Early outcomes from three prospective trials of image-guided proton therapy for prostate cancer

International Journal of Radiation Oncology Biology Physics

Volumn 82, Issue 1, 2012, Pages 213-221

  Mendenhall, Nancy P ^a   Li, Zuofeng ^a   Hoppe, Bradford S ^a   Marcus Jr , Robert B ^a   Mendenhall, William M ^a   Nichols, R Charles ^a   Morris, Christopher G ^a   Williams, Christopher R ^b   Costa, Joseph ^b   Henderson, Randal ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

outcomes; Prostate cancer; proton therapy; toxicity

Indexed keywords

ANDROGEN DEPRIVATION; CUMULATIVE INCIDENCE; DISEASE PROGRESSION; DOCETAXEL; DOSE ESCALATION; GI SYMPTOMS; GRAY EQUIVALENT; HIGH EFFICACY; HIGH-RISK PATIENTS; IMAGE-GUIDED; MULTI VARIATE ANALYSIS; OUTCOMES; POST TREATMENT; PRE-TREATMENT; PROSTATE CANCERS; PROTON THERAPY; RECTAL WALL; SYMPTOM MANAGEMENT; UNIVARIATE;

COBALT; DISEASES; FAULT TOLERANT COMPUTER SYSTEMS; MULTIVARIANT ANALYSIS; NATURAL LANGUAGE PROCESSING SYSTEMS; PROTON BEAMS; PROTONS; TOXICITY;

PATIENT TREATMENT;

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIANDROGEN; ANTIBIOTIC AGENT; DOCETAXEL;

ABDOMINAL CRAMP; ADULT; AGED; ANDROGEN DEPRIVATION THERAPY; ANTIBIOTIC THERAPY; ARTICLE; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER HORMONE THERAPY; CANCER PALLIATIVE THERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER RISK; CHEMORADIOTHERAPY; CLINICAL TRIAL; FECES INCONTINENCE; FOLLOW UP; GASTROINTESTINAL SYMPTOM; HEMATURIA; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROCTITIS; PROSTATE CANCER; PROSTATITIS; PROTON THERAPY; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIATION INJURY; RECTUM HEMORRHAGE; TREATMENT OUTCOME; URINARY TRACT OBSTRUCTION; URINARY URGENCY; URINE INCONTINENCE; URINE RETENTION; UROGENITAL TRACT DISEASE;

ADULT; AGED; AGED, 80 AND OVER; ANDROGEN ANTAGONISTS; DISEASE PROGRESSION; DOSE FRACTIONATION; FIDUCIAL MARKERS; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL TRACT; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROSPECTIVE STUDIES; PROSTATIC NEOPLASMS; PROSTATITIS; PROTONS; RADIATION-SENSITIZING AGENTS; RADIOTHERAPY, IMAGE-GUIDED; RECTUM; TAXOIDS; TREATMENT OUTCOME; URINARY INCONTINENCE; UROGENITAL SYSTEM;

EID: 83955164323     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2010.09.024     Document Type: Article

References (29)

1. W.M. Mendenhall, R.C. Nichols, and R. Henderson Is radical prostatectomy the "gold standard" for localized prostate cancer? Am J Clin Oncol 33 5 2010 Oct 511 515
2. W.M. Mendenhall, R.H. Henderson, and D.J. Indelicato Erectile dysfunction after radiotherapy for prostate cancer Am J Clin Oncol 32 2009 443 447
3. W.M. Mendenhall, R.H. Henderson, and R.C. Nichols Postprostatectomy radiotherapy for prostate cancer Am J Clin Oncol 2009 Jul 31 [Epub ahead of print]
4. W.M. Mendenhall, R.H. Henderson, and N.P. Mendenhall Definitive radiotherapy for prostate cancer Am J Clin Oncol 31 2008 496 503
5. S.T. Peeters, W.D. Heemsbergen, and P.C. Koper Dose-response in radiotherapy for localized prostate cancer: Results of the Dutch multicenter randomized phase III trial comparing 68 Gy of radiotherapy with 78 Gy J Clin Oncol 24 2006 1990 1996
6. D.P. Dearnaley, M.R. Sydes, and J.D. Graham Escalated-dose versus standard-dose conformal radiotherapy in prostate cancer: First results from the MRC RT01 randomised controlled trial Lancet Oncol 8 2007 475 487
7. D.A. Kuban, S.L. Tucker, and L. Dong Long-term results of the M.D. Anderson randomized dose-escalation trial for prostate cancer Int J Radiat Oncol Biol Phys 70 2008 67 74
8. J.M. Michalski, K. Bae, and M. Roach Long-term toxicity following 3D conformal radiation therapy for prostate cancer from the RTOG 9406 phase I/II dose escalation study Int J Radiat Oncol Biol Phys 76 2010 14 22
9. M.J. Zelefsky, Y. Yamada, and Z. Fuks Long-term results of conformal radiotherapy for prostate cancer: Impact of dose escalation on biochemical tumor control and distant metastases-free survival outcomes Int J Radiat Oncol Biol Phys 71 2008 1028 1033
10. B. Engels, G. Soete, and K. Tournel Helical tomotherapy with simultaneous integrated boost for high-risk and lymph node-positive prostate cancer: Early report on acute and late toxicity Technol Cancer Res Treat 8 2009 353 359
11. N.C. Townsend, B.J. Huth, and W. Ding Acute toxicity after CyberKnife-delivered hypofractionated radiotherapy for treatment of prostate cancer Am J Clin Oncol 2010 Jan 8 [Epub ahead of print]
12. M.G. Sanda, R.L. Dunn, and J. Michalski Quality of life and satisfaction with outcome among prostate-cancer survivors N Engl J Med 358 2008 1250 1261
13. M.J. Zelefsky, E.J. Levin, and M. Hunt Incidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for localized prostate cancer Int J Radiat Oncol Biol Phys 70 2008 1124 1129
14. P.A. Kupelian, J. Ciezki, and C.A. Reddy Effect of increasing radiation doses on local and distant failures in patients with localized prostate cancer Int J Radiat Oncol Biol Phys 71 2008 16 22
15. P.A. Kupelian, T.R. Willoughby, and C.A. Reddy Hypofractionated intensity-modulated radiotherapy (70 Gy at 2.5 Gy per fraction) for localized prostate cancer: Cleveland Clinic experience Int J Radiat Oncol Biol Phys 68 2007 1424 1430
16. G. Arcangeli, B. Saracino, and S. Gomellini A prospective phase III randomized trial of hypofractionation versus conventional fractionation in patients with high-risk prostate cancer Int J Radiat Oncol Biol Phys 78 1 2010 Sep 1 11 18 Epub 2010 Jan 4
17. H.D. Thames, D. Kuban, and L.B. Levy The role of overall treatment time in the outcome of radiotherapy of prostate cancer: An analysis of biochemical failure in 4839 men treated between 1987 and 1995 Radiother Oncol 96 1 2010 Jul 6 12 Epub 2010 Apr 17
18. J.M. Michalski, H. Gay, and A. Jackson Radiation dose-volume effects in radiation-induced rectal injury Int J Radiat Oncol Biol Phys 76 2010 S123 S129
19. J.D. Slater, C.J. Rossi Jr., and L.T. Yonemoto Proton therapy for prostate cancer: The initial Loma Linda University experience Int J Radiat Oncol Biol Phys 59 2004 348 352
20. A.L. Zietman, K. Bae, and J.J. Coen A Prospective Phase I/II Study using Proton Beam Radiation to Deliver 82GyE to Men with Localized Prostate Cancer: Preliminary Results of ACR 0312 [Abstr.] Int J Rad Oncol Bio Phys 72 2008 S77
21. C.J. Rossi Jr., J.D. Slater, and L.T. Yonemoto Influence of patient age on biochemical freedom from disease in patients undergoing conformal proton radiotherapy of organ-confined prostate cancer Urology 64 2004 729 732
22. A.L. Zietman Correction: Inaccurate analysis and results in a study of radiation therapy in adenocarcinoma of the prostate JAMA 299 2008 898 899
23. A.L. Zietman, K. Bae, and J.D. Slater Randomized trial comparing conventional-dose with high-dose conformal radiation therapy in early-stage adenocarcinoma of the prostate: Long-term results from Proton Radiation Oncology Group/American College of Radiology 95-09 J Clin Oncol 28 2010 1106 1111
24. A.L. Zietman, M.L. DeSilvio, and J.D. Slater Comparison of conventional-dose vs. high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: A randomized controlled trial JAMA 294 2005 1233 1239
25. U. Schneider, E. Pedroni, and A. Lomax The calibration of CT Hounsfield units for radiotherapy treatment planning Phys Med Biol 41 1996 111 124
26. A.N. Viswanathan, E.D. Yorke, and L.B. Marks Radiation dose-volume effects of the urinary bladder Int J Radiat Oncol Biol Phys 76 2010 S116 S122
27. C. Vargas, A. Fryer, and C. Mahajan Dose-volume comparison of proton therapy and intensity-modulated radiotherapy for prostate cancer Int J Radiat Oncol Biol Phys 70 2008 744 751
28. B.S. Chera, C. Vargas, and C.G. Morris Dosimetric study of pelvic proton radiotherapy for high-risk prostate cancer Int J Radiat Oncol Biol Phys 75 2009 994 1002
29. J.A. Talcott, C. Rossi, and W.U. Shipley Patient-reported long-term outcomes after conventional and high-dose combined proton and photon radiation for early prostate cancer JAMA 303 2010 1046 1053