Baicalein inhibits angiogenesis induced by lipopolysaccharide through TRAF6 mediated toll-like receptor 4 pathway

Biomedicine and Preventive Nutrition

Volumn 1, Issue 3, 2011, Pages 172-179

  Ling, Yun ^a   Wang, Ling ^a   Chen, Yan ^a   Feng, Feng ^a   You, Qidong ^a   Lu, Na ^a   Guo, Qinglong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Angiogenesis; Baicalein; TNF receptor associated factor 6

Indexed keywords

BAICALEIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL VIABILITY; CHICKEN; CHORIOALLANTOIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO CULTURE; INTRACELLULAR SIGNALING; MIGRATION INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR RING; WESTERN BLOTTING;

EID: 83655196866     PISSN: 22105239     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bionut.2011.06.013     Document Type: Article

References (32)

1. Chi Y.S., Lim H., Park H., Kim H.P. Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. Biochem Pharmacol 2003, 66:1271-1278.
2. Liu J.J., Huang T.S., Cheng W.F., Lu F.J. Baicalein and baicalin are potent inhibitors of angiogenesis: inhibition of endothelial cell proliferation, migration and differentiation. Int J Cancer 2003, 106:559-565.
3. Folkman J., Shing Y. Angiogenesis. J Biol Chem 1992, 267:10931-10934.
4. Li W.W., Grayson G., Folkman J., D'Amore P.A. Sustained-release endotoxin. A model for inducing corneal neovascularization. Invest Ophthalmol Vis Sci 1991, 32:2906-2911.
5. Garcia F.U., Wojta J., Broadley K.N., Davidson J.M., Hoover R.L. Bartonella bacilliformis stimulates endothelial cells in vitro and is angiogenic in vivo. Am J Pathol 1990, 136:1125-1135.
6. Harmey J.H., Bucana C.D., Lu W., Byrne A.M., McDonnell S., Lynch C., et al. Lipopolysaccharide-induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion. Int J Cancer 2002, 101:415-422.
7. Poltorak A., He X., Smirnova I., Liu M.Y., Van Huffel C., Du X., et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in TLR4 gene. Science 1998, 282:2085-2088.
8. Pollet I., Opina C.J., Zimmerman C., Leong K.G., Wong F., Karsan A. Bacterial lipopolysaccharide directly induces angiogenesis through TRAF6-mediated activation of NF-kappaB and c-Jun N-terminal kinase. Blood 2003, 102:1740-1742.
9. van Leyen K., Kim H.Y., Lee S.R., Jin G., Arai K., Lo E.H. Baicalein and 12/15-lipoxygenase in the ischemic brain. Stroke 2006, 37:3014-3018.
10. Hsieh C.J., Hall K., Ha T., Li C., Krishnaswamy G., Chi D.S. Baicalein inhibits IL-1beta- and TNF-alpha-induced inflammatory cytokine production from human mast cells via regulation of the NF-kappaB pathway. Clin Mol Allergy 2007, 5:5.
11. Shao Z.H., Vanden Hoek T.L., Qin Y., Becker L.B., Schumacker P.T., Li C.Q., et al. Baicalein attenuates oxidant stress in cardiomyocytes. Am J Physiol 2002, 282:H999-H1006.
12. Ma Z., Otsuyama K., Liu S., Abroun S., Ishikawa H., Tsuyama N., et al. Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells. Blood 2005, 105:3312-3318.
13. Staton C.A., Stribbling S.M., Tazzyman S., Hughes R., Brown N.J., Lewis C.E. Current methods for assaying angiogenesis in vitro and in vivo. Int J Exp Pathol 2004, 85:233-248.
14. Tan W.F., Lin L.P., Li M.H., Zhang Y.X., Tong Y.G., Xiao D., et al. Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential. Eur J Pharmacol 2003, 459:255-262.
15. Ashton A.W., Yokota R., John G., Zhao S., Suadicani S.O., Spray D.C., et al. Inhibition of endothelial cell migration, intercellular communication, and vascular tube formation by thromboxane A(2). J Biol Chem 1999, 274:35562-35570.
16. Hochman E., Castiel A., Jacob-Hirsch J., Amariglio N., Izraeli S. Molecular pathways regulating pro-migratory effects of Hedgehog signaling. J Biol Chem 2006, 281:33860-33870.
17. Berger A.C., Wang X.Q., Zalatoris A., Cenna J., Watson J.C. A murine model of ex vivo angiogenesis using aortic disks grown in fibrin clot. Microvasc Res 2004, 68:179-187.
18. Hu Y., Yang Y., You Q.D., Liu W., Gu H.Y., Zhao L., et al. Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity. Biochem Biophys Res Commun 2006, 351:521-527.
19. Hofseth L.J, Ying L. Identifying and defusing weapons of mass inflammation in carcinogenesis. Biochim Biophys Acta 2006, 1765:74-84.
20. Majno G. Chronic inflammation: links with angiogenesis and wound healing. Am J Pathol 1998, 153:1035-1039.
21. Albini A., Tosetti F., Benelli R., Noonan D.M. Tumor inflammatory angiogenesis and its chemoprevention. Cancer Res 2005, 65:10637-10641.
22. Brakenhielm E., Cao R., Cao Y. Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes. FASEB J 2001, 15:1798-1800.
23. Igura K., Ohta T., Kuroda Y., Kaji K. Resveratrol and quercetin inhibit angiogenesis in vitro. Cancer Lett 2001, 171:11-16.
24. Tajiri H., Kozaiwa K., Ozaki Y., Miki K., Shimuzu K., Okada S. Effect of sho-saiko-to (xiao-chai-hu-tang) on HBeAg clearance in children with chronic hepatitis B virus infection and with sustained liver disease. Am J Chin Med 1991, 19:121-129.
25. Yano H., Mizoguchi A., Fukuda K., Haramaki M., Ogasawara S., Momosaki S., et al. The herbal medicine sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase. Cancer Res 1994, 54:448-454.
26. Baylor N.W., Fu T., Yan Y.D., Ruscetti F.W. Inhibition of human T cell leukemia virus by the plant flavonoid baicalin (7-glucuronic acid, 5,6-dihydroxyflavone). J Infect Dis 1992, 165:433-437.
27. Lin C.C., Shieh D.E. The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, baicalin, baicalein and wogonin. Am J Chin Med 1996, 24:31-36.
28. Tsan M.F. Toll-like receptors, inflammation and cancer. Sem Cancer Biol 2006, 16:32-37.
29. Lee M.S., Kim Y.J. Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu Rev Biochem 2007, 76:447-480.
30. Martin M., Katz J., Vogel S.N., Michalek S.M. Differential induction of endotoxin tolerance by lipopolysaccharides derived from Porphyromonas gingivalis and Escherichia coli. J Immunol 2001, 167:5278-5285.
31. Martin M., Rehani K., Jope R.S., Michalek S.M. Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol 2005, 6:777-784.
32. Monick M.M., Carter A.B., Robeff P.K., Flaherty D.M., Peterson M.W., Hunninghake G.W. Lipopolysaccharide activates Akt in human alveolar macrophages resulting in nuclear accumulation and transcriptional activity of beta-catenin. J Immunol 2001, 166:4713-4720.