Gender effect on in vitro lymphocyte subset levels of healthy individuals

Cellular Immunology

Volumn 272, Issue 2, 2012, Pages 214-219

  Abdullah, Maha ^a,b   Chai, Pei Shin ^a   Chong, Mun Yee ^a   Tohit, Eusni Rahayu Mohd ^c   Ramasamy, Rajesh ^a   Pei, Chong Pei ^d   Vidyadaran, Sharmili ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b UPM   (Malaysia)

^c Hematology unit   (Malaysia)

^d UPM   (Malaysia)

Author keywords

Gender; Healthy individuals; In vitro; In vivo; PBMC; Phenotype; Whole blood

Indexed keywords

PHYTOHEMAGGLUTININ;

ADULT; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOCYTE CULTURE; LYMPHOCYTE SUBPOPULATION; MALE; NATURAL KILLER CELL; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SEX DIFFERENCE; T LYMPHOCYTE;

ADULT; ANTIGENS, CD3; B-LYMPHOCYTES; BLOOD CELL COUNT; CELLS, CULTURED; FEMALE; HUMANS; KILLER CELLS, NATURAL; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBSETS; MALE; PHYTOHEMAGGLUTININS; SEX FACTORS; T-LYMPHOCYTES; YOUNG ADULT;

EID: 83955165404     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2011.10.009     Document Type: Article

References (43)

1. Roitt I., Brostoff J., Male D. Immunology 2002, Mosby, New York. sixth ed.
2. Bouman A., Heineman M.J., Faas M.M. Sex hormonesand the immune response in humans. Hum. Reprod. Update 2005, 11:411-423.
3. Kennedy R.B., Ovsyannikova I.G., Pankratz V.S., Vierkant R.A., Jacobson R.M., Ryan M.A., Poland G.A. Gender effects on humoral immune responses to smallpox vaccine. Vaccine 2009, 27:3319-3323.
4. Choudhry M.A., Bland K.I., Chaudry I.H. Trauma and immune response-effect of gender differences. Injury 2007, 38:1382-1391. (Review).
5. Albright J.W., Albright J.F. Ageing alters the competence of the immune system to control parasitic Infection. Immunol. Lett. 1994, 40:279-285.
6. Caruso C., Candore G., Cigna D., DiLorenzo G., Sireci G., Dieli F., Salerno A. Cytokine production pathway in the elderly. Immunol. Res. 1996, 15:84-90.
7. Shaw A.C., Joshi S., Greenwood H., Panda A., Lord L.M. Aging of the innate immune system. Curr. Opin. Immunol. 2010, 22:507-513.
8. Beeson P.B. Age and sex associations of 40autoimmunediseases. Am. J. Med. 1994, 96:457-462.
9. Grimaldi C.M. Sex and systemic lupus erythematosus: the role of the sex hormones estrogen and prolactin on the regulation of autoreactive B cells. Curr. Opin. Rheumatol. 2006, 18:456-461.
10. PausJenssen E.S., Cockcrof D.W. Sex differences in asthma, atopy, and airway hyperresponsiveness in a university population. Ann. Allergy Asthma Immunol. 2003, 91:34-37.
11. Villar I.C., Hobbs A.J., Ahluwalia A. Sex differences in vascular function: implication of endothelium-derived hyperpolarizing factor. J. Endocrinol. 2008, 197:447-462.
12. Gillum T.L., Kuennen M.R., Schneider S., Moseley P. A review of sex differences in immune function after aerobic exercise. Exerc. Immunol. Rev. 2011, 17:104-121.
13. Giménez-Llort L., Arranz L., Maté I., De la Fuente M. Gender-specific neuroimmunoendocrine aging in a triple-transgenic 3xTg-AD mouse model for Alzheimer's disease and its relation with longevity. Neuroimmunomodulation 2008, 15:331-343.
14. Jevon M., Sabokbar A., Fujikawa Y., Hirayama T., Neale S.D., Wass J., Athanasou N.A. Gender- and age-related differences in osteoclast formation from circulating precursors. J. Endocrinol. 2002, 172:673-681.
15. Abdullah M., Chai P.S., Loh C.Y., Chong M.Y., Quay H.W., Vidyadaran S., Seman Z., Kandiah M., Seow H.F. Carica papaya increases regulatory T cells and reduces IFN-γ+ CD4+ T cells in healthy human subjects. Mol. Nutr. Food Res. 2011, 55:803-806.
16. Gupta V., Singh S.M. Gender dimorphism of macrophage response to GMCSF and IL-4 for differentiation into dendritic cells. Am. J. Reprod. Immunol. 2008, 60:43-54.
17. Girón-González J.A., Moral F.J., Elvira J., García-Gil D., Guerrero F., Gavilán I., Escobar L. Consistent production of a higher TH1:TH2 cytokine ratio by stimulated T cells in men compared with women. Eur. J. Endocrinol. 2000, 143:31-36.
18. Butler M. Animal Cell Culture and Technology: The Basics from Background to Bench 2004, BIOS Scientific Publishers, USA. second ed.
19. Chng W.J., Tan G.B., Kuperan P. Establishment of adult peripheral blood lymphocyte subset reference range for an Asian population by single-platform flow cytometry: influene of age sex and race and comparison with other published studies. Clin. Diagn. Lab. Immunol. 2004, 11:168-173.
20. Bain B.J. Ethnic and sex differences in the total and differential white cell count and platelet count. J. Clin. Pathol. 1996, 49:664-666.
21. Urassa W.K., Mbena E.M., Swai A.B., Gaines H., Mhalu F.S., Biberfeld G. Lymphocyte subset enumeration in HIV seronegative, HIV-1 seropositive adults in Dar es Salaam Tanzania: determination of reference values in males and females and comparison of two flow cytometric methods. J. Immunol. Methods 2003, 277:65-74.
22. Shan B., Yoshida Y., Sugiura T., Yamashita U. Stimulating activity of Chinese medicinal herbs on human lymphocytes in vitro. Int. J. Immunopharmacol. 1999, 21:149-159.
23. Hoffkes H., Schmidtke G., Uppenkamp M., Schmuker U. Multiparametric immunophenotyping of B cells in peripheral blood of healthy adults by flow cytometry. Clin. Diagn. Lab. Immunol. 1996, 3:30-36.
24. Mascarenhas R.E., Brodskyn C., Barbosa G., Clarencio J., Andrade-Filho A.S., Figueiroa F., et al. Peripheral blood mononuclear cells from individuals infected with human T cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens. Clin. Vaccine Immunol. 2006, 13:547-552.
25. Baran J., Kowalczyk D., Ozog M., Zembala M. Three-color flow cytometry detection of intracellular cytokines in peripheral blood mononuclear cells: comparative analysis of phorbol myristate acetate-ionomycin and phytohemagglutinin stimulation. Clin. Diagn. Lab. Immunol. 2001, 8:303-313.
26. Cherng J.M., Chiang W., Chiang L.C. Immunomodulatory activities of edible beans and related constituents from soybean. Food Chemistry 2007, 104:613-618.
27. Nielsen S.D., Afzelius P., Ersboll A.K., Nielsen J.O., Hansen J.E.S. Expression of the activation antigen CD69 predicts functionality of in vitro expanded peripheral blood mononuclear cells (PBMC) from healthy donors and HIV-infected patients. Clin. Exp. Immunol. 1998, 114:66-72.
28. Clement L.T., Dagg M.K., Lehmeyer J.E., Kiyotaki M. Two phenotypically distinct suppressor T cell subpopulations inhibit the induction of B cell differentiation by phytohemagglutinin. J. Immunol. 1983, 131:1214-1217.
29. Reddy M., Erikis E., Davis C., Davis H.M., Prabhakar U. Comparative analysis of lymphocyte activation marker expression and cytokine secretion profile in stimulated human peripheral blood mononuclear cell culture: an in vitro model to monitor cellular immune function. J. Immunol. Methods 2004, 293:127-142.
30. Biselli R., Matricardi P.M., D'amelio R., Fattorossi A. Multiparametric flow cytometric analysis of the kinetics of surface molecule expression after polyclonal activation of human peripheral blood T lymphocytes. Scand. J. Immunol. 1992, 35:439-447.
31. Ohta Y., Fujiwara K., Nishi T., Oka H. Normal values of peripheral lymphocyte populations and T cell subsets at a fixed time of day: a flow cytometric analysis with monoclonal antibodies in 210 healthy adults. Clin. Exp. Immunol. 1986, 64:146-149.
32. Roberts C.W., Walker W., Alexander J. Sex-associated hormones and immunity to protozoan parasites. Clin. Microbiol. Rev. 2001, 14:476-488.
33. Page G.G., Ben-Eliyahu S., Taylor A.N. The development of sexual dimorphism in natural killer cell activity and resistance to tumor metastasis in the Fischer 344 rat. J. Neuroimmunol. 1995, 63:69-77.
34. Dowdell K.C., Cua D.J., Kirkman E., Stohlman S.A. NKcells regulate CD4 responses prior to antigen encounter. J. Immunol. 2003, 171:234-239.
35. Cook I.F. Sexual dimorphism of humoral immunity with human vaccines. Vaccine 2008, 26:3551-3555.
36. Gabrilovac J., Marotti T. Gender-relateddifferencesin murine T- and B-lymphocyte proliferative ability in response to in vivo [Met(5)]enkephalin administration. Eur. J. Pharmacol. 2000, 392:101-108.
37. Brooks K.H. Adrenocorticotropin (ACTH) functions as a late-acting B cell growth factor and synergizes with interleukin 5. J. Mol. Cell Immunol. 1990, 4:327-335.
38. Das B.R., Bhanushali A.A., Khadapkar R., Jeswan K.D., Bhavsar M., Dasgupta A. Reference ranges for lymphocyte subsets in adults from western India: influence of sex, age and method of enumeration. Indian J. Med. Sci. 2008, 62:397-406.
39. Bofill M., Janossy G., Lee C.A., Macdonalds-Burns D., Phillips A.N., Sabin C., Timms A., Johnson M.A., Kernoff P.B.A. Laboratory control values for CD4 and CD8 T lymphocytes. Implications of r HIV-1 diagnosis. Clin. Exp. Immunol. 1992, 88:243-252.
40. Jiang L., Kang W., Lu H.Z., Pan X., Lin Q., Pan Q., Xue Y., Weng X., Tang Y.W. Normal values for CD4 and CD8 lymphocytes subsets in healthy Chinese adults from Shanghai. Clin. Diagn. Lab. Immunol. 2004, 11:811-813.
41. Athreya B.H., Pletcher J., Zulian F., Weiner D.B., Williams W.V. Subset-specific effects of sex hormones and pituitary gonadotropins on humanlymphocyteproliferation in vitro. Clin. Immunol. Immunopathol. 1993, 66:201-211.
42. Sato K., Nuki T., Gomita K., Weyand C.M., Hagiwara N. Statins reduce endothelial cell apoptosis via inhibition of TRAIL expression on activated CD4 T cells in acute coronary syndrome. Atherosclerosis 2010, 213:33-39.
43. Czyz A., Kołacz E., Angerer D., Zawilska K. Expression of activation antigens on lymphocyte surface and circulating platelet-leukocyte aggregates in ischaemicheart disease. Kardiol Pol. 2005, 62:189-200. (Discussion 201).