-
1
-
-
0004061813
-
-
2nd ed.; Blackwell Publishing: Malden, MA
-
Wagner, E. K.; Hewlett, M. J. Basic Virology, 2nd ed.; Blackwell Publishing: Malden, MA, 2004; pp 242-243.
-
(2004)
Basic Virology
, pp. 242-243
-
-
Wagner, E.K.1
Hewlett, M.J.2
-
2
-
-
33747131043
-
Selective inhibitors of hepatitis C virus replication
-
Neyts, J. Selective inhibitors of hepatitis C virus replication. Antiviral Res. 2006, 71, 363-371.
-
(2006)
Antiviral Res.
, vol.71
, pp. 363-371
-
-
Neyts, J.1
-
3
-
-
0028998145
-
Clinical outcomes after transfusion-associated hepatitis C
-
(a) Tong, M. J.; El-Ferra, N. S.; Reikes, A. R.; Co, R. L. Clinical outcomes after transfusion-associated hepatitis C. N. Engl. J. Med. 1995, 332, 1463-1466.
-
(1995)
N. Engl. J. Med.
, vol.332
, pp. 1463-1466
-
-
Tong, M.J.1
El-Ferra, N.S.2
Reikes, A.R.3
Co, R.L.4
-
4
-
-
0033545541
-
Rising incidence of hepatocellular carcinoma in the United States
-
(b) El-Serag, H. B.; Mason, A. Rising incidence of hepatocellular carcinoma in the United States. N. Engl. J. Med. 1999, 34, 745-750.
-
(1999)
N. Engl. J. Med.
, vol.34
, pp. 745-750
-
-
El-Serag, H.B.1
Mason, A.2
-
5
-
-
0034046820
-
Natural history of HCV infection
-
(c) Poynard, T.; Ratziu, V.; Benhamou, Y.; Opolon, P.; Cacoub, P.; Bedossa, P. Natural history of HCV infection. Best Pract. Res., Clin. Gastroenterol. 2000, 14, 211-228.
-
(2000)
Best Pract. Res., Clin. Gastroenterol.
, vol.14
, pp. 211-228
-
-
Poynard, T.1
Ratziu, V.2
Benhamou, Y.3
Opolon, P.4
Cacoub, P.5
Bedossa, P.6
-
6
-
-
0031059949
-
New hepatitis C virus (HCV) genotyping system that allows for identification of HCV genotypes 1a, 1b, 2a, 2b, 3a, 3b, 4, 5a, and 6a
-
Ohno, T.; Mizokami, M.; Wu, R.-R.; Saleh, M. G.; Ohba, K.; Orito, E.; Mukaide, M.; Williams, R.; Lau, J. Y. N. New hepatitis C virus (HCV) genotyping system that allows for identification of HCV genotypes 1a, 1b, 2a, 2b, 3a, 3b, 4, 5a, and 6a. J. Clin. Microbiol. 1997, 35, 201-207.
-
(1997)
J. Clin. Microbiol.
, vol.35
, pp. 201-207
-
-
Ohno, T.1
Mizokami, M.2
Wu, R.-R.3
Saleh, M.G.4
Ohba, K.5
Orito, E.6
Mukaide, M.7
Williams, R.8
Lau, J.Y.N.9
-
7
-
-
68149131155
-
New therapeutic approaches to hepatitis C virus
-
Sakamoto, N.; Watanabe, M. New therapeutic approaches to hepatitis C virus. J. Gastroenterol. 2009, 44, 643-649.
-
(2009)
J. Gastroenterol.
, vol.44
, pp. 643-649
-
-
Sakamoto, N.1
Watanabe, M.2
-
8
-
-
0037179698
-
Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
-
Fried, M. W.; Shiffman, M. L.; Reddy, K. R.; Smith, C.; Marinos, G.; Goncales, F. L. Jr.; Haussinger, D.; Diago, M.; Carosi, G.; Dhumeaux, D.; Craxi, A.; Lin, A.; Hoffman, J.; Yu, J. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N. Engl. J. Med. 2002, 347, 975-982.
-
(2002)
N. Engl. J. Med.
, vol.347
, pp. 975-982
-
-
Fried, M.W.1
Shiffman, M.L.2
Reddy, K.R.3
Smith, C.4
Marinos, G.5
Goncales Jr., F.L.6
Haussinger, D.7
Diago, M.8
Carosi, G.9
Dhumeaux, D.10
Craxi, A.11
Lin, A.12
Hoffman, J.13
Yu, J.14
-
9
-
-
0035934568
-
Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomized trial
-
Manns, M. P.; McHutchinson, J. G.; Gordon, S. C.; Rustgi, V. K.; Shiffman, M.; Reindollar, R.; Goodman, Z. D.; Koury, K.; Ling, M.; Albrecht, J. K. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomized trial. Lancet 2001, 358, 958-965.
-
(2001)
Lancet
, vol.358
, pp. 958-965
-
-
Manns, M.P.1
McHutchinson, J.G.2
Gordon, S.C.3
Rustgi, V.K.4
Shiffman, M.5
Reindollar, R.6
Goodman, Z.D.7
Koury, K.8
Ling, M.9
Albrecht, J.K.10
-
10
-
-
67649382240
-
Albinterferon alfa-2b, a novel fusion protein of human albumin and human interferon alfa-2b, for chronic hepatitis C
-
Rustgi, V. K. Albinterferon alfa-2b, a novel fusion protein of human albumin and human interferon alfa-2b, for chronic hepatitis C. Curr. Med. Res. Opin. 2009, 25, 991-1002.
-
(2009)
Curr. Med. Res. Opin.
, vol.25
, pp. 991-1002
-
-
Rustgi, V.K.1
-
11
-
-
66649105752
-
Gene expression and hepatitis C virus infection
-
Asselah, T.; Bieche, I.; Sabbagh, A.; Bedossa, P.; Moreau, R.; Valla, D.; Vidaud, M.; Marcellin, P. Gene expression and hepatitis C virus infection. Gut 2009, 58, 846-858.
-
(2009)
Gut
, vol.58
, pp. 846-858
-
-
Asselah, T.1
Bieche, I.2
Sabbagh, A.3
Bedossa, P.4
Moreau, R.5
Valla, D.6
Vidaud, M.7
Marcellin, P.8
-
12
-
-
33749360242
-
Rapid decline of viral RNA in hepatitis C patients treated with VX-950; a phase Ib, placebo-controlled, randomized study
-
Reesink, H. W.; Zeuzem, S.; Weegink, C. J.; Forestier, N.; van Vliet, A.; van de Wetering de Rooij, J.; McNair, L.; Purdy, S.; Kauffman, R.; Alam, J.; Jansem, P. L. M. Rapid decline of viral RNA in hepatitis C patients treated with VX-950; a phase Ib, placebo-controlled, randomized study. Gastroenterology 2006, 131, 997-1002.
-
(2006)
Gastroenterology
, vol.131
, pp. 997-1002
-
-
Reesink, H.W.1
Zeuzem, S.2
Weegink, C.J.3
Forestier, N.4
Van Vliet, A.5
Van De Wetering De Rooij, J.6
McNair, L.7
Purdy, S.8
Kauffman, R.9
Alam, J.10
Jansem, P.L.M.11
-
13
-
-
77958485628
-
A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactions
-
Znabet, A.; Polka, M. M.; Janssen, E.; de Kanter, F. J. J.; Turner, N. J.; Orru, R. V. A.; Ruitjer, E. A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactions. Chem. Commun. 2010, 46, 7918-7920.
-
(2010)
Chem. Commun.
, vol.46
, pp. 7918-7920
-
-
Znabet, A.1
Polka, M.M.2
Janssen, E.3
De Kanter, F.J.J.4
Turner, N.J.5
Orru, R.V.A.6
Ruitjer, E.7
-
14
-
-
33646036163
-
Identification and analysis of fitness of resistance mutations against the HCV protease inhibitor SCH 503034
-
Tong, X.; Chase, R.; Skelton, A.; Chen, T.; Wright-Minogue, J.; Malcolm, B. A. Identification and analysis of fitness of resistance mutations against the HCV protease inhibitor SCH 503034. Antiviral Res. 2006, 70, 28-38.
-
(2006)
Antiviral Res.
, vol.70
, pp. 28-38
-
-
Tong, X.1
Chase, R.2
Skelton, A.3
Chen, T.4
Wright-Minogue, J.5
Malcolm, B.A.6
-
15
-
-
79953173221
-
SPRINT-2 investigators. Boceprevir for untreated chronic HCV genotype 1 infection
-
Poordad, F.; McCone, J. Jr.; Bacon, B. R.; Bruno, S.; Manns, M. P.; Sulkowski, M. S.; Jacobson, I. M.; Reddy, K. R.; Goodman, Z. D.; Boparai, N; DiNubile, M. J.; Sniukiene, V.; Brass, C. A.; Albrecht, J. K.; Bronowicki, J. P. SPRINT-2 investigators. Boceprevir for untreated chronic HCV genotype 1 infection. N. Engl. J. Med. 2011, 364, 1195-1206.
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 1195-1206
-
-
Poordad, F.1
McCone Jr., J.2
Bacon, B.R.3
Bruno, S.4
Manns, M.P.5
Sulkowski, M.S.6
Jacobson, I.M.7
Reddy, K.R.8
Goodman, Z.D.9
Boparai, N.10
DiNubile, M.J.11
Sniukiene, V.12
Brass, C.A.13
Albrecht, J.K.14
Bronowicki, J.P.15
-
16
-
-
0037809239
-
Inhibition of hepatitis C virus RNA replication by 2′-modified nucleoside analogues
-
Carroll, S. S.; Tomassini, J. E.; Bosserman, M.; Getty, K.; Stahlhut, M. W.; Eldrup, A. B.; Bhat, B.; Hall, D.; Simcoe, A. L.; LaFemina, R.; Rutkowski, C. A.; Wolanski, B.; Yang, Z. C.; Migliaccio, G.; De Francesco, R.; Kuo, L. C.; MacCoss, M.; Olsen, D. B. Inhibition of hepatitis C virus RNA replication by 2′-modified nucleoside analogues. J. Biol. Chem. 2003, 278, 11979-11984.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 11979-11984
-
-
Carroll, S.S.1
Tomassini, J.E.2
Bosserman, M.3
Getty, K.4
Stahlhut, M.W.5
Eldrup, A.B.6
Bhat, B.7
Hall, D.8
Simcoe, A.L.9
LaFemina, R.10
Rutkowski, C.A.11
Wolanski, B.12
Yang, Z.C.13
Migliaccio, G.14
De Francesco, R.15
Kuo, L.C.16
MacCoss, M.17
Olsen, D.B.18
-
17
-
-
42949167169
-
The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogues than to nonnucleoside analogues or protease inhibitors
-
McCown, M. F.; Rajyaguru, S.; Le Pogam, S.; Ali, S.; Jiang, W. R.; Kang, H.; Symons, J.; Cammack, N.; Najera, I. The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogues than to nonnucleoside analogues or protease inhibitors. Antimicrob. Agents Chemother. 2008, 52, 1604-1612.
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 1604-1612
-
-
McCown, M.F.1
Rajyaguru, S.2
Le Pogam, S.3
Ali, S.4
Jiang, W.R.5
Kang, H.6
Symons, J.7
Cammack, N.8
Najera, I.9
-
18
-
-
79954831999
-
NS5A inhibitors: A new breakthrough for the treatment of chronic hepatitis C
-
Asselah, T. NS5A inhibitors: a new breakthrough for the treatment of chronic hepatitis C. J. Hepatol. 2011, 54, 1069-1072.
-
(2011)
J. Hepatol.
, vol.54
, pp. 1069-1072
-
-
Asselah, T.1
-
19
-
-
0142182744
-
Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes
-
Watashi, K.; Hijikata, M.; Hosaka, M.; Yamaji, M.; Shimotohno, K. Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes. Hepatology 2003, 38, 1282-1288.
-
(2003)
Hepatology
, vol.38
, pp. 1282-1288
-
-
Watashi, K.1
Hijikata, M.2
Hosaka, M.3
Yamaji, M.4
Shimotohno, K.5
-
20
-
-
33646015668
-
The non-immunosuppresive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro
-
(a) Paeshuyse, J.; Kaul, A.; De Clercq, E.; Rosenwirth, R.; Dumont, K.J.-M.; Scalfaro, P.; Bartenschlager, R.; Neyts, J. The non-immunosuppresive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro. Hepatology 2006, 53, 761-770.
-
(2006)
Hepatology
, vol.53
, pp. 761-770
-
-
Paeshuyse, J.1
Kaul, A.2
De Clercq, E.3
Rosenwirth, R.4
Dumont, K.J.-M.5
Scalfaro, P.6
Bartenschlager, R.7
Neyts, J.8
-
21
-
-
77958049066
-
8 cyclosporin A analogues as potential anti-HCV agents
-
8 cyclosporin A analogues as potential anti-HCV agents. Bioorg. Med. Chem. Lett. 2010, 20, 6542-6546.
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, pp. 6542-6546
-
-
Scribner, A.1
Houck, D.2
Huang, Z.3
Mosier, S.4
Peel, M.5
Scorneaux, B.6
-
22
-
-
0032694353
-
Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: Implications for the development of broad spectrum anti-hepatitis virus agents
-
(a) Zitzmann, N.; Mehta, A. S.; Carrouee, S.; Butters, T. D.; Platt, F. M.; McCauley, J.; Blumberg, B. S.; Dwek, R. A.; Block, T. M. Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: implications for the development of broad spectrum anti-hepatitis virus agents. Proc. Natl. Acad. Sci. U.S.A. 1999, 96, 11878-11882.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 11878-11882
-
-
Zitzmann, N.1
Mehta, A.S.2
Carrouee, S.3
Butters, T.D.4
Platt, F.M.5
McCauley, J.6
Blumberg, B.S.7
Dwek, R.A.8
Block, T.M.9
-
23
-
-
0036753024
-
The combination of interferon alpha-2b and N-butyl deoxynojirimycin has a greater than additive antiviral effect upon production of infectious bovine viral diarrhea virus (BVDV) in vitro: Implications for hepatitis C virus (HCV) therapy
-
(b) Ouzounov, S.; Mehta, A.; Dwek, R. A.; Block, T. M.; Jordan, R. The combination of interferon alpha-2b and N-butyl deoxynojirimycin has a greater than additive antiviral effect upon production of infectious bovine viral diarrhea virus (BVDV) in vitro: implications for hepatitis C virus (HCV) therapy. Antiviral Res. 2008, 55, 425-435.
-
(2008)
Antiviral Res.
, vol.55
, pp. 425-435
-
-
Ouzounov, S.1
Mehta, A.2
Dwek, R.A.3
Block, T.M.4
Jordan, R.5
-
24
-
-
79959448653
-
Thiazolides as novel antiviral agents: 1. Inhibition of hepatitis B virus replication
-
Stachulski, A. V.; Pidathala, C.; Row, E. C.; Sharma, R.; Berry, N. G.; Iqbal, M.; Bentley, J.; Allman, S. A.; Edwards, G.; Helm, A.; Hellier, J.; Korba, B. E.; Semple, E. J.; Rossignol, J.-F. Thiazolides as novel antiviral agents: 1. Inhibition of hepatitis B virus replication. J. Med. Chem. 2011, 54, 4119-4132.
-
(2011)
J. Med. Chem.
, vol.54
, pp. 4119-4132
-
-
Stachulski, A.V.1
Pidathala, C.2
Row, E.C.3
Sharma, R.4
Berry, N.G.5
Iqbal, M.6
Bentley, J.7
Allman, S.A.8
Edwards, G.9
Helm, A.10
Hellier, J.11
Korba, B.E.12
Semple, E.J.13
Rossignol, J.-F.14
-
25
-
-
37449014458
-
Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication
-
Korba, B. E.; Montero, A. B.; Farrar, K.; Gaye, K.; Mukerjee, S.; Ayers, M. S.; Rossignol, J.-F. Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication. Antiviral Res. 2008, 77, 56-63.
-
(2008)
Antiviral Res.
, vol.77
, pp. 56-63
-
-
Korba, B.E.1
Montero, A.B.2
Farrar, K.3
Gaye, K.4
Mukerjee, S.5
Ayers, M.S.6
Rossignol, J.-F.7
-
26
-
-
67649307146
-
Thiazolides: A new class of antiviral drugs
-
Rossignol, J.-F. Thiazolides: a new class of antiviral drugs. Expert Opin. Drug Metab. Toxicol. 2009, 5, 667-674.
-
(2009)
Expert Opin. Drug Metab. Toxicol.
, vol.5
, pp. 667-674
-
-
Rossignol, J.-F.1
-
27
-
-
55849149779
-
Potential for hepatitis C virus resistance to nitazoxanide or tizoxanide
-
Korba, B. E.; Elazar, M.; Lui, P.; Rossignol, J.-F.; Glenn, J. S. Potential for hepatitis C virus resistance to nitazoxanide or tizoxanide. Antimicrob. Agents Chemother. 2008, 52, 4069-4071.
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 4069-4071
-
-
Korba, B.E.1
Elazar, M.2
Lui, P.3
Rossignol, J.-F.4
Glenn, J.S.5
-
28
-
-
79960455704
-
Mutations in HCV non-structural genes do not contribute to resistance to nitazoxanide in replicon-containing cells
-
Yon, C.; Viswanathan, P.; Rossignol, J.-F.; Korba, B. E. Mutations in HCV non-structural genes do not contribute to resistance to nitazoxanide in replicon-containing cells. Antiviral Res. 2011, 91, 233-240.
-
(2011)
Antiviral Res.
, vol.91
, pp. 233-240
-
-
Yon, C.1
Viswanathan, P.2
Rossignol, J.-F.3
Korba, B.E.4
-
29
-
-
60449108708
-
Improved virologic response in chronic hepatitis C genotype 4 treated with nitazoxanide, peginterferon and ribavirin
-
Rossignol, J.-F.; Elfert, A.; El-Gohary, Y.; Keeffe, E. B. Improved virologic response in chronic hepatitis C genotype 4 treated with nitazoxanide, peginterferon and ribavirin. Gastroenterology 2009, 136, 856-862.
-
(2009)
Gastroenterology
, vol.136
, pp. 856-862
-
-
Rossignol, J.-F.1
Elfert, A.2
El-Gohary, Y.3
Keeffe, E.B.4
-
30
-
-
77955146829
-
Treatment of chronic hepatitis C using a 4-week lead-in with nitazoxanide before peginterferon plus nitazoxanide
-
(a) Rossignol, J.-F.; Elferty, A.; Keeffe, E. B. Treatment of chronic hepatitis C using a 4-week lead-in with nitazoxanide before peginterferon plus nitazoxanide. J. Clin. Gastroenterol. 2010, 44, 504-509.
-
(2010)
J. Clin. Gastroenterol.
, vol.44
, pp. 504-509
-
-
Rossignol, J.-F.1
Elferty, A.2
Keeffe, E.B.3
-
31
-
-
60449096365
-
Potential role for nitazoxanide in combination with STAT-C agents for the inhibition of HCV replication without the development of resistance
-
(b) Korba, B. E.; Elazar, M.; Lui, P.; Glenn, J. S.; Rossignol, J.-F. Potential role for nitazoxanide in combination with STAT-C agents for the inhibition of HCV replication without the development of resistance. Hepatology 2008, 48 (Suppl.), 356A.
-
(2008)
Hepatology
, vol.48
, Issue.SUPPL.
-
-
Korba, B.E.1
Elazar, M.2
Lui, P.3
Glenn, J.S.4
Rossignol, J.-F.5
-
32
-
-
0018216945
-
Recherches sur les dérivés nitrés d'intérêt biologique. XVI. Relations entre structures et activités protozoocides antheminthiques et molluscicides dans la série du benzamido-2 nitro-5 thiazole
-
Cavier, R.; Gayral, Ph.; Guillaumel, J.; Clavel, J. M.; Demerseman, P.; Royer, R. Recherches sur les dérivés nitrés d'intérêt biologique. XVI. Relations entre structures et activités protozoocides antheminthiques et molluscicides dans la série du benzamido-2 nitro-5 thiazole. Eur. J. Med. Chem. 1978, 13, 539-543.
-
(1978)
Eur. J. Med. Chem.
, vol.13
, pp. 539-543
-
-
Cavier, R.1
Gayral, Ph.2
Guillaumel, J.3
Clavel, J.M.4
Demerseman, P.5
Royer, R.6
-
33
-
-
4243383430
-
-
U.S. Patent 3,950,351, April 13
-
Rossignol, J. F.; Cavier, R. New Derivatives of 2-Benzamido 5-Nitrothiazoles. U.S. Patent 3,950,351, April 13, 1976.
-
(1976)
New Derivatives of 2-benzamido 5-nitrothiazoles
-
-
Rossignol, J.F.1
Cavier, R.2
-
34
-
-
12444265690
-
Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part I: Sar studies on the determination of the key scaffold
-
(a) Luo, Q.-L.; Li, J.-Y.; Liu, Z.-Y; Chen, L.-L.; Li, J.; Ye, Q.-Z.; Nan, F.-J. Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part I: SAR studies on the determination of the key scaffold. Bioorg. Med. Chem. Lett. 2005, 15, 635-638.
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 635-638
-
-
Luo, Q.-L.1
Li, J.-Y.2
Liu, Z.-Y.3
Chen, L.-L.4
Li, J.5
Ye, Q.-Z.6
Nan, F.-J.7
-
36
-
-
84055216896
-
-
U.S. Patent 2401522
-
(c) U.S. Patent 2401522, 1943; Sandoz.
-
(1943)
-
-
Sandoz1
-
38
-
-
0000729721
-
1-(Trifluoromethy1)ethenyl phenyl selenide and1-(trifluoromethy1)ethenyl phenyl sulfide
-
Feiring, A. E. 1-(Trifluoromethy1)ethenyl phenyl selenide and1-(trifluoromethy1)ethenyl phenyl sulfide. J. Org. Chem. 1980, 45, 1962-1964.
-
(1980)
J. Org. Chem.
, vol.45
, pp. 1962-1964
-
-
Feiring, A.E.1
-
39
-
-
12344307019
-
Investigations of the halogen dance reaction on N-substituted 2-thiazolamines
-
Stanetty, P.; Schnurch, M.; Mereiter, K.; Mihovilovic, M. D. Investigations of the halogen dance reaction on N-substituted 2-thiazolamines. J. Org. Chem. 2005, 70, 567-574.
-
(2005)
J. Org. Chem.
, vol.70
, pp. 567-574
-
-
Stanetty, P.1
Schnurch, M.2
Mereiter, K.3
Mihovilovic, M.D.4
-
40
-
-
0036291061
-
Preparation of N-tert-butoxycarbonylthiourea opens the way to protected 2-aminothiazoles
-
Schiavi, B.; Ahond, A.; Poupat, C.; Potier, P. Preparation of N-tert-butoxycarbonylthiourea opens the way to protected 2-aminothiazoles. Synth. Commun. 2002, 32, 1671-1674.
-
(2002)
Synth. Commun.
, vol.32
, pp. 1671-1674
-
-
Schiavi, B.1
Ahond, A.2
Poupat, C.3
Potier, P.4
-
41
-
-
0242362591
-
Design, synthesis, and biological evaluation of 6-substituted-3-(4- methanesulfonylphenyl)-4-phenylpyran-2-ones: A novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors
-
Praveen Rao, P. N.; Amini, M.; Li, H.; Habeeb, A. G.; Knaus, E. E. Design, synthesis, and biological evaluation of 6-substituted-3-(4- methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors. J. Med. Chem. 2003, 46, 4872-4882.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 4872-4882
-
-
Praveen Rao, P.N.1
Amini, M.2
Li, H.3
Habeeb, A.G.4
Knaus, E.E.5
-
42
-
-
24144477935
-
In vitro efficacy of nitazoxanide and other thiazolides against Neospora caninum tachyzoites reveals anti-parasitic activity independent of the nitro group
-
Esposito, M.; Stettler, R.; Moores, S. L.; Pidathala, C.; Muller, N.; Berry, N. G.; Stachulski, A. V.; Rossignol, J.-F.; Hemphill, A. In vitro efficacy of nitazoxanide and other thiazolides against Neospora caninum tachyzoites reveals anti-parasitic activity independent of the nitro group. Antimicrob. Agents Chemother. 2005, 49, 3715-3723.
-
(2005)
Antimicrob. Agents Chemother.
, vol.49
, pp. 3715-3723
-
-
Esposito, M.1
Stettler, R.2
Moores, S.L.3
Pidathala, C.4
Muller, N.5
Berry, N.G.6
Stachulski, A.V.7
Rossignol, J.-F.8
Hemphill, A.9
-
43
-
-
0035648818
-
Synthesis and antimycobacterial activity of salicylanilides substituted in position 5
-
Waisser, K.; Hladuvkova, J.; Kunes, J.; Kubicova, L.; Klimesova, V.; Karajannis, P.; Kaustova, J. Synthesis and antimycobacterial activity of salicylanilides substituted in position 5. Chem. Pap. 2001, 55, 121-129.
-
(2001)
Chem. Pap.
, vol.55
, pp. 121-129
-
-
Waisser, K.1
Hladuvkova, J.2
Kunes, J.3
Kubicova, L.4
Klimesova, V.5
Karajannis, P.6
Kaustova, J.7
-
44
-
-
0035153842
-
Computational methods to estimate drug development parameters
-
Podlogar, B. L.; Muegge, I.; Brice, L. J. Computational methods to estimate drug development parameters. Curr. Opin. Drug Discovery 2001, 4, 102-109.
-
(2001)
Curr. Opin. Drug Discovery
, vol.4
, pp. 102-109
-
-
Podlogar, B.L.1
Muegge, I.2
Brice, L.J.3
-
45
-
-
0043132440
-
Methods for reliability and uncertainty assessment and for applicability evaluations of classification- and regression-based QSARs
-
Eriksson, L.; Jaworska, J.; Worth, A. P.; Cronin, M. T. D.; McDowell, R. M. M.; Gramatica, P. Methods for reliability and uncertainty assessment and for applicability evaluations of classification- and regression-based QSARs. Environ. Health Perspect. 2003, 111, 1361-1375.
-
(2003)
Environ. Health Perspect.
, vol.111
, pp. 1361-1375
-
-
Eriksson, L.1
Jaworska, J.2
Worth, A.P.3
Cronin, M.T.D.4
McDowell, R.M.M.5
Gramatica, P.6
-
46
-
-
84855609127
-
-
(accessed Aug 19, 2011)
-
PHAKISO: Pharmacokinetics in Silico. http://www.phakiso.com/ (accessed Aug 19, 2011).
-
Pharmacokinetics in Silico
-
-
-
47
-
-
84867234414
-
-
DRAGON version 6.0; Talete srl: Milan, Italy
-
DRAGON (Software for Molecular Descriptor Calculation), version 6.0; Talete srl: Milan, Italy, 2010; http://www.talete.mi.it/.
-
(2010)
Software for Molecular Descriptor Calculation
-
-
-
49
-
-
0038724207
-
The importance of being earnest: Validation is the absolute essential for successful application and interpretation of QSAR models
-
Tropsha, A.; Gramatica, P.; Gombar, V. K. The importance of being earnest: validation is the absolute essential for successful application and interpretation of QSAR models. QSAR Comb. Sci. 2003, 22, 69-77.
-
(2003)
QSAR Comb. Sci.
, vol.22
, pp. 69-77
-
-
Tropsha, A.1
Gramatica, P.2
Gombar, V.K.3
-
50
-
-
84894887900
-
Computer aided design of experiments
-
Kennard, R. W.; Stone, L. A. Computer aided design of experiments. Technometric 1969, 11, 137-148.
-
(1969)
Technometric
, vol.11
, pp. 137-148
-
-
Kennard, R.W.1
Stone, L.A.2
-
52
-
-
20444410410
-
Virtual screening of molecular databases using a support vector machine
-
(a) Jorissen, R. N.; Gilson, M. K. Virtual screening of molecular databases using a support vector machine. J. Chem. Inf. Model. 2005, 45, 549-561.
-
(2005)
J. Chem. Inf. Model.
, vol.45
, pp. 549-561
-
-
Jorissen, R.N.1
Gilson, M.K.2
-
53
-
-
33646420101
-
Statistical learning approach for predicting specific pharmacodynamic, pharmacokinetic or toxicological properties of pharmaceutical agents
-
(b) Li, H.; Yap, C. W.; Xue, Y.; Li, Z. R.; Ung, C. Y.; Han, L. Y.; Chen, Y. Z. Statistical learning approach for predicting specific pharmacodynamic, pharmacokinetic or toxicological properties of pharmaceutical agents. Drug Dev. Res. 2006, 66, 245-259.
-
(2006)
Drug Dev. Res.
, vol.66
, pp. 245-259
-
-
Li, H.1
Yap, C.W.2
Xue, Y.3
Li, Z.R.4
Ung, C.Y.5
Han, L.Y.6
Chen, Y.Z.7
-
54
-
-
34247594930
-
Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir
-
Sarrazin, C.; Kieffer, T. L.; Bartels, D.; Hanzelka, B.; Muh, U.; Welker, M.; Wincheringer, D.; Zhou, Y.; Chu, H.-M.; Lin, C.; Weegink, C.; Reesink, H.; Zeuzem, S.; Kwong, A. D. Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir. Gastroenterology 2007, 132, 1767-1777.
-
(2007)
Gastroenterology
, vol.132
, pp. 1767-1777
-
-
Sarrazin, C.1
Kieffer, T.L.2
Bartels, D.3
Hanzelka, B.4
Muh, U.5
Welker, M.6
Wincheringer, D.7
Zhou, Y.8
Chu, H.-M.9
Lin, C.10
Weegink, C.11
Reesink, H.12
Zeuzem, S.13
Kwong, A.D.14
-
55
-
-
48449083690
-
Studies of the potential for resistance to nitazoxanide or tizoxanide
-
Korba, B. E.; Glenn, J. S.; Ayers, M. S.; Rossignol, J.-F. Studies of the potential for resistance to nitazoxanide or tizoxanide. J. Hepatol. 2008, 48, S11.
-
(2008)
J. Hepatol.
, vol.48
-
-
Korba, B.E.1
Glenn, J.S.2
Ayers, M.S.3
Rossignol, J.-F.4
-
56
-
-
70350365369
-
Thiazolides, a new class of anti-influenza molecules targeting viral haemagglutinin at the post-translational level
-
Rossignol, J.-F.; La Frazia, S.; Chiappa, L.; Ciucci, A.; Santoro, M. G. Thiazolides, a new class of anti-influenza molecules targeting viral haemagglutinin at the post-translational level. J. Biol. Chem. 2009, 284, 29798-29808.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 29798-29808
-
-
Rossignol, J.-F.1
La Frazia, S.2
Chiappa, L.3
Ciucci, A.4
Santoro, M.G.5
-
57
-
-
70350125916
-
The anti-hepatitis C agent nitazoxanide induces phosphorylation of eukaryotic initiation factor 2 alpha via protein kinase activated by double-stranded RNA activation
-
Elazar, M.; Liu, M.; McKenna, S. A.; Liu, P.; Gehrig, E. A.; Puglisi, J. D.; Rossignol, J.-F.; Glenn, J. S. The anti-hepatitis C agent nitazoxanide induces phosphorylation of eukaryotic initiation factor 2 alpha via protein kinase activated by double-stranded RNA activation. Gastroenterology 2009, 137, 1827-1835.
-
(2009)
Gastroenterology
, vol.137
, pp. 1827-1835
-
-
Elazar, M.1
Liu, M.2
McKenna, S.A.3
Liu, P.4
Gehrig, E.A.5
Puglisi, J.D.6
Rossignol, J.-F.7
Glenn, J.S.8
-
58
-
-
37549030572
-
Anion-triggered substituent-dependent conformational switching of salicylanilides. New hints for understanding the inhibitory mechanism of salicylanilides
-
Guo, L.; Wang, Q.-L.; Jiang, Q.-Q.; Jiang, Q.-J.; Jiang, Y.-B. Anion-triggered substituent-dependent conformational switching of salicylanilides. New hints for understanding the inhibitory mechanism of salicylanilides. J. Org. Chem. 2007, 72, 9947-9953.
-
(2007)
J. Org. Chem.
, vol.72
, pp. 9947-9953
-
-
Guo, L.1
Wang, Q.-L.2
Jiang, Q.-Q.3
Jiang, Q.-J.4
Jiang, Y.-B.5
-
59
-
-
33747154401
-
Targeting EGFR and HER-2 receptor tyrosine kinases for cancer drug discovery and development
-
Kamath, S.; Buolamwini, J. K. Targeting EGFR and HER-2 receptor tyrosine kinases for cancer drug discovery and development. Med. Res. Rev. 2006, 26, 569-594.
-
(2006)
Med. Res. Rev.
, vol.26
, pp. 569-594
-
-
Kamath, S.1
Buolamwini, J.K.2
-
60
-
-
84899871580
-
The anti-infective nitazoxanide shows strong immumodulating effects
-
155.21
-
Clerici, M.; Trabattoni, D.; Pacei, M.; Biasin, M.; Rossignol, J. F. The anti-infective nitazoxanide shows strong immumodulating effects. J. Immunol. 2011, 186, 155.21.
-
(2011)
J. Immunol.
, vol.186
-
-
Clerici, M.1
Trabattoni, D.2
Pacei, M.3
Biasin, M.4
Rossignol, J.F.5
-
61
-
-
0034623816
-
Efficient initiation of HCV RNA replication in cell culture
-
Blight, K. J.; Kolykhalov, A. A.; Rice, C. M. Efficient initiation of HCV RNA replication in cell culture. Science 2000, 290, 1972-1974.
-
(2000)
Science
, vol.290
, pp. 1972-1974
-
-
Blight, K.J.1
Kolykhalov, A.A.2
Rice, C.M.3
-
62
-
-
11844269964
-
Enhancement of antiviral activity against hepatitic C virus in vitro by interferon combination therapy
-
Okuse, C.; Rinaudo, J. A.; Farrar, K.; Wells, F.; Korba, B. E. Enhancement of antiviral activity against hepatitic C virus in vitro by interferon combination therapy. Antiviral Res. 2005, 65, 23-34.
-
(2005)
Antiviral Res.
, vol.65
, pp. 23-34
-
-
Okuse, C.1
Rinaudo, J.A.2
Farrar, K.3
Wells, F.4
Korba, B.E.5
-
63
-
-
0037370622
-
Efficient replication of hepatitis C virus genotype 1a RNAs in cell culture
-
Blight, K. J.; McKeating, J. A.; Marcotrigiano, J.; Rice, C. M. Efficient replication of hepatitis C virus genotype 1a RNAs in cell culture. J. Virol. 2003, 77, 3181-3190.
-
(2003)
J. Virol.
, vol.77
, pp. 3181-3190
-
-
Blight, K.J.1
McKeating, J.A.2
Marcotrigiano, J.3
Rice, C.M.4
-
64
-
-
84855574482
-
-
Wavefunction, Inc. http://www.wavefun.com/.
-
-
-
-
66
-
-
0024349286
-
Corchop, an interactive routine for the dimension reduction of large QSAR data sets
-
Livingstone, D. J.; Rahr, E. Corchop, an interactive routine for the dimension reduction of large QSAR data sets. Quant. Struct.-Act. Relat. 1989, 8, 103-108.
-
(1989)
Quant. Struct.-act. Relat.
, vol.8
, pp. 103-108
-
-
Livingstone, D.J.1
Rahr, E.2
-
67
-
-
0018709674
-
Chance factors in studies of quantitative structure-activity relationships
-
Topliss, J. G.; Edwards, R. P. Chance factors in studies of quantitative structure-activity relationships. J. Med. Chem. 1979, 22, 1238-1244.
-
(1979)
J. Med. Chem.
, vol.22
, pp. 1238-1244
-
-
Topliss, J.G.1
Edwards, R.P.2
-
68
-
-
78651076564
-
KNIME, the Konstanz information miner: Version 2.0 and beyond
-
Berthold, M. R.; Cebron, N.; Dill, F.; Gabriel, T. R.; Kötter, T.; Meinl, T.; Ohl, P.; Thiel, K.; Wiswedel, B. KNIME, the Konstanz information miner: version 2.0 and beyond. SIGKDD Explorations 2009, 11, 26-31.
-
(2009)
SIGKDD Explorations
, vol.11
, pp. 26-31
-
-
Berthold, M.R.1
Cebron, N.2
Dill, F.3
Gabriel, T.R.4
Kötter, T.5
Meinl, T.6
Ohl, P.7
Thiel, K.8
Wiswedel, B.9
-
69
-
-
76749092270
-
The WKEA data mining software: An update
-
Hall, M.; Frank, E.; Holmes, G.; Pfahringer, B.; Reutemann, P.; Witten, I. H. The WKEA Data Mining Software: An Update. SIGKDD Explor. 2009, 11, 10-18.
-
(2009)
SIGKDD Explor.
, vol.11
, pp. 10-18
-
-
Hall, M.1
Frank, E.2
Holmes, G.3
Pfahringer, B.4
Reutemann, P.5
Witten, I.H.6
-
70
-
-
4944228528
-
-
National Taiwan University: Taipei, Taiwan (accessed Aug 19, 2011)
-
Hsu, C.-W.; Chang, C.-C.; Lin, C.-J. A Practical Guide to Support Vector Classification; National Taiwan University: Taipei, Taiwan, 2010; http://www.csie.ntu.edu.tw/~cjlin/papers/guide/guide.pdf (accessed Aug 19, 2011).
-
(2010)
A practical guide to support vector classification
-
-
Hsu, C.-W.1
Chang, C.-C.2
Lin, C.-J.3
|