Effect of Increasing Radiation Doses on Local and Distant Failures in Patients With Localized Prostate Cancer

International Journal of Radiation Oncology Biology Physics

Volumn 71, Issue 1, 2008, Pages 16-22

  Kupelian, Patrick A ^a   Ciezki, Jay ^b   Reddy, Chandana A ^b   Klein, Eric A ^b   Mahadevan, Arul ^b  

^a M D ANDERSON CANCER CENTER ORLANDO   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Distant metastasis; Dose; Local control; Prostatic neoplasms; Radiotherapy

Indexed keywords

ANTIGENS; BIOCHEMICAL ENGINEERING; DOSIMETRY; FAILURE ANALYSIS; PATIENT MONITORING; RADIOTHERAPY;

DISTANT METASTASIS; DOSES; LOCAL CONTROL; PROSTATIC NEOPLASMS;

ONCOLOGY;

PROSTATE SPECIFIC ANTIGEN;

ADULT; AGED; ARTICLE; CANCER LOCALIZATION; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; DOSIMETRY; EXTERNAL BEAM RADIOTHERAPY; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; METASTASIS; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROSTATE CANCER; RADIATION DOSE; TREATMENT FAILURE;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; DISEASE-FREE SURVIVAL; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROPORTIONAL HAZARDS MODELS; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; RADIOTHERAPY DOSAGE;

EID: 41749108426     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2007.09.020     Document Type: Article

References (25)

1. Kupelian P., Kuban D., Thames H., et al. Improved biochemical relapse-free survival with increased external radiation doses in patients with localized prostate cancer: The combined experience of nine institutions in patients treated in 1994 and 1995. Int J Radiat Oncol Biol Phys 61 (2005) 415-419
2. Kupelian P.A., Mohan D.S., Lyons J., et al. Higher than standard radiation doses (72 Gy or greater) with or without androgen deprivation in the treatment of localized prostate cancer. Int J Radiat Oncol Biol Phys 46 (2000) 567-574
3. Pollack A., Zagars G.K., Starkschall G., et al. Prostate cancer radiation dose response: Results of the M.D. Anderson phase III randomized trial. Int J Radiat Oncol Biol Phys 53 (2002) 1097-1105
4. Zelefsky M.J., Leibel S.A., Gaudin P.B., et al. Dose escalation with three-dimensional conformal radiation therapy affects the outcome in prostate cancer. Int J Radiat Oncol Biol Phys 41 (1998) 491-500
5. Zietman A.L., DeSilvio M.L., Slater J.D., et al. Comparison of conventional-dose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: A randomized controlled trial. JAMA 294 (2005) 1233-1239
6. D'Amico A.V., Whittington R., Malkowicz S.B., et al. Pretreatment nomogram for prostate-specific antigen recurrence after radical prostatectomy or external-beam radiation therapy for clinically localized prostate cancer. J Clin Oncol 17 (1999) 168-172
7. Kupelian P.A., Thakkar V.V., Khuntia D., et al. Hypofractionated intensity-modulated radiotherapy (70 Gy at 2.5 Gy per fraction) for localized prostate cancer: Long-term outcomes. Int J Radiat Oncol Biol Phys 63 (2005) 1463-1468
8. Roach III M., Hanks G., Thames Jr. H., et al. Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: Recommendations of the RTOG-ASTRO Phoenix Consensus Conference. Int J Radiat Oncol Biol Phys 65 (2006) 965-974
9. Morgan P.B., Hanlon A.L., Horwitz E.M., et al. Radiation dose and late failures in prostate cancer. Int J Radiat Oncol Biol Phys 67 (2007) 1074-1081
10. Horwitz E.M., Thames H.D., Kuban D.A., et al. Definitions of biochemical failure that best predict clinical failure in patients with prostate cancer treated with external beam radiation alone: A multi-institutional pooled analysis. J Urol 173 (2005) 797-802
11. Thames H., Kuban D., Levy L., et al. Comparison of alternative biochemical failure definitions based on clinical outcome in 4839 prostate cancer patients treated by external beam radiotherapy between 1986 and 1995. Int J Radiat Oncol Biol Phys 57 (2003) 929-943
12. Pollack A., Hanlon A.L., Movsas B., et al. Biochemical failure as a determinant of distant metastasis and death in prostate cancer treated with radiotherapy. Int J Radiat Oncol Biol Phys 57 (2003) 19-23
13. Pickles T. Prostate-specific antigen (PSA) bounce and other fluctuations: Which biochemical relapse definition is least prone to PSA false calls? An analysis of 2030 men treated for prostate cancer with external beam or brachytherapy with or without adjuvant androgen deprivation therapy. Int J Radiat Oncol Biol Phys 64 (2006) 1355-1359
14. Williams S.G., Duchesne G.M., Gogna N.K., et al. An international multicenter study evaluating the impact of an alternative biochemical failure definition on the judgment of prostate cancer risk. Int J Radiat Oncol Biol Phys 65 (2006) 351-357
15. Williams S.G., Pickles T., Kestin L., et al. A multicenter study demonstrating discordant results from electronic prostate-specific antigen biochemical failure calculation systems. Int J Radiat Oncol Biol Phys 65 (2006) 1494-1500
16. Lyons J.A., Kupelian P.A., Mohan D.S., et al. Importance of high radiation doses (72 Gy or greater) in the treatment of stage T1-T3 adenocarcinoma of the prostate. Urology 55 (2000) 85-90
17. Zelefsky M.J., Fuks Z., Hunt M., et al. High-dose intensity modulated radiation therapy for prostate cancer: Early toxicity and biochemical outcome in 772 patients. Int J Radiat Oncol Biol Phys 53 (2002) 1111-1116
18. Zelefsky M.J., Chan H., Hunt M., et al. Long-term outcome of high dose intensity modulated radiation therapy for patients with clinically localized prostate cancer. J Urol 176 (2006) 1415-1419
19. Peeters S.T., Hoogeman M.S., Heemsbergen W.D., et al. Rectal bleeding, fecal incontinence, and high stool frequency after conformal radiotherapy for prostate cancer: Normal tissue complication probability modeling. Int J Radiat Oncol Biol Phys 66 (2006) 11-19
20. Michalski J.M., Winter K., Purdy J.A., et al. Preliminary evaluation of low-grade toxicity with conformal radiation therapy for prostate cancer on RTOG 9406 dose levels I and II. Int J Radiat Oncol Biol Phys 56 (2003) 192-198
21. Teh B., Uhl B., Augspurger M., et al. Intensity-modulated radiotherapy (IMRT) for localized prostate cancer: Preliminary results of acute toxicity compared to conventional and six-field conformal approach. [Abstract]. Int J Radiat Oncol Biol Phys 42 Suppl. 1 (1998) 219
22. Stock R.G., Stone N.N., Tabert A., et al. A dose-response study for I-125 prostate implants. Int J Radiat Oncol Biol Phys 41 (1998) 101-108
23. Zelefsky M.J., Fuks Z., Hunt M., et al. High dose radiation delivered by intensity modulated conformal radiotherapy improves the outcome of localized prostate cancer. J Urol 166 (2001) 876-881
24. Morgan P.B., Hanlon A.L., Horwitz E.M., et al. Timing of biochemical failure and distant metastatic disease for low-, intermediate-, and high-risk prostate cancer after radiotherapy. Cancer 110 (2007) 68-80
25. Eade T.N., Hanlon A.L., Horwitz E.M., et al. What dose of external-beam radiation is high enough for prostate cancer?. Int J Radiat Oncol Biol Phys 68 (2007) 682-689