Danshen-Gegen decoction protects against hypoxia/reoxygenation-induced apoptosis by inhibiting mitochondrial permeability transition via the redox-sensitive ERK/Nrf2 and PKCε/mK ATP pathways in H9c2 cardiomyocytes

Phytomedicine

Volumn 19, Issue 2, 2012, Pages 99-110

  Chiu, Po Yee ^a   Leung, Hoi Yan ^a   Leong, Pou Kuan ^a   Chen, Na ^a   Zhou, Limin ^b   Zuo, Zhong ^b   Lam, Philip Y ^a   Ko, Kam Ming ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b Prince of Wales Hospital   (Hong Kong)

Author keywords

Apoptosis; Extracellular signal regulated protein kinase (ERK); H9c2; Mitochondrial permeability transition; Protein kinase C epsilon (PKC ); Puerariae lobatae; Salviae miltiorrhizae

Indexed keywords

CHINESE DRUG; CYTOCHROME P450; GLUTATHIONE; HEME OXYGENASE 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN BAD; PROTEIN KINASE B; PROTEIN KINASE C EPSILON; PUERARIAE LOBATAE EXTRACT; REACTIVE OXYGEN METABOLITE; SALVIA MILTIORRHIZA EXTRACT; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL HYPOXIA; CELL LEVEL; CELL PROTECTION; CHINESE HERB; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME MECHANISM; HEART MUSCLE CELL; HEART PROTECTION; INTRACELLULAR TRANSPORT; MITOCHONDRIAL PERMEABILITY; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; PUERARIAE LOBATAE; RAT; REOXYGENATION; SALVIA MILTIORRHIZA;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BLOTTING, WESTERN; CALCIUM; CELL HYPOXIA; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; CYTOPROTECTION; CYTOSOL; DRUGS, CHINESE HERBAL; MAP KINASE SIGNALING SYSTEM; METHANOL; MITOCHONDRIA, HEART; MYOCYTES, CARDIAC; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; PERMEABILITY; PROTEIN KINASE C-EPSILON; PROTEIN TRANSPORT; PUERARIA; RATS; REACTIVE OXYGEN SPECIES; SALVIA MILTIORRHIZA;

EID: 83655163840     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2011.07.002     Document Type: Article

References (43)

1. J.D. Adams, R. Wang, J. Yang, and E.J. Lien Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions Chin. Med. 1 2006 3
2. C.P. Baines, J. Zhang, G.W. Wang, Y.T. Zheng, J.X. Xiu, E.M. Cardwell, R. Bolli, and P. Ping Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection Circ. Res. 90 2002 390 397 (Pubitemid 34633907)
3. S.V. Bannur, S.V. Kulgod, S.S. Metkar, S.K. Mahajan, and J.K. Sainis Protein determination by ponceau S using digital color image analysis of protein spots on nitrocellulose membranes Anal. Biochem. 267 1999 382 389 (Pubitemid 29095887)
4. S. Bansal, C.P. Liu, N.B. Sepuri, H.K. Anandatheerthavarada, V. Selvaraj, J. Hoek, G.L. Milne, F.P. Guengerich, and N.G. Avadhani Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress J. Biol. Chem. 285 2010 24609 24619
5. Q. Chang, L. Sun, R.H. Zhao, M.S. Chow, and Z. Zuo Simultaneous determination of ten active components in traditional Chinese medicinal products containing both Gegen (Pueraria lobata) and Danshen (Salvia miltiorrhiza) by high-performance liquid chromatography Phytochem. Anal. 19 2008 368 375
6. P.Y. Chiu, N. Chen, P.K. Leong, H.Y. Leung, and K.M. Ko Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in H9c2 cells Mol. Cell. Biochem. 350 2011 237 250
7. P.Y. Chiu, and K.M. Ko Schisandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats Mol. Cell. Biochem. 266 2004 139 144 (Pubitemid 39562314)
8. P.Y. Chiu, H.Y. Leung, M.K. Poon, D.H. Mak, and K.M. Ko (-)Schisandrin B is more potent than its enantiomer in enhancing cellular glutathione and heat shock protein production as well as protecting against oxidant injury in H9c2 cardiomyocytes Mol. Cell. Biochem. 289 2006 185 191 (Pubitemid 44322488)
9. P.Y. Chiu, K.F. Luk, H.Y. Leung, K.M. Ng, and K.M. Ko Schisandrin B stereoisomers protect against hypoxia/reoxygenation-induced apoptosis and inhibit associated changes in Ca2+-induced mitochondrial permeability transition and mitochondrial membrane potential in H9c2 cardiomyocytes Life Sci. 82 2008 1092 1101
10. P.Y. Chiu, S.M. Wong, H.Y. Leung, N. Chen, L. Zhou, Z. Zuo, P.Y. Lam, and K.M. Ko Acute treatment with Danshen-Gegen decoction protects the myocardium against ischemia/reperfusion injury via the redox-sensitive PKCε/mKATP pathway in rats Phytomedicine 2011 10.1016/j.phymed.2011.03.006
11. P.Y. Chiu, S.M. Wong, H.Y. Leung, P.K. Leong, N. Chen, L. Zhou, Z. Zuo, P.Y. Lam, and K.M. Ko Long-term treatment with Danshen-Gegen decoction protects the myocardium against ischemia/reperfusion injury via the redox-sensitive protein kinase C-epsilon/mK(ATP) pathway in rats Rejuven. Res. 14 2011 173 184
12. M.L. Circu, and T.Y. Aw Reactive oxygen species, cellular redox systems, and apoptosis Free Radical Biol. Med. 48 2010 749 762
13. A.D. Costa, and K.D. Garlid Intramitochondrial signaling: interactions among mitoKATP, PKCepsilon, ROS, and MPT Am. J. Physiol Heart Circ. Physiol. 295 2008 H874 H882
14. S.R. Datta, A. Katsov, L. Hu, A. Petros, S.W. Fesik, M.B. Yaffe, and M.E. Greenberg 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation Mol. Cell 6 2000 41 51
15. G.W. Dorn, M.C. Souroujon, T. Liron, C.H. Chen, M.O. Gray, H.Z. Zhou, M. Csukai, G. Wu, J.N. Lorenz, and D. Mochly-Rosen Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation Proc. Natl. Acad. Sci. U. S. A. 96 1999 12798 12803 (Pubitemid 29513582)
16. C.C. Franklin, D.S. Backos, I. Mohar, C.C. White, H.J. Forman, and T.J. Kavanagh Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase Mol. Aspects Med. 30 2009 86 98
17. Q. Gao, H.Y. Pan, S. Qiu, Y. Lu, I.C. Bruce, J.H. Luo, and Q. Xia Atractyloside and 5-hydroxydecanoate block the protective effect of puerarin in isolated rat heart Life Sci. 79 2006 217 224 (Pubitemid 43782549)
18. K.D. Garlid, A.D. Costa, C.L. Quinlan, S.V. Pierre, and S.P. Dos Cardioprotective signaling to mitochondria J. Mol. Cell. Cardiol. 46 2009 858 866
19. O.W. Griffith Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine Anal. Biochem. 106 1980 207 212 (Pubitemid 11246585)
20. A.P. Halestrap, S.J. Clarke, and I. Khaliulin The role of mitochondria in protection of the heart by preconditioning Biochim. Biophys. Acta 1767 2007 1007 1031 (Pubitemid 47101788)
21. D. Han, N. Hanawa, B. Saberi, and N. Kaplowitz Mechanisms of liver injury, III. Role of glutathione redox status in liver injury Am. J. Physiol Gastrointest. Liver Physiol. 291 2006 G1 G7 (Pubitemid 44024656)
22. J. Hescheler, R. Meyer, S. Plant, D. Xrautwurst, W. Rosenthal, and G. Schultz Morphological, biochemical and electrophysiological characterization of a clonal cell (H9c2) line from rat heart Circ. Res. 69 1991 1476 1486
23. M. Jaburek, A.D. Costa, J.R. Burton, C.L. Costa, and K.D. Garlid Mitochondrial PKC epsilon and mitochondrial ATP-sensitive K+ channel copurify and coreconstitute to form a functioning signaling module in proteoliposomes Circ. Res. 99 2006 878 883 (Pubitemid 44556387)
24. M. Jain, D.A. Brenner, L. Cui, C.C. Lim, B. Wang, D.R. Pimentel, S. Koh, D.B. Sawyer, J.A. Leopold, D.E. Handy, J. Loscalzo, C.S. Apstein, and R. Liao Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes Circ. Res. 93 2003 e9 e16
25. J. Jeyapaul, and A.K. Jaiswal Nrf2 and c-Jun regulation of antioxidant response element (ARE)-mediated expression and induction of gamma- glutamylcysteine synthetase heavy subunit gene Biochem. Pharmacol. 59 2000 1433 1439 (Pubitemid 30177361)
26. X. Ji, B.K. Tan, Y.C. Zhu, W. Linz, and Y.Z. Zhu Comparison of cardioprotective effects using ramipril and DanShen for the treatment of acute myocardial infarction in rats Life Sci. 73 2003 1413 1426 (Pubitemid 36794583)
27. X.Y. Ji, B.K. Tan, and Y.Z. Zhu Salvia miltiorrhiza and ischemic diseases Acta Pharmacol. Sin. 21 2000 1089 1094 (Pubitemid 32012715)
28. M. Juhaszova, D.B. Zorov, S.H. Kim, S. Pepe, Q. Fu, K.W. Fishbein, B.D. Ziman, S. Wang, K. Ytrehus, C.L. Antos, E.N. Olson, and S.J. Sollott Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore J. Clin. Invest. 113 2004 1535 1549 (Pubitemid 39071677)
29. A.M. Kabir, J.E. Clark, M. Tanno, X. Cao, J.S. Hothersall, S. Dashnyam, D.A. Gorog, M. Bellahcene, M.J. Shattock, and M.S. Marber Cardioprotection initiated by reactive oxygen species is dependent on activation of PKCepsilon Am. J. Physiol Heart Circ. Physiol. 291 2006 H1893 H1899 (Pubitemid 44497697)
30. T.W. Kensler, N. Wakabayashi, and S. Biswal Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway Annu. Rev. Pharmacol. Toxicol. 47 2007 89 116
31. J.W. Kim, Y.C. Jin, Y.M. Kim, S. Rhie, H.J. Kim, H.G. Seo, J.H. Lee, Y.L. Ha, and K.C. Chang Daidzein administration in vivo reduces myocardial injury in a rat ischemia/reperfusion model by inhibiting NF-kappaB activation Life Sci. 84 2009 227 234
32. W. Langston, M.L. Circu, and T.Y. Aw Insulin stimulation of gamma-glutamylcysteine ligase catalytic subunit expression increases endothelial GSH during oxidative stress: influence of low glucose Free Radic. Biol. Med. 45 2008 1591 1599
33. X.P. Liu, C.E. Goldring, I.M. Copple, H.Y. Wang, W. Wei, N.R. Kitteringham, and B.K. Park Extract of Ginkgo biloba induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway Life Sci. 80 2007 1586 1591 (Pubitemid 46412359)
34. E. Robin, R.D. Guzy, G. Loor, H. Iwase, G.B. Waypa, J.D. Marks, T.L. Hoek, and P.T. Schumacker Oxidant stress during simulated ischemia primes cardiomyocytes for cell death during reperfusion J. Biol. Chem. 282 2007 19133 19143 (Pubitemid 47100157)
35. D.P. Sieveking, K.S. Woo, K.P. Fung, P. Lundman, S. Nakhla, and D.S. Celermajer Chinese herbs Danshen and Gegen modulate key early atherogenic events in vitro Int. J. Cardiol. 105 2005 40 45 (Pubitemid 41408528)
36. J.R. Slupsky, A.S. Kamiguti, R.J. Harris, J.C. Cawley, and M. Zuzel Central role of protein kinase Cepsilon in constitutive activation of ERK1/2 and Rac1 in the malignant cells of hairy cell leukemia Am. J. Pathol. 170 2007 745 754 (Pubitemid 47339408)
37. W.Y. Tam, P. Chook, M. Qiao, L.T. Chan, T.Y. Chan, Y.K. Poon, K.P. Fung, P.C. Leung, and K.S. Woo The efficacy and tolerability of adjunctive alternative herbal medicine (Salvia miltiorrhiza and Pueraria lobata) on vascular function and structure in coronary patients J. Altern. Complement. Med. 15 2009 415 421
38. Y. Tan, M.R. Demeter, H. Ruan, and M.J. Comb BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival J. Biol. Chem. 275 2000 25865 25869
39. D. Trachootham, W. Lu, M.A. Ogasawara, R.D. Nilsa, and P. Huang Redox regulation of cell survival Antioxid. Redox Signal. 10 2008 1343 1374
40. G.Y. Wang, J.J. Zhou, J. Shan, and T.M. Wong Protein kinase C-epsilon is a trigger of delayed cardioprotection against myocardial ischemia of kappa-opioid receptor stimulation in rat ventricular myocytes J. Pharmacol. Exp. Ther. 299 2001 603 610 (Pubitemid 32979673)
41. S.M. Wong, P.Y. Chiu, H.Y. Leung, L. Zhou, Z. Zuo, P.Y. Lam, and K.M. Ko Myocardial post-conditioning with Danshen-Gegen decoction protects against isoproterenol-induced myocardial injury via a PKCε/mKATP-mediated pathway in rats Chinas Med. 6 2011 7
42. R.Q. Xie, J. Du, and Y.M. Hao Myocardial protection and mechanism of Puerarin Injection on patients of coronary heart disease with ischemia/reperfusion Zhongguo Zhong. Xi. Yi. Jie. He. Za Zhi. 23 2003 895 897 (in Chinese)
43. Y. Zhang, R. Munday, H.E. Jobson, C.M. Munday, C. Lister, P. Wilson, J.W. Fahey, and P. Mhawech-Fauceglia Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sprouts J. Agric. Food Chem. 54 2006 9370 9376 (Pubitemid 46086094)