Analysis of R- and S-hydroxywarfarin glucuronidation catalyzed by human liver microsomes and recombinant udp-glucuronosyltransferases

Journal of Pharmacology and Experimental Therapeutics

Volumn 340, Issue 1, 2012, Pages 46-55

  Bratton, Stacie M ^a   Mosher, Carrie M ^e   Khallouki, Farid ^a,c   Finel, Moshe ^d   Court, Michael H ^e   Moran, Jeffery H ^a,b   Radominska Pandya, Anna ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b Arkansas Public Health Laboratory   (United States)

^c MOULAY ISMAIL UNIVERSITY   (Morocco)

^d UNIVERSITY OF HELSINKI   (Finland)

^e TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 HYDROXYWARFARIN; 7 HYDROXYWARFARIN; 8 HYDROXYWARFARIN; DRUG METABOLITE; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A10; ISOENZYME; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; WARFARIN;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG GLUCURONIDATION; DRUG STRUCTURE; ENANTIOMER; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIVER MICROSOME; MASS SPECTROMETRY; PRIORITY JOURNAL; ULTRAVIOLET SPECTROSCOPY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; KINETICS; MICROSOMES, LIVER; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM; TANDEM MASS SPECTROMETRY; TISSUE BANKS; WARFARIN;

EID: 84055223405     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.184721     Document Type: Article

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