Building an ommatidium one cell at a time

Developmental Dynamics

Volumn 241, Issue 1, 2012, Pages 136-149

  Kumar, Justin P ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

Cone cell; Drosophila; Ommatidium; Photoreceptor; Pigment cell; Retina

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; NOTCH RECEPTOR; RAS PROTEIN;

APOPTOSIS; CELL COMMUNICATION; CELL MATURATION; CELL POLARITY; CELL PROLIFERATION; DROSOPHILA MELANOGASTER; ELECTRON MICROSCOPY; EMBRYO DEVELOPMENT; EYE; EYE COLOR; EYE DEVELOPMENT; INTERNALIZATION; LENS; LOSS OF FUNCTION MUTATION; MICROSCOPY; NONHUMAN; OMMATIDIUM; ORGANOGENESIS; PHENOTYPE; PHOTORECEPTOR; PHOTORECEPTOR CELL; PIGMENT CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RETINA CONE; REVIEW; SIGNAL TRANSDUCTION; TISSUE STRUCTURE; UBIQUITINATION;

ANIMALS; DROSOPHILA MELANOGASTER; GENE EXPRESSION REGULATION, DEVELOPMENTAL; ORGANOGENESIS; PHOTORECEPTOR CELLS, INVERTEBRATE; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 83655165387     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.23707     Document Type: Review

References (150)

1. Baker NE, Yu S, Han D. 1996. Evolution of proneural atonal expression during distinct regulatory phases in the developing Drosophila eye. Curr Biol 6: 1290-1301.
2. Banerjee U, Renfranz PJ, Hinton DR, Rabin BA, Benzer S. 1987a. The sevenless+ protein is expressed apically in cell membranes of developing Drosophila retina; it is not restricted to cell R7. Cell 51: 151-158.
3. Banerjee U, Renfranz PJ, Pollock JA, Benzer S. 1987b. Molecular characterization and expression of sevenless, a gene involved in neuronal pattern formation in the Drosophila eye. Cell 49: 281-291.
4. Barrio R, de Celis JF, Bolshakov S, Kafatos FC. 1999. Identification of regulatory regions driving the expression of the Drosophila spalt complex at different developmental stages. Dev Biol 215: 33-47.
5. Basler K, Hafen E. 1988. Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain. Cell 54: 299-311.
6. Basler K, Hafen E. 1989a. Dynamics of Drosophila eye development and temporal requirements of sevenless expression. Development 107: 723-731.
7. Basler K, Hafen E. 1989b. Ubiquitous expression of sevenless: position-dependent specification of cell fate. Science 243: 931-934.
8. Basler K, Siegrist P, Hafen E. 1989. The spatial and temporal expression pattern of sevenless is exclusively controlled by gene-internal elements. EMBO J 8: 2381-2386.
9. Basler K, Yen D, Tomlinson A, Hafen E. 1990. Reprogramming cell fate in the developing Drosophila retina: transformation of R7 cells by ectopic expression of rough. Genes Dev 4: 728-739.
10. Basler K, Christen B, Hafen E. 1991. Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye. Cell 64: 1069-1081.
11. Batterham P, Crew JR, Sokac AM, Andrews JR, Pasquini GM, Davies AG, Stocker RF, Pollock JA. 1996. Genetic analysis of the lozenge gene complex in Drosophila melanogaster: adult visual system phenotypes. J Neurogenet 10: 193-220.
12. Begemann G, Michon AM, vd Voorn L, Wepf R, Mlodzik M. 1995. The Drosophila orphan nuclear receptor seven-up requires the Ras pathway for its function in photoreceptor determination. Development 121: 225-235.
13. Benzer S. 1967. Behavioral mutants of Drosophila isolated by countercurrent distribution. Proc Natl Acad Sci U S A 58: 1112-1119.
14. Benzer S. 1971. From the gene to behavior. JAMA 218: 1015-1022.
15. Benzer S. 1973. Genetic dissection of behavior. Sci Am 229: 24-37.
16. Biggs WH III, Zavitz KH, Dickson B, van der Straten A, Brunner D, Hafen E, Zipursky SL. 1994. The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway. EMBO J 13: 1628-1635.
17. Bernard F. 1937. Rescherches sur la morphogenese des yeux composes d'arthropodes. Bull Biol Fr Belg 23( suppl).
18. Bonfini L, Karlovich CA, Dasgupta C, Banerjee U. 1992. The Son of sevenless gene product: a putative activator of Ras. Science 255: 603-606.
19. Bonini NM, Leiserson WM, Benzer S. 1993. The eyes absent gene: genetic control of cell survival and differentiation in the developing Drosophila eye. Cell 72: 379-395.
20. Bowtell DD, Simon MA, Rubin GM. 1988. Nucleotide sequence and structure of the sevenless gene of Drosophila melanogaster. Genes Dev 2: 620-634.
21. Bowtell DD, Kimmel BE, Simon MA, Rubin GM. 1989a. Regulation of the complex pattern of sevenless expression in the developing Drosophila eye. Proc Natl Acad Sci U S A 86: 6245-6249.
22. Bowtell DD, Simon MA, Rubin GM. 1989b. Ommatidia in the developing Drosophila eye require and can respond to sevenless for only a restricted period. Cell 56: 931-936.
23. Brachmann CB, Cagan RL. 2003. Patterning the fly eye: the role of apoptosis. Trends Genet 19: 91-96.
24. Brunner D, Oellers N, Szabad J, Biggs WH III, Zipursky SL, Hafen E. 1994. A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways. Cell 76: 875-888.
25. Cagan RL, Ready DF. 1989a. The emergence of order in the Drosophila pupal retina. Dev Biol 136: 346-362.
26. Cagan RL, Ready DF. 1989b. Notch is required for successive cell decisions in the developing Drosophila retina. Genes Dev 3: 1099-1112.
27. Cagan RL, Kramer H, Hart AC, Zipursky SL. 1992. The bride of sevenless and sevenless interaction: internalization of a transmembrane ligand. Cell 69: 393-399.
28. Campos-Ortega JA, Hofbauer A. 1977. Cell clones and pattern formation: On the lineage of photoreceptor cells in the compound eye of Drosophila. Wilhelm Roux's Archives 181: 227-245.
29. Carthew RW, Rubin GM. 1990. seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye. Cell 63: 561-577.
30. Cavodeassi F, del Corral RD, Campuzano S, Dominguez M. 1999. Compartments and organizing boundaries in the Drosophila eye: the role of the homeodomain Iroguois proteins. Development 128: 4933-4942.
31. Chang HC, Solomon NM, Wassarman DA, Karim FD, Therrien M, Rubin GM, Wolff T. 1995. phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila. Cell 80: 463-472.
32. Chanut F, Luk A, Heberlein U. 2000. A screen for dominant modifiers of ro(Dom), a mutation that disrupts morphogenetic furrow progression in Drosophila, identifies groucho and hairless as regulators of atonal expression. Genetics 156: 1203-1217.
33. Cheyette BN, Green PJ, Martin K, Garren H, Hartenstein V, Zipursky SL. 1994. The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system. Neuron 12: 977-996.
34. Cooper MT, Bray SJ. 2000. R7 photoreceptor specification requries Notch activity. Curr Biol 10: 1507-1510.
35. Daga A, Karlovich CA, Dumstrei K, Banerjee U. 1996. Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1. Genes Dev 10: 1194-1205.
36. de Nooij JC, Hariharan IK. 1995. Uncoupling cell fate determination from patterned cell division in the Drosophila eye. Science 270: 983-985.
37. Diaz-Benjumea FJ, Hafen E. 1994. The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development. Development 120: 569-578.
38. Dickson B, Sprenger F, Hafen E. 1992a. Prepattern in the developing Drosophila eye revealed by an activated torso--sevenless chimeric receptor. Genes Dev 6: 2327-2339.
39. Dickson B, Sprenger F, Morrison D, Hafen E. 1992b. Raf functions downstream of Ras1 in the Sevenless signal transduction pathway. Nature 360: 600-603.
40. Dickson BJ, Dominguez M, van der Straten A, Hafen E. 1995. Control of Drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the Raf kinase. Cell 80: 453-462.
41. Dietrich W. 1909. Die Fazettenaugen der Dipteren. Z Wiss Zool 92: 465-539.
42. Dokucu ME, Zipursky SL, Cagan RL. 1996. Atonal, rough and the resolution of proneural clusters in the developing Drosophila retina. Development 122: 4139-4147.
43. Domingos PM, Mlodzik M, Mendes CS, Brown S, Steller H, Mollereau B. 2004. Spalt transcription factors are required for R3/R4 specification and establishment of planar cell polarity in the Drosophila eye. Development 131: 5695-5702.
44. Dominguez M, De Celis JF. 1998. A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye. Nature 396: 276-279.
45. Dominguez M, Wasserman JD, Freeman M. 1998. Multiple functions of the EGF receptor in Drosophila eye development. Curr Biol 8: 1039-1048.
46. Dos-Santos N, Rubin T, Chalvet F, Gandille P, Cremazy F, Leroy J, Boissonneau E, Theodore L. 2008. Drosophila retinal pigment cell death is regulated in a position-dependent manner by a cell memory gene. Int J Dev Biol 52: 21-31.
47. Fanto M, Mlodzik M. 1999. Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye. Nature 397: 523-526.
48. Fanto M, Mayes CA, Mlodzik M. 1998. Linking cell-fate specification to planar polarity: determination of the R3/R4 photoreceptors is a prerequisite for the interpretation of the Frizzled mediated polarity signal. Mech Dev 74: 51-58.
49. Ferris GF. 1950. External morphoogy of the adult. In: Demerec M, editor. Biology of Drosophila. New York: Wiley. p 368-419.
50. Flores GV, Daga A, Kalhor HR, Banerjee U. 1998. Lozenge is expressed in pluripotent precursor cells and patterns multiple cell types in the Drosophila eye through the control of cell-specific transcription factors. Development 125: 3681-3687.
51. Flores GV, Duan H, Yan H, Nagaraj R, Fu W, Zou Y, Noll M, Banerjee U. 2000. Combinatorial signaling in the specification of unique cell fates. Cell 103: 75-85.
52. Fortini ME, Simon MA, Rubin GM. 1992. Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation. Nature 355: 559-561.
53. Fortini ME, Rebay I, Caron LA, Artvanis-Tsakonas S. 1993. An activated Notch receptor blocks cell fate commitment in the developing eye. Nature 365: 555-557.
54. Frankfort BJ, Mardon G. 2004. Senseless represses nuclear transduction of Egfr pathway activation. Development 131: 563-570.
55. Frankfort BJ, Nolo R, Zhang Z, Bellen H, Mardon G. 2001. senseless repression of rough is required for R8 photoreceptor differentiation in the developing Drosophila eye. Neuron 32: 403-414.
56. Freeman M. 1994. The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor. Mech Dev 48: 25-33.
57. Freeman M. 1996. Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87: 651-660.
58. Freeman M. 1997. Cell determination strategies in the Drosophila eye. Development 124: 261-270.
59. Freeman M, Klambt C, Goodman CS, Rubin GM. 1992. The argos gene encodes a diffusible factor that regulates cell fate decisions in the Drosophila eye. Cell 69: 963-975.
60. Fu W, Noll M. 1997. The Pax2 homolog sparkling is required for development of cone and pigment cells in the Drosophila eye. Genes Dev 11: 2066-2078.
61. Fu W, Duan H, Frei E, Noll M. 1998. shaven and sparkling are mutations in separate enhancers of the Drosophila Pax2 homolog. Development 125: 2943-2950.
62. Gaul U, Mardon G, Rubin GM. 1992. A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase. Cell 68: 1007-1019.
63. Gehring W. 1966. Cell heredity and changes of determination in cultures of imaginal discs in Drosophila melanogaster. J Embryol Exp Morphol 15: 77-111.
64. Hafen E, Basler K, Edstroem JE, Rubin GM. 1987. Sevenless, a cell-specific homeotic gene of Drosophila, encodes a putative transmembrane receptor with a tyrosine kinase domain. Science 236: 55-63.
65. Hafen E, Dickson B, Raabe T, Brunner D, Oellers N, van der Straten A. 1993. Genetic analysis of the sevenless signal transduction pathway of Drosophila. Dev Suppl 41-46.
66. Hanson TE, Ready DF, Benzer S. 1972. Use of mosaics in the analysis of pattern formation in the retina of Drosophila. Caltech Biol Annu Rept 40.
67. Harris WA, Stark WS, Walker JA. 1976. Genetic dissection of the photoreceptor system in the compound eye of Drosophila melanogaster. J Physiol 256: 415-439.
68. Hart AC, Kramer H, Van Vactor DL Jr, Paidhungat M, Zipursky SL. 1990. Induction of cell fate in the Drosophila retina: the bride of sevenless protein is predicted to contain a large extracellular domain and seven transmembrane segments. Genes Dev 4: 1835-1847.
69. Hayashi T, Kojima T, Saigo K. 1998. Specification of primary pigment cell and outer photoreceptor fates by BarH1 homeobox gene in the developing Drosophila eye. Dev Biol 200: 131-145.
70. Haynie JL, Bryant PJ. 1986. Development of the eye-antenna imaginal disc and morphogenesis of the adult head in Drosophila melanogaster. J Exp Zool 237: 293-308.
71. Heberlein U, Mlodzik M, Rubin GM. 1991. Cell-fate determination in the developing Drosophila eye: role of the rough gene. Development 112: 703-712.
72. Higashijima S, Kojima T, Michiue T, Ishimaru S, Emori Y, Saigo K. 1992. Dual Bar homeo box genes of Drosophila required in two photoreceptor cells, R1 and R6, and primary pigment cells for normal eye development. Genes Dev 6: 50-60.
73. Hiromi Y, Mlodzik M, West SR, Rubin GM, Goodman CS. 1993. Ectopic expression of seven-up causes cell fate changes during ommatidial assembly. Development 118: 1123-1135.
74. Hofbauer A, Campos-Ortega JA. 1976. Cell clones and pattern formation: genetic eye mosaics in Drosophila melanogaster. Wilhelm Roux Arch 179: 275-289.
75. Horowitz H, Berg CA. 1996. The Drosophila pipsqueak gene encodes a nuclear BTB-domain-containing protein required early in oogenesis. Development 122: 1859-1871.
76. Hsu JC, Perrimon N. 1994. A temperature-sensitive MEK mutation demonstrates the conservation of the signaling pathways activated by receptor tyrosine kinases. Genes Dev 8: 2176-2187.
77. Jarman AP, Grell EH, Ackerman L, Jan LY, Jan YN. 1994. atonal is the proneural gene for Drosophila photoreceptors. Nature 369: 398-400.
78. Jarman AP, Sun Y, Jan LY, Jan YN. 1995. Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors. Development 121: 2019-2030.
79. Jenny A. 2010. Planar cell polarity signaling in the Drosophila eye. Curr Top Dev Biol 93: 190-219.
80. Kimmel BE, Heberlein U, Rubin GM. 1990. The homeo domain protein rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype. Genes Dev 4: 712-727.
81. Kojima T, Ishimaru S, Higashijima S, Takayama E, Akimaru H, Sone M, Emori Y, Saigo K. 1991. Identification of a different-type homeobox gene, BarH1, possibly causing Bar (B) and Om(1D) mutations in Drosophila. Proc Natl Acad Sci U S A 88: 4343-4347.
82. Kramer H, Cagan RL, Zipursky SL. 1991. Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor. Nature 352: 207-212.
83. Kramer S, West SR, Hiromi Y. 1995. Cell fate control in the Drosophila retina by the orphan receptor seven-up: its role in the decisions mediated by the ras signaling pathway. Development 121: 1361-1372.
84. Kumar JP. 2010. Retinal determination: the beginning of eye development. Curr Top Dev Biol 93: 1-28.
85. Kumar JP. 2011. My what big eyes you have: how the Drosophila retina grows. Dev Neurobiol 71: 1133-1152.
86. Kumar JP, Tio M, Hsiung F, Akopyan S, Gabay L, Seger R, Shilo BZ, Moses K. 1998. Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation. Development 125: 3875-3885.
87. Lai ZC, Rubin GM. 1992. Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein. Cell 70: 609-620.
88. Lai ZC, Harrison SD, Karim F, Li Y, Rubin GM. 1996. Loss of tramtrack gene activity results in ectopic R7 cell formation, even in a sina mutant background. Proc Natl Acad Sci U S A 93: 5025-5030.
89. Larson DE, Liberman Z, Cagan RL. 2008. Cellular behavior in the developing pupal retina. Mech Dev 125: 223-232.
90. Larson DE, Johnson RI, Swat M, Cordero JB, Glazier JA, Cagan RL. 2010. Computer simulation of cellular patterning within the Drosophila pupal eye. PLoS Comput Biol 6: e1000841.
91. Lawrence PA, Green SM. 1979. Cell lineage in the developing retina of Drosophila. Dev Biol 71: 142-152.
92. Lesokhin AM, Yu SY, Katz J, Baker NE. 1999. Several levels of EGF receptor signaling during photoreceptor specification in wild-type, Ellipse, and null mutant Drosophila. Dev Biol 205: 129-144.
93. Li S, Xu C, Carthew RW. 2002. Phyllopod acts as an adaptor protein to link the sina ubiquitin ligase to the substrate protein tramtrack. Mol Cell Biol 22: 6854-6865.
94. Li S, Li Y, Carthew RW, Lai ZC. 1997. Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack. Cell 90: 469-478.
95. Madhaven MM, Schneiderman HA. 1977. Histological analysis of the dynamics of growth of imaginal discs and histoblast nests during the larval development of Drosophila melanogaster. Wilhelm Roux Arch 183: 269-305.
96. Meyerowitz EM, Kankel DR. 1978. A genetic analysis of visual system development in Drosophilia melanogaster. Dev Biol 62: 112-142.
97. Miller DT, Cagan RL. 1998. Local induction of patterning and programmed cell death in the developing drosophila retina. Development 125: 2327-2335.
98. Miller AC, Seymour H, King C, Herman TG. 2008. Loss of seven-up from Drosophila R1/R6 photoreceptors reveals a stochastic fate choice that is normally biased by Notch. Development 135: 707-715.
99. Mlodzik M, Hiromi Y, Weber U, Goodman CS, Rubin GM. 1990. The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates. Cell 60: 211-224.
100. Mollereau B, Wernet MF, Beaufils P, Killian D, Pichaud F, Kuhnlein R, Desplan C. 2000. A green fluorescent protein enhancer trap screen in Drosophila photoreceptor cells. Mech Dev 93: 151-160.
101. Morgan TH. 1910. Sex limited inheritance in Drosophila. Science 32: 120-122.
102. Mullins MC, Rubin GM. 1991. Isolation of temperature-sensitive mutations of the tyrosine kinase receptor sevenless (sev) in Drosophila and their use in determining its time of action. Proc Natl Acad Sci U S A 88: 9387-9391.
103. Nagaraj R, Banerjee U. 2007. Combinatorial signaling in the specification of primary pigment cells in the Drosophila eye. Development 134: 825-831.
104. Nolo R, Abbott LA, Bellen HJ. 2000. Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila. Cell 102: 349-362.
105. O'Neill EM, Rebay I, Tjian R, Rubin GM. 1994. The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell 78: 137-147.
106. Olivier JP, Raabe T, Henkemeyer M, Dickson B, Mbamalu G, Margolis B, Schlessinger J, Hafen E, Pawson T. 1993. A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell 73: 179-191.
107. Ouweneel WJ. 1970. Normal and abnormal determination in the imaginal discs of Drosophila, with special reference to the eye discs. Acta Embryol Exp (Palermo) 1: 95-119.
108. Pepple KL, Atkins M, Venken K, Wellnitz K, Harding M, Frankfort B, Mardon G. 2008. Two-step selection of a single R8 photoreceptor: a bistable loop between senseless and rough locks in R8 fate. Development 135: 4071-4079.
109. Pickup AT, Ming L, Lipshitz HD. 2009. Hindsight modulates Delta expression during Drosophila cone cell induction. Development 136: 975-982.
110. Poulson DF. 1950. Histogensis, organogenesis and differentiation in the embryo of Drosophila melanogaster. In: Demerec M, editor. Biology of Drosophila. New York: Wiley. p 368-419.
111. Protzer CE, Wech I, Nagel AC. 2008. Hairless induces cell death by downregulation of EGFR signaling activity. J Cell Sci 121: 3167-3176.
112. Quiring R, Walldorf U, Kloter U, Gehring WJ. 1994. Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans [see comments]. Science 265: 785-789.
113. Raabe T. 2000. The sevenless signaling pathway: variations of a common theme. Biochim Biophys Acta 1496: 151-163.
114. Ready DF, Hanson TE, Benzer S. 1976. Development of the Drosophila retina, a neurocrystalline lattice. Dev Biol 53: 217-240.
115. Rebay I, Rubin GM. 1995. Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway. Cell 81: 857-866.
116. Reinke R, Zipursky SL. 1988. Cell-cell interaction in the Drosophila retina: the bride of sevenless gene is required in photoreceptor cell R8 for R7 cell development. Cell 55: 321-330.
117. Rogge RD, Karlovich CA, Banerjee U. 1991. Genetic dissection of a neurodevelopmental pathway: son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases. Cell 64: 39-48.
118. Serikaku MA, O'Tousa JE. 1994. sine oculis is a homeobox gene required for Drosophila visual system development. Genetics 138: 1137-1150.
119. Shi Y, Noll M. 2009. Determination of cell fates in the R7 equivalence group of the Drosophila eye by the concerted regulation of D-Pax2 and TTK88. Dev Biol 331: 68-77.
120. Simon MA, Bowtell DD, Rubin GM. 1989. Structure and activity of the sevenless protein: a protein tyrosine kinase receptor required for photoreceptor development in Drosophila. Proc Natl Acad Sci U S A 86: 8333-8337.
121. Simon MA, Bowtell DD, Dodson GS, Laverty TR, Rubin GM. 1991. Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. Cell 67: 701-716.
122. Singh A, Lim J, Kwang-Wook C. 2005. Dorsoventral boundary for organizing growth and planar polarity in the Drosophila eye. Adv Dev Biol 14: 59-90.
123. Sun Y, Jan LY, Jan YN. 1998. Transcriptional regulation of atonal during development of the Drosophila peripheral nervous system. Development 125: 3731-3740.
124. Swanson CI, Evans NC, Barolo S. 2010. Structural rules and complex regulatory circuitry constrain expression of a Notch- and EGFR-regulated eye enhancer. Dev Cell 18: 359-370.
125. Tanenbaum SB, Gorski SM, Rusconi JC, Cagan RL. 2000. A screen for dominant modifiers of the irreC-rst cell death phenotype in the developing Drosophila retina. Genetics 156: 205-217.
126. Tang AH, Neufeld TP, Kwan E, Rubin GM. 1997. PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism. Cell 90: 459-467.
127. Tice SC. 1914. A new sex-linked character in Drosophila. Biol Bull 26: 221-230.
128. Tio M, Moses K. 1997. The Drosophila TGF alpha homolog Spitz acts in photoreceptor recruitment in the developing retina. Development 124: 343-351.
129. Tio M, Ma C, Moses K. 1994. spitz, a Drosophila homolog of transforming growth factor-alpha, is required in the founding photoreceptor cells of the compound eye facets. Mech Dev 48: 13-23.
130. Tomlinson A. 1985. The cellular dynamics of pattern formation in the eye of Drosophila. J Embryol Exp Morpol 89: 313-331.
131. Tomlinson A, Ready DF. 1986. sevenless: a cell specific homeotic mutation of the Drosophila eye. Science 231: 400-402.
132. Tomlinson A, Ready DF. 1987a. Cell fate in the Drosophila ommatidium. Dev Biol 123: 264-275.
133. Tomlinson A, Ready DF. 1987b. Neuronal differentiation in the Drosophila ommatidium. Dev Biol 120: 366-376.
134. Tomlinson A, Struhl G. 2001. Delta/Notch and Boss/Sevenless signals act combinatorially to specify the Drosophila R7 photoreceptor. Mol Cell 7: 487-495.
135. Tomlinson A, Bowtell DD, Hafen E, Rubin GM. 1987. Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila. Cell 51: 143-150.
136. Tomlinson A, Kimmel BE, Rubin GM. 1988. rough, a Drosophila homeobox gene required in photoreceptors R2 and R5 for inductive interactions in the developing eye. Cell 55: 771-784.
137. Tomlinson A, Mavromatakis YE, Struhl G. 2011. Three distinct roles for Notch in Drosophila R7 photoreceptor specification. PloS Biol 9: e100132.
138. Van Vactor DL Jr, Cagan RL, Kramer H, Zipursky SL. 1991. Induction in the developing compound eye of Drosophila: multiple mechanisms restrict R7 induction to a single retinal precursor cell. Cell 67: 1145-1155.
139. Vogt M. 1946. Zur labilen Determination der Imagin-alscheiben von Drosophila. I. Verhalten verschieden-altriger Imaginalanlagen bei operativer Defektsetzung. Biol Zbl 65: 223-238.
140. Waddington CH, Perry MM. 1960. The ultrastructure of the developing eye of Drosophila. Proc R Soc Biol Sci 153: 155-178.
141. Weber U, Siegel V, Mlodzik M. 1995. pipsqueak encodes a novel nuclear protein required downstream of seven-up for the development of photoreceptors R3 and R4. EMBO J 14: 6247-6257.
142. Wigglesworth VB. 1953. The origin of sensory neurones in an insect, Rhodnius prolixus (Hemiptera). Q J Microsc Sci 94: 93-112.
143. Wolff T, Ready DF. 1991a. The beginning of pattern formation in the Drosophila compound eye: the morphogenetic furrow and the second mitotic wave. Development 113: 841-850.
144. Wolff T, Ready DF. 1991b. Cell death in normal and rough eye mutants of Drosophila. Development 113: 825-839.
145. Xiong WC, Montell C. 1993. tramtrack is a transcriptional repressor required for cell fate determination in the Drosophila eye. Genes Dev 7: 1085-1096.
146. Xu T, Rubin GM. 1993. Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117: 1223-1237.
147. Yan H, Canon J, Banerjee U. 2003. A transcriptional chain linking eye specification to terminal determination of cone cells in the Drosophila eye. Dev Biol 263: 323-329.
148. Yang L, Baker NE. 2001. Role of the EGFR/Ras/Raf pathway in specification of photoreceptor cells in the Drosophila retina. Development 128: 1183-1191.
149. Zak NB, Shilo BZ. 1992. Localization of DER and the pattern of cell divisions in wild-type and Ellipse eye imaginal discs. Dev Biol 149: 448-456.
150. Zheng L, Zhang J, Carthew RW. 1995. frizzled regulates mirror-symmetric pattern formation in the Drosophila eye. Development 121: 3045-3055.