Genetic risk factors of thrombophilia in ischaemic childhood stroke of cardiac origin. A prospective ESPED survey

European Journal of Pediatrics, Supplement

Volumn 158, Issue 3, 1999, Pages

  Strater R ^a   Vielhaber, H ^a   Kassenbohmer R ^a   Von Kries, R ^c   Gobel U ^b   Nowak Gottl U ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^c NONE

Author keywords

Anticardiolipin antibodies; FV G1691A; Lipoprotein (a); Protein C deficiency; Prothrombin G20210A

Indexed keywords

ANTITHROMBIN; BLOOD CLOTTING FACTOR 5; CARDIOLIPIN ANTIBODY; LIPOPROTEIN A; PROTEIN C; PROTEIN S; PROTHROMBIN;

ADOLESCENT; ADULT; ANTITHROMBIN DEFICIENCY; ARTICLE; CEREBROVASCULAR ACCIDENT; CHILD; CLINICAL ARTICLE; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE MUTATION; GENETIC RISK; GERMANY; HEALTH SURVEY; HUMAN; INFANT; MALE; NEWBORN; PRIORITY JOURNAL; PROTEIN C DEFICIENCY; PROTEIN S DEFICIENCY; RISK FACTOR; THROMBOPHILIA;

ADOLESCENT; AGE OF ONSET; ANTIBODIES, ANTICARDIOLIPIN; BRAIN INFARCTION; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; FACTOR V; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GERMANY; HEART DISEASES; HUMANS; INFANT; INFANT, NEWBORN; LIPOPROTEIN(A); MALE; ODDS RATIO; PREVALENCE; PROTEIN C DEFICIENCY; PROTHROMBIN; RISK FACTORS; STATISTICS, NONPARAMETRIC; THROMBOPHILIA;

EID: 0343820052     PISSN: 09439676     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Becker S, Heller C, Gropp F, Scharrer I, Kreuz W (1998) Thromboembolic disorders in children with cerebral infarction. Lancet 352:1756-1757 (letter)
2. Biller J, Love BB (1994) Cardiac disorders and stroke in children and young adults. In: Biller J (ed) Stroke in children and young adults. Butterworth-Heinemann, Boston, pp 83-101
3. DeVeber G, Monagle P, Chan A, MacGregor D, Curtis R, Lee S, Vegh P, Adams M, Marzinotto V, Leaker M, Massicotte P, Lillicrap D, Andrew M (1998) Prothrombotic disorders in infants and children with cerebral thromboembolism. Arch Neurol 55:1539-1543
4. Ganesan V, Kelsey H, Cookson J, Osborn A, Kirkham FJ (1996) Activated protein C resistance in childhood stroke. Lancet 347:260
5. Jürgens G, Költringer P (1987) Lipoprotein (a) in ischemic cerebrovascular disease: A new approach to the assessment of risk of stroke. Neurology 37:513-515
6. Nicolaides P, Appleton RE (1996) Annotation - Stroke in children. Develop Med Child Neurol 38:172-180
7. McColl MD, Chalmers EA, Thomas A, Sproul A, Healey C, Rafferty I, McWilliam R, Eunson P (1999) Factor V Leiden, prothrombin 20210GA and the MTHFR C677T mutations in childhood stroke. Thromb Haemost 81:690-694
8. 506 to Gln mutation in the factor V gene. Blood Coagulat Fibrinol 7:684-688
9. Nowak-Göttl U, Wermes C, Junker R, Koch HG, Schobess R, Fleischhack G, Schwabe D, Ehrenforth S (1999) Prospective evaluation of the thrombotic risk in children with acute lymphoblastic leukemia carrying the MTHFR TT 677 genotype, the prothrombin G20210A variant, and further prothrombotic risk factors. Blood 93:1595-1599
10. Riikonen R, Santavuori P (1994) Hereditary and acquired risk factors for childhood stroke. Neuropediatr 24:227-233
11. Sträter R, Junker R, Göbel U, von Kries R, Vielhaber H, Nowak-Göttl U (1998) MTHFR C677T genotype, prothrombin G20210A gene mutation and further prothrombotic risk factors in childhood ischaemic stroke - Results of a multicenter case control study. Blood 92 (10):558 (abstract)
12. Zenz W, Bodo Z, Plotho J, Streif W, Male C, Bernert G, Rauter L, Ebetsberger G, Kaltenbrunner K, Kurnik P, Lischka A, Paky F, Ploier R, Höfler G, Mannhalter C, Muntean W (1998) Factor V Leiden and prothrombin gene G20210A variant in children with stroke. Thromb Haemost 80:763-766