Decrease in kidney calbindin-D 28kDa as a possible mechanism mediating cyclosporine A- and FK-506-induced calciuria and tubular mineralization

Biochemical Pharmacology

Volumn 53, Issue 5, 1997, Pages 723-731

  Aicher, Lothar ^a   Meier, Gabriele ^a   Norcross, Alastair J ^a   Jakubowski, Joseph ^a   Del Carmen Varela, Maria ^a   Cordier, André ^a   Steiner, Sandra ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

calbindin D 28kDa; calcium binding protein; calciuria; cyclosporine A; FK 506; kidney; rat; tubular mineralization

Indexed keywords

CALBINDIN; CYCLOSPORIN A; RAPAMYCIN; TACROLIMUS; VALSPODAR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIFICATION; CALCIUM METABOLISM; CALCIUM URINE LEVEL; CONTROLLED STUDY; HISTOCHEMISTRY; HISTOLOGY; KIDNEY; MALE; NEPHROTOXICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

ANIMALS; CALCINOSIS; CALCIUM; CALCIUM-BINDING PROTEIN, VITAMIN D-DEPENDENT; CYCLOSPORINE; IMMUNOSUPPRESSIVE AGENTS; KIDNEY; KIDNEY TUBULES; MALE; POLYENES; RATS; RATS, WISTAR; SIROLIMUS; TACROLIMUS;

EID: 0030933168     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(96)00772-1     Document Type: Article

References (37)

1. Handschumacher RE, Harding MW, Rice J and Drugge RJ, Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science 226: 544-547, 1984.
2. Liu J, Farmer J, Lane W, Friedman J, Weisman I and Schreiber SL, Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66: 807-815, 1991.
3. Fruman DA, Klee CB, Bierer BE and Burakoff SJ, Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A. Proc Nat Acad Sci USA 89: 3686-3690, 1992.
4. O'Keefe SJ, Tamura J, Kincaid RL, Tocci MJ and O'Neill EA, FK506 and cyclosporine A sensitive activation of the IL-2 promoter by calcineurin. Nature 357: 692-694, 1992.
5. Myers BD, Cyclosporine nephrotoxicity. Kidney Int 30: 964-974, 1986.
6. Ryffel B, Weber E and Mihatsch MJ, Nephrotoxicity of immunosuppressants in rats: comparison of macrolides with cyclosporin. Exp Nephrol 2: 324-333, 1994.
7. Mihatsch MJ, Thiel G, Spichtin HP, Oberholzer M, Brunner FP, Harder V, Bremer R, Stöcklin E, Torhorst J, Gudat F, Zollinger HU and Loertscher R, Morphological findings in kidney transplants after treatment with cyclosporine. Transplant Proc 4: 2821-2835, 1983.
8. Mihatsch MJ, Thiel G and Ryffel B, Cyclosporine A: action and side-effects. Prog Allergy 38: 447-457, 1989.
9. Racusen LC and Solez K, Nephrotoxicity of cyclosporine and other immunosuppressive and immunotherapeutic agents. In: Toxicology of the Kidney (Eds. Hook JB and Goldstein RS), pp. 319-360. Raven Press, New York, 1993.
10. Rooth P, Dawidson I, Diller K and Taljedal IB, Protection against cyclosporine-induced impairment of renal microcirculation by verapamil in mice. Transplantation 45: 433-437, 1988.
11. Wagner K, Albrecht S and Neumayer HH, Prevention of post-transplant acute tubular necrosis by calcium antagonist diltiazem: a prospective randomized study. Am J Nephrol 7: 287-291, 1987.
12. Shaikh MG, Heys SD, Brown PA and Whiting PH, Chronic cyclosporin A (CsA) nephrotoxicity in the rat: the effects of calcium blockade with verapamil. Int J Exp Pathol 74: 289-396, 1993.
13. Benito B, Wahl D, Steudel N, Cordier A and Steiner S, Effects of cyclosporine A on the rat liver and kidney protein pattern, and the influence of vitamin E and C coadministration. Electrophoresis 16: 1273-1283, 1995.
14. Steiner S, Aicher L, Raymackers J, Meheus L, Esquer-Blasco R, Anderson NL and Cordier A, Cyclosporine A decreases the protein level of the calcium binding protein calbindin-D 28kDa in rat kidney. Biochem Pharmacol 51: 253-258, 1996.
15. Bredderman PJ and Wasserman RH, Chemical composition, affinity for calcium, and some related properties of the vitamin D-dependent calcium-binding protein. Biochemistry 13: 1687-1694, 1974.
16. Feher JJ, Facilitated calcium diffusion by intestinal calcium-binding protein. Am J Physiol 244: C303-C307, 1983.
17. Gross M and Kumar R, Physiology and biochemistry of vitamin D-dependent calcium binding proteins. Am J Physiol 259: F195-F209, 1990.
18. Borke JL, Caride A, Verma AK, Penniston JT and Kumar R, Plasma membrane calcium pump and 28-kDa calcium binding protein in cells of rat kidney distal tubules. Am J Physiol 257: F842-F849, 1989.
19. Schreiner DS, Jande SS, Parkes CO, Lawson DEM and Thomaset M, Immunocytochemical demonstration of two vitamin D-dependent calcium binding proteins in mammalian kidney. Acta Anat 117: 1-14, 1993.
20. Rhoten WB and Christakos S, Cellular gene expression for calbindin-D28k in mouse kidney. Anat Rec 227: 145-151, 1990.
21. Allison AC, Novel immunosuppressive and anti-inflammatory drugs: A perspective. In: Immunosuppressive and anti-inflammatory drugs. (Eds. Allison AC, Lafferty K, Fliri H) pp. 11-22 New York Academy of Sciences, New York, 1993.
22. Dijoseph JF, Sharma RN and Chang JY, The effects of rapamycin on kidney function in the Sprague-Dawley rat. Transplantation 53: 507-513, 1992.
23. Keller RP, Altermatt HJ, Donatsch P, Zihlmann H, Laissue JA and Hiestand PC, Pharmacologic interactions between the resistance-modifying cyclosporine SDZ PSC-833 and etoposide (VP 16-213) enhance in vivo cytostatic activity and toxicity. Int J Cancer 51: 433-438, 1992.
24. Laemmli U, Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature Lond 227: 680-685, 1970.
25. Towbin H, Stahelin T and Gordon J, Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets. Proc Natl Acad Sci USA 76: 4350-4354, 1979.
26. Miller BE and Norman AW, Enzyme-linked immunoabsorbent assay (ELISA) and radioimmunoassay (RIA) for the vitamin D-dependent 28,000 Dalton calcium-binding-protein. Methods Enzymol 102: 291-296, 1993.
27. Ramagali LS and Rodriguez LV, Quantification of microgram amounts of protein in two-dimensional polyacrylamide gel electrophoresis sample buffer. Electrophoresis 6: 559-563, 1985.
28. Gitelman H, An improved automated procedure for the determination of calcium in biological specimens. Anal Biochem 18: 521-531, 1967.
29. Jaffe M, Ueber den Niederschlag, welchen Pikrinsaeure in normalem Harn erzeugt und ueber eine neue Reaktion des Kreatinins. Z Physiol Chem 10: 391-400, 1886.
30. Dryer RL and Routh JI, Determination of serum inorganic phosphorus. Stand Methods Clin Chem 4: 191, 1963.
31. Lillie RD and Fullmer HM, Histopathologic Technic and Practical Histochemistry. 4th ed. McGraw-Hill, New York, 1976.
32. Lemaire M, Maurer G and Wood AJ, Cyclosporine: Pharmacokinetics and metabolism. Prog Allergy 38: 93-107, 1986.
33. 3-mediated intestinal calcium absorption. Miner Electrolyte Metab 16: 109-114, 1990.
34. 3 in the rat and mouse. Endocrinology 128: 1369-1373, 1991.
35. 3 receptors: gene regulation and genetic circuitry. FASEB J 2: 3043-3053, 1988.
36. Chung J, Kuo C, Crabtree G and Blemis J, Rapamycin-FKBP specifically blocks growth dependent activation of an signaling by the 70 kD S6 protein kinases. Cell 69: 1227-1236, 1992.
37. Bell A, Wernli B and Franklin RM, Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin. Biochem Pharmacol 48: 495-503, 1994.