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Volumn 6, Issue 12, 2011, Pages

CCL5 neutralization restricts cancer growth and potentiates the targeting of PDGFRβ in colorectal carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR5; DNA VACCINE; IMMUNOGLOBULIN G ANTIBODY; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; RANTES; AMIDE; NEUTRALIZING ANTIBODY; QUATERNARY AMMONIUM DERIVATIVE;

EID: 83755183659     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028842     Document Type: Article
Times cited : (96)

References (48)
  • 1
    • 8144228952 scopus 로고    scopus 로고
    • Friends or foes - bipolar effects of the tumour stroma in cancer
    • Mueller MM, Fusenig NE, (2004) Friends or foes- bipolar effects of the tumour stroma in cancer. Nat Rev Cancer 4 (11): 839-49.
    • (2004) Nat Rev Cancer , vol.4 , Issue.11 , pp. 839-849
    • Mueller, M.M.1    Fusenig, N.E.2
  • 2
    • 9244227134 scopus 로고    scopus 로고
    • Stromal fibroblasts in cancer initiation and progression
    • Bhowmick NA, Neilson EG, Moses HL, (2004) Stromal fibroblasts in cancer initiation and progression. Nature 432 (7015): 332-7.
    • (2004) Nature , vol.432 , Issue.7015 , pp. 332-337
    • Bhowmick, N.A.1    Neilson, E.G.2    Moses, H.L.3
  • 3
    • 33645739790 scopus 로고    scopus 로고
    • Tumor stroma and regulation of cancer development
    • Tlsty TD, Coussens LM, (2006) Tumor stroma and regulation of cancer development. Annu Rev Pathol 1: 119-50.
    • (2006) Annu Rev Pathol , vol.1 , pp. 119-150
    • Tlsty, T.D.1    Coussens, L.M.2
  • 5
    • 0031708626 scopus 로고    scopus 로고
    • Clinical relevance of transforming growth factor alpha, epidermal growth factor receptor, p53, and Ki67 in colorectal liver metastases and corresponding primary tumors
    • De Jong KP, Stellema R, Karrenbeld A, Koudstaal J, Gouw AS, et al. (1998) Clinical relevance of transforming growth factor alpha, epidermal growth factor receptor, p53, and Ki67 in colorectal liver metastases and corresponding primary tumors. Hepatology 28 (4): 971-9.
    • (1998) Hepatology , vol.28 , Issue.4 , pp. 971-979
    • de Jong, K.P.1    Stellema, R.2    Karrenbeld, A.3    Koudstaal, J.4    Gouw, A.S.5
  • 6
    • 0026471016 scopus 로고
    • Prognostic markers of colorectal cancer: an evaluation of DNA content, epidermal growth factor receptor, and Ki-67
    • Hemming AW, Davis NL, Kluftinger A, Robinson B, Quenville NF, et al. (1992) Prognostic markers of colorectal cancer: an evaluation of DNA content, epidermal growth factor receptor, and Ki-67. J Surg Oncol 51 (3): 147-52.
    • (1992) J Surg Oncol , vol.51 , Issue.3 , pp. 147-152
    • Hemming, A.W.1    Davis, N.L.2    Kluftinger, A.3    Robinson, B.4    Quenville, N.F.5
  • 7
    • 0037431557 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma
    • Kuwai T, Kitadai Y, Tanaka S, Onogawa S, Matsutani N, et al. (2003) Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma. Int J Cancer 105 (2): 176-81.
    • (2003) Int J Cancer , vol.105 , Issue.2 , pp. 176-181
    • Kuwai, T.1    Kitadai, Y.2    Tanaka, S.3    Onogawa, S.4    Matsutani, N.5
  • 8
    • 2342591455 scopus 로고    scopus 로고
    • The discovery of receptor tyrosine kinases: targets for cancer therapy
    • Gschwind A, Fischer OM, Ullrich A, (2004) The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat Rev Cancer 4 (5): 361-70.
    • (2004) Nat Rev Cancer , vol.4 , Issue.5 , pp. 361-370
    • Gschwind, A.1    Fischer, O.M.2    Ullrich, A.3
  • 9
    • 3042822267 scopus 로고    scopus 로고
    • Cancer and the chemokine network
    • Balkwill F, (2004) Cancer and the chemokine network. Nat Rev Cancer 4 (7): 540-50.
    • (2004) Nat Rev Cancer , vol.4 , Issue.7 , pp. 540-550
    • Balkwill, F.1
  • 10
    • 65549143703 scopus 로고    scopus 로고
    • Expression of chemokines and chemokine receptors in human colon cancer
    • Erreni M, Bianchi P, Laghi L, Mirolo M, Fabbri M, et al. (2009) Expression of chemokines and chemokine receptors in human colon cancer. Methods Enzymol 460: 105-21.
    • (2009) Methods Enzymol , vol.460 , pp. 105-121
    • Erreni, M.1    Bianchi, P.2    Laghi, L.3    Mirolo, M.4    Fabbri, M.5
  • 11
    • 67349193581 scopus 로고    scopus 로고
    • Organ-specific inhibition of metastatic colon carcinoma by CXCR3 antagonism
    • Cambien B, Karimdjee BF, Richard-Fiardo P, Bziouech H, Barthel R, et al. (2009) Organ-specific inhibition of metastatic colon carcinoma by CXCR3 antagonism. Br J Cancer 100 (11): 1755-64.
    • (2009) Br J Cancer , vol.100 , Issue.11 , pp. 1755-1764
    • Cambien, B.1    Karimdjee, B.F.2    Richard-Fiardo, P.3    Bziouech, H.4    Barthel, R.5
  • 12
    • 70350707759 scopus 로고    scopus 로고
    • Antagonism of chemokine receptor CXCR3 inhibits osteosarcoma metastasis to lungs
    • Pradelli E, Karimdjee-Soilihi B, Michiels JF, Ricci JE, Millet MA, et al. (2009) Antagonism of chemokine receptor CXCR3 inhibits osteosarcoma metastasis to lungs. Int J Cancer 125 (11): 2586-94.
    • (2009) Int J Cancer , vol.125 , Issue.11 , pp. 2586-2594
    • Pradelli, E.1    Karimdjee-Soilihi, B.2    Michiels, J.F.3    Ricci, J.E.4    Millet, M.A.5
  • 13
    • 0033568215 scopus 로고    scopus 로고
    • Elevated expression of the CC chemokine regulated on activation, normal T cell expressed and secreted (RANTES) in advanced breast carcinoma
    • Luboshits G, Shina S, Kaplan O, Engelberg S, Nass D, et al. (1999) Elevated expression of the CC chemokine regulated on activation, normal T cell expressed and secreted (RANTES) in advanced breast carcinoma. Cancer Res 59 (18): 4681-7.
    • (1999) Cancer Res , vol.59 , Issue.18 , pp. 4681-4687
    • Luboshits, G.1    Shina, S.2    Kaplan, O.3    Engelberg, S.4    Nass, D.5
  • 14
    • 33646243769 scopus 로고    scopus 로고
    • Inflammation, genetic polymorphisms in proinflammatory genes TNF-α, RANTES, and CCR5, and risk of pancreatic adenocarcinoma
    • Duell EJ, Casella DP, Burk RD, Kelsey KT, Holly EA, (2006) Inflammation, genetic polymorphisms in proinflammatory genes TNF-α, RANTES, and CCR5, and risk of pancreatic adenocarcinoma. Cancer Epidemiol Biomarkers Prev 15 (4): 726-31.
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , Issue.4 , pp. 726-731
    • Duell, E.J.1    Casella, D.P.2    Burk, R.D.3    Kelsey, K.T.4    Holly, E.A.5
  • 15
    • 33748445084 scopus 로고    scopus 로고
    • Elevated serum RANTES levels in patients with ovarian cancer correlate with the extent of the disorder
    • Tsukishiro S, Suzumori N, Nishikawa H, Arakawa A, Suzumori K, (2006) Elevated serum RANTES levels in patients with ovarian cancer correlate with the extent of the disorder. Gynecol Oncol 102 (3): 542-5.
    • (2006) Gynecol Oncol , vol.102 , Issue.3 , pp. 542-545
    • Tsukishiro, S.1    Suzumori, N.2    Nishikawa, H.3    Arakawa, A.4    Suzumori, K.5
  • 16
    • 0035120421 scopus 로고    scopus 로고
    • Correlation of tissue and plasma RANTES levels with disease course in patients with breast or cervical cancer
    • Niwa Y, Akamatsu H, Niwa H, Sumi H, Ozaki Y, et al. (2001) Correlation of tissue and plasma RANTES levels with disease course in patients with breast or cervical cancer. Clin Cancer Res 7 (2): 285-9.
    • (2001) Clin Cancer Res , vol.7 , Issue.2 , pp. 285-289
    • Niwa, Y.1    Akamatsu, H.2    Niwa, H.3    Sumi, H.4    Ozaki, Y.5
  • 17
    • 0037220119 scopus 로고    scopus 로고
    • Elevated levels of circulating platelet microparticles, VEGF, IL-6 and RANTES in patients with gastric cancer: possible role of a metastasis predictor
    • Kim HK, Song KS, Park YS, Kang YH, Lee YJ, et al. (2003) Elevated levels of circulating platelet microparticles, VEGF, IL-6 and RANTES in patients with gastric cancer: possible role of a metastasis predictor. Eur J Cancer 39 (2): 184-91.
    • (2003) Eur J Cancer , vol.39 , Issue.2 , pp. 184-191
    • Kim, H.K.1    Song, K.S.2    Park, Y.S.3    Kang, Y.H.4    Lee, Y.J.5
  • 18
    • 31944433180 scopus 로고    scopus 로고
    • Expression of CCL5 (RANTES) and CCR5 in prostate cancer
    • Vaday GG, Peehl DM, Kadam PA, Lawrence DM, (2006) Expression of CCL5 (RANTES) and CCR5 in prostate cancer. Prostate 66 (2): 124-34.
    • (2006) Prostate , vol.66 , Issue.2 , pp. 124-134
    • Vaday, G.G.1    Peehl, D.M.2    Kadam, P.A.3    Lawrence, D.M.4
  • 19
    • 33748061991 scopus 로고    scopus 로고
    • The chemokine CCL5 as a potential prognostic factor predicting disease progression in stage II breast cancer patients
    • Yaal-Hahoshen N, Shina S, Leider-Trejo L, Barnea I, Shabtai EL, et al. (2006) The chemokine CCL5 as a potential prognostic factor predicting disease progression in stage II breast cancer patients. Clin Cancer Res 12 (15): 4474-80.
    • (2006) Clin Cancer Res , vol.12 , Issue.15 , pp. 4474-4480
    • Yaal-Hahoshen, N.1    Shina, S.2    Leider-Trejo, L.3    Barnea, I.4    Shabtai, E.L.5
  • 20
    • 41549127804 scopus 로고    scopus 로고
    • Gastric cancer cells exploit CD4+ cell-derived CCL5 for their growth and prevention of CD8+ cell-involved tumor elimination
    • Sugasawa H, Ichikura T, Kinoshita M, Ono S, Majima T, et al. (2008) Gastric cancer cells exploit CD4+ cell-derived CCL5 for their growth and prevention of CD8+ cell-involved tumor elimination. Int J Cancer 122 (11): 2535-41.
    • (2008) Int J Cancer , vol.122 , Issue.11 , pp. 2535-2541
    • Sugasawa, H.1    Ichikura, T.2    Kinoshita, M.3    Ono, S.4    Majima, T.5
  • 21
    • 34948896045 scopus 로고    scopus 로고
    • Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
    • Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, et al. (2007) Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449 (7162): 557-63.
    • (2007) Nature , vol.449 , Issue.7162 , pp. 557-563
    • Karnoub, A.E.1    Dash, A.B.2    Vo, A.P.3    Sullivan, A.4    Brooks, M.W.5
  • 22
    • 63149148047 scopus 로고    scopus 로고
    • Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer
    • Tan MC, Goedegebuure PS, Belt BA, Flaherty B, Sankpal N, et al. (2009) Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer. J Immunol 182 (3): 1746-55.
    • (2009) J Immunol , vol.182 , Issue.3 , pp. 1746-1755
    • Tan, M.C.1    Goedegebuure, P.S.2    Belt, B.A.3    Flaherty, B.4    Sankpal, N.5
  • 23
    • 77955430866 scopus 로고    scopus 로고
    • Anibamine, a natural product CCR5 antagonist, as a novel lead for the development of anti-prostate cancer agents
    • Zhang X, Haney KM, Richardson AC, Wilson E, Gewirtz DA, et al. (2010) Anibamine, a natural product CCR5 antagonist, as a novel lead for the development of anti-prostate cancer agents. Bioorg Med Chem Lett 20 (15): 4627-30.
    • (2010) Bioorg Med Chem Lett , vol.20 , Issue.15 , pp. 4627-4630
    • Zhang, X.1    Haney, K.M.2    Richardson, A.C.3    Wilson, E.4    Gewirtz, D.A.5
  • 24
    • 70350497687 scopus 로고    scopus 로고
    • Invasion associated up-regulation of nuclear factor kappaB target genes in colorectal cancer
    • Horst D, Budczies J, Brabletz T, Kirchner T, Hlubek F, (2009) Invasion associated up-regulation of nuclear factor kappaB target genes in colorectal cancer. Cancer 115 (21): 4946-58.
    • (2009) Cancer , vol.115 , Issue.21 , pp. 4946-4958
    • Horst, D.1    Budczies, J.2    Brabletz, T.3    Kirchner, T.4    Hlubek, F.5
  • 25
    • 68249095090 scopus 로고    scopus 로고
    • DNA/amphiphilic block copolymer nanospheres promote low-dose DNA vaccination
    • McIlroy D, Barteau B, Cany J, Richard P, Gourden C, et al. (2009) DNA/amphiphilic block copolymer nanospheres promote low-dose DNA vaccination. Mol Ther 17 (8): 1473-81.
    • (2009) Mol Ther , vol.17 , Issue.8 , pp. 1473-1481
    • McIlroy, D.1    Barteau, B.2    Cany, J.3    Richard, P.4    Gourden, C.5
  • 26
    • 78649636062 scopus 로고    scopus 로고
    • AFP-specific immunotherapy impairs growth of autochthonous hepatocellular carcinoma in mice
    • Cany J, Barteau B, Tran L, Gauttier V, Archambeaud I, et al. (2010) AFP-specific immunotherapy impairs growth of autochthonous hepatocellular carcinoma in mice. J Hepatol 54 (1): 115-21.
    • (2010) J Hepatol , vol.54 , Issue.1 , pp. 115-121
    • Cany, J.1    Barteau, B.2    Tran, L.3    Gauttier, V.4    Archambeaud, I.5
  • 27
    • 34047181954 scopus 로고    scopus 로고
    • Tissue-specific differential antitumour effect of molecular forms of fractalkine in a mouse model of metastatic colon cancer
    • Vitale S, Cambien B, Karimdjee BF, Barthel R, Staccini P, et al. (2007) Tissue-specific differential antitumour effect of molecular forms of fractalkine in a mouse model of metastatic colon cancer. Gut 56 (3): 365-72.
    • (2007) Gut , vol.56 , Issue.3 , pp. 365-372
    • Vitale, S.1    Cambien, B.2    Karimdjee, B.F.3    Barthel, R.4    Staccini, P.5
  • 28
    • 13044256383 scopus 로고    scopus 로고
    • A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity
    • Baba M, Nishimura O, Kanzaki N, Okamoto M, Sawada H, et al. (1999) A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Proc Natl Acad Sci U S A 96 (10): 5698-703.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.10 , pp. 5698-5703
    • Baba, M.1    Nishimura, O.2    Kanzaki, N.3    Okamoto, M.4    Sawada, H.5
  • 29
    • 0842284040 scopus 로고    scopus 로고
    • Neurons and astrocytes respond to prion infection by inducing microglia recruitment
    • Marella M, Chabry J, (2004) Neurons and astrocytes respond to prion infection by inducing microglia recruitment. J Neurosci 24 (3): 620-7.
    • (2004) J Neurosci , vol.24 , Issue.3 , pp. 620-627
    • Marella, M.1    Chabry, J.2
  • 30
    • 40249117273 scopus 로고    scopus 로고
    • PDGFRalpha/beta expression correlates with the metastatic behavior of human colorectal cancer: a possible rationale for a molecular targeting strategy
    • Wehler TC, Frerichs K, Graf C, Drescher D, Schimanski K, et al. (2008) PDGFRalpha/beta expression correlates with the metastatic behavior of human colorectal cancer: a possible rationale for a molecular targeting strategy. Oncol Rep 19 (3): 697-704.
    • (2008) Oncol Rep , vol.19 , Issue.3 , pp. 697-704
    • Wehler, T.C.1    Frerichs, K.2    Graf, C.3    Drescher, D.4    Schimanski, K.5
  • 32
    • 0035835829 scopus 로고    scopus 로고
    • Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation
    • Elenbaas B, Weinberg RA, (2001) Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation. Exp Cell Res 10;264 (1): 169-84.
    • (2001) Exp Cell Res , vol.10-264 , Issue.1 , pp. 169-184
    • Elenbaas, B.1    Weinberg, R.A.2
  • 33
    • 34247576326 scopus 로고    scopus 로고
    • Chemokine expression is associated with the accumulation of tumour associated macrophages (TAMs) and progression in human colorectal cancer
    • Bailey C, Negus R, Morris A, Ziprin P, Goldin R, et al. (2007) Chemokine expression is associated with the accumulation of tumour associated macrophages (TAMs) and progression in human colorectal cancer. Clin Exp Metastasis 24 (2): 121-30.
    • (2007) Clin Exp Metastasis , vol.24 , Issue.2 , pp. 121-130
    • Bailey, C.1    Negus, R.2    Morris, A.3    Ziprin, P.4    Goldin, R.5
  • 35
    • 78649719727 scopus 로고    scopus 로고
    • Targeting non-malignant disorders with tyrosine kinase inhibitors
    • Grimminger F, Schermuly RT, Ghofrani HA, Targeting non-malignant disorders with tyrosine kinase inhibitors. Nat Rev Drug Discov 9 (12): 956-70.
    • Nat Rev Drug Discov , vol.9 , Issue.12 , pp. 956-970
    • Grimminger, F.1    Schermuly, R.T.2    Ghofrani, H.A.3
  • 36
    • 0033816156 scopus 로고    scopus 로고
    • Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors
    • Buchdunger E, Cioffi CL, Law N, Stover D, Ohno-Jones S, et al. (2000) Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther 295 (1): 139-45.
    • (2000) J Pharmacol Exp Ther , vol.295 , Issue.1 , pp. 139-145
    • Buchdunger, E.1    Cioffi, C.L.2    Law, N.3    Stover, D.4    Ohno-Jones, S.5
  • 37
    • 17644383328 scopus 로고    scopus 로고
    • Chemosensitization by STI571 targeting the platelet-derived growth factor/platelet-derived growth factor receptor-signaling pathway in the tumor progression and angiogenesis of gastric carcinoma
    • Kim R, Emi M, Arihiro K, Tanabe K, Uchida Y, et al. (2005) Chemosensitization by STI571 targeting the platelet-derived growth factor/platelet-derived growth factor receptor-signaling pathway in the tumor progression and angiogenesis of gastric carcinoma. Cancer 103 (9): 1800-9.
    • (2005) Cancer , vol.103 , Issue.9 , pp. 1800-1809
    • Kim, R.1    Emi, M.2    Arihiro, K.3    Tanabe, K.4    Uchida, Y.5
  • 38
    • 34547643983 scopus 로고    scopus 로고
    • Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth and metastasis of human colon carcinoma
    • Kitadai Y, Sasaki T, Kuwai T, Nakamura T, et al. (2006) Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth and metastasis of human colon carcinoma. Am J Pathol 169 (6): 2054-65.
    • (2006) Am J Pathol , vol.169 , Issue.6 , pp. 2054-2065
    • Kitadai, Y.1    Sasaki, T.2    Kuwai, T.3    Nakamura, T.4
  • 39
    • 44449129861 scopus 로고    scopus 로고
    • Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy
    • Kuwai T, Nakamura T, Sasaki T, Kitadai Y, et al. (2008) Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy. Clin Exp Metastasis 25 (4): 477-89.
    • (2008) Clin Exp Metastasis , vol.25 , Issue.4 , pp. 477-489
    • Kuwai, T.1    Nakamura, T.2    Sasaki, T.3    Kitadai, Y.4
  • 40
    • 33846255485 scopus 로고    scopus 로고
    • A novel DNA vaccine encoding PDGFRbeta suppresses growth and dissemination of murine colon, lung and breast carcinoma
    • Kaplan CD, Kruger JA, Zhou H, Luo Y, Xiang R, et al. (2006) A novel DNA vaccine encoding PDGFRbeta suppresses growth and dissemination of murine colon, lung and breast carcinoma. Vaccine 24 (47-48): 6994-7002.
    • (2006) Vaccine , vol.24 , Issue.47-48 , pp. 6994-7002
    • Kaplan, C.D.1    Kruger, J.A.2    Zhou, H.3    Luo, Y.4    Xiang, R.5
  • 41
    • 0029039982 scopus 로고
    • Expression of platelet-derived growth factor B-chain and the platelet-derived growth factor receptor beta subunit in human breast tissue and breast carcinoma
    • Coltrera MD, Wang J, Porter PL, Gown AM, (1995) Expression of platelet-derived growth factor B-chain and the platelet-derived growth factor receptor beta subunit in human breast tissue and breast carcinoma. Cancer Res 55 (12): 2703-8.
    • (1995) Cancer Res , vol.55 , Issue.12 , pp. 2703-2708
    • Coltrera, M.D.1    Wang, J.2    Porter, P.L.3    Gown, A.M.4
  • 42
    • 0029978211 scopus 로고    scopus 로고
    • Localization of platelet-derived growth factor beta receptor expression in the periepithelial stroma of human breast carcinoma
    • Bhardwaj B, Klassen J, Cossette N, Sterns E, Tuck A, et al. (1996) Localization of platelet-derived growth factor beta receptor expression in the periepithelial stroma of human breast carcinoma. Clin Cancer Res 2 (4): 773-82.
    • (1996) Clin Cancer Res , vol.2 , Issue.4 , pp. 773-782
    • Bhardwaj, B.1    Klassen, J.2    Cossette, N.3    Sterns, E.4    Tuck, A.5
  • 43
    • 0030725954 scopus 로고    scopus 로고
    • Expression in lung carcinomas of platelet-derived growth factor and its receptors
    • Kawai T, Hiroi S, Torikata C, (1997) Expression in lung carcinomas of platelet-derived growth factor and its receptors. Lab Invest 77 (5): 431-6.
    • (1997) Lab Invest , vol.77 , Issue.5 , pp. 431-436
    • Kawai, T.1    Hiroi, S.2    Torikata, C.3
  • 44
    • 11244303506 scopus 로고    scopus 로고
    • Expression of tyrosine kinases in human malignancies as potential targets for kinase-specific inhibitors
    • Singer CF, Hudelist G, Lamm W, Mueller R, Czerwenka K, et al. (2004) Expression of tyrosine kinases in human malignancies as potential targets for kinase-specific inhibitors. Endocr Relat Cancer 11 (4): 861-9.
    • (2004) Endocr Relat Cancer , vol.11 , Issue.4 , pp. 861-869
    • Singer, C.F.1    Hudelist, G.2    Lamm, W.3    Mueller, R.4    Czerwenka, K.5
  • 45
    • 0033763567 scopus 로고    scopus 로고
    • Involvement of platelet-derived growth factor in disease: development of specific antagonists
    • Ostman A, Heldin CH, (2001) Involvement of platelet-derived growth factor in disease: development of specific antagonists. Adv Cancer Res 80: 1-38.
    • (2001) Adv Cancer Res , vol.80 , pp. 1-38
    • Ostman, A.1    Heldin, C.H.2
  • 47
    • 2942670180 scopus 로고    scopus 로고
    • PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma
    • Ostman A, (2004) PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma. Cytokine Growth Factor Rev 15 (4): 275-86.
    • (2004) Cytokine Growth Factor Rev , vol.15 , Issue.4 , pp. 275-286
    • Ostman, A.1
  • 48
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G, Song S, Meyer-Morse N, Bergsland E, Hanahan D, (2004) Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 111 (9): 1287-95.
    • (2004) J Clin Invest , vol.111 , Issue.9 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5


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