Fluoride toxicity and status of serum thyroid hormones, brain histopathology, and learning memory in rats: A multigenerational assessment

Biological Trace Element Research

Volumn 144, Issue 1-3, 2011, Pages 1083-1094

  Basha, Piler Mahaboob ^a   Rai, Puja ^a   Begum, Shabana ^b  

^a BANGALORE UNIVERSITY   (India)

^b Maharani's Science College for Women   (India)

Author keywords

Fluoride; Multigenerational effects

Indexed keywords

ACETYLCHOLINESTERASE; FLUORIDE; LIOTHYRONINE; THYROID HORMONE; THYROXINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; BRAIN REGION; CELL VACUOLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; FLUOROSIS; GRANULAR CELL; HISTOPATHOLOGY; LEARNING; LIOTHYRONINE BLOOD LEVEL; MALE; MAZE TEST; MENTAL CAPACITY; NERVE CELL DEGENERATION; NONHUMAN; PURKINJE CELL; RAT; THYROXINE BLOOD LEVEL;

ACETYLCHOLINESTERASE; ANIMALS; BRAIN; FEMALE; FLUORIDE POISONING; FLUORIDES; LEARNING; MALE; MEMORY; MOTOR ACTIVITY; RATS; RATS, WISTAR; REPRODUCTION; THYROID HORMONES; WATER;

RATTUS;

EID: 84155167846     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-011-9137-3     Document Type: Article

References (51)

1. Varner JA, Jensen KF, Horvath W, Isaacson RL (1998) Chronic administration of aluminum-fluoride or sodium-fluoride to rats in drinking water: alterations in neuronal and cerebrovascular integrity. Brain Res 784:284-298 (Pubitemid 28137871)
2. Mullenix PJ, Denbesten PK, Schunior A, Kernan WJ (1995) Neurotoxicity of sodium fluoride in rats. Neurotoxicol Teratol 17:169-177
3. Shashi A (1992) Studies on alterations in brain lipid metabolism following experimental fluorosis. Fluoride 25:77-84
4. Shashi A, Singh JP, Thapar SP (1994) Effect of long-term administration of fluoride on levels of proteins, free amino acids and RNA in rabbit brain. Fluoride 27:155-159 (Pubitemid 24236572)
5. Vani ML, Reddy KP (2000) Effects of fluoride accumulation on some enzymes of brain and gastrocnemius muscle of mice. Fluoride 33:17-26 (Pubitemid 30390023)
6. He H, Chen ZS, Liu XM (1989) The influence of fluoride on human embryo. Chin J Ctrl Endem Dis 4:136-137
7. Xiang Q, Liang Y, Chen L, Wang C, Chen B, Chen X (2003) Effect of fluoride in drinking water on children's intelligence. Fluoride 36:84-94 (Pubitemid 36935062)
8. Nunez J, Couchie D, Aniello F, Bridoux AM (1991) Regulation by thyroid hormone of microtubule assembly and neuronal differentiation. Neurochem Res 16:975-982
9. Thompson CC, Potter GB (2000) Thyroid hormone action in neural development. Cereb Cortex 10:939-945
10. Anderson GW (2001) Thyroid hormones and the brain. Front Neuroendocrinol 22:1-17 (Pubitemid 32099715)
11. Bernal J (2002) Action of thyroid hormone in brain. J Endocrinol Invest 25:268-288 (Pubitemid 34295885)
12. Guan ZZ (1986) Morphology of the brain of the offspring of rats with chronic fluorosis. Zhonghua Bing Li Xue Za Zhi 15:297-299
13. Lu Y, Sun ZR, Wu LN, Wang X, Lu W, Liu SS (2000) Study of cognitive function impairment caused by fluorosis. Fluoride 33:74-78
14. Trivedi MH, Verma RJCN, Patel RS, Sathawara NG (2007) Effect of high fluoride water on children's intelligence in India. Fluoride 40:178-183 (Pubitemid 47612346)
15. Niu RY, Sun ZL,Wang JM, Cheng Z, Wang JD (2008) Effects of fluoride and lead on locomotor behavior and expression of Nissl body in brain of adult rats. Fluoride 41:276-282
16. Wu CX, Gu XL, Ge YM, Zhang JH, Wang JD (2006) Effects of high fluoride and arsenic on brain biochemical indexes and learning-memory in rats. Fluoride 39:274-279
17. Parveen M, Kumar S (2002) Acetylcholinesterase enzyme: a tool for monitoring environmental toxicity in mammals. In: Modern trends in environmental biology. CBS Publishers, New Delhi pp 307-323
18. Collins TF, Sprando RL, Black TN, Shackelford ME, Bryant MA, Olejnik N, Ames MJ, Rorie JI, Ruggles DI (2001) Multigenerational evaluation of sodium fluoride in rats. Food Chem Toxicol 39:601-613 (Pubitemid 32429474)
19. CollinsTF SRL, Black TN, Shackelford ME, Olejnik N, Ames MJ, Rorie JI, Ruggles DI (2001) Developmental toxicity of sodium fluoride measured during multiple generations. Food Chem Toxicol 39:867-876 (Pubitemid 32575253)
20. Cicek E, Aydin G, Akdogan M, Okutan H (2005) Effects of chronic ingestion of sodium fluoride on myocardium in a second generation of rats. Hum Exp Toxicol 24:79-87 (Pubitemid 40523966)
21. Aydin G, Cicek E, Akdogan M, Gokalp O (2003) Histopathological and biochemical changes in lung tissues of rats following administration of fluoride over several generations. J Appl Toxicol 23:437-446 (Pubitemid 37461719)
22. Karaoz E, Oncu M, Gulle K, Kanter M, Gultekin F, Karaoz S, Mumcu E (2004) Effect of chronic fluorosis on lipid peroxidation and histology of kidney tissues in first-and second-generation rats. Biol Trace Elem Res 102:199-208 (Pubitemid 40105018)
23. Meral O, Ahmet K, Erdal K, Hakan D, Emin S, Fatih G (2007) Effect of long-term fluoride exposure on lipid preoxidation and histology of testes in first and second generation rats. Biol Trace Elem Res 118:260-268
24. Thomas JA (1996) Endocrine methods. Academic, New York, pp 157-186
25. Ellman GL, Courtney KD, Andres VJR, Feather-Stone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88-95
26. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275
27. Inkielewicz I, Czarnowski W, Krechniak J (2003) Determination of fluoride in soft tissues. Fluoride 36:16-20 (Pubitemid 36858038)
28. Bures J, Buresova O, Huston JP (1983) Techniques and basic experiments for the study of brain and behaviour. Elsevier, Amsterdam
29. Madan J, Puri JP, Singh JK (2009) Growth, feed efficiency and blood profile of buffalo calves consuming high levels of fluoride. Trop Anim Heal Prod 41:295-298
30. Zhan XA, Li JX, Wang M, Xu ZR (2006) Effects of fluoride on growth and thyroid function in young pigs. Fluoride 39:95-100 (Pubitemid 44065932)
31. Trabelsi M, Guermazi F, Zeghal N (2001) Effect of fluoride on thyroid function and cerebellar development in mice. Fluoride 34:165-173 (Pubitemid 34086969)
32. Wu C, Gu X, Wu Y, Wang J (2008) Effects of fluoride and arsenic on serum thyroid hormone in rats. Journal of Herbal Medicine and Toxicology 2:39-43
33. Das K, Chainy GB (2004) Thyroid hormone influences antioxidant defense system in adult rat brain. Neurochem Res 29:1755-1766 (Pubitemid 39070067)
34. Basha PM, Rai P, Begum S (2011) Evaluation of fluoride-induced oxidative stress in rat brain: a multigeneration study. Biol Trace Elem Res doi:10.1007/s12011-010-8780-4
35. Gao Q, Liu YJ, Guan ZZ (2009) Decreased learning and memory ability in rats with fluorosis: increased oxidative stress and reduced cholinesterase activity in the brain. Fluoride 42:277-285
36. Pereira M, Dombrowski PA, Losso EM, Chioca LR, Cunha CD, Andreatini R (2011) Memory impairment induced by sodium fluoride is associated with changes in brain monoamine levels. Neurotox Res 19:55-62. doi:10.1007/s12640-009-9139-5
37. El Lethey HS, Kamel MM, Shaheed IB (2010) Neurobehavioral toxicity produced by sodium fluoride in drinking water of laboratory rats. Journal of American Science 6(5):54-63
38. Thiel C, Huston J, Schwarting R (1998) Hippocampal acetylcholine and habituation learning. Neuroscience 85:1253-1262 (Pubitemid 28293428)
39. Leussis M, Bolivar V (2006) Habituation in rodents: a review of behaviour, neurobiology and genetics. Neurosci Biobehav Rev 30:1045-1064 (Pubitemid 44308646)
40. Thiel C, Müller C, Huston J, Schwarting R (1999) High versus low reactivity to a novel environment: behavioural pharmacology and neurochemical assessments. Neurosci 93:243-251 (Pubitemid 29290704)
41. Long Y, Wang Y, Chen J, Jiang S, Nordberg A, Guan Z (2002) Decreased number of nicotinic acetylcholine receptors in the brain of rats with chronic fluorosis. Neurotoxicol Teratol 24:751-757 (Pubitemid 35375779)
42. Wang JD, Ge YM, Ning HM, Wang SL (2004) Effects of high fluoride and low iodine on biochemical indexes of the brain and learning-memory of offspring rats. Fluoride 37:201-208
43. Bhatnagar M, Rao P, Saxena A, Bhatnagar R, Meena P, Barbar S, Chouhan A, Vimal S (2006) Biochemical changes in brain and other tissues of young adult female mice from fluoride in their drinking water. Fluoride 39:280-284 (Pubitemid 46182099)
44. Zhai JX, Guo ZY, Hu CL, Wang QN, Zhu QX (2003) Studies on fluoride concentration and cholinesterase activity in rat hippocampus. Chin J Ind Hyg Occup Dis 21:102-104
45. Wen XP, Sang ZP, Chen YX (1998) The effect of fluoride on ChE and acetylcholine. Chin J Endemiol 17:56-57
46. Chinoy NJ, Memon MR (2001) Beneficial effects of some vitamins and calcium on fluoride and aluminium toxicity on gastrocnemius muscle and liver of male mice. Fluoride 34:21-33 (Pubitemid 32525270)
47. Blaylock RL (2004) Excitotoxicity: a possible central mechanism in fluoride neurotoxicity. Fluoride 37:301-314 (Pubitemid 40110618)
48. Blaylock RL (2007) Fluoride neurotoxicity and excitotoxicity/microglial activation: critical need for more research. Fluoride 40:89-92 (Pubitemid 47218614)
49. Goodlett CR, Hamre KM, West JR (1992) Dissociation of spatial navigation and visual guidance performance in Purkinje cell degeneration (pcd) mutant mice. Behav Brain Res 47:129-141
50. Klein JA, Ackerman SL (2003) Oxidative stress, cell cycle, and neurodegeneration. J Clin Invest 111:785-793 (Pubitemid 37074950)
51. Shivarajashankara YM, Shivashankara AR, Bhat PG, Rao SM, Rao SH (2002) Histological changes in the brain of young fluoride-intoxicated rats. Fluoride 35:12-21 (Pubitemid 34664155)