World Health Organization/International Society for Biomedical Research on Alcoholism Study on State and Trait Markers of Alcohol Use and Dependence: Back to the future

Alcoholism: Clinical and Experimental Research

Volumn 29, Issue 7, 2005, Pages 1268-1275

  Wurst, Friedrich M ^a   Tabakoff, Boris ^b,c   Alling, Christer ^d   Aradottir, Steina ^d   Wiesbeck, Gerhard A ^a   Müller Spahn, Franz ^a   Pragst, Fritz ^e   Johnson, Bankole ^f   Javors, Marty ^g   Ait Daoud, Nassima ^g,h   Skipper, Gregory E ⁱ   Spies, Claudia ^j   Nachbar, Yvonne ^j   Lesch, Otto ^k   Ramskogler, Katrin ^k   Hartmann, Susanne ^a   Wolfersdorf, Manfred ^l   Dresen, Sebastian ^m   Weinmann, Wolfgang ^m   Hines, Lisa ^b   Kaiser, Alan ^b   Lu, Ru Band ⁿ   Ko, Huei Chen ^h   Huang, San Yuan ^h   Wang, Tso Jen ^h   Wu, Yi Syuan ⁿ   Whitfield, John ^o,p   Snell, Larry D ^b,c   Wu, Christine ^b   Hoffman, Paula L ^b   more..

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY OF COLORADO   (United States)

^c Lohocla Research Corporation   (United States)

^d LUND UNIVERSITY   (Sweden)

^e HUMBOLDT UNIVERSITY   (Germany)

^f UNIVERSITY OF VIRGINIA   (United States)

^g UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^h Department of Psychiatry ^*

ⁱ UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^j CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^k MEDICAL UNIVERSITY OF VIENNA   (Austria)

^l KLINIKUM MÜNCHEN OST   (Germany)

^m UNIVERSITY OF FREIBURG   (Germany)

ⁿ NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^o NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^p ROYAL PRINCE ALFRED HOSPITAL   (Australia)

more..

Author keywords

Affective disorders; Alcoholism; Biomarkers; CDT; Direct ethanol metabolites; Genetics; GGT; Proteomics; Subtypes; WHO ISBRA study

Indexed keywords

ADENYLATE CYCLASE; ALCOHOL; ALCOHOL DEHYDROGENASE; BIOLOGICAL MARKER; CARBOHYDRATE DEFICIENT TRANSFERRIN; CATECHOL METHYLTRANSFERASE; ETHYL GLUCURONIDE; FATTY ACID ESTER; GAMMA GLUTAMYLTRANSFERASE; GLUCURONIDE; HYDROXYTYROSOL; PHOSPHATIDYLETHANOLAMINE; SULFATE; UNCLASSIFIED DRUG;

AC7 GENE; ADH1B GENE; ADH1C GENE; ALCOHOL METABOLISM; ALCOHOLISM; CONFERENCE PAPER; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; GENE; GENE IDENTIFICATION; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; GERMANY; HUMAN; MEDICAL RESEARCH; MEDICAL SOCIETY; MOOD DISORDER; PRIORITY JOURNAL; PROTEOMICS; SINGLE NUCLEOTIDE POLYMORPHISM; WORLD HEALTH ORGANIZATION;

ALCOHOLISM; BIOLOGICAL MARKERS; BIOMEDICAL RESEARCH; COMORBIDITY; FORECASTING; HUMANS; INTERNATIONAL AGENCIES; MOOD DISORDERS; RISK FACTORS; SENSITIVITY AND SPECIFICITY; SOCIETIES, MEDICAL; WORLD HEALTH ORGANIZATION;

EID: 23044517178     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ALC.0000171483.93724.96     Document Type: Conference Paper

References (50)

1. Allen JP, Litten RZ (2001) The role of laboratory testing in alcoholism treatment. J Subst Abuse Treat 20:81-85.
2. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265
3. Chen CC, Lu RB, Chen YC, Wang MF, Chang YC, Li TK, Yin SJ (1999) Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism. Am J Hum Genet 65:795-807.
4. Chen J, Conigrave KM, Macaskill P, Whitfield JB, Irwig L (2003) Combining carbohydrate-deficient transferrin and gamma-glutamyltransferase to increase diagnostic accuracy for problem drinking. Alcohol Alcohol 38:574-582.
5. Conigrave KM, Degenhardt LJ, Whitfield JB, Saunders JB, Helander A, Tabakoff B (2002) CDT, GOT, and AST as markers of alcohol use: the WHO/ISBRA Collaborative Project. Alcohol Clin Exp Res 26:332-339.
6. De Feo TM, Fargion S, Duca L, Mattioli M, Cappellini MD, Sampietro M, Cesana BM, Fiorelli G (1999) Carbohydrate-deficient transferrin, a sensitive marker of chronic alcohol abuse, is highly influenced by body iron. Hepatology 29:658-663.
7. Diczfalusy MA, von Wachenfeldt M, Holmberg I, Alexson SEH (2001) Possible role of long chain fatty acid ethyl esters in organ injury and as short-term markers of ethanol intake in humans. In Wurst FM, ed. New and Upcoming Markers of Alcohol Consumption. Darmstadt, Steinkopff-Springer Verlag, pp 17-34.
8. Dresen S, Weinmann W, Wurst FM (2004) forensic confirmatory analysis of ethyl sulfate-a new marker for alcohol consumption-by liquid chromatography/electrospray ionisation/tandem mass spectrometry. J Am Soc Mass Spectrom 15:1644-1648.
9. Fagerberg B, Agewall S, Berglund A, Wysocki M, Lundberg PA, Lindstedt G (1994a) Is carbohydrate-deficient transferrin in serum useful for detecting excessive alcohol consumption in hypertensive patients? Clin Chem 40:2057-2063.
10. Fagerberg B, Agewall S, Urbanavicius V, Attvall S, Lundberg PA, Lindstedt G (1994b) Carbohydrate-deficient transferrin is associated with insulin sensitivity in hypertensive men. J Clin Endocrinol Metab 79:712-715.
11. Figlie NB, Benedito-Silva AA, Monteiro MG, Souza-Formigoni ML; WHO/ISBRA Collaborative Study on State and Trait Markers of Alcohol Use and Dependence Investigators (2002) Biological markers of alcohol consumption in nondrinkers, drinkers, and alcohol-dependent Brazilian patients. Alcohol Clin Exp Res 26:1062-1069.
12. Fleming MF, Anton RF, Spies CD (2004) A review of genetic, biological, pharmacological, and clinical factors that affect carbohydrate-deficient transferrin levels. Alcohol Clin Exp Res 28:1347-1355.
13. Glanz J, Grant B, Moteiro M, Tabakoff B: WHO/ISBRA Collaborative Study on State and Trait Markers of Alcohol Use and Dependence Investigators (2002) Analysis of demographic, behavioral, physiologic, and drinking variables that contribute to dependence and seeking treatment. Alcohol Clin Exp Res 26:1047-1061.
14. Grant BF, Stinson FS, Dawson DA, Chou SP, Dufour MC, Compton W, Pickering RP, Kaplan K (2004) Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch Gen Psychiatry 61:807-816.
15. Helander A, Beck O (2004) Mass spectrometric identification of ethyl sulfate as an ethanol metabolite in humans. Clin Chem 5:936-937.
16. Helander A, Eriksson CJ; WHO/ISBRA Collaborative Study on State and Trait Markers of Alcohol Use and Dependence Investigators (2002) Laboratory tests for acute alcohol consumption. Alcohol Clin Exp Res 26:1070-1077.
17. Hellevuo K, Berry R, Sikela JM, Tabakoff B (1995) Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16. Hum Genet 95:197-200.
18. Hellevuo K, Welborn R, Menninger JA, Tabakoff B (1997) Human adenylyl cyclase type 7 contains polymorphic repeats in the 3′ untranslated region: investigations of association with alcoholism. Am J Med Genet 74:95-98.
19. Hellevuo K, Yoshimura M, Kao M, Hoffman PL, Cooper DM, Tabakoff B (1993) A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line. Biochem Biophys Res Commun 192:311-318.
20. Hoffman PL, Glanz J, Tabakoff B (2002) Platelet adenylyl cyclase activity as a state or trait marker in alcohol dependence: results of the WHO/ISBRA Study on State and Trait Markers of Alcohol Use and Dependence. Alcohol Clin Exp Res 26:1078-1087.
21. Huang SY, Lin WW, Ko HC, Lee JF, Wang TJ, Chou YH, Yin SJ, Lu RB (2004) Possible interaction of ADH and ALDH genes with dopamine D2 receptor (DRD2) gene in anxiety-depressive alcoholic dependence. Alcohol Clin Exp Res 28:374-384.
22. Keung WM, Vallee BL (1998) Daidzin and its antidipsotropic analog inhibit serotonin and dopamine metabolism in isolated mitochondria. Proc Natl Acad Sci U S A 95:2198-2203.
23. Kovac I, Merette C, Legault L, Dongier M, Palmour RM B; WHO/ISBRA Collaborative Study on State and Trait Markers of Alcohol Use and Dependence Investigators (2002) Evidence in an international sample of alcohol-dependent subjects of subgroups with specific symptom patterns of antisocial personality disorder. Alcohol Clin Exp Res 26:1088-1096.
24. Laposata M (1999) Assessment of ethanol intake: current tests and new assays on the horizon. Am J Clin Pathol 112:443-450.
25. Martinez LD, Baron AE, Helander A, Conigrave KM, Tabakoff B; WHO/ISBRA Collaborative Study on State and Trait Markers of Alcohol Use and Dependence Investigators (2002) The effect of total body water on the relationship between alcohol consumption and carbohydrate-deficient transferrin. Alcohol Clin Exp 26:1097-1104.
26. Menninger JA, Tabakoff B (1997) Forskolin-stimulated platelet adenylyl cyclase activity is lower in persons with major depression. Biol Psychiatry 42:30-38.
27. Nikkari ST, Koivu TA, Kalela A, Strid N, Sundvall J, Poikolainen K, Jousilahti P, Alho H, Sillanaukee P (2001) Association of carbohydrate-deficient transferrin (CDT) and gamma-glutamyl-transferase (GOT) with serum lipid profile in the Finnish population. Atherosclerosis 154:485-492.
28. Osier MV, Pakstis AJ, Kidd JR, Lee JF, Yin SJ, Ko HC, Edenberg HJ, Lu RB, Kidd KK (1999) Linkage disequilibrium at the ADH1B and ADH1C loci and risk of alcoholism. Arch Gen Psychiatry 55:593-602.
29. Peng GS, Wang MF, Chen CY, Luu SU, Chou HC, Li TK, Yin SJ (1999) Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians. Pharmacogenetics 9:463-476.
30. Rooke N, Li DJ, Li J, Keung WM (2000) The mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway: a potential site of action of daidzin. J Med Chem 43:4169-4179.
31. Saunders JB, Lee NK (2000) Hazardous alcohol use: its delineation as a subthreshold disorder, and approaches to its diagnosis and management. Compr Psychiatry 41:95-103.
32. Sillanaukee P, Olsson U (2001) Improved diagnostic classification of alcohol abusers by combining carbohydrate-deficient transferrin and gamma-glutamyltransferase. Clin Chem 47:681-685.
33. Snell LD, Glanz J, Tabakoff B; WHO/ISBRA Collaborative Study on State and Trait Markers of Alcohol Use and Dependence Investigators (2002) Relationships between effects of smoking, gender, and alcohol dependence on platelet momoamine oxidase-B: activity, affinity labeling, and protein measurements. Alcohol Clin Exp Res 26:1105-113.
34. Stauber RE, Vollmann H, Pesserl I, Jauk B, Lipp R, Halwachs G, Wilders-Truschnig M (1996) Carbohydrate-deficient transferrin in healthy women: relation to estrogens and iron status. Alcohol Clin Exp Res 20:1114-1117.
35. Stephens M, Donnelly P (2003) A comparison of Bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Gen 73:1162-1169.
36. Stephens M, Smith N, Donnelly P (2001) A new statistical method for haplotype reconstruction from population data. Am J Hum Gen 68:978-989.
37. Tabakoff B, Hoffman PL, Lee JM, Saito T, Willard B, De Leon-Jones F (1988) Differences in platelet enzyme activity between alcoholics and nonalcoholics. N Engl J Med 318:134-139.
38. Thomasson HR, Edenberg HJ, Crabb DW, Mai XL, Jerome RE, Li TK, Wang SP, Lin YT, Lu RB, Yin SJ (1991) Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet 48:677-681.
39. Varga A, Moller K, Hanson P, Aradottir S, Alling C (2001) Phosphatidylethanol; clinical significance and biochemical basis. In Wurst FM, ed. New and Upcoming Markers of Alcohol Consumption. Darmstadt, Steinkopff-Springer Verlag, pp 75-92.
40. Vestermark A, Boström H (1959) Studies on ester sulfates, V: on the enzymatic formation of ester sulfates of primary aliphatic alcohols. Exp Cell Res 18:174-177.
41. Weinmann W, Schaefer P, Thierauf A, Schreiber A, Wurst FM (2004) Confirmatory Analysis of Ethyl glucuronide in urine by liquid-chromatography/ electrospray-tandem-mass-spectrometry. J Am Soc Mass Spectrom 15:188-193.
42. Whitfield JB, Fletcher LM, Murphy TL, Powell LW, Halliday J, Heath AC, Martin PR (1998) Smoking, obesity, and hypertension alter the dose-response curve and test sensitivity of CDT as a marker of alcohol intake. Clin Chem 44:2480-2489.
43. Whitfield JB, Zhu G, Heath AC, Powell LW, Martin NG (2001) Effects of alcohol consumption on indices of iron stores and of iron stores on alcohol intake markers. Alcohol Clin Exp Res 25:1037-1045.
44. World Heath Organization (WHO). Global Status Report on Alcohol (WHO/HSC/SAB/49.11) (1999) Available at: http://www.who.int/substance_abuse/ pubs_alcohol.hem. Accessed September 10, 2001.
45. Wu CC, Yates JR (2003) The application of mass spectrometry to membrane proteomics. Nat Biotechnol 21:262-267.
46. Wurst FM, Metzger J; WHO/ISBRA Collaborative Study on State and Trait Markers of Alcohol Use and Dependence Investigators (2002) The ethanol conjugate ethyl glucuronide is a useful marker of recent alcohol consumption. Alcohol Clin Exp Res 26:1114-1119.
47. Wurst FM, Vogel R, Jachau K, Varga A, Alling C, Skipper GE, Alt A (2003a) Ethyl glucuronide detects recent alcohol use in forensic psychiatric inpatients. Alcohol Clin Exp Res 27:471-476.
48. Wurst FM, Skipper GE, Weinmann W (2003b) Ethyl glucuronide: the direct ethanol metabolite on the threshold from science to routine use. Addiction 98(Suppl 2):51-61.
49. Wurst FM, Alexson S, Wolfersdorf M, Bechtel G, Forster S, Alling C, Aradottir S, Jachau K, Huber P, Allen JP, Auwärter V, Pragst F (2004a) Concentration of fatty acid ethyl esters in hair of alcoholics: comparison to other biological state markers and self reported ethanol intake. Alcohol Alcohol 39:33-38.
50. Wurst FM, Wiesbeck GA, Metzger JW, Weinmann W, Graf M on behalf of the WHO/ISBRA study on biological state and trait markers of alcohol use and dependence (2004b) On sensitivity, specificity and the influence of various parameters on ethyl glucuronide levels in urine: results from the WHO/ISBRA Study. Alcohol Clin Exp Res 28:1220-1228.