-
1
-
-
29144523534
-
A human transporter protein that mediates the final excretion step for toxic organic cations
-
DOI 10.1073/pnas.0506483102
-
Otsuka M, Matsumoto T, Morimoto R, Arioka S, Omote H, Moriyama Y. A human transporter protein that mediates the fi nal excretion step for toxic organic cations. Proc Natl Acad Sci USA 2005;102:17923-8. (Pubitemid 41798478)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.50
, pp. 17923-17928
-
-
Otsuka, M.1
Matsumoto, T.2
Morimoto, R.3
Arioka, S.4
Omote, H.5
Moriyama, Y.6
-
2
-
-
34250005960
-
+-organic cation antiporters
-
DOI 10.1016/j.bcp.2007.04.010, PII S0006295207002298
-
Tanihara Y, Masuda S, Sato T, Katsura T, Ogawa O, Inui K. Substrate specifi city of MATE1 and MATE2-K, human multidrug and toxin extrusions/H( + )-organic cation antiporters. Biochem Pharmacol 2007;74:359-71. (Pubitemid 46890818)
-
(2007)
Biochemical Pharmacology
, vol.74
, Issue.2
, pp. 359-371
-
-
Tanihara, Y.1
Masuda, S.2
Sato, T.3
Katsura, T.4
Ogawa, O.5
Inui, K.-i.6
-
3
-
-
59649105503
-
Functional characterization of multidrug and toxin extrusion protein 1 as a facilitative transporter for fl uoroquinolones
-
Ohta K, Imamura Y, Okudaira N, Atsumi R, Inoue K, Yuasa H. Functional characterization of multidrug and toxin extrusion protein 1 as a facilitative transporter for fl uoroquinolones. J Pharmacol Exp Ther 2009;328:628-34.
-
(2009)
J Pharmacol Exp Ther
, vol.328
, pp. 628-34
-
-
Ohta, K.1
Imamura, Y.2
Okudaira, N.3
Atsumi, R.4
Inoue, K.5
Yuasa, H.6
-
4
-
-
0031836031
-
NorM, putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli
-
Morita Y, Kodama K, Shiota S, Mine T, Kataoka A, Mizushima T, et al. NorM, a putative multidrug effl ux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli. Antimicrob Agents Chemother 1998;42:1778-82. (Pubitemid 28311578)
-
(1998)
Antimicrobial Agents and Chemotherapy
, vol.42
, Issue.7
, pp. 1778-1782
-
-
Morita, Y.1
Kodama, K.2
Shiota, S.3
Mine, T.4
Kataoka, A.5
Mizushima, T.6
Tsuchiya, T.7
-
5
-
-
0032949426
-
The multidrug efflux protein NorM is a prototype of a new family of transporters [2]
-
DOI 10.1046/j.1365-2958.1999.01162.x
-
Brown MH, Paulsen IT, Skurray RA. The multidrug effl ux protein NorM is a prototype of a new family of transporters. Mol Microbiol 1999;42:394-5. (Pubitemid 29012178)
-
(1999)
Molecular Microbiology
, vol.31
, Issue.1
, pp. 394-395
-
-
Brown, M.H.1
Paulsen, I.T.2
Skurray, R.A.3
-
6
-
-
41949113401
-
Physiological and Pharmacokinetic Roles of H + /Organic Cation Antiporters (MATE/SLC47A)
-
Terada T, Inui KI. Physiological and pharmacokinetic roles of H + /organic cation antiporters (MATE/SLC47A)11. Biochem Pharmacol 2008;75:1689-96.
-
(2008)
Biochem Pharmacol
, vol.11
, Issue.75
, pp. 1689-96
-
-
Terada, T.1
Inui, K.I.2
-
7
-
-
33751168746
-
Cisplatin and Oxaliplatin, but Not Carboplatin and Nedaplatin, Are Substrates for Human Organic Cation Transporters (SLC22A1-3 and Multidrug and Toxin Extrusion Family)
-
Yonezawa A, Masuda S, Yokoo S, Katsura T, Inui Ki. Cisplatin and Oxaliplatin, but Not Carboplatin and Nedaplatin, Are Substrates for Human Organic Cation Transporters (SLC22A1-3 and Multidrug and Toxin Extrusion Family). J Pharmacol Exp Ther 2006;319:879-86.
-
(2006)
J Pharmacol Exp Ther
, vol.319
, pp. 879-86
-
-
Yonezawa, A.1
Masuda, S.2
Yokoo, S.3
Katsura, T.4
Inui, Ki.5
-
8
-
-
77950852256
-
Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: Functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms
-
Meyer zu Schwabedissen HE, Verstuyft C, Kroemer HK, Becquemont L, Kim RB. Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms. Am J Physiol Renal Physiol 2010;298:F997-1005.
-
(2010)
Am J Physiol Renal Physiol
, vol.298
-
-
Meyer, Z.1
Schwabedissen, H.E.2
Verstuyft, C.3
Kroemer, H.K.4
Becquemont, L.5
Kim, R.B.6
-
9
-
-
33746548445
-
+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2
-
DOI 10.1681/ASN.2006030205
-
Masuda S, Terada T, Yonezawa A, Tanihara Y, Kishimoto K, Katsura T, et al. Identifi cation and functional characterization of a new human kidney-specifi c H + /organic cation antiporter, kidney-specifi c multidrug and toxin extrusion 2. J Am Soc Nephrol 2006;17:2127-35. (Pubitemid 44141902)
-
(2006)
Journal of the American Society of Nephrology
, vol.17
, Issue.8
, pp. 2127-2135
-
-
Masuda, S.1
Terada, T.2
Yonezawa, A.3
Tanihara, Y.4
Kishimoto, K.5
Katsura, T.6
Ogawa, O.7
Inui, K.-I.8
-
10
-
-
60549103094
-
Expression of human organic cation transporter 3 in kidney carcinoma cell lines increases chemosensitivity to melphalan, irinotecan, and vincristine
-
Shnitsar V, Eckardt R, Gupta S, Grottker J, Muller GA, Koepsell H, et al. Expression of human organic cation transporter 3 in kidney carcinoma cell lines increases chemosensitivity to melphalan, irinotecan, and vincristine. Cancer Res 2009;69:1494-501.
-
(2009)
Cancer Res
, vol.69
, pp. 1494-501
-
-
Shnitsar, V.1
Eckardt, R.2
Gupta, S.3
Grottker, J.4
Muller, G.A.5
Koepsell, H.6
-
11
-
-
77954905149
-
Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1- defi cient mice
-
Watanabe S, Tsuda M, Terada T, Katsura T, Inui K. Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1- defi cient mice. J Pharmacol Exp Ther 2010;334:651-6.
-
(2010)
J Pharmacol Exp Ther
, Issue.334
, pp. 651-6
-
-
Watanabe, S.1
Tsuda, M.2
Terada, T.3
Katsura, T.4
Inui, K.5
-
12
-
-
79955092770
-
Interactions of tyrosine kinase inhibitors with organic cation transporters and multidrug and toxic compound extrusion proteins
-
Minematsu T, Giacomini KM. Interactions of tyrosine kinase inhibitors with organic cation transporters and multidrug and toxic compound extrusion proteins. Mol Cancer Ther 2011;10:531-9.
-
(2011)
Mol Cancer Ther
, Issue.10
, pp. 531-9
-
-
Minematsu, T.1
Giacomini, K.M.2
-
13
-
-
34547103001
-
Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family
-
DOI 10.1124/jpet.107.123554
-
Chen Y, Zhang S, Sorani M, Giacomini KM. Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family. J Pharmacol Exp Ther 2007;322:695-700. (Pubitemid 47105798)
-
(2007)
Journal of Pharmacology and Experimental Therapeutics
, vol.322
, Issue.2
, pp. 695-700
-
-
Chen, Y.1
Zhang, S.2
Sorani, M.3
Giacomini, K.M.4
-
14
-
-
77957929019
-
Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity
-
Nakamura T, Yonezawa A, Hashimoto S, Katsura T, Inui Ki. Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity. Biochem Pharmacol 2010;80:1762-7.
-
(2010)
Biochem Pharmacol
, Issue.80
, pp. 1762-7
-
-
Nakamura, T.1
Yonezawa, A.2
Hashimoto, S.3
Katsura, T.4
Inui, Ki.5
-
15
-
-
33749037182
-
Organic cation transporters are determinants of oxaliplatin cytotoxicity
-
DOI 10.1158/0008-5472.CAN-06-0769
-
Zhang S, Lovejoy KS, Shima JE, Lagpacan LL, Shu Y, Lapuk A, et al. Organic Cation Transporters Are Determinants of Oxaliplatin Cytotoxicity. Cancer Res 2006;66:8847-57. (Pubitemid 44449203)
-
(2006)
Cancer Research
, vol.66
, Issue.17
, pp. 8847-8857
-
-
Zhang, S.1
Lovejoy, K.S.2
Shima, J.E.3
Lagpacan, L.L.4
Shu, Y.5
Lapuk, A.6
Chen, Y.7
Komori, T.8
Gray, J.W.9
Chen, X.10
Lippard, S.J.11
Giacomini, K.M.12
-
16
-
-
51249105551
-
Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1
-
Sato T, Masuda S, Yonezawa A, Tanihara Y, Katsura T, Inui K. Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1. Biochem Pharmacol 2008;76:894-903.
-
(2008)
Biochem Pharmacol
, vol.76
, pp. 894-903
-
-
Sato, T.1
Masuda, S.2
Yonezawa, A.3
Tanihara, Y.4
Katsura, T.5
Inui, K.6
-
17
-
-
0027096415
-
A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues
-
DOI 10.1002/jps.2600810718
-
Fassberg J, Stella VJ. A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues. J Pharm Sci 1992; 81:676-84. (Pubitemid 23006796)
-
(1992)
Journal of Pharmaceutical Sciences
, vol.81
, Issue.7
, pp. 676-684
-
-
Fassberg, J.1
Stella, V.J.2
-
18
-
-
63849121023
-
Involvement of Human Multidrug and Toxin Extrusion 1 in the Drug Interaction between Cimetidine and Metformin in Renal Epithelial Cells
-
Tsuda M, Terada T, Ueba M, Sato T, Masuda S, Katsura T, et al. Involvement of Human Multidrug and Toxin Extrusion 1 in the Drug Interaction between Cimetidine and Metformin in Renal Epithelial Cells. J Pharmacol Exp Ther 2009;329:185-91.
-
(2009)
J Pharmacol Exp Ther
, vol.329
, pp. 185-91
-
-
Tsuda, M.1
Terada, T.2
Ueba, M.3
Sato, T.4
Masuda, S.5
Katsura, T.6
-
19
-
-
79956333806
-
Effects of a MATE Protein Inhibitor, Pyrimethamine, on the Renal Elimination of Metformin at Oral Microdose and at Therapeutic Dose in Healthy Subjects
-
Kusuhara H, Ito S, Kumagai Y, Jiang M, Shiroshita T, Moriyama Y, et al. Effects of a MATE Protein Inhibitor, Pyrimethamine, on the Renal Elimination of Metformin at Oral Microdose and at Therapeutic Dose in Healthy Subjects. Clin Pharmacol Ther 2011;89:837-44.
-
(2011)
Clin Pharmacol Ther
, Issue.89
, pp. 837-44
-
-
Kusuhara, H.1
Ito, S.2
Kumagai, Y.3
Jiang, M.4
Shiroshita, T.5
Moriyama, Y.6
-
20
-
-
0037348402
-
+ diffusion to the acidic pH of tumors
-
Schornack PA, Gillies RJ. Contributions of cell metabolism and H + diffusion to the acidic pH of tumors. Neoplasia 2003;5:135-45. (Pubitemid 36369009)
-
(2003)
Neoplasia
, vol.5
, Issue.2
, pp. 135-145
-
-
Schomack, P.A.1
Gillies, R.J.2
-
21
-
-
33745110220
-
Tumor pH controls the in vivo efficacy of weak acid and base chemotherapeutics
-
DOI 10.1158/1535-7163.MCT-06-0024
-
Gerweck LE, Vijayappa S, Kozin S. Tumor pH controls the in vivo effi cacy of weak acid and base chemotherapeutics. Mol Cancer Ther 2006;5:1275-9. (Pubitemid 43881320)
-
(2006)
Molecular Cancer Therapeutics
, vol.5
, Issue.5
, pp. 1275-1279
-
-
Gerweck, L.E.1
Vijayappa, S.2
Kozin, S.3
-
22
-
-
0036194956
-
Combined vascular and extracellular pH imaging of solid tumors
-
DOI 10.1002/nbm.743
-
Bhujwalla ZM, Artemov D, Ballesteros P, Cerdan S, Gillies RJ, Solaiyappan M. Combined vascular and extracellular pH imaging of solid tumors. NMR Biomed 2002;15:114-9. (Pubitemid 34213401)
-
(2002)
NMR in Biomedicine
, vol.15
, Issue.2
, pp. 114-119
-
-
Bhujwalla, Z.M.1
Artemov, D.2
Ballesteros, P.3
Cerdan, S.4
Gillies, R.J.5
Solaiyappan, M.6
-
23
-
-
77649216536
-
Membrane transporters in drug development
-
Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, et al. Membrane transporters in drug development. Nat Rev Drug Discov 2010;9:215-36.
-
(2010)
Nat Rev Drug Discov
, Issue.9
, pp. 215-36
-
-
Giacomini, K.M.1
Huang, S.M.2
Tweedie, D.J.3
Benet, L.Z.4
Brouwer, K.L.5
Chu, X.6
-
24
-
-
49949105228
-
Kidney-specifi c expression of human organic cation transporter 2 (OCT2/SLC22A2) is regulated by DNA methylation
-
Aoki M, Terada T, Kajiwara M, Ogasawara K, Ikai I, Ogawa O, et al. Kidney-specifi c expression of human organic cation transporter 2 (OCT2/SLC22A2) is regulated by DNA methylation. Am J Physiol Renal Physiol 2008;295:F165-170.
-
(2008)
Am J Physiol Renal Physiol
, vol.295
-
-
Aoki, M.1
Terada, T.2
Kajiwara, M.3
Ogasawara, K.4
Ikai, I.5
Ogawa, O.6
-
25
-
-
79956326438
-
And Effl ux: Important Determinants of Adverse Drug Reactions
-
Zolk O, Fromm MF. Transporter-Mediated Drug Uptake and Effl ux: Important Determinants of Adverse Drug Reactions. Clin Pharmacol Ther 2011;89:798-805.
-
(2011)
Clin Pharmacol Ther
, Issue.89
, pp. 798-805
-
-
Zolk, O.1
Fromm, M.F.2
Drug Uptake, T.3
-
26
-
-
33847139479
-
Organic anion transporters of the SLC22 family: Biopharmaceutical, physiological, and pathological roles
-
DOI 10.1007/s11095-006-9181-4
-
Rizwan AN, Burckhardt G. Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles. Pharm Res 2007;24:450-70. (Pubitemid 46295167)
-
(2007)
Pharmaceutical Research
, vol.24
, Issue.3
, pp. 450-470
-
-
Rizwan, A.N.1
Burckhardt, G.2
-
27
-
-
79955903884
-
Doubletransfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: Determinants of uptake and transcellular translocation of organic cations
-
Koenig J, Zolk O, Singer K, Hoffmann C, Fromm MF. Doubletransfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: determinants of uptake and transcellular translocation of organic cations. Br J Pharmacol 2001;163: 546-55.
-
(2001)
Br J Pharmacol
, vol.163
, pp. 546-55
-
-
Koenig, J.1
Zolk, O.2
Singer, K.3
Hoffmann, C.4
Fromm, M.F.5
-
28
-
-
77956235037
-
Preclinical and Clinical Evidence for the Collaborative Transport and Renal Secretion of an Oxazolidinone Antibiotic by Organic Anion Transporter 3 (OAT3/SLC22A8) and Multidrug and Toxin Extrusion Protein 1 (MATE1/SLC47A1)
-
Lai Y, Sampson KE, Balogh LM, Brayman TG, Cox SR, Adams WJ, et al. Preclinical and Clinical Evidence for the Collaborative Transport and Renal Secretion of an Oxazolidinone Antibiotic by Organic Anion Transporter 3 (OAT3/SLC22A8) and Multidrug and Toxin Extrusion Protein 1 (MATE1/SLC47A1). J Pharmacol Exp Ther 2010;334:936-44.
-
(2010)
J Pharmacol Exp Ther
, Issue.334
, pp. 936-44
-
-
Lai, Y.1
Sampson, K.E.2
Balogh, L.M.3
Brayman, T.G.4
Cox, S.R.5
Adams, W.J.6
-
29
-
-
70349440952
-
Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity
-
Filipski KK, Mathijssen RH, Mikkelsen TS, Schinkel AH, Sparreboom A. Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity. Clin Pharmacol Ther 2009;86:396-402.
-
(2009)
Clin Pharmacol Ther
, vol.86
, pp. 396-402
-
-
Filipski, K.K.1
Mathijssen, R.H.2
Mikkelsen, T.S.3
Schinkel, A.H.4
Sparreboom, A.5
-
30
-
-
78651376392
-
SLC22 transporter family proteins as targets for cytostatic uptake into tumor cells
-
Gupta S, Burckhardt G, Hagos Y. SLC22 transporter family proteins as targets for cytostatic uptake into tumor cells. Biol Chem 2011;392:117-24.
-
(2011)
Biol Chem
, Issue.392
, pp. 117-24
-
-
Gupta, S.1
Burckhardt, G.2
Hagos, Y.3
-
31
-
-
20744450287
-
Characterization of the organic cation transporter SLC22A16: A doxorubicin importer
-
DOI 10.1016/j.bbrc.2005.05.174, PII S0006291X05011873
-
Okabe M, Unno M, Harigae H, Kaku M, Okitsu Y, Sasaki T, et al. Characterization of the organic cation transporter SLC22A16: a doxorubicin importer. Biochem Biophys Res Commun 2005;333:754-62. (Pubitemid 40854224)
-
(2005)
Biochemical and Biophysical Research Communications
, vol.333
, Issue.3
, pp. 754-762
-
-
Okabe, M.1
Unno, M.2
Harigae, H.3
Kaku, M.4
Okitsu, Y.5
Sasaki, T.6
Mizoi, T.7
Shiiba, K.8
Takanaga, H.9
Terasaki, T.10
Matsuno, S.11
Sasaki, I.12
Ito, S.13
Abe, T.14
-
32
-
-
54049145153
-
Profi ling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters
-
Okabe M, Szakacs G, Reimers MA, Suzuki T, Hall MD, Abe T, et al. Profi ling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters. Mol Cancer Ther 2008;7:3081-91.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3081-91
-
-
Okabe, M.1
Szakacs, G.2
Reimers, M.A.3
Suzuki, T.4
Hall, M.D.5
Abe, T.6
|