Impact of persistent antiphospholipid antibodies on risk of incident symptomatic thromboembolism in children: A systematic review and meta-analysis

Seminars in Thrombosis and Hemostasis

Volumn 37, Issue 7, 2011, Pages 802-809

  Kenet, Gili ^a   Aronis, Sofia ^b   Berkun, Yackov ^a   Bonduel, Mariana ^c   Chan, Anthony ^d   Goldenberg, Neil A ^e   Holzhauer, Susanne ^f   Iorio, Alfonso ^g   Journeycake, Janna ^h   Junker, Ralf ⁱ   Male, Christoph ^j   Manco Johnson, Marilyn ^d   Massicotte, Patti ^k   Mesters, Rolf ^l   Monagle, Paul ^m   Van Ommen, Heleen ⁿ   Rafini, Leslie ^o   Simioni, Paolo ^p   Young, Guy ^q   Nowak Göttl, Ulrike ⁱ  

^a SHEBA MEDICAL CENTER   (Israel)

^b AGHIA SOPHIA CHILDREN S HOSPITAL   (Greece)

^c Hospital de Pediatra JPGarrahan   (Argentina)

^d MCMASTER UNIVERSITY   (Canada)

^e UNIVERSITY OF COLORADO   (United States)

^f CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^g MCMASTER UNIVERSITY   (Canada)

^h UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

ⁱ UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^j MEDICAL UNIVERSITY OF VIENNA   (Austria)

^k Department of Pediatrics   (Canada)

^l UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^m ROYAL CHILDREN'S HOSPITAL   (Australia)

ⁿ EMMA CHILDREN S HOSPITAL   (Netherlands)

^o UNIVERSITY OF PENNSYLVANIA   (United States)

^p UNIVERSITY OF PADOVA   (Italy)

^q CHILDREN S HOSPITAL LOS ANGELES   (United States)

more..

Author keywords

Antiphospholipid antibodies; children; meta analysis; recurrence; thromboembolism

Indexed keywords

ANTICOAGULANT AGENT; PHOSPHOLIPID ANTIBODY;

ANTICOAGULATION; ARTERIAL THROMBOEMBOLISM; ARTICLE; CARDIOVASCULAR RISK; COCHRANE LIBRARY; EMBASE; ETHNICITY; HUMAN; MEDLINE; META ANALYSIS; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PUBLICATION; SCREENING; SYSTEMATIC REVIEW; THROMBOEMBOLISM; THROMBOPHILIA; THROMBOSIS; VEIN THROMBOSIS; VENOUS THROMBOEMBOLISM;

ADOLESCENT; ANTIBODIES, ANTIPHOSPHOLIPID; ANTIPHOSPHOLIPID SYNDROME; CHILD; CHILD, PRESCHOOL; HUMANS; INFANT; INFANT, NEWBORN; RISK; THROMBOEMBOLISM;

EID: 84055176572     PISSN: 00946176     EISSN: 10989064     Source Type: Journal    
DOI: 10.1055/s-0031-1297171     Document Type: Article

References (38)

1. Miyakis S, Lockshin M D., Atsumi T et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006 4 2 295-306
2. Levine J S., Branch D W., Rauch J. The antiphospholipid syndrome. N Engl J Med 2002 346 10 752-763 (Pubitemid 34983997)
3. Levy D M., Massicotte M P., Harvey E, Hebert D, Silverman E D. Thromboembolism in paediatric lupus patients. Lupus 2003 12 10 741-746 (Pubitemid 37295808)
4. Campos L M., Kiss M H., D'Amico E A., Silva C A. Antiphospholipid antibodies and antiphospholipid syndrome in 57 children and adolescents with systemic lupus erythematosus. Lupus 2003 12 11 820-826 (Pubitemid 37463098)
5. Cervera R, Piette J C., Font J et al, Euro-Phospholipid Project Group. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis Rheum 2002 46 4 1019-1027 (Pubitemid 34303815)
6. Avcin T, Cimaz R, Rozman B, Ped-APS Registry Collaborative Group. The Ped-APS Registry: the antiphospholipid syndrome in childhood. Lupus 2009 18 10 894-899
7. Berkun Y, Padeh S, Barash J et al. Antiphospholipid syndrome and recurrent thrombosis in children. Arthritis Rheum 2006 55 6 850-855 (Pubitemid 44917456)
8. Kenet G, Lütkhoff L K., Albisetti M et al. Impact of inherited thrombophilia on arterial ischemic stroke and cerebral sinovenous thrombosis in children: a systematic review and meta-analysis of observational studies. Circulation 2010 121 1838-1847
9. Male C, Mitchell L, Julian J et al. Acquired activated protein C resistance is associated with lupus anticoagulants and thrombotic events in pediatric patients with systemic lupus erythematosus. Blood 2001 97 4 844-849 (Pubitemid 32154263)
10. Levy D M., Massicotte M P., Harvey E, Hebert D, Silverman E D. Thromboembolism in paediatric lupus patients. Lupus 2003 12 10 741-746 (Pubitemid 37295808)
11. Bonduel M, Sciuccati G, Hepner M et al. Factor V Leiden and prothrombin gene G20210A mutation in children with cerebral thromboembolism. Am J Hematol 2003 73 2 81-86 (Pubitemid 36578428)
12. Günes A M., Baytan B, Günay U. The influence of risk factors in promoting thrombosis during childhood: the role of acquired factors. Pediatr Hematol Oncol 2006 23 5 399-410 (Pubitemid 44174046)
13. Nowak-Göttl U, Junker R, Hartmeier M et al. Increased lipoprotein(a) is an important risk factor for venous thromboembolism in childhood. Circulation 1999a 100 7 743-748 (Pubitemid 29383645)
14. Sträter R, Vielhaber H, Kassenböhmer R, von Kries R, Göbel U, Nowak-Göttl U. Genetic risk factors of thrombophilia in ischaemic childhood stroke of cardiac origin. A prospective ESPED survey. Eur J Pediatr 1999 158 Suppl 3 S122-S125 (Pubitemid 30014017)
15. Heller C, Schobess R, Kurnik K et al, For the Childhood Thrombophilia Study Group. Abdominal venous thrombosis in neonates and infants: role of prothrombotic risk factors - a multicentre case-control study. Br J Haematol 2000 111 2 534-539
16. Günther G, Junker R, Sträter R et al, Childhood Stroke Study Group. Symptomatic ischemic stroke in full-term neonates: role of acquired and genetic prothrombotic risk factors. Stroke 2000 31 10 2437-2441
17. Kenet G, Sadetzki S, Murad H et al. Factor V Leiden and antiphospholipid antibodies are significant risk factors for ischemic stroke in children. Stroke 2000 31 6 1283-1288 (Pubitemid 30351246)
18. Heller C, Heinecke A, Junker R et al, Childhood Stroke Study Group. Cerebral venous thrombosis in children: a multifactorial origin. Circulation 2003 108 11 1362-1367 (Pubitemid 37174415)
19. Kurnik K, Kosch A, Sträter R, Schobess R, Heller C, Nowak-Göttl U, Childhood Stroke Study Group. Recurrent thromboembolism in infants and children suffering from symptomatic neonatal arterial stroke: a prospective follow-up study. Stroke 2003 34 12 2887-2892 (Pubitemid 37517762)
20. Gürgey A, Balta G, Gumruk F, Altay C. Analysis of some clinical and laboratory aspects of adolescent patients with thrombosis. Blood Coagul Fibrinolysis 2004 15 8 657-662 (Pubitemid 39612971)
21. Kenet G, Waldman D, Lubetsky A et al. Paediatric cerebral sinus vein thrombosis. A multi-center, case-controlled study. Thromb Haemost 2004 92 4 713-718 (Pubitemid 39386695)
22. Kosch A, Kuwertz-Bröking E, Heller C, Kurnik K, Schobess R, Nowak-Göttl U. Renal venous thrombosis in neonates: prothrombotic risk factors and long-term follow-up. Blood 2004 104 5 1356-1360 (Pubitemid 39166511)
23. Duran R, Biner B, Demir M, Celtik C, Karasaliholu S. Factor V Leiden mutation and other thrombophilia markers in childhood ischemic stroke. Clin Appl Thromb Hemost 2005 11 1 83-88 (Pubitemid 40194202)
24. Ünal S, Varan A, Yalçin B, Büyükpamukçu M, Gürgey A. Evaluation of thrombotic children with malignancy. Ann Hematol 2005 84 6 395-399 (Pubitemid 40823354)
25. Bonduel M, Sciuccati G, Hepner M et al. Arterial ischemic stroke and cerebral venous thrombosis in children: a 12-year Argentinean registry. Acta Haematol 2006 115 3-4 180-185
26. Nowak-Göttl U, Langer C, Bergs S, Thedieck S, Sträter R, Stoll M. Genetics of hemostasis: differential effects of heritability and household components influencing lipid concentrations and clotting factor levels in 282 pediatric stroke families. Environ Health Perspect 2008 116 6 839-843 (Pubitemid 351943943)
27. Simchen M J., Goldstein G, Lubetsky A, Strauss T, Schiff E, Kenet G. Factor v Leiden and antiphospholipid antibodies in either mothers or infants increase the risk for perinatal arterial ischemic stroke. Stroke 2009 40 1 65-70
28. Avcin T, Ambrozic A, Kuhar M, Kveder T, Rozman B. Anticardiolipin and 2 glycoprotein I antibodies in sera of 61 apparently healthy children at regular preventive visits. Rheumatology 2001 40 555-573
29. Berkun Y, Kenet G. Pediatric antiphospholipid syndrome. Isr Med Assoc J 2008 10 1 45-47 (Pubitemid 351649464)
30. Vandenbroucke J P., von Elm E, Altman D G. et al, STROBE initiative. Strengthening the reporting of observational studies in epidemiology (STROBE): explanation and elaboration. Ann Intern Med 2007 147 8 W163-94 (Pubitemid 351664503)
31. Mayer D. Essential Evidence-Based Medicine. UK, Cambridge University Press 2004 347-360
32. Kirkwood B R., Sterne JAC. Medical Statistics. 2nd ed. Oxford, Blackwell Science 2003 180-387
33. Higgins JPT, Thompson S G., Deeks J J., Altman D G. Measuring inconsistency in meta-analyses. BMJ 2003 327 7414 557-560 (Pubitemid 37088507)
34. Harbord R M., Egger M, Sterne JAC. A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints. Stat Med 2006 25 20 3443-3457 (Pubitemid 44575162)
35. Avin T, Cimaz R, Silverman E D. et al. Pediatric antiphospholipid syndrome: clinical and immunologic features of 121 patients in an international registry. Pediatrics 2008 122 5 e1100-e1107
36. Avcin T, Cimaz R, Meroni PL. Recent advances in antiphospholipid antibodies and antiphospholipid syndromes in pediatric populations. Lupus 2002 11 1 4-10 (Pubitemid 34178113)
37. Boffa MCAM, Aurousseau M H., Lachassinne E et al. European register of babies born to mothers with antiphospholipid syndrome. Lupus 2004 13 9 713-717 (Pubitemid 39279790)
38. Boffa M C., Lachassinne E. Infant perinatal thrombosis and antiphospholipid antibodies: a review. Lupus 2007 16 8 634-641 (Pubitemid 47360000)