메뉴 건너뛰기




Volumn 87, Issue 1, 2012, Pages 45-50

Tailored temozolomide therapy according to MGMT methylation status for elderly patients with acute myeloid leukemia

Author keywords

[No Author keywords available]

Indexed keywords

METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; TEMOZOLOMIDE;

EID: 84155163830     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.22191     Document Type: Article
Times cited : (12)

References (40)
  • 3
    • 84155164626 scopus 로고    scopus 로고
    • SEER Cancer Statistics Review, 1975-2004, National Cancer Institute. Bethesda, MD. Available at:, based on November 2006 SEER data submission, posted to the SEER web site, Accessed September 14, 2010.
    • Ries LG, Melbert D, Krapcho M. SEER Cancer Statistics Review, 1975-2004, National Cancer Institute. Bethesda, MD. Available at:, based on November 2006 SEER data submission, posted to the SEER web site, 2007. Accessed September 14, 2010.
    • (2007)
    • Ries, L.G.1    Melbert, D.2    Krapcho, M.3
  • 4
    • 0037158110 scopus 로고    scopus 로고
    • The outcomes and costs of acute myeloid leukemia among the elderly
    • Menzin J, Lang K, Earle et al. The outcomes and costs of acute myeloid leukemia among the elderly. Arch Int Med 2002; 162: 1597-1603.
    • (2002) Arch Int Med , vol.162 , pp. 1597-1603
    • Menzin, J.1    Lang, K.2    Earle3
  • 5
    • 0036332588 scopus 로고    scopus 로고
    • The treatment of acute myeloid leukemia in first relapse: a comprehensive review of the literature
    • Leopold LH, Willemze R. The treatment of acute myeloid leukemia in first relapse: a comprehensive review of the literature. Leuk Lymphoma 2002; 43: 1715-27.
    • (2002) Leuk Lymphoma , vol.43 , pp. 1715-1727
    • Leopold, L.H.1    Willemze, R.2
  • 6
    • 0028817014 scopus 로고
    • Triazene compounds induce apoptosis in O6-alkylguanine-DNA alkyltransferase deficient leukemia cell lines
    • Tentori L, Graziani G, Gilberti S, et al. Triazene compounds induce apoptosis in O6-alkylguanine-DNA alkyltransferase deficient leukemia cell lines. Leukemia 1995; 9: 1888-1895.
    • (1995) Leukemia , vol.9 , pp. 1888-1895
    • Tentori, L.1    Graziani, G.2    Gilberti, S.3
  • 7
    • 0032890957 scopus 로고    scopus 로고
    • Evaluation of temozolomide in a SCID mouse model of human B-cell precursor leukemia
    • Messinger Y, Reaman GH, Ek O, et al. Evaluation of temozolomide in a SCID mouse model of human B-cell precursor leukemia. Leuk Lymphoma 1999; 33: 289-293.
    • (1999) Leuk Lymphoma , vol.33 , pp. 289-293
    • Messinger, Y.1    Reaman, G.H.2    Ek, O.3
  • 8
    • 0036682038 scopus 로고    scopus 로고
    • Phase I study of temozolomide in relapsed/refractory acute leukemia
    • Seiter K, Liu D, Loughran T, et al. Phase I study of temozolomide in relapsed/refractory acute leukemia. J Clin Oncol 2002; 20: 3249-3253.
    • (2002) J Clin Oncol , vol.20 , pp. 3249-3253
    • Seiter, K.1    Liu, D.2    Loughran, T.3
  • 9
    • 36848999377 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of temozolomide in pediatric patients with refractory or recurrent leukemia: a Children's Oncology Group Study
    • Horton TM, Thompson PA, Berg SL, et al. Phase I pharmacokinetic and pharmacodynamic study of temozolomide in pediatric patients with refractory or recurrent leukemia: a Children's Oncology Group Study. J Clin Oncol 2007; 25: 4922-4928.
    • (2007) J Clin Oncol , vol.25 , pp. 4922-4928
    • Horton, T.M.1    Thompson, P.A.2    Berg, S.L.3
  • 10
    • 33947417078 scopus 로고    scopus 로고
    • A phase II study of temozolomide therapy for poor-risk patients aged >or=60 years with acute myeloid leukemia: low levels of MGMT predict for response
    • Brandwein JM, Yang L, Schimmer AD, et al. A phase II study of temozolomide therapy for poor-risk patients aged >or=60 years with acute myeloid leukemia: low levels of MGMT predict for response. Leukemia 2007; 21: 821-824.
    • (2007) Leukemia , vol.21 , pp. 821-824
    • Brandwein, J.M.1    Yang, L.2    Schimmer, A.D.3
  • 11
    • 0027336891 scopus 로고
    • Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells
    • Baer JC, Freeman AA, Newlands ES, et al. Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells. Br J Cancer 1993; 67: 1299-1302.
    • (1993) Br J Cancer , vol.67 , pp. 1299-1302
    • Baer, J.C.1    Freeman, A.A.2    Newlands, E.S.3
  • 12
    • 0034626988 scopus 로고    scopus 로고
    • Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
    • Esteller M, Garcia-Foncillas J, Andion E, et al. Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med 2000; 343: 1350-1354.
    • (2000) N Engl J Med , vol.343 , pp. 1350-1354
    • Esteller, M.1    Garcia-Foncillas, J.2    Andion, E.3
  • 13
    • 0026616913 scopus 로고
    • Influence of O6-methylguanine on DNA damage and cytotoxicity of temozolomide in L1210 mouse leukemia sensitive and resistant to chloroethylnitrosoureas
    • Taverna P, Catapano CV, Citti L, et al. Influence of O6-methylguanine on DNA damage and cytotoxicity of temozolomide in L1210 mouse leukemia sensitive and resistant to chloroethylnitrosoureas. Anticancer Drugs 1992; 3: 401-405.
    • (1992) Anticancer Drugs , vol.3 , pp. 401-405
    • Taverna, P.1    Catapano, C.V.2    Citti, L.3
  • 14
    • 0028227862 scopus 로고
    • Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells
    • Costello JF, Futscher BW, Tano K, et al. Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells. J Biol Chem 1994; 269: 17228-17237.
    • (1994) J Biol Chem , vol.269 , pp. 17228-17237
    • Costello, J.F.1    Futscher, B.W.2    Tano, K.3
  • 15
    • 4844221344 scopus 로고    scopus 로고
    • Promoter methylation and expression of DNA repair genes hMLH1 and MGMT in acute myeloid leukemia
    • Lenz G, Hutter G, Hiddemann W, et al. Promoter methylation and expression of DNA repair genes hMLH1 and MGMT in acute myeloid leukemia. Ann Hematol 2004; 83: 628-633.
    • (2004) Ann Hematol , vol.83 , pp. 628-633
    • Lenz, G.1    Hutter, G.2    Hiddemann, W.3
  • 16
    • 0035870248 scopus 로고    scopus 로고
    • A gene hypermethylation profile of human cancer
    • Esteller M, Corn PG, Baylin SB, et al. A gene hypermethylation profile of human cancer. Cancer Res. 2001; 61: 3225-3229.
    • (2001) Cancer Res. , vol.61 , pp. 3225-3229
    • Esteller, M.1    Corn, P.G.2    Baylin, S.B.3
  • 17
    • 0025196019 scopus 로고
    • Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents
    • Dolan ME, Moschel RC, Pegg AE. Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. Proc Natl Acad Sci USA 1990; 87: 5368-5372.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 5368-5372
    • Dolan, M.E.1    Moschel, R.C.2    Pegg, A.E.3
  • 18
    • 0029017802 scopus 로고
    • Cisplatin increases sensitivity of human leukemic blasts to triazene compounds
    • Piccioni D, D'Atri S, Papa G, et al. Cisplatin increases sensitivity of human leukemic blasts to triazene compounds. J Chemother. 1995; 7: 224-229.
    • (1995) J Chemother. , vol.7 , pp. 224-229
    • Piccioni, D.1    D'Atri, S.2    Papa, G.3
  • 19
    • 62449096923 scopus 로고    scopus 로고
    • Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma
    • Quinn JA, Jiang SX, Reardon DA, et al. Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma. J Clin Oncol. 2009; 27: 1262-1267.
    • (2009) J Clin Oncol. , vol.27 , pp. 1262-1267
    • Quinn, J.A.1    Jiang, S.X.2    Reardon, D.A.3
  • 20
    • 0037692954 scopus 로고    scopus 로고
    • Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules
    • Tolcher AW, Gerson SL, Denis L, et al. Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules. Br J Cancer 2003; 88: 1004-1011.
    • (2003) Br J Cancer , vol.88 , pp. 1004-1011
    • Tolcher, A.W.1    Gerson, S.L.2    Denis, L.3
  • 21
    • 1542753559 scopus 로고    scopus 로고
    • Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia
    • Cheson BD, Bennett JM, Kopecky KJ, et al. Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia. J Clin Oncol 2003; 21: 4642-4649.
    • (2003) J Clin Oncol , vol.21 , pp. 4642-4649
    • Cheson, B.D.1    Bennett, J.M.2    Kopecky, K.J.3
  • 22
    • 0034672269 scopus 로고    scopus 로고
    • Karyotypic analysis predicts outcome of pre-remission and postremission therapy in adult acute myeloid leukemia (AML): a Southwest Oncology Group/Eastern Cooperative Oncology Group study
    • Slovak ML, Kopecky KJ, Cassileth PA, et al. Karyotypic analysis predicts outcome of pre-remission and postremission therapy in adult acute myeloid leukemia (AML): a Southwest Oncology Group/Eastern Cooperative Oncology Group study. Blood 2000; 96: 4075-4083.
    • (2000) Blood , vol.96 , pp. 4075-4083
    • Slovak, M.L.1    Kopecky, K.J.2    Cassileth, P.A.3
  • 23
    • 77449159028 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet
    • Döhner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 2010; 115: 453-474.
    • (2010) Blood , vol.115 , pp. 453-474
    • Döhner, H.1    Estey, E.H.2    Amadori, S.3
  • 24
    • 0024536437 scopus 로고
    • Optimal two-stage designs for phase II clinical trials
    • Simon R. Optimal two-stage designs for phase II clinical trials. Control Clin Trials 1989; 10: 1-10.
    • (1989) Control Clin Trials , vol.10 , pp. 1-10
    • Simon, R.1
  • 25
    • 33846433493 scopus 로고    scopus 로고
    • The haematopoietic cell transplantation comorbidity index score is predictive of early death and survival in patients over 60 years of age receiving induction therapy for acute myeloid leukaemia
    • Giles FJ, Borthakur G, Ravandi F, et al. The haematopoietic cell transplantation comorbidity index score is predictive of early death and survival in patients over 60 years of age receiving induction therapy for acute myeloid leukaemia. Br J Haemat 2007; 136: 624-627.
    • (2007) Br J Haemat , vol.136 , pp. 624-627
    • Giles, F.J.1    Borthakur, G.2    Ravandi, F.3
  • 26
    • 79951495012 scopus 로고    scopus 로고
    • Phase 2 study of high-dose lenalidomide as initial therapy for older patients with acute myeloid leukemia
    • Fehniger TA, Uy GL, Trinkaus K, et al. Phase 2 study of high-dose lenalidomide as initial therapy for older patients with acute myeloid leukemia. Blood 2011; 117: 1828-1833.
    • (2011) Blood , vol.117 , pp. 1828-1833
    • Fehniger, T.A.1    Uy, G.L.2    Trinkaus, K.3
  • 27
    • 33644985390 scopus 로고    scopus 로고
    • Attitude towards remission induction for elderly patients with acute myeloid leukemia influences survival
    • Juliusson G, Billstrom R, Gruber A, et al. Attitude towards remission induction for elderly patients with acute myeloid leukemia influences survival. Leukemia 2006; 20: 42-47.
    • (2006) Leukemia , vol.20 , pp. 42-47
    • Juliusson, G.1    Billstrom, R.2    Gruber, A.3
  • 28
    • 0028986307 scopus 로고
    • 6-alkylguanine DNA alkyltransferase levels: studies with blasts of leukemia patients
    • 6-alkylguanine DNA alkyltransferase levels: studies with blasts of leukemia patients. Ann Oncol 1995; 6: 389-393.
    • (1995) Ann Oncol , vol.6 , pp. 389-393
    • D'Atri, S.1    Piccioni, D.2    Castellano, A.3
  • 29
    • 33947205565 scopus 로고    scopus 로고
    • A comparison of low-dose cytarabine and hydrxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fir for intensive therapy
    • Burnett AK, Milligan D, Prentice AG, et al. A comparison of low-dose cytarabine and hydrxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fir for intensive therapy. Cancer 2007; 109: 1114-1124.
    • (2007) Cancer , vol.109 , pp. 1114-1124
    • Burnett, A.K.1    Milligan, D.2    Prentice, A.G.3
  • 30
    • 77449149374 scopus 로고    scopus 로고
    • Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia
    • Cashen AF, Schiller GJ, O'Donnell MR, et al. Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia. J Clin Oncol 2010; 28: 556-561.
    • (2010) J Clin Oncol , vol.28 , pp. 556-561
    • Cashen, A.F.1    Schiller, G.J.2    O'Donnell, M.R.3
  • 31
    • 61549137657 scopus 로고    scopus 로고
    • Continued low-dose decitabine (DAC) is an active first-line treatment in all cytogenetic groups of older AML patients. Results of the FR00331 multicenter phase II study
    • Lubbert M, Ruter B, Claus R, et al. Continued low-dose decitabine (DAC) is an active first-line treatment in all cytogenetic groups of older AML patients. Results of the FR00331 multicenter phase II study. Blood 2007; 110: 300.
    • (2007) Blood , vol.110 , pp. 300
    • Lubbert, M.1    Ruter, B.2    Claus, R.3
  • 32
    • 77449149373 scopus 로고    scopus 로고
    • Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia
    • Fenaux P, Mufti GJ, Hellström-Lindberg E, et al. Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia. J Clin Oncol 2010; 28: 562-569.
    • (2010) J Clin Oncol , vol.28 , pp. 562-569
    • Fenaux, P.1    Mufti, G.J.2    Hellström-Lindberg, E.3
  • 33
    • 77449159668 scopus 로고    scopus 로고
    • Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavorable prognostic factors
    • Kantarjian H, Erba HP, Claxton D, et al. Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavorable prognostic factors. J Clin Oncol 2010; 28: 549-555.
    • (2010) J Clin Oncol , vol.28 , pp. 549-555
    • Kantarjian, H.1    Erba, H.P.2    Claxton, D.3
  • 34
    • 77952491723 scopus 로고    scopus 로고
    • European development of Clofarabine as treatment for older patients with acute myeloid leukemia considered unsuitable for intensive chemotherapy
    • Burnett AK, Russell NH, Kell J, et al. European development of Clofarabine as treatment for older patients with acute myeloid leukemia considered unsuitable for intensive chemotherapy. J Clin Oncol 2010; 28: 2389-2395.
    • (2010) J Clin Oncol , vol.28 , pp. 2389-2395
    • Burnett, A.K.1    Russell, N.H.2    Kell, J.3
  • 35
    • 69849092737 scopus 로고    scopus 로고
    • A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older
    • Harousseau JL, Martinelli G, Jedrzejczak WW, et al. A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older. Blood. 2009; 114: 1166-1173.
    • (2009) Blood. , vol.114 , pp. 1166-1173
    • Harousseau, J.L.1    Martinelli, G.2    Jedrzejczak, W.W.3
  • 36
    • 33847001315 scopus 로고    scopus 로고
    • A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia
    • Lancet JE, Gojo I, Gotlib J, et al. A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia. Bloods 2007; 109: 1387-1394.
    • (2007) Bloods , vol.109 , pp. 1387-1394
    • Lancet, J.E.1    Gojo, I.2    Gotlib, J.3
  • 37
    • 78650171819 scopus 로고    scopus 로고
    • Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: A web-based application for prediction of outcomes
    • Krug U, Röllig C, Koschmieder A, et al. Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: A web-based application for prediction of outcomes. Lancet 2010; 376: 2000-2008.
    • (2010) Lancet , vol.376 , pp. 2000-2008
    • Krug, U.1    Röllig, C.2    Koschmieder, A.3
  • 38
    • 0030862884 scopus 로고    scopus 로고
    • Activity of temozolomide against human colony-forming units
    • Raymond E, Izbicka E, Soda H, et al. Activity of temozolomide against human colony-forming units. Clin Can Res 1997; 3: 1769-1774.
    • (1997) Clin Can Res , vol.3 , pp. 1769-1774
    • Raymond, E.1    Izbicka, E.2    Soda, H.3
  • 39
    • 62849111092 scopus 로고    scopus 로고
    • Homogeneous MGMT immunoreactivity correlates with an unmethylated MGMT promoter status in brain metastases of various solid tumors
    • Ingold B, Schraml P, Heppner FL, et al. Homogeneous MGMT immunoreactivity correlates with an unmethylated MGMT promoter status in brain metastases of various solid tumors. PLoS ONE. 2009; 4: e4775.
    • (2009) PLoS ONE. , vol.4
    • Ingold, B.1    Schraml, P.2    Heppner, F.L.3
  • 40
    • 84155167622 scopus 로고    scopus 로고
    • Identification of AML and MDS patients who could potentially benefit from temozolomide therapy: proportion of patients with low methyl guanine methyltransferase (MGMT) expression level
    • Brandwein J, Kassis J, Leber B, et al. Identification of AML and MDS patients who could potentially benefit from temozolomide therapy: proportion of patients with low methyl guanine methyltransferase (MGMT) expression level. Blood (ASH Annual Meeting Abstracts) 2010; 116: 3985.
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , pp. 3985
    • Brandwein, J.1    Kassis, J.2    Leber, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.