Factor V Leiden mutation and other thrombophilia markers in childhood ischemic stroke

Clinical and Applied Thrombosis/Hemostasis

Volumn 11, Issue 1, 2005, Pages 83-88

  Duran, Ridvan ^a   Biner, Betül ^a   Demir, Muzaffer ^a   Çeltik, Coşkun ^a   Karasalihoǧlu, Serap ^a  

^a TRAKYA UNIVERSITY   (Turkey)

Author keywords

Child; Factor V Leiden; Ischemic stroke; Thrombophilia

Indexed keywords

ACTIVATED PROTEIN C; ANTITHROMBIN; BLOOD CLOTTING FACTOR 5 LEIDEN; BLOOD CLOTTING FACTOR 8; CARDIOLIPIN ANTIBODY; DNA; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; PROTEIN C; PROTEIN S;

ADOLESCENT; ARTICLE; BLOOD CLOTTING TEST; BLOOD SAMPLING; BRAIN ISCHEMIA; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA POLYMORPHISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FAMILY HISTORY; FEMALE; GENE MUTATION; HUMAN; INFANT; MALE; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; STROKE; THROMBOPHILIA;

ADOLESCENT; BIOLOGICAL MARKERS; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CHILD; CHILD, PRESCHOOL; FACTOR V; FEMALE; HUMANS; INFANT; MALE; MUTATION; RETROSPECTIVE STUDIES; THROMBOPHILIA;

EID: 13244260855     PISSN: 10760296     EISSN: None     Source Type: Journal    
DOI: 10.1177/107602960501100110     Document Type: Article

References (35)

1. Riela A, Roach E. Etiology of stroke in children. J Child Neurol 1993;8:201.
2. Broderick J, Talbot T, Prenger E, et al. Stroke in children within a major metropolitan area: The surprising importance of intracerebral hemorrhage. J Child Neurol 1993;8:250.
3. Schoenberg BS, Mellingier JF, Schoenberg DG. Cerebrovascular disease in infants and children: A study of incidence, clinical features and survival. Neurology 1978;28:763.
4. Daniels SR, Bates S, Lukinn RR, et al. Cerebrovascular arteriopathy (arteriosclerosis) and ischemic childhood stroke. Stroke 1982;13:360.
5. Giroud M, Lemesle M, Gouyon JB, et al. Cerebrovascular disease in children under 16 years of age in the city of Dijon, France: A study of incidence and clinical features from 1985 to 1993. J Clin Epidemiol 1995;48:1343.
6. De Veber G, Monagle P, Chan A, et al. Prothrombotic disorders in infants and children with cerebral thromboembolism. Arch Neurol 1998;55:1539.
7. Nowak-Gottl U, Strater R, Heinecke A, et al. Lipoprotein (a) and genetic polymorphisms of clotting factor V, prothrombin, and methylentetrahydrofolate reductase are risk factors of spontaneous ischemic stroke in childhood. Blood 1999;94:3678.
8. Israels SJ, Seshia SS. Childhood stroke associated with protein C or protein S deficiency. J Pediatr 1987;111:562.
9. Roddy SM, Giang DW. Antiphospholipid antibodies and stroke in an infant. Pediatrics 1991;87:933.
10. Bick RL. Antiphospholipid thrombosis syndromes. Hematol Oncol Clin North Am 2003;17:115.
11. Andrew M, David M, de Veber G, et al. Arterial thromboembolic complications in paediatric patients. Thromb Haemost 1997;78:715.
12. Simioni P, de Ronde H, Prandoni P, et al. Ischemic stroke in young patients with activated protein C resistance. A report of three cases belonging to three different kindreds. Stroke 1995;26:885.
13. Ganesan V, Kelsy H, Cookson J, et al. Activated protein C resistance in childhood stroke. Lancet 1996;347:260.
14. Gurgey A. Clinical manifestations in thrombotic children with factor V Leiden mutation. Pediatr Hematol Oncol 1999;16:233.
15. Nowak-Göttle U, Koch HG, Aschka I, et al. Resistance to activated protein C (APC) in children venous or arterial thromboembolism. Br J Haematol 1996;92:992.
16. Hagstrom JN, Walter J, Bluebond-Langner R, et al. Prevalence of the factor V Leiden mutation in children and neonates with thromboembolic disease. J Pediatr 1998;133:777.
17. Becker S, Heller Ch, Gropp F, et al. Thrombophilic disorders in children with cerebral infarction. Lancet 1998;352:1756.
18. McColl MD, Chalmers EA, Thomas A, et al. Factor V Leiden, prothrombin 20210G A, and the MTHFR C677T mutations in childhood stroke. Thromb Haemost 1999;81:690.
19. Riikonen RS, Vahtera EM, Kekomaki RM. Physiological anticoagulants and activated protein C resistance in childhood stroke. Acta Pediatr 1996;85:242.
20. Kamphuisen PW, Eikenboom JC. Elevated factor VIII levels and the risk of thrombosis. Arterioscler Thromb Vasc Biol 2001;21:731.
21. Kyrle PA, Minar E, Hirschl M, et al. High plasma levels of factor VIII and the risk of recurrent venous thromboembolism. N Engl J Med 2000;343:457.
22. Kurekci AE, Gokce H, Akar N. F VIII levels in children with thrombosis. Pediatr Int 2003;45:159.
23. Andrew M. Developmental hemostasis: Relevance to thromboembolic complications in pediatric patients. Thromb Haemost 1995;74:415.
24. Salomon O, Steinberg DM, Zivelin A, et al. Single and combined prothrombotic factors in patients with idiopathic venous thromboembolism. Arterioscler Thromb Vasc Biol 1999;19:511.
25. Dahlback B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C; Prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993;90:1004.
26. Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995;346:1133.
27. Dahlback B. New molecular insights into the genetics of thrombophilia: Resistance to activated protein C, caused by Arg 506 to Gln mutation in factor V as a pathogenetic risk factor for venous thrombosis. Thromb Haemost 1995;74:139.
28. Ridker PM, Hennekens CH, Lindpainter K, et al. Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke and venous thrombosis in apparently healthy men. N Engl J Med 1995;332:912.
29. Halbmayer WM, Haushofer A, Angerer V, et al. APC resistance and factor V Leiden (FV:Q506) mutation in patients with ischemic cerebral events. Blood Coagul Fibrinolysis 1997;8:361.
30. Bick RL, Kaplan H. Syndromes of thrombosis and hypercoagulability congenital and acquired causes of thrombosis. Med Clin North Am 1998;82:409.
31. Ganesan V, McShane MA, Liesner R, et al. Inherited prothrombotic states and ischaemic stroke in childhood. J Neurol Neurosurg Psychiatry 1998;65:508.
32. Demir M, Vural O, Sunar H, et al. The prevalence of hereditary thrombophilia in the Trakya Region of Turkey. Yonsei Med J 2000;41:436.
33. Zenz W, Bodo Z, Plotho J, et al. Factor V Leiden and prothrombin gene G 20210 A variant in children with ischemic stroke. Thromb Haemost 1998;80:763.
34. Levine SR, Brey RL. Neurological aspects of antiphospholipid antibody syndrome. Lupus 1996;5:347.
35. Kenet G, Sadetzki S, Murad H, et al. Factor V Leiden and antiphospholipid antibodies are significant risk factors for ischemic stroke in children. Stroke 2000;31:1283.