Angiotensin-(1-7) through Mas receptor up-regulates neuronal norepinephrine transporter via Akt and Erk1/2-dependent pathways

Journal of Neurochemistry

Volumn 120, Issue 1, 2012, Pages 46-55

  Lopez Verrilli, María A ^a   Rodriguez Fermepín, Martín ^a   Longo Carbajosa, Nadia ^a   Landa, Silvina ^b   Cerrato, Bruno D ^a   García, Silvia ^b   Fernandez, Belisario E ^a   Gironacci, Mariela M ^a  

^a Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^b INSTITUTO DE INVESTIGACIONES MÉDICAS ALFREDO LANARI   (Argentina)

Author keywords

angiotensin (1 7); hypertension; Mas receptor; norepinephrine transporter; norepinephrine uptake

Indexed keywords

ANGIOTENSIN[1-7]; CYCLOHEXIMIDE; G PROTEIN COUPLED RECEPTOR; MAS RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NORADRENALIN TRANSPORTER; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HYPOTHALAMUS; MALE; NEWBORN; NONHUMAN; NORADRENALIN UPTAKE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SYNAPSE; UPREGULATION; WESTERN BLOTTING;

ANGIOTENSIN I; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEURONS; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; ONCOGENE PROTEIN V-AKT; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECEPTORS, G-PROTEIN-COUPLED; RNA, MESSENGER; SIGNAL TRANSDUCTION; UP-REGULATION;

RATTUS;

EID: 83855163444     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07552.x     Document Type: Article

References (40)

1. Alessi D. R., Andjelkovic M., Caudwell B., Cron P., Morrice N., Cohen P., and, Hemmings B. A., (1996) Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15, 6541-6551. (Pubitemid 26413787)
2. Apparsundaram S., Sung U., Price R. D., and, Blakely R. D., (2001) Trafficking-dependent and -independent pathways of neurotransmitter transporter regulation differentially involving p38 mitogen-activated protein kinase revealed in studies of insulin modulation of norepinephrine transport in SK-N-SH cells. J. Pharmacol. Exp. Ther. 299, 666-77. (Pubitemid 32979681)
3. Bönisch H., and, Brüss M., (2006) The norepinephrine transporter in physiology and disease. Handb. Exp. Pharmacol. 175, 485-524.
4. De Wardener H. E., (2001) The hypothalamus and hypertension. Physiol. Rev. 81, 1599-1658. (Pubitemid 32947779)
5. Di Nunzio A. S., Legaz G., Rodano V., Bianciotti L. G., and, Vatta M. S., (2004) Modulatory effect of endothelin-1 and -3 on neuronal norepinephrine release in the rat posterior hypothalamus. Regul. Pept. 118, 51-59. (Pubitemid 38167367)
6. Dias-Peixoto M. F., Santos R. A. S., Gomes E. R. M., et al. (2008) Molecular mechanisms involved in the angiotensin-(1-7)/Mas signaling pathway in cardiomyocytes. Hypertension 52, 542-548.
7. Eisenhofer G., (2001) The role of neuronal and extraneuronal plasma membrane transporters in the inactivation of peripheral catecholamines. Pharmacol. Ther. 91, 35-62. (Pubitemid 33055773)
8. Esler M., Jackman G., Bobik A., Leonard P., Kelleher D., Skews H., Jennings G., and, Korner P., (1981) Norepinephrine kinetics in essential hypertension. Defective neuronal uptake of norepinephrine in some patients. Hypertension 3, 149-156. (Pubitemid 11117990)
9. Ferrario C. M., Chappell M. C., Tallant E. A., Brosnihan K. B., and, Diz D. I., (1997) Counterregulatory actions of angiotensin-(1-7). Hypertension 30 [ 2 ], 535-541. (Pubitemid 27444228)
10. Ferrario C. M., Ahmad S., Joyner J., and, Varagic J., (2010) Advances in the renin angiotensin system focus on angiotensin-converting enzyme 2 and angiotensin-(1-7). Adv. Pharmacol. 59, 197-233.
11. Ferreira A. J., Santos R. A. S., Bradford C. N., Mecca C. N., Sumners C., Katovich M. J., and, Raizada M. K., (2010) Therapeutic implications of the vasoprotective axis of the renin-angiotensin system in cardiovascular diseases. Hypertension 55, 207-213.
12. Gelband C. H., Sumners C., Lu D., and, Raizada M. K., (1997) Angiotensin receptors and norepinephrine neuromodulation: implications of functional coupling. Regul. Pept. 72, 139-144.
13. Giani J. F., Gironacci M. M., Muñoz M. C., Peña C., Turyn D., and, Dominici F. P., (2007) Angiotensin-(1-7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in vivo: role of the AT1 and Mas receptors. Am. J. Physiol. Heart Circ. Physiol. 293, H1154-H1163. (Pubitemid 47254217)
14. Gironacci M. M., Rodríguez-Fermepín M., Vatta M., Fernandez B. E., Rubio M., and, Peña C., (2000) Angiotensin-(1-7) does not affect norepinephrine neuronal uptake or catabolism in rat hypothalamus and atria. Cell. Mol. Neurobiol. 20, 773-779.
15. Gironacci M. M., Valera M. S., Yujnovsky I., and, Peña C., (2004a) Angiotensin-(1-7) inhibitory mechanism of norepinephrine release in hypertensive rats. Hypertension 44, 783-787. (Pubitemid 39435254)
16. Gironacci M. M., Yujnovsky I., Gorzalczany S., Taira C., and, Peña C., (2004b) Angiotensin-(1-7) inhibits the angiotensin II-enhanced norepinephrine release in coarcted hypertensive rats. Regul. Pept. 118, 45-49. (Pubitemid 38167366)
17. Habecker B. A., Willison B. D., Shi X., and, Woodward W. R., (2006) Chronic depolarization stimulates norepinephrine transporter expression via catecholamines. J. Neurochem. 97, 1044-1051.
18. Hahn M. K., Robertson D., and, Blakely R. D., (2003) A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters. J. Neurosci. 23, 4470-4478. (Pubitemid 36706177)
19. Höcht C., Gironacci M. M., Mayer M. A., Schuman M., Bertera F. M., and, Taira C. A., (2008) Involvement of angiotensin-(1-7) in the hypothalamic hypotensive effect of captopril in sinoaortic denervated rats. Regul. Pept. 146, 58-66.
20. Hope S. I., Nabhen S. L., Soria C., Bianciotti L. G., and, Vatta M. S., (2010) Endothelin-1 and -3 modulate the neuronal norepinephrine transporter through multiple signalling pathways in the rat posterior hypothalamus. Neurochem. Int. 57, 306-313.
21. Kaye D. M., Gruskin S., Smith A. I., and, Esler M. D., (2000) Nitric oxide mediated modulation of norepinephrine transport: identification of a potential target for S-nitrosylation. Br. J. Pharmacol. 130, 1060-1064. (Pubitemid 30453540)
22. Kvetnansky R., Sabban E. L., and, Palkovits M., (2009) Catecholaminergic systems in stress: structural and molecular genetic approaches. Physiol. Rev. 89, 535-606.
23. Lambert E., Eikelis N., Ester M., et al. (2008) Altered sympathetic nervous reactivity and norepinephrine transporter expression in patients with postural tachycardia syndrome. Circ. Arrhythmia Electrophysiol. 1, 103-109.
24. Lopez Verrilli M. A., Pirola C. J., Pascual M. M., Dominici F. P., Turyn D., and, Gironacci M. M., (2009) Angiotensin-(1-7) through AT2 receptors mediates tyrosine hydroxylase degradation via the ubiquitin-proteasome pathway. J. Neurochem. 109, 326-35.
25. Lu D., Yu K., Paddy M. R., Rowland N. E., and, Raizada M. K., (1996) Regulation of norepinephrine transport system by angiotensin II in neuronal cultures of normotensive and spontaneously hypertensive rat brains. Endocrinology 137, 763-772. (Pubitemid 26049888)
26. Mandela P., and, Ordway G. A., (2006) The norepinephrine transporter and its regulation. J. Neurochem. 97, 310-333.
27. Ono K., Iwanaga Y., Mannami T., Kokubo Y., Tomoike H., Komamura K., Shioji K., Yasui N., Tago N., and, Iwai N., (2003) Epidemiological evidence of an association between SLC6A2 genepolymorphism and hypertension. Hypertens. Res. 26, 685-689. (Pubitemid 37258654)
28. Padia S. H., Kemp B. A., Howell N. L., Fournie-Zaluski M. C., Roques B. P., and, Carey R. M., (2008) Conversion of renal angiotensin II to angiotensin III is critical for AT2 receptor-mediated natriuresis in rats. Hypertension 51, 460-465. (Pubitemid 351156433)
29. Pearson G., Robinson F., Beers Gibson T., Xu B., Karandikar M., Berman K., and, Cobb M. H., (2001) Mitogen-activated protein kinase pathways: regulation and physiological functions. Endocr. Rev. 22, 153-183. (Pubitemid 32458157)
30. Raizada M. K., Lu D., Tang W., Kurian P., and, Sumners C., (1993) Increased angiotensin II type-1 receptor gene expression in neuronal cultures from spontaneously hypertensive rats. Endocrinology 132, 1715-1722. (Pubitemid 23110547)
31. Ramamoorthy S., Shippenberg T. S., and, Jayanthi L. D., (2011) Regulation of monoamine transporters: role of transporter phosphorylation. Pharm. Ther. 129, 220-238.
32. Sampaio W. O., Souza dos Santos R. A., Faria-Silva R., da Mata Machad L. T., Schiffrin E. L., and, Touyz R. M., (2007) Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways. Hypertension 49, 185-192. (Pubitemid 46360359)
33. Torres G. E., Gainetdinov R. R., and, Caron M. G., (2003) Plasma membrane monoamine transporters: structure, regulation and function. Nat. Rev. Neurosci. 4, 13-25. (Pubitemid 37271085)
34. Veerasingham S. J., and, Raizada M. K., (2003) Brain renin-angiotensin system dysfunction in hypertension: recent advances and perspectives. Br. J. Pharmacol. 139, 191-202. (Pubitemid 36760351)
35. Wright J. W., Tamura-Myers E., Wilson W. L., Roques B. P., Llorens-Cortes C., Speth R. C., and, Harding J. W., (2003) Conversion of brain angiotensin II to angiotensin III is critical for pressor response in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284, R725-733. (Pubitemid 36342805)
36. Xu P., Sriramula S., and, Lazartigues E., (2011) ACE2/Ang-(1-7)/Mas pathway in the brain: the Axis of Good. Am. J. Physiol. Regul. Integr. Comp. Physiol. 300, R804-R817.
37. Yamazaki S., and, Takeshige K., (2008) Protein synthesis inhibitors enhance the expression of mRNAs for early inducible inflammatory genes via mRNA stabilization. Biochem. Biophys. Acta 1779, 108-114.
38. Yang H., and, Raizada M. K., (1999) Role of phosphatidylinositol 3-kinase in angiotensin II regulation of norepinephrine neuromodulation in brain neurons of the spontaneously hypertensive rat. J. Neurosci. 19, 2413-2423. (Pubitemid 29162391)
39. Yu K., Lu D., Rowland N. E., and, Raizada M. K., (1996) Angiotensin II regulation of tyrosine hydroxylase gene expression in the neuronal cultures of normotensive and spontaneously hypertensive rats. Endocrinology 137, 3566-3576. (Pubitemid 26250213)
40. Zimpelmann J., and, Burns K. D., (2009) Angiotensin-(1-7) activates growth-stimulatory pathways in human mesangial cells. Am. J.Physiol. Renal Physiol. 296, F337-F346.