Med 321:1725-1738, 1989
2. Bennett WM, DeMattos A, Meyer MM, Andoh T, Barry JM: Chronic cyclosporine nephropathy: The Achilles' heel of immunosuppressive therapy. Kidney Int 50:1089-1100, 1996
3. English J, Evan A, Houghton DC, Bennett WM: Cyclosporine-induced acute renal dysfunction in the rat. Transplantation 44:135-141, 1987
4. Myers BD, Ross JC, Newton LD, Luetscher JA, Periroth MG: Cyclosporine-associated chronic nephropathy. N Engl J Med 311:600-705, 1984
5. Rosen S, Greenfeld Z, Brezis M: Chronic cyclosporine-induced nephropathy in the rat. Transplantation 49:445-452, 1990
6. Elzinga LW, Rosen S, Bennett WM: Dissociation of glomerular filtration rate from tubulointerstitial fibrosis in experimental chronic cyclosporine nephropathy: Role of sodium intake. J Am Soc Nephrol 4:214-221, 1993
7. Young BA, Burdmann EA, Johnson RJ, Andoh T, Bennett WM, Couser WG, Alpers CE: Cyclosporine A induced arteriolopathy in a rat model of chronic cyclosporine nephropathy. Kidney Int 48:431-438, 1995
8. Shihab FS, Andoh TF, Tanner AM, Noble NA, Border WA, Franceschini N, Bennett WM: Role of transforming growth factor-β1 in experimental chronic cyclosporine nephropathy. Kidney Int 49:1141-1151, 1996
9. Wolf G, Killen PD, Neilson EG: Cyclosporin A stimulates transcription and procollagen secretion in tubulointerstitial fibroblasts and proximal tubular cells. J Am Soc Nephrol 1:918-922, 1990
10. Wolf G, Thaiss F, Stahl RAK: Cyclosporine stimulates expression of transforming growth factor-β in renal cells. Transplantation 60:237-241, 1995
11. Prashar Y, Khanna A, Sehajpal P, Sharma VK, Suthanthiran M: Stimulation of transforming growth factor-β1 transcription by cyclosporine. FEBS Lett 358:109-112, 1995
12. Shehata M, Cope GH, Johnson TS, Raftery AT, El Nahas AM: Cyclosporine enhances the expression of TGF-β in the juxtaglomerular cells of the rat kidney. Kidney Int 48:1487-1496, 1995
13. Border WA, Noble NA: Transforming growth factor β in tissue fibrosis. N Engl J Med 331:1286-1292, 1994
14. Ruscetti FW, Palladino MA: Transforming growth factor-β and the immune system. Prog Growth Factor Res 3:159-175, 1991
15. Khanna A, Li B, Sehajpal PK, Sharma VK, Suthanthiran M: Mechanism of action of cyclosporine: A new hypothesis implicating transforming growth factor-β. Transplant Rev 9:41-48, 1995
16. Burdmann EA, Andoh TF, Rosen S, Lindsley J, Munar MY, Elzinga LW, Bennett WM: Experimental nephrotoxicity, hepatotoxicity and pharmacokinetics of cyclosporin G versus cyclosporin A. Kidney Int 45:684-691, 1994
17. Derynck R, Jarrett JA, Chen EY, Goeddel DV: The murine transforming growth factor-β precursor. J Biol Chem 261:4377-4379, 1986
18. Zeheb R, Gelehrter TD: Cloning and sequencing of cDNA for the rat plasminogen activator inhibitor-1. Gene 73:459-468, 1988
19. Fisher LW, Termine JD, Young MF: Deduced protein sequence of small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species. J Biol Chem 264:4571-4576, 1989
20. Genovese C, Rowe D, Kream B: Construction of DNA sequences complementary to rat α1 and α1 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1,25-dihydroxyvitamin D. Biochemistry 23:6210-6216, 1984
21. Fort P, Marty L, Piechaczyk M, El Saboury S, Dani C, Jeanteur P, Blanchard JM: Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate dehydrogenase multigenic family. Nucl Acid Res 13:1431-1442, 1985
22. Shihab FS, Yamamoto T, Nast CC, Cohen AH, Noble NA, Gold LI, Border WA: Transforming growth factor-β and matrix protein expression in acute and chronic rejection of human renal allografts. J Am Soc Nephrol 6:286-294, 1995
23. Shihab FS, Tanner AM, Shao Y, Weffer MI: Expression of TGF-β1 and matrix proteins is elevated in rats with chronic rejection. Kidney Int 50:1904-1913, 1996
24. Ohnishi A, Ohnishi T, Stevenhead W, Robinson PD, Glick A, O'Day DM, Satra R, Jackson EK, Branch RA: Sodium status influences amphotericin nephrotoxicity in rats. Antimicrob Agents Chemother 33:1222-1227, 1989
25. Llanos A, Cieza J, Bernardo J, Echevarria J, Biaggioni I, Satra R, Branch PA: Effect of salt supplementation on amphotericin B nephrotoxicity. Kidney Int 40:302-308, 1991
26. Rasmussen HH, Ibels LS: Acute renal failure. Multivariate analysis of causes and risk factors. Am J Med 73:211-218, 1982
27. Shusterman N, Storm BL, Murray TG, Morrison G, West SL, Maislin G: Risk factors and outcome of hospital-acquired acute renal failure. Am J Med 83:65-71, 1987
28. Bertani T, Perico N, Abbate M, Battaglia C, Remuzzi G: Renal injury induced by long-term administration of cyclosporine A to rats. Am J Pathol 127:569-579, 1987
29. Baricos WH, Cortez SL, El Dahr SS, Schnaper HW: ECM degradation by cultured human mesangial cells is mediated by a PA/plasmin/MMP-2 cascade. Kidney Int 47:1039-1047, 1995
30. Burdmann EA, Andoh TF, Nast CC, Evan A, Connors BA, Coffman TM, Lindsley J, Bennett WM: Prevention of experimental cyclosporin-induced interstitial fibrosis by losartan and enalapril. Am J Physiol 269:F491-F499, 1995
31. Pichler RH, Franceschini N, Young BA, Hugo C, Andoh TF, Burdmann EA, Shankland SJ, Alpers CE, Bennett WM, Couser WG, Johnson RJ: Pathogenesis of cyclosporine nephropathy: Roles of angiotensin II and osteopontin. J Am Soc Nephrol 6:1186-1196, 1995
32. Fox J, Guan S, Hymel AA, Navar LG: Dietary Na and ACE inhibition effects on renal tissue angiotensin I and II and ACE activity in rats. Am J Physiol 262:F902-F909, 1992
33. Holmer S, Eckardt K-U, LeHir M, Schricker K, Riegger G, Kurtz A: Influence of dietary NaCl intake on renin gene expression in the kidneys and adrenal glands of rats. Pfluegers Arch 425:62-67, 1993
34. Mason J, Muller-Schweinitzer E, Dupont M, Casellas D, Mihatsch M, Moore L, Kaskel F: Cyclosporine and the renin-angiotensin system. Kidney Int 39:S28-S32, 1991 (suppl 32)
35. Bantle JP, Nath KA, Sutherlant DE, Najarian JS, Ferris TF: Effects of cyclosporin on the renin-angiotensin-aldosterone system and potassium excretion in renal transplant recipients. Arch Intern Med 145:505-508, 1985
36. Myers BD, Sibley R, Newton L, Tomlanovich SJ, Boshkos C, Stinson E, Luetscher JA, Whitney DJ, Krasny D, Coplon NS, Perlroth MG: The long-term course of cyclosporin-associated chronic nephropathy. Kidney Int 33:590-600, 1988
37. Julien J, Farge D, Kreft-Jais C, Thanh-Tam P, Pierre-François P, Houssin D, Carpentier A, Corvol P: Cyclosporine-induced stimulation of the renin-angiotensin system after liver and heart transplantation. Transplantation 56:885-891, 1993
38. Gardiner DS, Watson MA, Junor BR, Briggs JD, More IAR, Lindop GBM: The effect of conversion from cyclosporin A to azathioprine on renin-containing cells in renal allograft biopsies. Nephrol Dial Transplant 6:363-367, 1991
39. Young BA, Burdmann EA, Johnson RJ, Alpers CE, Ghiachelli CM, Eng E, Andoh T, Bennett WM, Couser WG: Cellular proliferation and macrophage influx precede interstitial fibrosis in cyclosporine nephrotoxicity. Kidney Int 48:439-448, 1995
40. Lafayette RA, Mayer G, Meyer TW: The effects of blood pressure reduction on cyclosporin nephrotoxicity in the rat. J Am Soc Nephrol 3:1892-1899, 1993
41. Sechi LA, Grady EF, Griffin CA, Kalinyak JE, Schambelan M: Distribution of angiotensin II receptor subtypes in rat and human kidney. Am J Physiol 262:F236-F240, 1992
42. Dieperink H, Hansen HV, Kemp M, Leyssac PP, Starklint H, Kemp E: Antagonist capacity of felodipine on cyclosporin A nephrotoxicity in the rat. Nephrol Dial Transplant 7:1124-1129, 1992
43. Kon V, Hunley TE, Fogo A: Combined antagonism of endothelin A/B receptors links endothelin to vasoconstriction whereas angiotensin II effects fibrosis. Transplantation 60:89-95, 1995
44. Itoh H, Mukoyama M, Pratt RE, Gibbons GH, Dzau VJ: Multiple autocrine growth factors modulate vascular smooth muscle cell growth responses to angiotensin II. J Clin Invest 91:2268-2274, 1993
45. Kagami S, Border WA, Miller DE, Noble NA: Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-β expression in rat glomerular mesangial cells. J Clin Invest 93:2431-2437, 1994
46. Wolf G, Mueller E, Stahl RAK, Ziyadeh FN: Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-β. J Clin Invest 92:1366-1372, 1993
47. Olson JA Jr, Shiverick KT, Ogilvie S, Buhi WC, Raizada MK: Angiotensin II induces secretion of plasminogen activator inhibitor 1 and a tissue metalloprotease inhibitor-related protein from rat brain astrocytes. Proc Natl Acad Sci USA 88:1928-1932, 1991
48. Zelezna B, Rydzewski B, Lu D, Olson JA, Shiverick KT, Tang W, Sumners C, Raizada MK: Angiotensin II-induction of plasminogen activator inhibitor-1 gene expression in astroglial cells of normotensive and spontaneously hypertensive rat brain. Mol Endocrinol 6:2009-2017, 1992
49. Laiho M, Saksela O, Keski-Oja J: Transforming growth factor-β induction of type-1 plasminogen activator inhibitor. J Biol Chem 262:17467-17474, 1987
50. Curtis JJ, Luke JG, Jones P, Diethelm AG: Hypertension in cyclosporine-treated renal transplant recipients is sodium dependent. Am J Med 85:134-138, 1988